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European Journal of Human Genetics, ISSN 1018-4813, 09/2012, Volume 20, Issue 9, pp. 984 - 985
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2011, Volume 186, Issue 2, pp. 1131 - 1139
The regulation of neutrophil recruitment, activation, and disposal is pivotal for circumscribed inflammation. SHP1(Y208N/Y208N) mutant mice develop severe... 
MOTH-EATEN MICE | DEATH DOMAIN | RESPIRATORY BURST | MUTANT MICE | NPM-ALK | CELL LYMPHOMA | GENE-EXPRESSION | NECROSIS-FACTOR-ALPHA | INFLUENZA-VIRUS | IMMUNOLOGY | TYROSINE-PHOSPHATASE | Humans | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - physiology | Skin Diseases - pathology | Paracrine Communication - immunology | Skin Diseases - prevention & control | Signal Transduction - immunology | Mice, Mutant Strains | Bone Marrow Cells - immunology | Inflammation Mediators - metabolism | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptors - physiology | Inflammation Mediators - antagonists & inhibitors | Interleukin-1beta - biosynthesis | Autoimmune Diseases - pathology | Inflammation Mediators - physiology | Neutrophils - metabolism | Interleukin-1beta - antagonists & inhibitors | Neutrophils - pathology | Severity of Illness Index | Interleukin-1beta - physiology | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Bone Marrow Cells - pathology | Neutrophils - immunology | Paracrine Communication - genetics | Autoimmune Diseases - prevention & control | Skin Diseases - immunology | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Mice, Knockout | Animals | Mice | Bone Marrow Cells - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2010, Volume 35, Issue 4, pp. 299 - 308
Abstract Proteinase 3 (PR3)-specific antineutrophil cytoplasmic antibodies (ANCA) are highly specific for the autoimmune small vessel vasculitis, Wegener’s... 
Allergy and Immunology | Vasculitis | ANCA | Wegener’s granulomatosis | Proteinase 3 | proteinase 3 | vasculitis
Journal Article
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 08/2018, Volume 37, Issue 8, p. 1021
Vascular damage and primary graft dysfunction increase with prolonged preservation times of transplanted donor lungs. Hence, storage and conservation of... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2014, Volume 124, Issue 10, p. 4445
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2014, Volume 124, Issue 10, pp. 4445 - 4445
In this paper, the authors determined that in aging neutrophils, the cleavage and activation of caspase-3 is independent of the canonical caspase-8-or... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2008, Volume 105, Issue 37, p. 13799
  How granzymes gain entry into the cytosol of target cells during killer cell attack has been the subject of several studies in the past, but the effective... 
Enzymes | Cells | Binding sites | Apoptosis
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/2010, Volume 185, Issue 1, pp. 387 - 399
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 2001, Volume 69, Issue 3, pp. 516 - 527
Homologous recombination between poorly characterized regions flanking the NF1 locus causes the constitutional loss of ∼1.5 Mb from 17q11.2 covering ⩾11 genes... 
GROSS DELETIONS | DELETION PATIENTS | RECOMBINATION | ENTIRE NF1 GENE | SEQUENCES | GENOMIC DISORDERS | GENETICS & HEREDITY | PHENOTYPE | REARRANGEMENTS | HNPP DELETION | CMT1A | Genetic aspects | Chromosome deletion | Genetic recombination | Neurofibromatosis | Analysis
Journal Article
FEBS Letters, ISSN 0014-5793, 03/2004, Volume 562, Issue 1-3, pp. 87 - 92
Granzyme B (GzmB) is a potent apoptosis-inducing serine protease of cytotoxic lymphocytes. Following receptor-mediated endocytosis, GzmB is supposed to enter... 
Lewis Y | Tumor | Immunotoxin | Granzyme B | Apoptosis | CI-MPR, cation-independent mannose-6-phosphate/insulin-like growth factor receptor | BSA, bovine serum albumin | FACS, fluorescence-activated cell sorter | PI, propidium iodide | GzmB, granzyme B | α1-AT, α1-antitrypsin | PBS, phosphate-buffered saline | NK, natural killer | CTL, cytotoxic T lymphocytes | CrmA, cytokine response modifier A | SLO, streptolysin O | PR3, proteinase 3 | PE38, Pseudomonas exotoxin fragment 38 | RT, room temperature | AT, α | antitrypsin | CYTOSOLIC DELIVERY | granzyme B | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXINS | apoptosis | RECEPTOR | DEATH | MEDIATED APOPTOSIS | FV FRAGMENT | CELL BIOLOGY | BIOPHYSICS | tumor | immunotoxin | PSEUDOMONAS EXOTOXIN | Recombinant Fusion Proteins - immunology | T-Lymphocytes, Cytotoxic - immunology | Cell Line | Peptide Fragments - metabolism | Membrane Glycoproteins - metabolism | Bacterial Toxins - immunology | Granzymes | Humans | Receptors, Cell Surface - metabolism | Recombinant Fusion Proteins - metabolism | Bacterial Toxins - metabolism | Animals | T-Lymphocytes, Cytotoxic - metabolism | Peptide Fragments - immunology | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Recombinant Fusion Proteins - genetics | Lewis Blood-Group System - metabolism | Lewis Blood-Group System - genetics | Pore Forming Cytotoxic Proteins | Serine Endopeptidases - metabolism | Apoptosis - physiology | Perforin | Lewis Blood-Group System - immunology
Journal Article
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