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Pharmaceutical Research, ISSN 0724-8741, 3/2019, Volume 36, Issue 3, pp. 1 - 14
Fast-acting insulin aspart (faster aspart) is a novel formulation of insulin aspart containing two additional excipients: niacinamide, to increase early... 
Biochemistry, general | Biomedicine | oligomerization | absorption | fast-acting insulin aspart | vasodilation | Pharmacy | niacinamide | Medical Law | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | absorption; fast-acting insulin aspart; niacinamide; oligomerization; vasodilation | SUBCUTANEOUS INJECTION | GLYCEMIC CONTROL | PROFILES | HYDROTROPIC SOLUBILIZATION | NICOTINAMIDE | BLOOD-FLOW | CHEMISTRY, MULTIDISCIPLINARY | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | ONSET | Hypoglycemic Agents - pharmacokinetics | Endothelial Cells - metabolism | Humans | Cells, Cultured | Insulin Aspart - pharmacokinetics | Scattering, Small Angle | Subcutaneous Absorption - drug effects | Diabetes Mellitus, Type 1 - drug therapy | Dose-Response Relationship, Drug | Insulin Aspart - administration & dosage | Animals | Regional Blood Flow - drug effects | Hypoglycemic Agents - administration & dosage | Models, Biological | X-Ray Diffraction | Diabetes Mellitus, Type 1 - blood | Injections, Subcutaneous | Subcutaneous Tissue - blood supply | Female | Niacinamide - pharmacology | Vasodilation - drug effects | Subcutaneous Tissue - metabolism | Sus scrofa | Subcutaneous Tissue - drug effects | Oligomers | Niacinamide | Arginine | Swine | Vasodilators | Permeability | Insulin | Endothelium | Pharmacology | Stability analysis | Small angle X ray scattering | Arteries | Monomers | Endothelial cells | Vasodilation | Blood flow | X-ray scattering | Absorption | Perfusion | Skin | X ray scattering | Transport | Research Paper
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2007, Volume 104, Issue 3, pp. 937 - 942
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 08/2007, Volume 17, Issue 15, p. 4144
Y-shaped molecules bearing alkynylallylic moieties were found to be potent and selective PPARdelta activators. The alkynylallylic moiety was synthesized from... 
PPAR delta - agonists | Models, Molecular | Molecular Structure
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2007, Volume 17, Issue 15, p. 4144
Selective PPAR[delta] agonists, 6, were obtained by SAR study of structural changes of the PPARpan agonist 5. 
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 08/2007, Volume 17, Issue 16, p. 4625
Structure based ligand design was used in order to design a partial agonist for the PPARdelta receptor. The maximum activation in the transactivation assay was... 
Phenylurea Compounds - chemistry | Butyrates - pharmacology | PPAR delta - agonists | Butyrates - chemistry | Drug Design | Models, Molecular | Thiazoles - chemistry | Molecular Structure | Phenylurea Compounds - pharmacology | Structure-Activity Relationship | Thiazoles - pharmacology
Journal Article
Diabetes, ISSN 0012-1797, 06/2005, Volume 54, p. A239
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2007, Volume 50, Issue 7, pp. 1495 - 1503
The aim was to identify a novel selective PPARδ agonist with full efficacy on free fatty acid (FFA) oxidation in vitro and plasma lipid correction in vivo.... 
ACTIVATED-RECEPTOR-DELTA | SKELETAL-MUSCLE | CELLS | BETA/DELTA | CHEMISTRY, MEDICINAL | ACID | PIOGLITAZONE | ACCURATE DOCKING | ALPHA | 3,4,5-TRISUBSTITUTED ISOXAZOLES | EXPRESSION
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2007, Volume 17, Issue 16, pp. 4625 - 4629
Structure based ligand design was used in order to design a partial agonist for the PPARδ receptor. The maximum activation in the transactivation assay was... 
Design | Docking | Agonist | Partial | PPARd | ACTIVATION | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | GLIDE | agonist | docking | IN-VITRO | PIOGLITAZONE | METABOLISM | ACCURATE DOCKING | design | partial | PEROXISOME
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 11, pp. 3198 - 3202
Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARα agonists. Optimum PPARα... 
PPARα | Docking | Agonist | docking | CHEMISTRY, MEDICINAL | ACCURATE DOCKING | CHEMISTRY, ORGANIC | PPAR alpha | GLIDE | agonist
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 06/2007, Volume 17, Issue 11, p. 3198
Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARalpha agonists. Optimum... 
Computers | Phenylpropionates - pharmacology | Animals | Phenylpropionates - chemistry | Drug Design | Phenylpropionates - chemical synthesis | Ligands | PPAR alpha - agonists | Crystallography | PPAR alpha - chemistry
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 01/2007, Volume 104, Issue 3, pp. 937 - 942
The peptide hormone glucagon-like peptide (GLP)-1 has important actions resulting in glucose lowering along with weight loss in patients with type 2 diabetes.... 
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 03/1988, Volume 16, Issue 5, pp. 2127 - 2148
Journal Article
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