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Experimental Hematology, ISSN 0301-472X, 09/2017, Volume 53, pp. S93 - S93
Journal Article
Experimental Hematology, ISSN 0301-472X, 09/2017, Volume 53, pp. S82 - S82
Journal Article
Developmental Cell, ISSN 1534-5807, 05/2019, Volume 49, Issue 3, pp. 311 - 312
Dormant cancer cells often survive treatment and increase the risk for tumor relapse, associated with dismal prognosis. Two recent papers describe mechanisms... 
SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | LEUKEMIA | CELL BIOLOGY | Leukemia | Hematopoietic stem cells
Journal Article
Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6367, p. eaan4368
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug... 
REFINEMENT | PROTEIN | CHEMICAL PROTEOMICS | INHIBITOR SELECTIVITY | DATA QUALITY | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | INTEGRATIVE GENOMICS VIEWER | SALT-INDUCIBLE KINASES | CANCER | COMPREHENSIVE ANALYSIS | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Lung Neoplasms - enzymology | Cytokines - metabolism | Humans | Drug Discovery - methods | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Xenograft Model Antitumor Assays | Leukemia, Myeloid, Acute - enzymology | Protein Kinase Inhibitors - chemistry | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Proteomics - methods | Salts | Target recognition | Lung cancer | Selectivity | Drug development | Cancer therapies | Signal transduction | Biomolecules | Protein-tyrosine kinase | Tyrosine | Medical research | Imatinib | Decision making | Medical treatment | Mass spectroscopy | Tumor necrosis factor-α | Embryos | Bruton's tyrosine kinase | Mode of action | Side effects | Inhibitors | Interleukin 10 | Affinity | Drug discovery | Mass spectrometry | Acute myeloid leukemia | Drugs | Deregulation | Leukemia | Interleukin | Medical services | Clinical trials | Leucine | Kinases | Biological effects | Epidermal growth factor | Salt-inducible kinase | Xenografts | Cell survival | Epidermal growth factor receptors | Research & development--R&D | Therapeutic applications | Myeloid leukemia | Markers | Data processing | Lead compounds | Leucine zipper proteins | Signaling | Proteomics | Cancer | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 69 - 78
In acute myeloid leukemia (AML), therapy resistance frequently occurs, leading to high mortality among patients. However, the mechanisms that render leukemic... 
TRANSFORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | SOMATIC MUTATIONS | CELL BIOLOGY | THERAPY | GENE EZH2 | DIFFERENTIATION | INHIBITOR | EXPRESSION | Immunohistochemistry | CDC2 Protein Kinase | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Neoplasm Transplantation | Cyclin-Dependent Kinases - metabolism | Cytarabine - pharmacology | Immunoprecipitation | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Bortezomib - pharmacology | Gene Knockdown Techniques | Young Adult | Flow Cytometry | Mass Spectrometry | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Blotting, Western | Homeodomain Proteins - genetics | Drug Resistance, Neoplasm - genetics | Protein Kinase Inhibitors | Animals | Proteomics | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Aged | Mice | Protein Processing, Post-Translational | Histones - metabolism | Proteasome Endopeptidase Complex - metabolism | Pyridones - pharmacology | Leukemia, Myeloid, Acute - genetics | Genetic aspects | Methyltransferases | Drug resistance | Health aspects | Drugs | Therapy | Hsp90 protein | Phosphorylation | Leukemia | Chemoresistance | Cytotoxicity | Kinases | Degradation | Proteins | Cytarabine | Restoration | Histone methyltransferase | HOX gene | Protein-tyrosine kinase | Tyrosine | Bortezomib | Myeloid leukemia | Heat shock proteins | Gene expression | Patients | Sensitivity | Inhibitors | Derepression | Cell lines | Proteasomes | Blast resistance | Methylation | Acute myeloid leukemia | Heat shock | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0120925 - e0120925
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1801 - 18
Journal Article
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2018, Volume 1100, pp. 127 - 139
Journal Article
Cell Reports, ISSN 2211-1247, 12/2015, Volume 13, Issue 12, pp. 2715 - 2727
Journal Article
Experimental Hematology, ISSN 0301-472X, 09/2017, Volume 53, pp. S73 - S73
Journal Article
Cell Communication and Signaling, ISSN 1478-811X, 2012, Volume 10, Issue 1, pp. 8 - 8
Background: Signaling studies in cell lines are hampered by non-physiological alterations obtained in vitro. Physiologic primary tumor cells from patients with... 
APOPTOSIS | RESISTANT | DISEASE | GENE-EXPRESSION | TUMOR-CELLS | PROLIFERATION | MODEL | CANCER | CHILDHOOD | LINES | CELL BIOLOGY | Development and progression | Cellular signal transduction | Research | Acute lymphocytic leukemia | Pediatrics | Mutation | Efficiency | Experiments | Leukemia | Apoptosis
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5378 - 13
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, pp. e52798 - e52798
Background: Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary... 
IMPACT | EVOLUTION | THERAPY | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | STEM-CELL | CANCER | MOUSE MODELS | LUCIFERASE | XENOGRAFTS | Gene Expression | Humans | Child, Preschool | Infant | Male | Recombinant Proteins - genetics | Antineoplastic Agents - administration & dosage | Recombinant Proteins - biosynthesis | Mice, SCID | Xenograft Model Antitumor Assays - methods | Cell Tracking | Luciferases - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Tumor Burden - drug effects | Adolescent | Female | Whole Body Imaging | Mice | Tumor Cells, Cultured | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Child | Luciferases - biosynthesis | Precision Medicine | Growth | Oncology, Experimental | Luciferase | Bone marrow | Transplantation | Research | Cancer | Biotechnology | Bioluminescence | Animal models | Design parameters | Disease | Leukemia | Medical services | Clinical trials | Oncology | Kinases | Ethics | Light emission | Xenografts | Monitoring | Medical research | Image resolution | Acute lymphatic leukemia | Hematology | Tumor cells | Environmental health | Minimal residual disease | Lymphatic leukemia | Patients | Studies | Dilution | Cell number | Pharmacy | Cell lines | Stem cells | In vivo methods and tests | Genetic engineering | Bone imaging | Tumors | Pharmaceuticals | Index Medicus
Journal Article