Frontiers in Immunology, ISSN 1664-3224, 10/2019, Volume 10
The concept of immunizing against gonorrhea has received renewed interest because of the recent emergence of strains of Neisseria gonorrhoeae that are...
vaccine | antibodies | Neisseria gonorrhoeae | immunity | antigens | T cells
vaccine | antibodies | Neisseria gonorrhoeae | immunity | antigens | T cells
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2018, Volume 62, Issue 8
ABSTRACTThe gonococcal NorM efflux pump exports substrates with a cationic moiety, including quaternary ammonium compounds such as berberine (BE) and ethidium...
Journal Article
Annual Review of Microbiology, ISSN 0066-4227, 01/2017, Volume 71, p. 665
Gonorrhea, an obligate human infection, is on the rise worldwide and gonococcal strains resistant to many antibiotics are emerging. Appropriate antimicrobial...
Animal models | Sexually transmitted diseases--STD | Genital tract | Pathogenesis | Pharmacology | Accelerated tests | Infections | Vaccines | Gonorrhea | Drug resistance | Chemical compounds | Antiinfectives and antibacterials | Immunosuppression | Reviews | Antibiotics | Rodents | Females | Fitness
Animal models | Sexually transmitted diseases--STD | Genital tract | Pathogenesis | Pharmacology | Accelerated tests | Infections | Vaccines | Gonorrhea | Drug resistance | Chemical compounds | Antiinfectives and antibacterials | Immunosuppression | Reviews | Antibiotics | Rodents | Females | Fitness
Journal Article
Antimicrobial agents and chemotherapy, 08/2018, Volume 62, Issue 8
The gonococcal NorM efflux pump exports substrates with a cationic moiety, including quaternary ammonium compounds such as berberine (BE) and ethidium bromide...
Journal Article
Methods in molecular biology (Clifton, N.J.), 2019, Volume 1997, p. 413
Mouse models of infection are important tools in the study of infectious disease or host the development of products to prevent or treat infections. The...
Journal Article
Vaccine, ISSN 0264-410X, 11/2019, Volume 37, Issue 50, pp. 7419 - 7426
There is a growing public health interest in controlling sexually transmitted infections (STIs) through vaccination due to increasing recognition of the global...
Vaccine | Pelvic inflammatory disease | Gonorrhea | Ophthalmia neonatorum | Infertility | Antibiotic resistance | Neonates | Sexually transmitted diseases--STD | Vaccination | Medical services | Infections | Vaccines | Inflammatory diseases | Reproduction | Chlamydia | Human immunodeficiency virus--HIV | Public health | Pathogens | Antigens | Reproductive systems | Immunoglobulins | Research & development--R&D | Complications | Medical treatment | Socio-economic aspects | Antimicrobial agents | Disease control | Pregnancy | Antibiotics | Surveillance | Womens health | Feasibility
Vaccine | Pelvic inflammatory disease | Gonorrhea | Ophthalmia neonatorum | Infertility | Antibiotic resistance | Neonates | Sexually transmitted diseases--STD | Vaccination | Medical services | Infections | Vaccines | Inflammatory diseases | Reproduction | Chlamydia | Human immunodeficiency virus--HIV | Public health | Pathogens | Antigens | Reproductive systems | Immunoglobulins | Research & development--R&D | Complications | Medical treatment | Socio-economic aspects | Antimicrobial agents | Disease control | Pregnancy | Antibiotics | Surveillance | Womens health | Feasibility
Journal Article
Sexually Transmitted Infections, ISSN 1368-4973, 12/2013, Volume 89, Issue 8, p. IV63
Journal Article
Annual Review of Microbiology, ISSN 0066-4227, 9/2017, Volume 71, Issue 1, pp. 665 - 686
Gonorrhea, an obligate human infection, is on the rise worldwide and gonococcal strains resistant to many antibiotics are emerging. Appropriate antimicrobial...
mouse models | antibiotic resistance | gonorrhea | vaccines | Gonorrhea | Vaccines | Mouse models | Antibiotic resistance | GENITAL-TRACT INFECTION | MOLECULAR-MECHANISM | SERUM RESISTANCE | GONOCOCCAL-INFECTION | MICROBIOLOGY | ANTIMICROBIAL RESISTANCE | IN-VIVO SELECTION | EFFLUX-PUMP SYSTEM | OUTER-MEMBRANE PROTEIN | IMMUNE-RESPONSES | ANTIGEN-SPECIFICITY | Gonorrhea - microbiology | Neisseria gonorrhoeae - drug effects | Drug Resistance, Bacterial | Bacterial Vaccines - isolation & purification | Drug Discovery | Gonorrhea - drug therapy | Anti-Bacterial Agents - therapeutic use | Animals | Bacterial Vaccines - immunology | Female | Neisseria gonorrhoeae - immunology | Anti-Bacterial Agents - pharmacology | Mice | Gonorrhea - prevention & control | Disease Models, Animal | Physiological aspects | Drug resistance in microorganisms | Neisseria gonorrhoeae | Health aspects | Vaccination | Patient outcomes
mouse models | antibiotic resistance | gonorrhea | vaccines | Gonorrhea | Vaccines | Mouse models | Antibiotic resistance | GENITAL-TRACT INFECTION | MOLECULAR-MECHANISM | SERUM RESISTANCE | GONOCOCCAL-INFECTION | MICROBIOLOGY | ANTIMICROBIAL RESISTANCE | IN-VIVO SELECTION | EFFLUX-PUMP SYSTEM | OUTER-MEMBRANE PROTEIN | IMMUNE-RESPONSES | ANTIGEN-SPECIFICITY | Gonorrhea - microbiology | Neisseria gonorrhoeae - drug effects | Drug Resistance, Bacterial | Bacterial Vaccines - isolation & purification | Drug Discovery | Gonorrhea - drug therapy | Anti-Bacterial Agents - therapeutic use | Animals | Bacterial Vaccines - immunology | Female | Neisseria gonorrhoeae - immunology | Anti-Bacterial Agents - pharmacology | Mice | Gonorrhea - prevention & control | Disease Models, Animal | Physiological aspects | Drug resistance in microorganisms | Neisseria gonorrhoeae | Health aspects | Vaccination | Patient outcomes
Journal Article
Vaccine, ISSN 0264-410X, 2013, Volume 32, Issue 14, pp. 1579 - 1587
Highlights • Multiple drug resistance in Neisseria gonorrhoeae impels renewed vaccine efforts. • Poor natural immunity, antigen variation, and gender factors...
Allergy and Immunology | Antibodies | Gonococcal antigens | Immune regulation | T cells | Innate defenses | Immunity | TOXIN-B-SUBUNIT | MEDICINE, RESEARCH & EXPERIMENTAL | FEMALE GENITAL-TRACT | SEROVAR-SPECIFIC IMMUNITY | IMMUNOLOGY | EXPERIMENTAL GONOCOCCAL-INFECTION | SEXUALLY-TRANSMITTED-DISEASES | OUTER-MEMBRANE PROTEIN | SYSTEMIC ANTIBODY-RESPONSES | PATHOGENIC NEISSERIA | NEISSERIA-GONORRHOEAE | INTRANASAL IMMUNIZATION | Adaptive Immunity | Neisseria gonorrhoeae - drug effects | Gonorrhea - immunology | Humans | Antigens, Bacterial - immunology | Drug Resistance, Bacterial | Mice, Transgenic | Immunity, Innate | Th1 Cells - immunology | Animals | Bacterial Vaccines - therapeutic use | Vaccination - trends | Female | Mice | Gonorrhea - prevention & control | Adjuvants, Immunologic - therapeutic use | Disease Models, Animal | Sexually transmitted diseases | Vaccines | Drug resistance | Analysis | Antigens | Bacterial infections | Mortality | Antimicrobial agents | Infections | Gonorrhea | Inflammatory diseases | Cell adhesion & migration | Pregnancy | Infectious diseases | Disease transmission | Antibiotics | Womens health | Infertility | Public health | antibodies | immunity | gonococcal antigens | innate defenses | immune regulation
Allergy and Immunology | Antibodies | Gonococcal antigens | Immune regulation | T cells | Innate defenses | Immunity | TOXIN-B-SUBUNIT | MEDICINE, RESEARCH & EXPERIMENTAL | FEMALE GENITAL-TRACT | SEROVAR-SPECIFIC IMMUNITY | IMMUNOLOGY | EXPERIMENTAL GONOCOCCAL-INFECTION | SEXUALLY-TRANSMITTED-DISEASES | OUTER-MEMBRANE PROTEIN | SYSTEMIC ANTIBODY-RESPONSES | PATHOGENIC NEISSERIA | NEISSERIA-GONORRHOEAE | INTRANASAL IMMUNIZATION | Adaptive Immunity | Neisseria gonorrhoeae - drug effects | Gonorrhea - immunology | Humans | Antigens, Bacterial - immunology | Drug Resistance, Bacterial | Mice, Transgenic | Immunity, Innate | Th1 Cells - immunology | Animals | Bacterial Vaccines - therapeutic use | Vaccination - trends | Female | Mice | Gonorrhea - prevention & control | Adjuvants, Immunologic - therapeutic use | Disease Models, Animal | Sexually transmitted diseases | Vaccines | Drug resistance | Analysis | Antigens | Bacterial infections | Mortality | Antimicrobial agents | Infections | Gonorrhea | Inflammatory diseases | Cell adhesion & migration | Pregnancy | Infectious diseases | Disease transmission | Antibiotics | Womens health | Infertility | Public health | antibodies | immunity | gonococcal antigens | innate defenses | immune regulation
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Full Text
Neisseria gonorrhoeae MlaA influences gonococcal virulence and membrane vesicle production
PLOS PATHOGENS, ISSN 1553-7366, 03/2019, Volume 15, Issue 3, p. e1007385
The six-component maintenance of lipid asymmetry (Mla) system is responsible for retrograde transport of phospholipids, ensuring the barrier function of the...
MICROBIOLOGY | PHOSPHOLIPASE-A ACTIVITY | IDENTIFICATION | GENITAL-TRACT | COMPLEMENTATION ANALYSIS | VIROLOGY | CELL-ENVELOPE | VIRB OPERON | BINDING PROTEINS | GENES | BIOLOGY | TRANSPORT-SYSTEMS | PARASITOLOGY | Phospholipids | Neisseria gonorrhoeae | Research | Escherichia coli | Anaerobiosis | Health sciences | Genital tract | Adhesins | Peptides | Pathogenesis | Virulence | Homeostasis | Antibodies | Lipids | Iron | mRNA | Infections | Inactivation | Polymyxin B | Mimicry | Proteins | Mining | Vesicles | Immunology | E coli | Virulence factors | Cell cycle | Antimicrobial peptides | Bacteria | Pharmaceutical sciences | Stationary phase | Pathogens | RNA editing | Starvation | Deactivation | Therapeutic applications | Membrane vesicles | Retrograde transport | Fatty acids | Asymmetry | Pharmacy | Proteomics | Viability | Cell envelopes
MICROBIOLOGY | PHOSPHOLIPASE-A ACTIVITY | IDENTIFICATION | GENITAL-TRACT | COMPLEMENTATION ANALYSIS | VIROLOGY | CELL-ENVELOPE | VIRB OPERON | BINDING PROTEINS | GENES | BIOLOGY | TRANSPORT-SYSTEMS | PARASITOLOGY | Phospholipids | Neisseria gonorrhoeae | Research | Escherichia coli | Anaerobiosis | Health sciences | Genital tract | Adhesins | Peptides | Pathogenesis | Virulence | Homeostasis | Antibodies | Lipids | Iron | mRNA | Infections | Inactivation | Polymyxin B | Mimicry | Proteins | Mining | Vesicles | Immunology | E coli | Virulence factors | Cell cycle | Antimicrobial peptides | Bacteria | Pharmaceutical sciences | Stationary phase | Pathogens | RNA editing | Starvation | Deactivation | Therapeutic applications | Membrane vesicles | Retrograde transport | Fatty acids | Asymmetry | Pharmacy | Proteomics | Viability | Cell envelopes
Journal Article