American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 08/2004, Volume 287, Issue 2, pp. 199 - 206
The available evidence suggests that about two-thirds of the insulin response to an oral glucose load is due to the potentiating effect of gut-derived incretin...
Glucagon-like peptide 1 | Glucose-dependent insulinotropic polypeptide | Diabetes | GLYCEMIC CONTROL | PHYSIOLOGY | GLUCOSE-INTOLERANCE | glucagon-like peptide 1 | SMALL-INTESTINE | glucose-dependent insulinotropic polypeptide | DEFECTIVE AMPLIFICATION | PHYSIOLOGICAL INCRETIN | GLUCAGON-LIKE PEPTIDE-1 | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | ORAL GLUCOSE | GASTRIC-INHIBITORY POLYPEPTIDE | GIP RECEPTOR | diabetes | Glucagon-Like Peptide 1 | Peptide Fragments - metabolism | Peptide Hormones - pharmacology | Gastric Inhibitory Polypeptide - metabolism | Humans | Diabetes Mellitus, Type 2 - metabolism | Protein Precursors - metabolism | Peptide Hormones - metabolism | Insulin - metabolism | Animals | Glucagon - metabolism | Gastrointestinal Hormones - physiology | Insulin Secretion | Neurosecretory Systems - physiopathology
Glucagon-like peptide 1 | Glucose-dependent insulinotropic polypeptide | Diabetes | GLYCEMIC CONTROL | PHYSIOLOGY | GLUCOSE-INTOLERANCE | glucagon-like peptide 1 | SMALL-INTESTINE | glucose-dependent insulinotropic polypeptide | DEFECTIVE AMPLIFICATION | PHYSIOLOGICAL INCRETIN | GLUCAGON-LIKE PEPTIDE-1 | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | ORAL GLUCOSE | GASTRIC-INHIBITORY POLYPEPTIDE | GIP RECEPTOR | diabetes | Glucagon-Like Peptide 1 | Peptide Fragments - metabolism | Peptide Hormones - pharmacology | Gastric Inhibitory Polypeptide - metabolism | Humans | Diabetes Mellitus, Type 2 - metabolism | Protein Precursors - metabolism | Peptide Hormones - metabolism | Insulin - metabolism | Animals | Glucagon - metabolism | Gastrointestinal Hormones - physiology | Insulin Secretion | Neurosecretory Systems - physiopathology
Journal Article
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2011, Volume 22, Issue 7, pp. 266 - 274
In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment for insulin biosynthesis, which accounts for half of the total...
Endocrinology & Metabolism | DIABETES-MELLITUS | MESSENGER-RNAS | GLUCOSE-HOMEOSTASIS | OXIDATIVE STRESS | UNFOLDED PROTEIN RESPONSE | INSULIN GENE | ER STRESS | ENDOCRINOLOGY & METABOLISM | ISLET AMYLOID POLYPEPTIDE | FACTOR-KAPPA-B | GENOME-WIDE ASSOCIATION | Protein Biosynthesis | Oxidative Stress | Humans | Diabetes Mellitus - drug therapy | Stress, Physiological | Diabetes Mellitus - metabolism | Endoplasmic Reticulum - metabolism | Molecular Targeted Therapy | Unfolded Protein Response | Disease Progression | Diabetes Mellitus - prevention & control | Insulin-Secreting Cells - metabolism | Animals | Cell Death
Endocrinology & Metabolism | DIABETES-MELLITUS | MESSENGER-RNAS | GLUCOSE-HOMEOSTASIS | OXIDATIVE STRESS | UNFOLDED PROTEIN RESPONSE | INSULIN GENE | ER STRESS | ENDOCRINOLOGY & METABOLISM | ISLET AMYLOID POLYPEPTIDE | FACTOR-KAPPA-B | GENOME-WIDE ASSOCIATION | Protein Biosynthesis | Oxidative Stress | Humans | Diabetes Mellitus - drug therapy | Stress, Physiological | Diabetes Mellitus - metabolism | Endoplasmic Reticulum - metabolism | Molecular Targeted Therapy | Unfolded Protein Response | Disease Progression | Diabetes Mellitus - prevention & control | Insulin-Secreting Cells - metabolism | Animals | Cell Death
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Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
Hepatology, ISSN 0270-9139, 01/2015, Volume 61, Issue 1, pp. 108 - 118
A sequence polymorphism (rs738409, I148M) in patatin‐like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty...
OVEREXPRESSION | HEPATOCELLULAR-CARCINOMA | COMMON VARIANT | FATTY LIVER-DISEASE | NONALCOHOLIC STEATOHEPATITIS | I148M | GASTROENTEROLOGY & HEPATOLOGY | ADIPONUTRIN | Sucrose | Membrane Proteins - genetics | Humans | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Lipid Metabolism | Male | Mice, Transgenic | Lipase - metabolism | Gene Knock-In Techniques | 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism | Animals | Female | Membrane Proteins - metabolism | Lipid Droplets - metabolism | Fatty Acids - metabolism | Fatty Liver - etiology | Lipase - genetics | Lipids | Rodents | Physiology | Steatohepatitis | Metabolic Liver Disease
OVEREXPRESSION | HEPATOCELLULAR-CARCINOMA | COMMON VARIANT | FATTY LIVER-DISEASE | NONALCOHOLIC STEATOHEPATITIS | I148M | GASTROENTEROLOGY & HEPATOLOGY | ADIPONUTRIN | Sucrose | Membrane Proteins - genetics | Humans | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Lipid Metabolism | Male | Mice, Transgenic | Lipase - metabolism | Gene Knock-In Techniques | 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism | Animals | Female | Membrane Proteins - metabolism | Lipid Droplets - metabolism | Fatty Acids - metabolism | Fatty Liver - etiology | Lipase - genetics | Lipids | Rodents | Physiology | Steatohepatitis | Metabolic Liver Disease
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 40, pp. 16109 - 16114
Angiopoietin-like protein (ANGPTL)8 (alternatively called TD26, RIFL, Lipasin, and Betatrophin) is a newly recognized ANGPTL family member that has been...
Adipose tissues | Lipoproteins | Fasting | Refeeding | Mice | Triglycerides | Lipid metabolism | Insulin | Fatty acids | Blood plasma | FATTY-ACID SYNTHESIS | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | LIVER | ELEMENT-BINDING PROTEIN | ANGIOPOIETIN-LIKE PROTEIN-4 | TARGET GENE | LIPOPROTEIN-LIPASE | DEFICIENCY | TRANSGENIC MICE | Dyslipidemias - drug therapy | Mice, Inbred C57BL | Immunoblotting | Male | Peptide Hormones - deficiency | Calorimetry, Indirect | Cholesterol, VLDL - blood | Peptide Hormones - genetics | Sequence Analysis, DNA | Mice, Knockout | Triglycerides - metabolism | Adipose Tissue - metabolism | Animals | Angiopoietin-like Proteins | Homeostasis - physiology | Triglycerides - blood | Dyslipidemias - metabolism | Glucose - metabolism | Biological Transport - physiology | Real-Time Polymerase Chain Reaction | Homeostasis | Physiological aspects | Glucose metabolism | Research | Membrane proteins | Biological Sciences
Adipose tissues | Lipoproteins | Fasting | Refeeding | Mice | Triglycerides | Lipid metabolism | Insulin | Fatty acids | Blood plasma | FATTY-ACID SYNTHESIS | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | LIVER | ELEMENT-BINDING PROTEIN | ANGIOPOIETIN-LIKE PROTEIN-4 | TARGET GENE | LIPOPROTEIN-LIPASE | DEFICIENCY | TRANSGENIC MICE | Dyslipidemias - drug therapy | Mice, Inbred C57BL | Immunoblotting | Male | Peptide Hormones - deficiency | Calorimetry, Indirect | Cholesterol, VLDL - blood | Peptide Hormones - genetics | Sequence Analysis, DNA | Mice, Knockout | Triglycerides - metabolism | Adipose Tissue - metabolism | Animals | Angiopoietin-like Proteins | Homeostasis - physiology | Triglycerides - blood | Dyslipidemias - metabolism | Glucose - metabolism | Biological Transport - physiology | Real-Time Polymerase Chain Reaction | Homeostasis | Physiological aspects | Glucose metabolism | Research | Membrane proteins | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12553 - 12558
Fibroblast growth factor 21 (FGF21) has been identified as a potent metabolic regulator. Administration of recombinant FGF21 protein to rodents and rhesus...
Adenoviruses | Homeostasis | Oxygen consumption | Fibroblast growth factors | Gene expression regulation | Mice | Adipocytes | Lipid metabolism | Gene expression | Regulator genes | Obesity | Diabetes | Mitochondrial function | BETA-KLOTHO | PPAR-ALPHA | mitochondrial function | SIGNALING PATHWAYS | FIBROBLAST-GROWTH-FACTOR-21 | MITOCHONDRIAL BIOGENESIS | PROTEIN-KINASE | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | SIRT1 | GLUCOSE-HOMEOSTASIS | adipocytes | diabetes | obesity | CALORIE RESTRICTION | Biological Sciences
Adenoviruses | Homeostasis | Oxygen consumption | Fibroblast growth factors | Gene expression regulation | Mice | Adipocytes | Lipid metabolism | Gene expression | Regulator genes | Obesity | Diabetes | Mitochondrial function | BETA-KLOTHO | PPAR-ALPHA | mitochondrial function | SIGNALING PATHWAYS | FIBROBLAST-GROWTH-FACTOR-21 | MITOCHONDRIAL BIOGENESIS | PROTEIN-KINASE | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | SIRT1 | GLUCOSE-HOMEOSTASIS | adipocytes | diabetes | obesity | CALORIE RESTRICTION | Biological Sciences
Journal Article
Endocrine Reviews, ISSN 0163-769X, 02/2007, Volume 28, Issue 1, pp. 84 - 116
Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for blood glucose homeostasis. It is the major counterpart to insulin and...
DEPENDENT DIABETES-MELLITUS | GLUCAGON GENE-EXPRESSION | MESSENGER-RIBONUCLEIC-ACID | SOMATOSTATIN RECEPTOR SUBTYPES | IONOTROPIC GLUTAMATE RECEPTORS | SENSITIVE K+ CHANNELS | FREE FATTY-ACIDS | ENDOCRINOLOGY & METABOLISM | ISOLATED-PERFUSED RAT | PLASMA-GLUCOSE CONCENTRATION | STIMULATES INSULIN-SECRETION | Diabetes Mellitus - pathology | Animals | Glucagon-Secreting Cells - pathology | Models, Biological | Diabetes Mellitus - therapy | Glucagon-Secreting Cells - metabolism | Humans | Autonomic Nervous System - physiology | Cell Communication | Glucagon-Secreting Cells - physiology
DEPENDENT DIABETES-MELLITUS | GLUCAGON GENE-EXPRESSION | MESSENGER-RIBONUCLEIC-ACID | SOMATOSTATIN RECEPTOR SUBTYPES | IONOTROPIC GLUTAMATE RECEPTORS | SENSITIVE K+ CHANNELS | FREE FATTY-ACIDS | ENDOCRINOLOGY & METABOLISM | ISOLATED-PERFUSED RAT | PLASMA-GLUCOSE CONCENTRATION | STIMULATES INSULIN-SECRETION | Diabetes Mellitus - pathology | Animals | Glucagon-Secreting Cells - pathology | Models, Biological | Diabetes Mellitus - therapy | Glucagon-Secreting Cells - metabolism | Humans | Autonomic Nervous System - physiology | Cell Communication | Glucagon-Secreting Cells - physiology
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2016, Volume 374, Issue 12, pp. 1123 - 1133
This study showed an association of loss-of-function mutations in ANGPTL4 with low triglyceride levels and protection against coronary artery disease....
MEDICINE, GENERAL & INTERNAL | HEART-DISEASE | GENE | CHOLESTEROL | TRIGLYCERIDES | MICE | ANGIOPOIETIN-LIKE PROTEIN-4 | MUTATIONS | LIPOPROTEIN-LIPASE | PARTICIPANTS | LIPIDS | Cholesterol - blood | Humans | Middle Aged | Risk Factors | Gene Silencing | Male | Angiopoietins - antagonists & inhibitors | Macaca mulatta | Angiopoietin-like 4 Protein | Animals | Coronary Artery Disease - genetics | Triglycerides - blood | Female | Heterozygote | Aged | Mice | Mutation | Angiopoietins - genetics | Disease Models, Animal | Care and treatment | Triglycerides | Dosage and administration | Research | Coronary heart disease | Risk factors | Antilipemic agents | Enzymes | Angiopoietin | Exons | Genes | Coronary artery | Heterozygotes | Cardiovascular disease | Lipoprotein lipase | Lipase | Cholesterol | Homozygotes | Ischemia | Monoclonal antibodies | Cardiovascular diseases | Lipoproteins (high density) | Heart diseases
MEDICINE, GENERAL & INTERNAL | HEART-DISEASE | GENE | CHOLESTEROL | TRIGLYCERIDES | MICE | ANGIOPOIETIN-LIKE PROTEIN-4 | MUTATIONS | LIPOPROTEIN-LIPASE | PARTICIPANTS | LIPIDS | Cholesterol - blood | Humans | Middle Aged | Risk Factors | Gene Silencing | Male | Angiopoietins - antagonists & inhibitors | Macaca mulatta | Angiopoietin-like 4 Protein | Animals | Coronary Artery Disease - genetics | Triglycerides - blood | Female | Heterozygote | Aged | Mice | Mutation | Angiopoietins - genetics | Disease Models, Animal | Care and treatment | Triglycerides | Dosage and administration | Research | Coronary heart disease | Risk factors | Antilipemic agents | Enzymes | Angiopoietin | Exons | Genes | Coronary artery | Heterozygotes | Cardiovascular disease | Lipoprotein lipase | Lipase | Cholesterol | Homozygotes | Ischemia | Monoclonal antibodies | Cardiovascular diseases | Lipoproteins (high density) | Heart diseases
Journal Article
Endocrinology, ISSN 0013-7227, 02/2006, Volume 147, Issue 2, pp. 672 - 673
ACTIVATION | STIMULATED INSULIN-SECRETION | GPR120 | RAT | ISLETS | LINE | ENDOCRINOLOGY & METABOLISM | CURRENTS | RELEASE | Fatty Acids, Nonesterified - metabolism | Insulin-Secreting Cells - metabolism | Animals | Potassium Channels, Voltage-Gated - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Signal Transduction - physiology
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2011, Volume 17, Issue 11, pp. 1481 - 1489
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone...
MEDICINE, RESEARCH & EXPERIMENTAL | GLP-1 | BENEFICIAL ROLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXERCISE | CELL BIOLOGY | SKELETAL-MUSCLE | IN-VITRO | GLUCOSE-HOMEOSTASIS | HORMONE | BETA-CELL | MICE | EXPRESSION | Interleukin-6 - antagonists & inhibitors | Humans | Male | Diabetes Mellitus, Type 2 - metabolism | Glucagon-Secreting Cells - drug effects | Diet, High-Fat | Glucagon-Secreting Cells - metabolism | Female | Enteroendocrine Cells - metabolism | Insulin Secretion | Interleukin-6 - metabolism | Physical Conditioning, Animal | Disease Models, Animal | Glucose Tolerance Test | Glucagon-Like Peptide 1 - metabolism | Interleukin-6 - genetics | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Insulin - metabolism | Animals | Diabetes Mellitus, Type 2 - physiopathology | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Blood Glucose - metabolism | Enteroendocrine Cells - drug effects | Type 2 diabetes | Care and treatment | Physiological aspects | Genetic aspects | Research | Insulin | Interleukin-6 | Peptides | Cellular biology | Pharmacology | Diabetes | Pancreas | Endocrinology
MEDICINE, RESEARCH & EXPERIMENTAL | GLP-1 | BENEFICIAL ROLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXERCISE | CELL BIOLOGY | SKELETAL-MUSCLE | IN-VITRO | GLUCOSE-HOMEOSTASIS | HORMONE | BETA-CELL | MICE | EXPRESSION | Interleukin-6 - antagonists & inhibitors | Humans | Male | Diabetes Mellitus, Type 2 - metabolism | Glucagon-Secreting Cells - drug effects | Diet, High-Fat | Glucagon-Secreting Cells - metabolism | Female | Enteroendocrine Cells - metabolism | Insulin Secretion | Interleukin-6 - metabolism | Physical Conditioning, Animal | Disease Models, Animal | Glucose Tolerance Test | Glucagon-Like Peptide 1 - metabolism | Interleukin-6 - genetics | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Insulin - metabolism | Animals | Diabetes Mellitus, Type 2 - physiopathology | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Blood Glucose - metabolism | Enteroendocrine Cells - drug effects | Type 2 diabetes | Care and treatment | Physiological aspects | Genetic aspects | Research | Insulin | Interleukin-6 | Peptides | Cellular biology | Pharmacology | Diabetes | Pancreas | Endocrinology
Journal Article
Nature Reviews Endocrinology, ISSN 1759-5029, 12/2018, Volume 14, Issue 12, pp. 694 - 704
Findings from the past 10 years have placed the glucagon-secreting pancreatic alpha-cell centre stage in the development of diabetes mellitus, a disease...
LACTATE-DEHYDROGENASE | DELTA-CELLS | GLUCOSE-HOMEOSTASIS | EUROPEAN SUBJECTS | GLUCAGON RECEPTOR INHIBITION | DEPENDENT REGULATION | INSULIN-SECRETION | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | TRANSCRIPTOMES REVEAL | CA2+ OSCILLATIONS
LACTATE-DEHYDROGENASE | DELTA-CELLS | GLUCOSE-HOMEOSTASIS | EUROPEAN SUBJECTS | GLUCAGON RECEPTOR INHIBITION | DEPENDENT REGULATION | INSULIN-SECRETION | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | TRANSCRIPTOMES REVEAL | CA2+ OSCILLATIONS
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 3, pp. 211 - 221
Loss-of-function variants in ANGPTL3 were associated with lower plasma levels of lipids and lower rates of coronary disease. A monoclonal antibody against...
MEDICINE, GENERAL & INTERNAL | HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | IMMUNOGLOBULIN GENES | ATHEROSCLEROSIS | RISK | CORONARY-ARTERY-DISEASE | FAMILIAL COMBINED HYPOLIPIDEMIA | LIPOPROTEIN-LIPASE GENE | TRANSGENIC MICE | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Angiopoietins - antagonists & inhibitors | Dose-Response Relationship, Drug | Dyslipidemias - blood | Angiopoietin-like Proteins | Lipids - blood | Female | Disease Models, Animal | Dyslipidemias - drug therapy | Atherosclerosis - drug therapy | Double-Blind Method | Antibodies, Monoclonal - pharmacology | Coronary Artery Disease - metabolism | Mice, Inbred Strains | Atherosclerosis - metabolism | Animals | Antibodies, Monoclonal - administration & dosage | Coronary Artery Disease - genetics | Lipid Metabolism - drug effects | Aged | Mice | Mutation | Angiopoietins - genetics | Cholesterol, LDL | Research | Antibiosis | Atherosclerosis | Lipoproteins (low density) | Medical research | Angiopoietin | Genomics | Genes | Coronary artery | Triglycerides | Biochemistry | Gene expression | Cholesterol | Serum levels | Proteins | Antagonism | Arteriosclerosis | Plasma levels | Cardiovascular diseases | Lipoproteins (high density) | Heart diseases | Drug dosages | Pharmaceuticals
MEDICINE, GENERAL & INTERNAL | HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | IMMUNOGLOBULIN GENES | ATHEROSCLEROSIS | RISK | CORONARY-ARTERY-DISEASE | FAMILIAL COMBINED HYPOLIPIDEMIA | LIPOPROTEIN-LIPASE GENE | TRANSGENIC MICE | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Angiopoietins - antagonists & inhibitors | Dose-Response Relationship, Drug | Dyslipidemias - blood | Angiopoietin-like Proteins | Lipids - blood | Female | Disease Models, Animal | Dyslipidemias - drug therapy | Atherosclerosis - drug therapy | Double-Blind Method | Antibodies, Monoclonal - pharmacology | Coronary Artery Disease - metabolism | Mice, Inbred Strains | Atherosclerosis - metabolism | Animals | Antibodies, Monoclonal - administration & dosage | Coronary Artery Disease - genetics | Lipid Metabolism - drug effects | Aged | Mice | Mutation | Angiopoietins - genetics | Cholesterol, LDL | Research | Antibiosis | Atherosclerosis | Lipoproteins (low density) | Medical research | Angiopoietin | Genomics | Genes | Coronary artery | Triglycerides | Biochemistry | Gene expression | Cholesterol | Serum levels | Proteins | Antagonism | Arteriosclerosis | Plasma levels | Cardiovascular diseases | Lipoproteins (high density) | Heart diseases | Drug dosages | Pharmaceuticals
Journal Article
Diabetes, ISSN 0012-1797, 09/2006, Volume 55, Issue 9, pp. 2470 - 2478
Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling...
ERK, extracellular signal-regulated kinase | p90RSK, 90-kDa ribosomal S6 kinase | FGF, fibroblast growth factor | FRS, FGF receptor substrate | ELISA, enzyme-linked immunosorbent assay | BAD, Bcl-XL/Bcl-2-associated death promoter | GLP, glucagon-like peptide | DIABETES-MELLITUS | PROTEIN-KINASE | GLUCOSE | ENDOCRINOLOGY & METABOLISM | RECEPTOR | DEATH | INSULIN GENE-TRANSCRIPTION | SECRETION | METABOLIC-RATE | EXPRESSION | EXPOSURE | Insulin-Secreting Cells - physiology | Cell Survival - drug effects | Glucose Tolerance Test | Phosphorylation | Apoptosis - drug effects | Rats | Male | Fibroblast Growth Factors - pharmacology | Diabetes Mellitus, Type 2 - metabolism | Insulin - biosynthesis | Animals | Caspases - metabolism | Insulin-Secreting Cells - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Insulinoma - metabolism | Caspase 3 | Cell Line, Tumor | Insulin-Secreting Cells - cytology | Membrane Proteins - metabolism | Mice | Caspase 7 | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
ERK, extracellular signal-regulated kinase | p90RSK, 90-kDa ribosomal S6 kinase | FGF, fibroblast growth factor | FRS, FGF receptor substrate | ELISA, enzyme-linked immunosorbent assay | BAD, Bcl-XL/Bcl-2-associated death promoter | GLP, glucagon-like peptide | DIABETES-MELLITUS | PROTEIN-KINASE | GLUCOSE | ENDOCRINOLOGY & METABOLISM | RECEPTOR | DEATH | INSULIN GENE-TRANSCRIPTION | SECRETION | METABOLIC-RATE | EXPRESSION | EXPOSURE | Insulin-Secreting Cells - physiology | Cell Survival - drug effects | Glucose Tolerance Test | Phosphorylation | Apoptosis - drug effects | Rats | Male | Fibroblast Growth Factors - pharmacology | Diabetes Mellitus, Type 2 - metabolism | Insulin - biosynthesis | Animals | Caspases - metabolism | Insulin-Secreting Cells - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Insulinoma - metabolism | Caspase 3 | Cell Line, Tumor | Insulin-Secreting Cells - cytology | Membrane Proteins - metabolism | Mice | Caspase 7 | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Diabetes, ISSN 0012-1797, 06/2005, Volume 54, Issue 6, pp. 1808 - 1815
β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release Isobel Franklin 1 , Jesper Gromada 2 , Asllan Gjinovci 1...
INSULINOTROPIC POLYPEPTIDE | ENDOCRINE PANCREAS | PERFUSED RAT PANCREAS | SENSITIVE K+ CHANNELS | GLUCOSE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | PANCREATIC A-CELLS | ISLET CELLS | ZINC | PEPTIDE-I | Islets of Langerhans - physiology | Insulin - physiology | Rats, Wistar | Potassium Channels - physiology | Rats | Male | Animals | Zinc - physiology | Islets of Langerhans - metabolism | Pyruvic Acid - metabolism | Glucagon - metabolism | Adenosine Triphosphate - physiology | In Vitro Techniques
INSULINOTROPIC POLYPEPTIDE | ENDOCRINE PANCREAS | PERFUSED RAT PANCREAS | SENSITIVE K+ CHANNELS | GLUCOSE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | PANCREATIC A-CELLS | ISLET CELLS | ZINC | PEPTIDE-I | Islets of Langerhans - physiology | Insulin - physiology | Rats, Wistar | Potassium Channels - physiology | Rats | Male | Animals | Zinc - physiology | Islets of Langerhans - metabolism | Pyruvic Acid - metabolism | Glucagon - metabolism | Adenosine Triphosphate - physiology | In Vitro Techniques
Journal Article