Composite Structures, ISSN 0263-8223, 02/2013, Volume 96, pp. 833 - 849
In view of the significant increase in research activity and publications in functionally graded materials (FGMs) and structures in the last few years, the...
Material gradient | Thermo-elastic static analysis | Vibration and stability analysis | Functionally graded materials | NONLINEAR BENDING RESPONSE | STATIC ANALYSIS | MATERIALS SCIENCE, COMPOSITES | DEFORMATION-THEORY | HIGHER-ORDER SHEAR | LARGE DEFLECTION ANALYSIS | SANDWICH PLATES | TRANSIENT THERMAL-STRESSES | ANNULAR FGM PLATES | FREE-VIBRATION ANALYSIS | FINITE-ELEMENT-ANALYSIS | Analysis | Vibration
Material gradient | Thermo-elastic static analysis | Vibration and stability analysis | Functionally graded materials | NONLINEAR BENDING RESPONSE | STATIC ANALYSIS | MATERIALS SCIENCE, COMPOSITES | DEFORMATION-THEORY | HIGHER-ORDER SHEAR | LARGE DEFLECTION ANALYSIS | SANDWICH PLATES | TRANSIENT THERMAL-STRESSES | ANNULAR FGM PLATES | FREE-VIBRATION ANALYSIS | FINITE-ELEMENT-ANALYSIS | Analysis | Vibration
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 09/2019, pp. 1 - 8
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 10/2018, Volume 52, p. 23
Breast cancer is one of the leading causes of cancers among the variety of cancers in woman all over the world. Compounds with phenylindole scaffold were found...
Women | Statistical analysis | Computer simulation | Toxicity | Breast | Cytotoxicity | Breast cancer | Mathematical models | Derivatives | Structure-activity relationships | Monte Carlo simulation | Cancer
Women | Statistical analysis | Computer simulation | Toxicity | Breast | Cytotoxicity | Breast cancer | Mathematical models | Derivatives | Structure-activity relationships | Monte Carlo simulation | Cancer
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 10/2018, Volume 52, pp. 23 - 32
Breast cancer is one of the leading causes of cancers among the variety of cancers in woman all over the world. Compounds with phenylindole scaffold were found...
Cytotoxicity | Breast cancer | MCF7 cell line | Phenylindole | Monte Carlo-based modelling | QSAR | QSAR MODELS | TUBULIN POLYMERIZATION | ANTIMITOTIC AGENTS | TOXICOLOGY | INHIBITORS | 2-PHENYLINDOLE-3-CARBALDEHYDES | Analysis
Cytotoxicity | Breast cancer | MCF7 cell line | Phenylindole | Monte Carlo-based modelling | QSAR | QSAR MODELS | TUBULIN POLYMERIZATION | ANTIMITOTIC AGENTS | TOXICOLOGY | INHIBITORS | 2-PHENYLINDOLE-3-CARBALDEHYDES | Analysis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2017, Volume 129, pp. 72 - 109
Uncontrolled regulation of specific metalloenzymes plays important roles in several diseases like tumor metastasis and inflammation. Therefore, selective...
Zinc binding group | Structure-activity relationship (SAR) | Selectivity | Metalloenzyme | Matrix metalloproteinase-2 | Arylsulfonamide | CHEMISTRY, MEDICINAL | CATALYTIC DOMAIN | CRYSTAL-STRUCTURES | COLLAGENASE INHIBITORS | SULFONYL PYRROLIDINE DERIVATIVES | POTENTIAL THERAPEUTIC AGENTS | OBSTRUCTIVE PULMONARY-DISEASE | MMP INHIBITORS | GELATINASE INHIBITORS | BIOLOGICAL EVALUATION | QUANTITATIVE STRUCTURE | Matrix Metalloproteinase Inhibitors - pharmacology | Matrix Metalloproteinase 2 - drug effects | Sulfonamides - chemistry | Sulfonamides - therapeutic use | Humans | Sensitivity and Specificity | Drug Design | Matrix Metalloproteinase Inhibitors - chemistry | Structure-Activity Relationship | Sulfonamides - pharmacology | Matrix Metalloproteinase Inhibitors - therapeutic use | Arthritis | Metastasis | Metalloenzymes | Sulfonamides
Zinc binding group | Structure-activity relationship (SAR) | Selectivity | Metalloenzyme | Matrix metalloproteinase-2 | Arylsulfonamide | CHEMISTRY, MEDICINAL | CATALYTIC DOMAIN | CRYSTAL-STRUCTURES | COLLAGENASE INHIBITORS | SULFONYL PYRROLIDINE DERIVATIVES | POTENTIAL THERAPEUTIC AGENTS | OBSTRUCTIVE PULMONARY-DISEASE | MMP INHIBITORS | GELATINASE INHIBITORS | BIOLOGICAL EVALUATION | QUANTITATIVE STRUCTURE | Matrix Metalloproteinase Inhibitors - pharmacology | Matrix Metalloproteinase 2 - drug effects | Sulfonamides - chemistry | Sulfonamides - therapeutic use | Humans | Sensitivity and Specificity | Drug Design | Matrix Metalloproteinase Inhibitors - chemistry | Structure-Activity Relationship | Sulfonamides - pharmacology | Matrix Metalloproteinase Inhibitors - therapeutic use | Arthritis | Metastasis | Metalloenzymes | Sulfonamides
Journal Article
Composite Structures, ISSN 0263-8223, 02/2013, Volume 96, pp. 799 - 823
Free vibration response of functionally graded (FG) elastic, rectangular, and simply (diaphragm) supported plates is presented based on higher order...
Natural frequency | Navier solution | Free vibration | Higher order shear and normal deformations theory | Material gradient index | Functionally graded plates | SANDWICH PLATES | STABILITY | MATERIALS SCIENCE, COMPOSITES | Mechanical properties | Analysis | Vibration
Natural frequency | Navier solution | Free vibration | Higher order shear and normal deformations theory | Material gradient index | Functionally graded plates | SANDWICH PLATES | STABILITY | MATERIALS SCIENCE, COMPOSITES | Mechanical properties | Analysis | Vibration
Journal Article
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2018, Volume 18, Issue 13, pp. 1796 - 1814
Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline type of alkaloid. Apart from various traditional uses, it is mainly used as...
Camptothecin | Homocamptothecin | Quantitative structure-activity relationship | Structure-activity relationship | Topoisomerase | Cytotoxicity | Cancer cell lines | CHEMISTRY, MEDICINAL | C-RING ANALOGS | CANCER CELLS | DNA TOPOISOMERASE-II | ANTICANCER AGENTS | PLANT ANTITUMOR AGENTS | PHYSIOLOGICAL PH | cancer cell lines | IN-VITRO CYTOTOXICITY | quantitative structure-activity relationship | ONCOLOGY | homocamptothecin | BIOLOGICAL EVALUATION | topoisomerase | 20(S)-CAMPTOTHECIN | structure-activity relationship | DERIVATIVES | cytotoxicity
Camptothecin | Homocamptothecin | Quantitative structure-activity relationship | Structure-activity relationship | Topoisomerase | Cytotoxicity | Cancer cell lines | CHEMISTRY, MEDICINAL | C-RING ANALOGS | CANCER CELLS | DNA TOPOISOMERASE-II | ANTICANCER AGENTS | PLANT ANTITUMOR AGENTS | PHYSIOLOGICAL PH | cancer cell lines | IN-VITRO CYTOTOXICITY | quantitative structure-activity relationship | ONCOLOGY | homocamptothecin | BIOLOGICAL EVALUATION | topoisomerase | 20(S)-CAMPTOTHECIN | structure-activity relationship | DERIVATIVES | cytotoxicity
Journal Article
Archives of Orthopaedic and Trauma Surgery, ISSN 0936-8051, 4/2018, Volume 138, Issue 4, pp. 495 - 504
Acetabular fractures are amongst the most challenging fractures to treat because of complex anatomy. Open reduction and internal fixation remains the standard...
Virtual surgical planning | Medicine & Public Health | Orthopedics | Acetabular fracture | 3D model | Pre-contoured plate | Plate template | 3D printing | SURGERY | DESIGN | REDUCTION | ORTHOPEDICS | Acetabulum - surgery | Fractures, Bone - surgery | Humans | Acetabulum - injuries | Fracture Fixation, Internal - methods | Surgery, Computer-Assisted - methods | Fractures, Bone - diagnostic imaging | Patient-Specific Modeling | Acetabulum - diagnostic imaging | Printing, Three-Dimensional | Patients | Surgery
Virtual surgical planning | Medicine & Public Health | Orthopedics | Acetabular fracture | 3D model | Pre-contoured plate | Plate template | 3D printing | SURGERY | DESIGN | REDUCTION | ORTHOPEDICS | Acetabulum - surgery | Fractures, Bone - surgery | Humans | Acetabulum - injuries | Fracture Fixation, Internal - methods | Surgery, Computer-Assisted - methods | Fractures, Bone - diagnostic imaging | Patient-Specific Modeling | Acetabulum - diagnostic imaging | Printing, Three-Dimensional | Patients | Surgery
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2016, Volume 26, Issue 23, pp. 5712 - 5718
Huntington’s disease (HD) is caused by mutation of huntingtin protein (mHtt) leading to neuronal cell death. The mHtt induced toxicity can be rescued by...
Pharmacophore mapping | Kynurenine monooxygenase | Bayesian modeling | Huntington’s disease | Support vector machine | Artificial neural network | Linear discriminant analysis | Molecular docking
Pharmacophore mapping | Kynurenine monooxygenase | Bayesian modeling | Huntington’s disease | Support vector machine | Artificial neural network | Linear discriminant analysis | Molecular docking
Journal Article
Current Drug Discovery Technologies, ISSN 1570-1638, 03/2017, Volume 14, Issue 1, pp. 39 - 52
Background: Thiazol-2-ethylamine is recently reported to be an interesting scaffold having antitrypansomal activity for the treatment of sleeping sickness....
Antitrypansomal agent | Thiazol-2-ethylamines | MLR | QSAR | Bayesian modeling | LDA | K-MCA
Antitrypansomal agent | Thiazol-2-ethylamines | MLR | QSAR | Bayesian modeling | LDA | K-MCA
Journal Article
Pharmaceutical patent analyst, 11/2018, Volume 7, Issue 6, pp. 259 - 276
Histone deacetylase 8 (HDAC8) is one of the attractive therapeutic anticancer targets. HDAC8 has been overexpressed in a variety of human cancers. Therefore,...
benzamide | selectivity | thiol | histone deacetylase 8 | cancer | HDAC8 inhibitors | hydroxamate | carboxylate | epigenetics
benzamide | selectivity | thiol | histone deacetylase 8 | cancer | HDAC8 inhibitors | hydroxamate | carboxylate | epigenetics
Journal Article
International Journal of Renewable Energy Technology, ISSN 1757-3971, 01/2018, Volume 9, Issue 4, pp. 439 - 452
Photovoltaic (PV) energy is one of the most prominent renewable and non-polluting energy to fulfil the rising demand of electricity. But availability of sun...
Literature reviews | Solar cells | Energy | Photovoltaic cells | Electricity consumption | Shading | Maximum power tracking | Tracking control | Arrays | Photovoltaics | Exploitation | Tracking techniques
Literature reviews | Solar cells | Energy | Photovoltaic cells | Electricity consumption | Shading | Maximum power tracking | Tracking control | Arrays | Photovoltaics | Exploitation | Tracking techniques
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e107164
Crude decoction of Chenopodium album seed showed spermicidal effect at MIC 2 mg/ml in earlier studies. Systematic isolation, characterization and evaluation...
IN-VITRO | TRANSMISSION | HIV | MULTIDISCIPLINARY SCIENCES | ACQUISITION | SPERMATOZOA | LACTOBACILLI | HUMAN-IMMUNODEFICIENCY-VIRUS | VIABILITY ASSESSMENT | ALBUM SEED EXTRACT | FERTILITY | Cell Survival - drug effects | Apoptosis - drug effects | Plant Extracts - pharmacology | Humans | Contraceptive Agents - pharmacology | Rats | Male | Spermatozoa - drug effects | Chenopodium album | Sperm Motility - drug effects | Animals | Nonoxynol - pharmacology | Lipid Peroxidation - drug effects | Spermatocidal Agents - pharmacology | Steroids - pharmacology | Saponins - pharmacology | Contraceptives | Mitochondrial DNA | Surface active agents | Microbiota (Symbiotic organisms) | Cell culture | Surgical implants | Sexually transmitted diseases--STD | Spermatozoa | Sperm | Immobilization | Lipid peroxidation | Microflora | Biology | Lactobacillus acidophilus | Mitochondria | Microorganisms | Uterus | Industrial research | Peroxidation | Family planning | Lactobacilli | Vagina | Implantation | Electron microscopy | Chromatography | Nonoxynol | Studies | Birth control | Chemistry | Acids | Councils | Womens health | Minimum inhibitory concentration | In vivo methods and tests | Apoptosis | STD | Sexually transmitted diseases
IN-VITRO | TRANSMISSION | HIV | MULTIDISCIPLINARY SCIENCES | ACQUISITION | SPERMATOZOA | LACTOBACILLI | HUMAN-IMMUNODEFICIENCY-VIRUS | VIABILITY ASSESSMENT | ALBUM SEED EXTRACT | FERTILITY | Cell Survival - drug effects | Apoptosis - drug effects | Plant Extracts - pharmacology | Humans | Contraceptive Agents - pharmacology | Rats | Male | Spermatozoa - drug effects | Chenopodium album | Sperm Motility - drug effects | Animals | Nonoxynol - pharmacology | Lipid Peroxidation - drug effects | Spermatocidal Agents - pharmacology | Steroids - pharmacology | Saponins - pharmacology | Contraceptives | Mitochondrial DNA | Surface active agents | Microbiota (Symbiotic organisms) | Cell culture | Surgical implants | Sexually transmitted diseases--STD | Spermatozoa | Sperm | Immobilization | Lipid peroxidation | Microflora | Biology | Lactobacillus acidophilus | Mitochondria | Microorganisms | Uterus | Industrial research | Peroxidation | Family planning | Lactobacilli | Vagina | Implantation | Electron microscopy | Chromatography | Nonoxynol | Studies | Birth control | Chemistry | Acids | Councils | Womens health | Minimum inhibitory concentration | In vivo methods and tests | Apoptosis | STD | Sexually transmitted diseases
Journal Article
Structural Chemistry, ISSN 1040-0400, 12/2017, Volume 28, Issue 6, pp. 1663 - 1678
Influenza endonuclease plays important role in the viral transcription and translation processes. Inhibition of endonuclease enzyme may be an interesting...
Theoretical and Computational Chemistry | Chemistry | Pharmacophore mapping | Influenza endonuclease inhibitors | Open3DQSAR | Physical Chemistry | HQSAR | Bayesian classification modelling | Computer Applications in Chemistry | CoMSIA | VIRUS PA ENDONUCLEASE | ANTIPROLIFERATIVE AGENTS | CHEMISTRY, PHYSICAL | COMFA | EXTERNAL VALIDATION | CRYSTALLOGRAPHY | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | RECEPTOR-BINDING AFFINITIES | PROMOTER-BINDING | QSPR MODELS | COMPARATIVE QSAR | RNA-POLYMERASE | Nucleases | Models | Hydroxides | Hydrogen | Analysis | Influenza
Theoretical and Computational Chemistry | Chemistry | Pharmacophore mapping | Influenza endonuclease inhibitors | Open3DQSAR | Physical Chemistry | HQSAR | Bayesian classification modelling | Computer Applications in Chemistry | CoMSIA | VIRUS PA ENDONUCLEASE | ANTIPROLIFERATIVE AGENTS | CHEMISTRY, PHYSICAL | COMFA | EXTERNAL VALIDATION | CRYSTALLOGRAPHY | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | RECEPTOR-BINDING AFFINITIES | PROMOTER-BINDING | QSPR MODELS | COMPARATIVE QSAR | RNA-POLYMERASE | Nucleases | Models | Hydroxides | Hydrogen | Analysis | Influenza
Journal Article
Pharmacological Research, ISSN 1043-6618, 08/2017, Volume 122, pp. 8 - 19
For the last three decades, metalloenzymes such as histone deacetylases (HDACs) and matrix metalloproteinases (MMPs) have been identified in promoting solid as...
Histone deacetylase (HDAC) | Matrix metalloproteinase (MMP) | Structure-activity relationship (SAR) | Leukemia | Hematological malignancies | HYDROXAMIC ACIDS | T-CELL LEUKEMIA/LYMPHOMA | ANTICANCER AGENTS | CRYSTAL-STRUCTURE | DOWN-REGULATION | ACUTE MYELOID-LEUKEMIA | CANCER-THERAPY | MATRIX-METALLOPROTEINASE INHIBITORS | PHARMACOLOGY & PHARMACY | HISTONE DEACETYLASE INHIBITORS | SHORTER SURVIVAL | Humans | Neoplasm Invasiveness - prevention & control | Hematologic Neoplasms - enzymology | Leukemia - metabolism | Repressor Proteins - antagonists & inhibitors | Matrix Metalloproteinase Inhibitors - therapeutic use | Matrix Metalloproteinase 2 - chemistry | Hematologic Neoplasms - metabolism | Molecular Targeted Therapy - methods | Repressor Proteins - metabolism | Repressor Proteins - chemistry | Matrix Metalloproteinase 2 - metabolism | Leukemia - enzymology | Histone Deacetylases - chemistry | Leukemia - drug therapy | Models, Molecular | Histone Deacetylases - metabolism | Matrix Metalloproteinase Inhibitors - chemistry | Histone Deacetylase Inhibitors - chemistry | Drug Discovery | Matrix Metalloproteinase Inhibitors - pharmacology | Animals | Hematologic Neoplasms - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylase Inhibitors - therapeutic use | Metalloenzymes | Niacinamide | Epigenetic inheritance | Cysteine | Amyloid beta-protein | Molecular dynamics | Metastasis | Non-Hodgkin's lymphomas | T cells | Lung cancer, Non-small cell | Stem cells | Growth factors | Index Medicus
Histone deacetylase (HDAC) | Matrix metalloproteinase (MMP) | Structure-activity relationship (SAR) | Leukemia | Hematological malignancies | HYDROXAMIC ACIDS | T-CELL LEUKEMIA/LYMPHOMA | ANTICANCER AGENTS | CRYSTAL-STRUCTURE | DOWN-REGULATION | ACUTE MYELOID-LEUKEMIA | CANCER-THERAPY | MATRIX-METALLOPROTEINASE INHIBITORS | PHARMACOLOGY & PHARMACY | HISTONE DEACETYLASE INHIBITORS | SHORTER SURVIVAL | Humans | Neoplasm Invasiveness - prevention & control | Hematologic Neoplasms - enzymology | Leukemia - metabolism | Repressor Proteins - antagonists & inhibitors | Matrix Metalloproteinase Inhibitors - therapeutic use | Matrix Metalloproteinase 2 - chemistry | Hematologic Neoplasms - metabolism | Molecular Targeted Therapy - methods | Repressor Proteins - metabolism | Repressor Proteins - chemistry | Matrix Metalloproteinase 2 - metabolism | Leukemia - enzymology | Histone Deacetylases - chemistry | Leukemia - drug therapy | Models, Molecular | Histone Deacetylases - metabolism | Matrix Metalloproteinase Inhibitors - chemistry | Histone Deacetylase Inhibitors - chemistry | Drug Discovery | Matrix Metalloproteinase Inhibitors - pharmacology | Animals | Hematologic Neoplasms - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylase Inhibitors - therapeutic use | Metalloenzymes | Niacinamide | Epigenetic inheritance | Cysteine | Amyloid beta-protein | Molecular dynamics | Metastasis | Non-Hodgkin's lymphomas | T cells | Lung cancer, Non-small cell | Stem cells | Growth factors | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 214 - 240
The histone deacetylases (HDACs) enzymes provided crucial role in transcriptional regulation of cells through deacetylation of nuclear histone proteins....
Histone deacetylase | HDAC8 inhibitor | Structure-activity relationship (SAR) | HDAC8 | Quantitative structure-activity relationship (QSAR) | Cancer | DESIGN | CHEMISTRY, MEDICINAL | ZINC-BINDING GROUP | SUBEROYLANILIDE HYDROXAMIC ACID | CRYSTAL-STRUCTURE | ACTIVITY ASSAY | BIOLOGICAL EVALUATION | DE-LANGE-SYNDROME | PHASE-I | UP-REGULATION | MOLECULAR-MECHANISMS | Humans | Protein Isoforms | Drug Design | Histone Deacetylases | Structure-Activity Relationship | Histone Deacetylase Inhibitors - chemistry | Repressor Proteins - antagonists & inhibitors | Histones | Epigenetic inheritance | Parasitic diseases | Therapeutics | Homeopathy | Materia medica and therapeutics
Histone deacetylase | HDAC8 inhibitor | Structure-activity relationship (SAR) | HDAC8 | Quantitative structure-activity relationship (QSAR) | Cancer | DESIGN | CHEMISTRY, MEDICINAL | ZINC-BINDING GROUP | SUBEROYLANILIDE HYDROXAMIC ACID | CRYSTAL-STRUCTURE | ACTIVITY ASSAY | BIOLOGICAL EVALUATION | DE-LANGE-SYNDROME | PHASE-I | UP-REGULATION | MOLECULAR-MECHANISMS | Humans | Protein Isoforms | Drug Design | Histone Deacetylases | Structure-Activity Relationship | Histone Deacetylase Inhibitors - chemistry | Repressor Proteins - antagonists & inhibitors | Histones | Epigenetic inheritance | Parasitic diseases | Therapeutics | Homeopathy | Materia medica and therapeutics
Journal Article