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Journal Article
Cancer Letters, ISSN 0304-3835, 2013, Volume 337, Issue 2, pp. 226 - 236
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 368, Issue 1, pp. 126 - 134
Highlights • A new matrine derivative WM130 was prepared and demonstrated to exhibit better pharmacological activities than matrine. • WM130 inhibits the... 
Hematology, Oncology and Palliative Medicine | Signaling | Hepatocellular carcinoma | Matrine derivative | Therapeutic effect | Apoptosis | UNITED-STATES | RECEPTOR | PROLIFERATION | GASTRIC-CANCER CELLS | IN-VITRO | INVASION | ONCOLOGY | COLORECTAL-CANCER | EPIDERMAL-GROWTH-FACTOR | OUTCOMES | Apoptosis - drug effects | Humans | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Dose-Response Relationship, Drug | Receptor, Epidermal Growth Factor - metabolism | Carcinoma, Hepatocellular - drug therapy | Time Factors | Liver Neoplasms - pathology | Liver Neoplasms - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Alkaloids - pharmacology | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Liver Neoplasms - drug therapy | PTEN Phosphohydrolase - metabolism | Quinolizines - pharmacology | Carcinoma, Hepatocellular - enzymology | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice, Inbred BALB C | Antineoplastic Agents, Phytogenic - pharmacology | Cancer | Immunohistochemistry | Alkaloids | Hepatoma | Health aspects | Cell proliferation | Intravenous administration | Bax protein | Bcl-2 protein | Xenotransplantation | Science | Colonies & territories | AKT protein | Metastasis | Kinases | Phosphatase | Cancer therapies | Anticancer properties | Proteins | Liver cancer | Signal transduction | Pathways | Xenografts | Conflicts of interest | Inhibition | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Pharmacology | Biological activity | Gelatinase A | Medical prognosis | Antitumor activity | Cell migration | PTEN protein | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 09/2013, Volume 337, Issue 2, pp. 226 - 236
MicroRNAs (miRNAs) have been believed to associate with malignant progression including cancer cell proliferation, apoptosis, differentiation, angiogenesis,... 
Epithelial-mesenchymal transition | Signaling | HSPG | Human sulfatase-1 | MicroRNA | HCC | Hepatocellular carcinoma | AKT | EMT | HSulf-1 | QRT-PCR | ERK
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49693 - e49693
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2017, Volume 7, Issue 1, pp. 41254 - 41254
Our previous studies demonstrated that volatile oil from saussurea lappa root (VOSL), rich in two natural sesquiterpene lactones, costunolide (Cos) and... 
SAUSSUREA-LAPPA | KINASE ANCHORING PROTEINS | CARCINOMA CELLS | BETULINIC ACID | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | TELOMERASE ACTIVITY | PROSTATE-CANCER | C-MYC | LEUKEMIA-CELLS | AKAP SIGNALING COMPLEXES | Apoptosis - drug effects | Protein Interaction Maps - drug effects | Humans | Oils, Volatile - pharmacology | Lactones - pharmacology | Sesquiterpenes - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Oils, Volatile - therapeutic use | Female | Proto-Oncogene Proteins c-akt - metabolism | Lactones - chemistry | Sesquiterpenes - chemistry | Tumor Suppressor Protein p53 - metabolism | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Lactones - therapeutic use | 14-3-3 Proteins - metabolism | Cyclic AMP - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Mice, Nude | Cell Line, Tumor | Mice, Inbred BALB C | Sesquiterpenes - pharmacology | Protein kinase A | Bax protein | Bcl-2 protein | p53 Protein | c-Myc protein | AKT protein | Breast cancer | Myc protein | Kinases | Lactones | BID protein | Signal transduction | 14-3-3 protein | Side effects | Sesquiterpene lactones | Molecular modelling | Proteomics | Cell cycle | Bcl protein | Apoptosis | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 07/2018, Volume 425, pp. 54 - 64
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 381, Issue 2, pp. 349 - 358
Highlights • The high sulfation status of HSPG endowed GBC with highly malignant biological behaviors and poor prognosis. • Desulfation of HSPG using hSulf-1... 
Hematology, Oncology and Palliative Medicine | Growth factor receptor signal pathway | Target therapy | Heparan sulfate proteoglycan | Sulfation | Gallbladder carcinoma | SIGNALING PATHWAYS | PROTEIN | BILIARY-TRACT | GEMCITABINE | GROWTH-FACTOR RECEPTOR | BREAST-CANCER CELLS | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | ROLES | HEPARAN-SULFATE PROTEOGLYCANS | EXPRESSION | Cell Proliferation | Humans | Middle Aged | Male | Gallbladder Neoplasms - enzymology | Transfection | Time Factors | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Sulfotransferases - metabolism | Adenocarcinoma - genetics | Cell Differentiation | Gallbladder Neoplasms - therapy | Sulfotransferases - genetics | Neoplasm Invasiveness | Adenocarcinoma - enzymology | Kaplan-Meier Estimate | Gallbladder Neoplasms - genetics | Tumor Burden | Adenocarcinoma - secondary | Xenograft Model Antitumor Assays | Disease-Free Survival | Animals | Adenocarcinoma - therapy | Heparan Sulfate Proteoglycans - metabolism | Mice, Nude | Cell Line, Tumor | Aged | Gallbladder Neoplasms - pathology | Mice, Inbred BALB C | Neoplasm Staging | Cell Movement | Genetic Therapy - methods | Care and treatment | Drug therapy | Analysis | Gallbladder cancer | Cancer | Heparan sulfate | Radiation therapy | Metastasis | Kinases | Signal transduction | Cell growth | Chemotherapy | Surgery | Conflicts of interest | Gallbladder | Growth factors | Tumors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, pp. e23274 - e23274
Background: Human sulfatase 1 (hSulf-1) is a heparin-degrading endosulfatase that desulfates cell surface heparan sulfate proteoglycans (HSPGs) in... 
BREAST-CANCER | CELLS | HEPATOCELLULAR-CARCINOMA | HEPARAN-SULFATE GLYCOSAMINOGLYCANS | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | IN-VIVO | OVARIAN-CANCER | TUMOR-GROWTH | EXPRESSION | BINDING | Immunohistochemistry | Neoplasms - metabolism | Genetic Therapy | Phosphorylation | Adenoviridae | Cell Proliferation | Humans | Antineoplastic Agents - therapeutic use | Neoplasms - therapy | Sulfotransferases - genetics | Signal Transduction | Cell Survival | Sulfotransferases - therapeutic use | Down-Regulation | Neoplasms - enzymology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Treatment Outcome | Xenograft Model Antitumor Assays | Angiogenesis Inhibitors - metabolism | Animals | Mice, Nude | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Enzyme Activation | Neoplasms - pathology | Care and treatment | Cytokines | Genes | Anticoagulants (Medicine) | Sulfates | Analysis | Adenoviruses | Exhibitions | Fibroblast growth factors | Genetic aspects | Gene therapy | Health aspects | Vascular endothelial growth factor | Cancer | Cell proliferation | Animal models | Xenotransplantation | Systematic review | Kinases | Cell surface | Ovarian cancer | Anticancer properties | Angiogenesis | Cell growth | Xenografts | Extracellular matrix | Inhibition | Heparan sulfate | Proteoglycans | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Vascular endothelial growth factor receptors | Signaling | Cell lines | Heparan sulfate proteoglycans | Antitumor activity | Heparin | Sulfate | Index Medicus | RNA | Ribonucleic acid
Journal Article