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Cancer Science, ISSN 1347-9032, 11/2018, Volume 109, Issue 11, pp. 3591 - 3601
Gastrointestinal stromal tumor (GIST) is a type of KIT‐driven cancer. KIT gene mutations are found in approximately 80% of GISTs, and most of these mutations... 
Cell proliferation | Medical research | Imatinib | Phosphorylation | Senescence | Myeloid leukemia | Therapeutic applications | Leukemia | Aurora kinase | Kinases | Cell growth | Cell cycle | KIT protein | Mutation | Growth factors | Acute myeloid leukemia | Research centers | Apoptosis | Tumors
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2014, Volume 58, Issue 1, pp. 110 - 119
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
Virus Replication - drug effects | Antiviral Agents - pharmacology | Cricetinae | Animals | Replicon - drug effects | Dengue Virus - drug effects | Small Molecule Libraries | Dengue Virus - enzymology | Drug Resistance, Viral | Serine Endopeptidases - metabolism | Antiviral Agents
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 06/2011, Volume 11, Issue 12, pp. 1447 - 1463
Dipeptidyl peptidase-IV (DPP-IV), a serine protease that specifically cleaves the N-terminal dipeptide with a preference for L-proline or L-alanine at the... 
Inhibitor | GLP-1 | Diabetes | Drug development | Dipeptidyl peptidase | CHEMISTRY, MEDICINAL | drug development | DPP-4 INHIBITOR | SUBSTRATE-SPECIFICITY | dipeptidyl peptidase | inhibitor | GLUCAGON-LIKE PEPTIDE-1 | IN-VIVO | SERINE-PROTEASE | STROMAL FIBROBLASTS | MOLECULAR-CLONING | HIGHLY POTENT | TUMOR-GROWTH | RATIONAL DESIGN
Journal Article
by Wu, TS and Lin, WH and Tsai, HJ and Hsueh, CC and Hsu, T and Wang, PC and Lin, HY and Peng, YH and Lu, CT and Lee, LC and Tu, CH and Kung, FC and Shiao, HY and Yeh, TK and Song, JS and Chang, JY and Su, YC and Chen, LT and Chen, CT and Jiaang, WT and Wu, SY
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2019, Volume 62, Issue 8, pp. 3940 - 3957
Drug resistance due to acquired mutations that constitutively activate c-KIT is a significant challenge in the treatment of patients with gastrointestinal... 
POCKET INHIBITORS | AUTOINHIBITION | CHEMISTRY, MEDICINAL | STRUCTURAL BASIS | IMATINIB | SUNITINIB | DRUG-RESISTANCE | MUTATIONS | GASTROINTESTINAL STROMAL TUMORS | BINDING | RECEPTOR TYROSINE KINASE
Journal Article
Cancer Science, ISSN 1347-9032, 11/2018, Volume 109, Issue 11, pp. 3591 - 3601
Gastrointestinal stromal tumor ( GIST ) is a type of KIT ‐driven cancer. KIT gene mutations are found in approximately 80% of GIST s, and most of these... 
1J373 | multitargeted kinase inhibitor | gastrointestinal stromal tumor | BPR | Aurora kinase A | KIT | BPR1J373 | POSITIVE CELLS | EFFICACY | ABL TYROSINE KINASE | SAFETY | C-KIT | CANCER | SU11248 | CHRONIC MYELOID-LEUKEMIA | ONCOLOGY | KIT MUTATIONS | IMATINIB MESYLATE | Gene mutations | Development and progression | Tumors | Original
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2016, Volume 15, Issue 10, pp. 2323 - 2333
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2013, Volume 56, Issue 13, pp. 5247 - 5260
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e83160
Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic... 
INTERNAL TANDEM DUPLICATION | CELLS | HISTONE DEACETYLASE INHIBITOR | ACTIVATING MUTATION | IN-VITRO | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOGENOUS LEUKEMIA | TYROSINE KINASE INHIBITOR | ACUTE MYELOID-LEUKEMIA | PKC412 | APOPTOSIS INDUCTION | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Apoptosis - drug effects | Benzamides - pharmacokinetics | Urea - pharmacokinetics | Male | Antineoplastic Agents - therapeutic use | Urea - chemistry | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Leukemia, Myeloid, Acute - enzymology | Benzamides - therapeutic use | Urea - analogs & derivatives | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Hydroxamic Acids - pharmacology | Benzamides - chemistry | Leukemia, Myeloid, Acute - pathology | Rats | fms-Like Tyrosine Kinase 3 - metabolism | Urea - therapeutic use | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - therapeutic use | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Mice | Protein Kinase Inhibitors - pharmacology | Urea - pharmacology | Health aspects | Analysis | Cancer | Apoptosis | Histone deacetylase | Biotechnology | Phosphorylation | Animal models | Pathogenesis | Leukemia | Kinases | Blood | Anticancer properties | Proteins | Xenografts | Bone marrow | Inhibition | Medical research | Myeloid leukemia | Pharmacology | Stat5 protein | Regression analysis | Mcl-1 protein | Inhibitors | Medical prognosis | Antitumor activity | Mutation | Prostate | Acute myeloid leukemia | Pharmaceuticals
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2015, Volume 100, pp. 151 - 161
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2013, Volume 57, Issue 2, pp. 723 - 733
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2013, Volume 21, Issue 11, pp. 2856 - 2867
Journal Article