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Neuropharmacology, ISSN 0028-3908, 03/2013, Volume 66, pp. 158 - 169
Group III metabotropic glutamate (mGlu) receptors are localized in presynaptic terminals within basal ganglia (BG) circuitry that become hyperactive due to... 
Striatum | Basal ganglia | Akinesia | Rat | Lu AF21934 | l-DOPA-induced dyskinesia | Electrophysiology | HIGH-FREQUENCY STIMULATION | NEUROLOGICAL DISEASES | NEUROSCIENCES | RAT MODEL | STRIATAL SYNAPTIC PLASTICITY | MEDIATED MODULATION | SUBTHALAMIC NUCLEUS | UNILATERAL 6-HYDROXYDOPAMINE LESIONS | PHARMACOLOGY & PHARMACY | DEEP BRAIN-STIMULATION | L-DOPA-induced dyskinesia | MOLECULAR-MECHANISMS | Anilides - therapeutic use | Catalepsy - drug therapy | Synaptic Transmission - physiology | Excitatory Amino Acid Agonists - therapeutic use | Receptors, Metabotropic Glutamate - physiology | Male | Aminobutyrates - pharmacology | Anilides - pharmacokinetics | Parkinson Disease - drug therapy | Oxidopamine | Aminobutyrates - therapeutic use | Excitatory Postsynaptic Potentials - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Haloperidol - antagonists & inhibitors | Allosteric Regulation - physiology | Dyskinesia, Drug-Induced - drug therapy | Catalepsy - chemically induced | Synaptic Transmission - drug effects | Haloperidol - pharmacology | Disease Models, Animal | Allosteric Regulation - drug effects | Aminobutyrates - agonists | Levodopa - pharmacology | Cyclohexanecarboxylic Acids - therapeutic use | Phosphinic Acids - agonists | Levodopa - therapeutic use | Phosphinic Acids - therapeutic use | Rats | Excitatory Amino Acid Agonists - pharmacology | Rats, Sprague-Dawley | Drug Synergism | Animals | Cyclohexanecarboxylic Acids - pharmacology | Levodopa - adverse effects | Phosphinic Acids - pharmacology | Anilides - pharmacology | Excitatory Amino Acid Agonists - pharmacokinetics | Cyclohexanecarboxylic Acids - pharmacokinetics | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Physiological aspects | Phenols | Amino acids | Parkinson's disease | Glutamate | Drug therapy | 6-Hydroxydopamine | Phosphinic Acids | Excitatory Amino Acid Agonists | Allosteric Regulation | Catalepsy | Haloperidol | Aminobutyrates | Cellular Biology | Synaptic Transmission | Receptors, Metabotropic Glutamate | Parkinson Disease | Anilides | Life Sciences | Excitatory Postsynaptic Potentials | Cyclohexanecarboxylic Acids | Dyskinesia, Drug-Induced | Levodopa
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 11/2011, Volume 21, Issue 21, pp. 6500 - 6504
Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16 are described. 2-Pyridylaminothiazole based compounds such as 8c and... 
Journal Article
ChemMedChem, ISSN 1860-7179, 03/2012, Volume 7, Issue 3, pp. 440 - 451
A series of compounds based on the mGluR5-selective ligand 2-methyl-6-(phenylethynyl)pyridine (MPEP) were designed and synthesized. The compounds were found to... 
Cross-coupling | Allosteric modulators | Structure-activity relationships | MGluR5 | Molecular modeling | CHEMISTRY, MEDICINAL | ANTAGONIST | CRYSTAL-STRUCTURE | PROTEIN-COUPLED RECEPTORS | METABOTROPIC GLUTAMATE RECEPTORS | MPEP | TRANSMEMBRANE REGION | GENOME | SIGNAL-TRANSDUCTION | structure-activity relationships | molecular modeling | AMINO-ACIDS | allosteric modulators | cross-coupling | PHARMACOLOGY & PHARMACY | BINDING POCKETS | mGluR5 | Alkynes - chemical synthesis | Allosteric Regulation | Humans | Molecular Sequence Data | Receptors, Metabotropic Glutamate - metabolism | Structure-Activity Relationship | Brain - metabolism | Anti-Anxiety Agents - chemical synthesis | Receptor, Metabotropic Glutamate 5 | Alkynes - pharmacology | Anxiety Disorders - metabolism | Anti-Anxiety Agents - therapeutic use | Anxiety Disorders - drug therapy | Binding Sites | Dimerization | CHO Cells | Pyridines - therapeutic use | Amino Acid Sequence | Cricetinae | Pyridines - chemical synthesis | Anti-Anxiety Agents - pharmacology | Models, Molecular | Alkynes - therapeutic use | Brain - drug effects | Animals | Protein Binding | Glutamic Acid - metabolism | Pyridines - pharmacology | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Alkaloids | Pyridine | Peptides | Analysis | Benzene | Universities and colleges | Nitrogen | Glutamate | Ligands | Chemistry
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 11/2011, Volume 21, Issue 21, pp. 6500 - 6504
Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16are described. 2-Pyridylaminothiazole based compounds such as 8c and... 
Inhibition of cPP induced feeding | Sulfamides | NPY5 antagonists | 5-(20-Pyridyl)-2-aminothiazoles | Sulfonamides | CHEMISTRY, MEDICINAL | FOOD-INTAKE | FEEDING-BEHAVIOR | CHEMISTRY, ORGANIC | 5-(2 '-Pyridyl)-2-aminothiazoles | DISCOVERY | NEUROPEPTIDE-Y
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 21, pp. 6500 - 6504
Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series and are described. 2-Pyridylaminothiazole based compounds such as and exhibit... 
NPY 5 antagonists | 5-(2′-Pyridyl)-2-aminothiazoles | Sulfonamides | Inhibition of cPP induced feeding | Sulfamides
Journal Article
Bioorganic & medicinal chemistry letters, 11/2011, Volume 21, Issue 21, p. 6500
Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16 are described. 2-Pyridylaminothiazole based compounds such as 8c and... 
Animals | Sulfonamides - chemistry | Humans | Injections, Intraventricular | Solubility | Rats | Receptors, Neuropeptide Y - antagonists & inhibitors | Sulfonamides - pharmacology | Sulfonamides - administration & dosage | Feeding Behavior - drug effects
Journal Article
10/2016
Η παρούσα εφεύρεση παρέχει παράγωγα αδαμαντυλο-διαμιδίου του τύπου (Ι): όπου τα R1 και R2 είναι όπως ορίζονται εδώ, ή ένα φαρμακευτικός αποδεκτό άλας αυτών˙... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HETEROCYCLIC COMPOUNDS | HUMAN NECESSITIES | ACYCLIC OR CARBOCYCLIC COMPOUNDS
Patent
07/2014
THE PRESENT INVENTION PROVIDES ADAMANTYL-DIAMIDE DERIVATIVES OF FORMULA (I): WHEREIN R1 AND R2 ARE AS DEFINED HEREIN, OR A PHARMACEUTICALLY ACCEPTABLE SALT... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | ACYCLIC OR CARBOCYCLIC COMPOUNDS
Patent
05/2014
The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | ACYCLIC OR CARBOCYCLIC COMPOUNDS
Patent
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