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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, pp. 19532 - 19537
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may... 
Protein isoforms | T lymphocytes | Chronic lymphocytic leukemia | Messenger RNA | Cyclic nucleotides | B lymphocytes | Medical treatment | Apoptosis | Vehicles | B cell leukemia | B cell | Survivin | cAMP | survivin | CELLS | CAMP-SPECIFIC PHOSPHODIESTERASE | AMP | INHIBITOR-INDUCED APOPTOSIS | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | apoptosis | HUMAN B-LYMPHOCYTES | THEOPHYLLINE | PATHWAY | THERAPEUTIC TARGET | GENE-EXPRESSION | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | RNA, Messenger - metabolism | Enzyme Activation - immunology | Cell Division - immunology | Cyclic Nucleotide Phosphodiesterases, Type 7 - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology | Membrane Potential, Mitochondrial | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Phosphodiesterase 3 Inhibitors | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Gene Expression Regulation, Leukemic | Gene Expression Regulation, Enzymologic | Apoptosis - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors | Physiological aspects | Genetic aspects | Cyclic adenylic acid | Research | Drug therapy | Phosphodiesterases | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 41, pp. 12681 - 12686
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 41, p. 12681
  Cyclic AMP/protein kinase A (cAMP/PKA) and glucocorticoids promote the death of many cell types, including cells of hematopoietic origin. In wild-type (WT)... 
Mitochondria | Fractionation | Lymphomas | Kinases | Cells | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2005, Volume 102, Issue 24, pp. 8561 - 8566
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 10/2015, Volume 112, Issue 41, pp. 12681 - 12681
Cyclic AMP/protein kinase A (cAMP/PKA) and glucocorticoids promote the death of many cell types, including cells of hematopoietic origin. In wild-type (WT) S49... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2005, Volume 102, Issue 24, p. 8561
  Although a substantial number of hormones and drugs increase cellular cAMP levels, the global impact of cAMP and its major effector mechanism, protein kinase... 
Proteins | Cellular biology | Cell cycle | Lymphomas | Circadian rhythm | Gene expression
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 06/2005, Volume 102, Issue 24, pp. 8561 - 8566
Although a substantial number of hormones and drugs increase cellular cAMP levels, the global impact of cAMP and its major effector mechanism, protein kinase A... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, p. 19532
  Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may... 
Enzymes | Protein folding | Leukemia | Gene expression | Ribonucleic acid--RNA | Cells | Apoptosis
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2011, Volume 129, Issue 5, pp. 1162 - 1169
A cost‐ and time‐efficient means to define the prognosis of patients with chronic lymphocytic leukemia (CLL) is desirable but does not yet exist. On the basis... 
chronic lymphocytic leukemia | quantitative reverse transcriptase‐polymerase chain reaction (QPCR) | prognostic factor | cyclic nucleotide phosphodiesterase 7B | quantitative reverse transcriptase-polymerase chain reaction (QPCR) | DIAGNOSIS | PROGNOSIS | GUIDELINES | REAL-TIME PCR | B-CELLS | ZAP-70 | MUTATION STATUS | ONCOLOGY | DISEASE | CD38 | EXPRESSION | Prognosis | Follow-Up Studies | Humans | Middle Aged | Immunoglobulin Variable Region - metabolism | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | RNA, Messenger - metabolism | Case-Control Studies | Time Factors | Cyclic Nucleotide Phosphodiesterases, Type 7 - genetics | ZAP-70 Protein-Tyrosine Kinase - metabolism | Adult | Female | RNA, Messenger - genetics | Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism | ZAP-70 Protein-Tyrosine Kinase - genetics | Survival Rate | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Immunoglobulin Heavy Chains - metabolism | Immunoglobulin Variable Region - genetics | Aged | Immunoglobulin Heavy Chains - genetics | Polymerase chain reaction | Chronic lymphatic leukemia | Immunoglobulins | 3',5'-Cyclic-nucleotide phosphodiesterase | Protein kinase | CD38 antigen | biomarkers | Peripheral blood mononuclear cells | Mutation | ZAP-70 protein | Gene expression | quantitative reverse transcriptase polymerase chain reaction (QPCR)
Journal Article
Blood, ISSN 0006-4971, 11/2006, Volume 108, Issue 11, pp. 2802 - 2802
Abstract Non-specific inhibition of cyclic nucleotide phosphodiesterase (PDE) in chronic lymphocytic leukemia (CLL) cells leads to intracellular accumulation... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/1999, Volume 274, Issue 14, p. 9581
Peptide toxins selective for particular subunit interfaces of the nicotinic acetylcholine receptor have proven invaluable in assigning candidate residues... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2002, Volume 277, Issue 49, p. 47878
The identification of phosphoinositide-dependent kinase-1 (PDK-1) as an activating kinase for members of the AGC family of kinases has led to its implication... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/1998, Volume 273, Issue 18, p. 10958
α-Neurotoxins are potent inhibitors of the nicotinic acetylcholine receptor (nAChR), binding with high affinity to the two agonist sites located on the... 
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 07/2000, Volume 32, Issue 7, pp. 1211 - 1221
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2002, Volume 277, Issue 49, pp. 47878 - 47884
Journal Article
Journal Article
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