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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 46, pp. 20087 - 20092
At present, there are few means to track symptomatic stages of CNS aging. Thus, although metabolic changes are implicated in mtDNA mutation-driven aging, the... 
Lactates | Brain | Cerebral cortex | Messenger RNA | Dehydrogenases | Neurons | Mitochondrial DNA | Premature aging | Mice | Hippocampus | Proton magnetic resonance spectroscopy | MtDNA mutator mouse | In situ hybridization | HPLC | COX/SDH enzyme histochemistry | OXIDATIVE-PHOSPHORYLATION | PROTEIN | MUTATOR MICE | MULTIDISCIPLINARY SCIENCES | MOUSE | proton magnetic resonance spectroscopy | POINT MUTATIONS | SKELETAL-MUSCLE | GLUCOSE | mtDNA mutator mouse | MITOCHONDRIAL-DNA DELETIONS | CEREBROSPINAL-FLUID LACTATE | in situ hybridization | AGE | L-Lactate Dehydrogenase - metabolism | Mitochondria - enzymology | Isoenzymes - genetics | Lactic Acid - metabolism | Brain - enzymology | Mitochondria - pathology | Mutation - genetics | Organ Specificity | Gene Expression Regulation, Enzymologic | Animals | DNA, Mitochondrial - genetics | L-Lactate Dehydrogenase - genetics | Isoenzymes - metabolism | Aging - metabolism | Aging | Lactate dehydrogenase | Nuclear magnetic resonance spectroscopy | Genetic aspects | Research | Properties | Methods | Enzymes | Transcription | Isoenzymes | Central nervous system | Pyruvic acid | High-performance liquid chromatography | Metabolism | L-Lactate dehydrogenase | Magnetic resonance spectroscopy | Mitochondria | Lactic acid | Electron transport | Spectrophotometry | Biological Sciences | SDH enzyme histochemistry | COX
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