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by Abarca-Gómez, Leandra and Abdeen, Ziad A and Hamid, Zargar Abdul and Abu-Rmeileh, Niveen M and Acosta-Cazares, Benjamin and Acuin, Cecilia and Adams, Robert J and Aekplakorn, Wichai and Afsana, Kaosar and Aguilar-Salinas, Carlos A and Agyemang, Charles and Ahmadvand, Alireza and Ahrens, Wolfgang and Ajlouni, Kamel and Akhtaeva, Nazgul and Al-Hazzaa, Hazzaa M and Al-Othman, Amani Rashed and Al-Raddadi, Rajaa and Al Buhairan, Fadia and Al Dhukair, Shahla and Ali, Osman and Ali, Mohamed M and Alkerwi, Ala'a and Alvarez-Pedrerol, Mar and Aly, Eman and Amarapurkar, Deepak N and Amouyel, Philippe and Amuzu, Antoinette and Andersen, Lars Bo and Anderssen, Sigmund A and Andrade, Dolores S and Ängquist, Lars H and Anjana, Ranjit Mohan and Aounallah-Skhiri, Hajer and Araújo, Joana and Ariansen, Inger and Aris, Tahir and Arlappa, Nimmathota and Arveiler, Dominique and Aryal, Krishna K and Aspelund, Thor and Assah, Felix K and Assunção, Maria Cecília F and Aung, May Soe and Avdicová, Mária and Azevedo, Ana and Azizi, Fereidoun and Babu, Bontha V and Bahijri, Suhad and Baker, Jennifer L and Balakrishna, Nagalla and Bamoshmoosh, Mohamed and Banach, Maciej and Bandosz, Piotr and Banegas, José R and Barbagallo, Carlo M and Barceló, Alberto and Barkat, Amina and Barros, Aluisio JD and Barros, Mauro VG and Bata, Iqbal and Batieha, Anwar M and Batista, Rosangela L and Batyrbek, Assembekov and Baur, Louise A and Beaglehole, Robert and Romdhane, Habiba Ben and Benedics, Judith and Benet, Mikhail and Bennett, James E and Bernabe-Ortiz, Antonio and Bernotiene, Gailute and Bettiol, Heloisa and Bhagyalaxmi, Aroor and Bharadwaj, Sumit and Bhargava, Santosh K and Bhatti, Zaid and Bhutta, Zulfiqar A and Bi, Hongsheng and Bi, Yufang and Biehl, Anna and Bikbov, Mukharram and Bista, Bihungum and Bjelica, Dusko J and Bjerregaard, Peter and Bjertness, Marius B and Bjertness, Espen and Björkelund, Cecilia and Blokstra, Anneke and Bo, Simona and Bobak, Martin and Boddy, Lynne M and Boehm, Bernhard O and Boeing, Heiner and Boggia, Jose G and Boissonnet, Carlos P and Bonaccio, Marialaura and Bongard, Vanina and Bovet, Pascal and Braeckevelt, Lien and ... and NCD Risk Factor Collaboration (NCD-RisC) and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Omvårdnad
The Lancet, ISSN 0140-6736, 12/2017, Volume 390, Issue 10113, pp. 2627 - 2642
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
by Gakidou, Emmanuela and Afshin, Ashkan and Abajobir, Amanuel Alemu and Abate, Kalkidan Hassen and Abbafati, Cristiana and Abbas, Kaja M and Abd-Allah, Foad and Abdulle, Abdishakur M and Abera, Semaw Ferede and Aboyans, Victor and Abu-Raddad, Laith J and Abu-Rmeileh, Niveen M E and Abyu, Gebre Yitayih and Adedeji, Isaac Akinkunmi and Adetokunboh, Olatunji and Afarideh, Mohsen and Agrawal, Sutapa and Agrawal, Anurag and Ahmadieh, Hamid and Ahmed, Muktar Beshir and Aichour, Amani Nidhal and Aichour, Miloud Taki Eddine and Aichour, Ibtihel and Akinyemi, Rufus Olusola and Akseer, Nadia and Alahdab, Fares and Al-Aly, Ziyad and Alam, Tahiya and Alam, Noore and Alam, Khurshid and Alasfoor, Deena and Alene, Kefyalew Addis and Ali, Komal and Alizadeh-Navaei, Reza and Alkerwi, Ala'a and Alla, François and Allebeck, Peter and Al-Raddadi, Rajaa and Alsharif, Ubai and Altirkawi, Khalid A and Alvis-Guzman, Nelson and Amare, Azmeraw T and Amini, Erfan and Ammar, Walid and Amoako, Yaw Ampem and Ansari, Hossein and Antó, Josep M and Antonio, Carl Abelardo T and Anwari, Palwasha and Arian, Nicholas and Ärnlöv, Johan and Artaman, Al and Aryal, Krishna Kumar and Asayesh, Hamid and Asgedom, Solomon Weldegebreal and Atey, Tesfay Mehari and Avila-Burgos, Leticia and Avokpaho, Euripide Frinel G Arthur and Awasthi, Ashish and Azzopardi, Peter and Bacha, Umar and Badawi, Alaa and Balakrishnan, Kalpana and Ballew, Shoshana H and Barac, Aleksandra and Barber, Ryan M and Barker-Collo, Suzanne L and Bärnighausen, Till and Barquera, Simon and Barregard, Lars and Barrero, Lope H and Batis, Carolina and Battle, Katherine E and Baumgarner, Blair R and Baune, Bernhard T and Beardsley, Justin and Bedi, Neeraj and Beghi, Ettore and Bell, Michelle L and Bennett, James R and Bennett, Derrick A and Bensenor, Isabela M and Berhane, Adugnaw and Berhe, Derbew Fikadu and Bernabé, Eduardo and Betsu, Balem Demtsu and Beuran, Mircea and Beyene, Addisu Shunu and Bhansali, Anil and Bhutta, Zulfiqar A and Bicer, Burcu Kucuk and Bikbov, Boris and Birungi, Charles and Biryukov, Stan and Blosser, Christopher D and Boneya, Dube Jara and Bou-Orm, Ibrahim R and Brauer, Michael and Breitborde, Nicholas J K and Brenner, Hermann and ... and GBD Risk Factors Collaborators and GBD 2016 Risk Factors Collaborators and Medicinska fakulteten and Klinisk kemi and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper
The Lancet, ISSN 0140-6736, 09/2017, Volume 390, Issue 10100, pp. 1345 - 1422
The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable... 
MORTALITY | WOMEN | MEDICINE, GENERAL & INTERNAL | OBESITY | HEALTH-RISKS | PREVENTION | DEATHS | HYPERTENSION | TRENDS | Global Burden of Disease - statistics & numerical data | Humans | Middle Aged | Water Supply - standards | Child, Preschool | Infant | Male | Water Supply - statistics & numerical data | Young Adult | Occupational Diseases - mortality | Life Expectancy | Metabolic Diseases - mortality | Aged, 80 and over | Adult | Disabled Persons - statistics & numerical data | Female | Child | Communicable Diseases - mortality | Infant, Newborn | Body Mass Index | Quality-Adjusted Life Years | Air Pollution - statistics & numerical data | Smoking - mortality | Risk Assessment | Noncommunicable Diseases - mortality | Environmental Health - statistics & numerical data | Adolescent | Sex Distribution | Cause of Death - trends | Aged | Medicine, Experimental | Medical research | Comparative analysis | Risk assessment | Outdoor air quality | Disease | Premature birth | Mortality | Regional analysis | Alcohol | Metabolism | Ecological risk assessment | Disease prevention | Studies | Domestic violence | Tobacco | Diet | Blood pressure | Trends | Risk exposure | Health risk assessment | Injuries | Public health | Glucose | Gestation | Blood | Risk factors | Counting methods | Clusters | Aging | Population | Age | Environmental assessment | Fasting | Population growth | Health | Causation | Health risks | Exposure | Risk analysis | Charities | Air pollution | Fatalities | Birth weight | Kidney diseases | Indoor air pollution | Smoking | Index Medicus | Abridged Index Medicus | Samfunnsmedisin, sosialmedisin: 801 | Community medicine, Social medicine: 801 | VDP | Helsefag: 800 | Health sciences: 800 | Medisinske Fag: 700 | Medical disciplines: 700 | Salut | Risk factors in diseases | Factors de risc en les malalties | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences | Nutrition and Disease | HNE Nutrition and Disease | Chair Nutrition and Disease | Voeding en Ziekte | VLAG | HNE Voeding en Ziekte
Journal Article