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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4476 - 4481
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously... 
Anti-angiogenic therapy | Macrophage polarization | Tumor microenvironment | Microglia reprogramming | Anti-tumor immunity | anti-angiogenic therapy | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | macrophage polarization | RANDOMIZED-TRIAL | ANGIOPOIETIN-2 | CANCER | THERAPY | microglia reprogramming | TIE2-EXPRESSING MONOCYTES | BLOOD-VESSELS | TUMOR-ASSOCIATED MACROPHAGES | tumor microenvironment | NORMALIZATION | anti-tumor immunity | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Antibodies, Bispecific - pharmacology | Vesicular Transport Proteins - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms, Experimental - pathology | Xenograft Model Antitumor Assays | Macrophages - metabolism | Vesicular Transport Proteins - antagonists & inhibitors | Animals | Antibodies, Neoplasm - pharmacology | Ribonuclease, Pancreatic - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Mice | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Models | Macrophages | Vascular endothelial growth factor | Health aspects | Glioblastoma multiforme | Genotype & phenotype | Survival analysis | Protein expression | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4470 - 4475
Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2)... 
Anti-angiogenic therapy | Colony-stimulating factor 1 | Tumor immunity | Tumor microenvironment | Macrophage | anti-angiogenic therapy | ANGIOPOIETIN-2 FUNCTIONS | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | macrophage | BEVACIZUMAB PLUS IRINOTECAN | RANDOMIZED-TRIAL | ANTIBODY | tumor immunity | KINASE INHIBITOR | ANTIANGIOGENIC THERAPY | PHASE-II TRIAL | colony-stimulating factor 1 | tumor microenvironment | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Macrophages - metabolism | Animals | Antibodies, Neoplasm - pharmacology | Receptors, Vascular Endothelial Growth Factor - metabolism | Ribonuclease, Pancreatic - metabolism | Neovascularization, Pathologic - drug therapy | Glioblastoma - pathology | Cell Line, Tumor | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Glioblastoma - metabolism | Mice | Neovascularization, Pathologic - metabolism | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Quinazolines - pharmacology | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Survival analysis | Gene expression | Kinases | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 37, pp. E8717 - E8726
Blood-brain/blood-tumor barriers (BBB and BTB) and interstitial transport may constitute major obstacles to the transport of therapeutics in brain tumors. In... 
Blood–brain/blood–tumor barrier | Brain tumor | Drug transport | Focused ultrasound | Pharmacokinetics | blood-brain/blood-tumor barrier | EFFICACY | MULTIDISCIPLINARY SCIENCES | SIZE | drug transport | brain tumor | EMERGING STRATEGIES | TRASTUZUMAB EMTANSINE | BREAST-CANCER | PRESSURE | TRANSPORT | FLUORESCENCE MICROSCOPY | THERAPY | FLUID | pharmacokinetics | focused ultrasound | Brain - diagnostic imaging | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Trastuzumab - pharmacokinetics | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Brain - metabolism | Brain Neoplasms - secondary | Microbubbles | Doxorubicin - administration & dosage | Ultrasonography - methods | Maytansine - analogs & derivatives | Trastuzumab - administration & dosage | Brain Neoplasms - drug therapy | Blood-Brain Barrier - drug effects | Breast Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Blood-Brain Barrier - metabolism | Xenograft Model Antitumor Assays | Maytansine - administration & dosage | Animals | Breast Neoplasms - pathology | Maytansine - pharmacokinetics | Brain - pathology | Cell Line, Tumor | Mice | Drug Delivery Systems - methods | Drugs | Drug delivery systems | Care and treatment | Blood-brain barrier | Brain cancer | Physiological aspects | Metastasis | Drug therapy | Methods | Vehicles | Brain | Brain tumors | Xenotransplantation | Drug delivery | Doxorubicin | Blood | Optimization | Metastases | Anticancer properties | FUS protein | Antitumor agents | Extravasation | Xenografts | Modelling | Ultrasound | Experimental data | Data processing | Breast cancer | Pharmacology | ErbB-2 protein | Endothelial cells | Chemotherapy | Microscopy | Barriers | Disruption | Transport | Trastuzumab | Tumors | Cancer | Index Medicus | Biological Sciences | Physical Sciences | PNAS Plus | blood–tumor barrier | blood–brain
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 02/2016, Volume 108, Issue 2, p. djv313
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2018, Volume 33, Issue 5, pp. 874 - 889.e7
Journal Article
Science Translational Medicine, ISSN 1946-6234, 05/2017, Volume 9, Issue 391, p. eaal4682
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2018, Volume 20, Issue suppl_6, pp. vi281 - vi281
Abstract Blood-brain/blood-tumor barriers (BBB and BTB) and interstitial transport may constitute major obstacles to the transport of therapeutics in brain... 
Journal Article
Cell research, 02/2018, Volume 28, Issue 2, p. 221
The cerebral cortex is essential for integration and processing of information that is required for most behaviors. The exquisitely precise laminar... 
Journal Article
Journal of Plastic, Reconstructive & Aesthetic Surgery, ISSN 1748-6815, 2008, Volume 61, Issue 10, pp. 1170 - 1176
Summary Background A lack of scientific data about the complex three dimensional changes in relation to the rest of the face is the reason for the multitude of... 
Plastic Surgery | Aging | Upper lip | Perioral | Rejuvenation | SURGERY | PHENOL CHEMICAL PEEL | CARBON-DIOXIDE LASER | RHYTIDES | LIFT | FACE | Lip - anatomy & histology | Anthropometry | Humans | Middle Aged | Child, Preschool | Male | Magnetic Resonance Imaging | Aging - physiology | Image Processing, Computer-Assisted | Adolescent | Face - anatomy & histology | Aged, 80 and over | Adult | Female | Aged | Skin Aging - physiology | Child | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. LB-346 - LB-346
OBJECTIVE: Here we aimed to overcome resistance to anti-VEGF therapy in glioblastoma (GBM), the most common and aggressive adult primary brain tumor. 
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 02/2016, Volume 108, Issue 2, p. 1
  Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer... 
Prescription drugs | Brain | Epidermal growth factor | Metastasis | Variance analysis
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14_Supplement, pp. LB - 347-LB-347
OBJECTIVE: We aimed to enhance the efficacy of anti-VEGF therapy in glioblastoma (GBM) through additional inhibition of Angiopoietin-2 (Ang-2), a potential... 
Journal Article
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