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Organic and Biomolecular Chemistry, ISSN 1477-0520, 7/2016, Volume 14, Issue 28, pp. 6611 - 6637
New advances in synthetic methodologies that allow rapid access to a wide variety of functionalized heterocyclic compounds are of critical importance to the... 
BORONIC ACIDS | MEDICINAL CHEMISTRY | VISIBLE-LIGHT | DIRECT ARYLATION | ONE-POT SYNTHESIS | LIGHT PHOTOREDOX CATALYSIS | CHEMISTRY, ORGANIC | ALDEHYDE OXIDASE | C-H FUNCTIONALIZATION | LATE-STAGE FUNCTIONALIZATION | ALKYL-HALIDES
Journal Article
Chemical Science, ISSN 2041-6520, 4/2015, Volume 6, Issue 5, pp. 265 - 2659
Sulfonyl fluoride electrophiles have found significant utility as reactive probes in chemical biology and molecular pharmacology. As warheads they possess the... 
Tyrosine | Enzymes | Utilities | Target recognition | Tools | Biology | Fluorides | Warheads
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 07/2018, Volume 57, Issue 30, pp. 9220 - 9223
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2019, Volume 27, Issue 15, pp. 3451 - 3453
Chemogenomics expedites the discovery of therapeutically-relevant targets from phenotypic screens. However, the vast majority of proteins in the proteome lack... 
Chemical probes | Chemoproteomics | Chemogenomics | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | LIGAND | PROTEINS | DISCOVERY | PROBES | Proteins | Mass spectrometry | Analysis
Journal Article
Nature Chemistry, ISSN 1755-4330, 11/2015, Volume 7, Issue 12, pp. 952 - 960
Vaccines have typically been prepared using whole organisms. These are normally either attenuated bacteria or viruses that are live but have been altered to... 
GLYCOCONJUGATE VACCINES | IMMUNOGENICITY | PROTEIN | GLYCANS | CONSTRUCTION | DOUBLE-BLIND | ANTIGENS | CRM197 | CHEMISTRY, MULTIDISCIPLINARY | CYTOTOXIC T-LYMPHOCYTES | STRATEGIES | Molecular Biology | Vaccines, Synthetic | Drug Design
Journal Article
Angewandte Chemie, ISSN 0044-8249, 07/2018, Volume 130, Issue 30, pp. 9362 - 9365
Das Handwerkszeug: Die Reaktion von niedermolekularen chemischen Sonden mit Proteinen wurde zur Entwicklung von kovalenten Inhibitoren und Technologien zur... 
Chemoproteomik | Lysin | Chemische Sonden | Tyrosin | Kinasen | Organic chemistry
Journal Article
Angewandte Chemie, ISSN 0044-8249, 07/2018, Volume 130, Issue 30, pp. 9362 - 9365
Journal Article
Molecular BioSystems, ISSN 1742-206X, 5/2016, Volume 12, Issue 6, pp. 1725 - 1727
Journal Article
ISSN 1359-7345, 5/2017, Volume 53, Issue 37, pp. 5182 - 5185
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a... 
Journal Article
Chemical Science, ISSN 2041-6520, 05/2015, Volume 6, Issue 5, pp. 2650 - 2659
Sulfonyl fluoride electrophiles have found significant utility as reactive probes in chemical biology and molecular pharmacology. As warheads they possess the... 
4-(FLUOROSULFONYL)BENZOIC ACID | ACID AMIDE HYDROLASE | ACTIVE-SITE | PROTEIN-KINASE | NUCLEOTIDE-BINDING SITES | IRREVERSIBLE ENZYME INHIBITORS | LIVER GLUTAMATE-DEHYDROGENASE | GLUTATHIONE-S-TRANSFERASE | CHEMISTRY, MULTIDISCIPLINARY | ACTIVITY-BASED PROBES | PHENYLMETHYLSULFONYL FLUORIDE | Chemistry
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 04/2017, Volume 16, Issue 4, pp. 285 - 296
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2014, Volume 88, pp. 1 - 2
Journal Article
Journal Article
Chemical Communications (Cambridge, England), ISSN 1359-7345, 5/2017, Volume 53, Issue 37, pp. 5182 - 5185
Protein targets of sulforaphane identified, and their affinities quantified, through competition-based chemical proteomics in two live breast cancer cell... 
Chemistry
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2018, Volume 9, Issue 7, pp. 584 - 586
Aryl fluorosulfates are finding widespread utility in chemical biology and medicinal chemistry. The context-dependent engagement of tyrosine, lysine, serine,... 
sulfonyl fluoride | protein labeling | chemoproteomics | Fluorosulfate | sulfur(VI)-fluoride | CHEMISTRY, MEDICINAL | SUFEX CLICK CHEMISTRY | WARHEADS | REACTIVITY | FLUORIDES
Journal Article
Future Medicinal Chemistry, ISSN 1756-8919, 10/2011, Volume 3, Issue 13, pp. 1585 - 1605
Journal Article
Future Medicinal Chemistry, ISSN 1756-8919, 2014, Volume 6, Issue 9, pp. 969 - 970
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2012, Volume 51, Issue 26, pp. 6320 - 6326
Heteromultifunctional scaffolds that harness sequential “click” reactions will find significant utility in the areas of chemical biology and chemically... 
bioconjugation | click chemistry | molecular scaffolds | chemical biology | SOLID-PHASE | CHEMISTRY | LIGATION | CLICK | CHEMISTRY, MULTIDISCIPLINARY | Oximes - chemistry | Sulfhydryl Compounds - chemistry | Cross-Linking Reagents - chemistry | Azides - chemistry | Drug Discovery | Utilities | Pocket | Tools | Transformations | Biology | Conjugation | Scaffolds | Harnesses | Cutlery
Journal Article