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1. Full Text Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
by Pinzone, Marilia Rita and VanBelzen, D. Jake and Weissman, Sam and Bertuccio, Maria Paola and Cannon, LaMont and Venanzi-Rullo, Emmanuele and Migueles, Stephen and Jones, R. Brad and Mota, Talia and Joseph, Sarah B and Groen, Kevin and Pasternak, Alexander O and Hwang, Wei-Ting and Sherman, Brad and Vourekas, Anastasios and Nunnari, Giuseppe and O’Doherty, Una
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 728 - 12
After initiating antiretroviral therapy (ART), a rapid decline in HIV viral load is followed by a long period of undetectable viremia. Viral outgrowth assay... 
INTACT HIV-1 | REPLICATION-COMPETENT HIV-1 | MULTIDISCIPLINARY SCIENCES | VIRAL PROTEIN | IMMUNODEFICIENCY-VIRUS TYPE-1 | DOWN-REGULATION | CD4(+) T-CELLS | ANTIRETROVIRAL THERAPY | LATENT RESERVOIR | RALTEGRAVIR INTENSIFICATION | PROVIRUSES | Antiviral Agents - therapeutic use | HIV-1 - drug effects | Proviruses - classification | HIV Infections - virology | Humans | Middle Aged | Male | Phylogeny | HIV-1 - genetics | Virus Latency - drug effects | Antiretroviral Therapy, Highly Active | Proviruses - drug effects | HIV-1 - physiology | Proviruses - genetics | Viremia - prevention & control | Adult | Female | HIV Infections - drug therapy | High-Throughput Nucleotide Sequencing | Mutation | Viral Load - drug effects | Longitudinal Studies | Antiretroviral drugs | Splicing | Viremia | Exons | Cloning | Proviruses | Antiretroviral therapy | Gene sequencing | Proteins | Antiretroviral agents | Human immunodeficiency virus--HIV | Reservoirs | Expansion | Index Medicus
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2. Full Text HLA-C downregulation by HIV-1 adapts to host HLA genotype
by Bachtel, Nathaniel D and Umviligihozo, Gisele and Pickering, Suzanne and Mota, Talia M and Liang, Hua and Del Prete, Gregory Q and Chatterjee, Pramita and Lee, Guinevere Q and Thomas, Rasmi and Brockman, Mark A and Neil, Stuart and Carrington, Mary and Bwana, Bosco and Bangsberg, David R and Martin, Jeffrey N and Kallas, Esper G and Donini, Camila S and Cerqueira, Natalia B and O’Doherty, Una T and Hahn, Beatrice H and Jones, R. Brad and Brumme, Zabrina L and Nixon, Douglas F and Apps, Richard
PLoS Pathogens, ISSN 1553-7366, 09/2018, Volume 14, Issue 9, pp. e1007257 - e1007257
HIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of this downregulation varies widely between primary HIV-1... 
IMMUNE CONTROL | NATURAL-KILLER-CELLS | NEF PROTEIN | IMMUNODEFICIENCY-VIRUS | SURFACE EXPRESSION | MICROBIOLOGY | CYTOTOXIC T-LYMPHOCYTES | VIROLOGY | NK CELLS | INFECTED CELLS | COMPLEX CLASS-I | CLASS-I MOLECULES | PARASITOLOGY | Amino Acid Sequence | HIV-1 - pathogenicity | Human Immunodeficiency Virus Proteins - immunology | Viral Regulatory and Accessory Proteins - immunology | Disease Reservoirs - virology | Down-Regulation | HIV Infections - genetics | HIV Infections - virology | Humans | Viral Regulatory and Accessory Proteins - genetics | Genotype | Host-Pathogen Interactions - immunology | Genetic Variation | HIV Infections - immunology | HIV-1 - immunology | Immune Evasion | Host-Pathogen Interactions - genetics | Human Immunodeficiency Virus Proteins - chemistry | Human Immunodeficiency Virus Proteins - genetics | HLA-C Antigens - genetics | Viral Regulatory and Accessory Proteins - chemistry | Histocompatibility antigens | HLA histocompatibility antigens | Physiological aspects | Genetic aspects | Research | HIV (Viruses) | Gene expression | Health sciences | Therapy | Residues | Peptides | Laboratories | Funding | Chronic infection | Cytotoxicity | Viruses | Lymphocytes T | Genomes | Infections | Immunology | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Genotypes | Supervision | Medical research | Preservation | Inflammation | Medicine | Hospitals | Infectious diseases | Alleles | Reservoirs | Histocompatibility antigen HLA | Science programs | Binding sites | Cancer | Index Medicus | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
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3. Full Text Susceptibility to Neutralization by Broadly Neutralizing Antibodies Generally Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs
by Ren, Yanqin and Ren, Yanqin and Korom, Maria and Korom, Maria and Truong, Ronald and Truong, Ronald and Chan, Dora and Chan, Dora and Huang, Szu-Han and Huang, Szu-Han and Kovacs, Colin C and Kovacs, Colin C and Benko, Erika and Safrit, Jeffrey T and Safrit, Jeffrey T and Lee, John and Lee, John and Garbán, Hermes and Garbán, Hermes and Apps, Richard and Apps, Richard and Goldstein, Harris and Goldstein, Harris and Lynch, Rebecca M and Lynch, Rebecca M and Jones, R Brad and Brad Jones, R
Journal of virology, ISSN 0022-538X, 12/2018, Volume 92, Issue 23
Efforts to cure human immunodeficiency virus (HIV) infection are obstructed by reservoirs of latently infected CD4(+) T cells that can reestablish viremia. HIV... 
bNAb | broadly neutralizing antibody | infected cell binding | correlation | neutralization | human immunodeficiency virus | ADCC | antibody-dependent cell cytotoxicity | RECOGNITION | ENVELOPE GLYCOPROTEIN | IDENTIFICATION | HIV-1-INFECTED CELLS | CD4 | VIROLOGY | NK CELLS | POTENCY | IMMUNODEFICIENCY-VIRUS TYPE-1 | CYTOTOXICITY | T-CELLS
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4. Full Text Current challenges and recent advances in the search for a cure for HIV
by Jones, R Brad
Journal of the International AIDS Society, ISSN 1758-2652, 02/2019, Volume 22, Issue 2, pp. e25248 - n/a
HIV | ARV | virology | clonal expansion | cure | reservoir | immunology | HIV reservoir | HIV cure | INFECTIOUS DISEASES | INTACT HIV-1 | CD4(+) T-CELLS | PROLIFERATION | LATENT RESERVOIR | PROVIRUSES | Medicine, Experimental | Highly active antiretroviral therapy | Medical research | Care and treatment | Usage | HIV infection
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5. Full Text Modeling HIV-1 Latency Using Primary CD4(+) T Cells from Virally Suppressed HIV-1-Infected Individuals on Antiretroviral Therapy
by Takata, H and Kessing, C and Sy, A and Lima, N and Sciumbata, J and Mori, L and Jones, RB and Chomont, N and Michael, NL and Valente, S and Trautmann, L
JOURNAL OF VIROLOGY, ISSN 0022-538X, 06/2019, Volume 93, Issue 11
The low frequency of latently HIV-infected cells in vivo limits the testing of potential HIV cure strategies using cells from successfully suppressed... 
RESERVOIR | VIROLOGY | INTEGRATION | PERSISTENCE | REACTIVATION | human immunodeficiency virus | latency model | ELIMINATION | INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | EXPRESSION | primary CD4 T cells
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6. Full Text HIV-specific [CD8.sup.+] T cells and HIV eradication
by Jones, R. Brad and Walker, Bruce D
Journal of Clinical Investigation, ISSN 0021-9738, 02/2016, Volume 126, Issue 2, p. 455
Immune response | Viral proteins | Development and progression | Genetic aspects | Genetic transcription | T cells | Observations | Properties | HIV infection | Health aspects
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7. Full Text HIV-specific CD8^sup +^ T cells and HIV eradication
by R Brad Jones and Bruce D Walker
Journal of Clinical Investigation, ISSN 0021-9738, 02/2016, Volume 126, Issue 2, p. 455
  After the success of combination antiretroviral therapy (cART) to treat HIV infection, the next great frontier is to cure infected persons, a formidable... 
Studies | Antigens | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Viruses | T cell receptors | Infections | Immune system
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8. Full Text HIV-specific CD8 super( +) T cells and HIV eradication
by Jones, R Brad and Walker, Bruce D
Journal of Clinical Investigation, ISSN 0021-9738, 02/2016, Volume 126, Issue 2, pp. 455 - 455
After the success of combination antiretroviral therapy (cART) to treat HIV infection, the next great frontier is to cure infected persons, a formidable... 
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9. Full Text Publisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir
by Osuna, Christa E and Lim, So-Yon and Kublin, Jessica L and Apps, Richard and Chen, Elsa and Mota, Talia M and Huang, Szu-Han and Ren, Yanqin and Bachtel, Nathaniel D and Tsibris, Athe M and Ackerman, Margaret E and Jones, R Brad and Nixon, Douglas F and Whitney, James B
Nature, ISSN 0028-0836, 11/2018, Volume 563, Issue 7733, pp. E33 - E33
In this Brief Communications Arising Comment, the first three authors (Osuna, Lim and Kublin) should have been listed as equally contributing authors; this has... 
HIV (Viruses) | Vaccines
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10. Full Text HIV Antibodies Decline During Antiretroviral Therapy but Remain Correlated with HIV DNA and HIV-specific T Cell Responses
by Keating, Sheila M and Jones, R Brad and Lalama, Christina M and Bosch, Ronald J and McMahon, Deborah and Hampton, Dylan and Cyktor, Joshua and Eron, Joseph J and Mellors, John W and Busch, Michael P and Gandhi, Rajesh T and and the ACTG 5321 team and ACTG 5321 Team
Journal of acquired immune deficiency syndromes (1999), ISSN 1525-4135, 04/2019, Volume 81, Issue 5, pp. 594 - 599
In people with HIV on antiretroviral therapy (ART), the relationship between HIV-specific immune responses and measures of HIV persistence is uncertain. We... 
INFECTIOUS DISEASES | HIV antibodies | RNA | HIV persistence | ASSAYS | HIV T-cell responses | IMMUNOLOGY | HIV reservoir | DECAY KINETICS | Medical research | Antigens | Antiretroviral drugs | Therapy | Correlation | Immune response | Clinical trials | Antibodies | Lymphocytes T | Ribonucleic acid--RNA | Antiretroviral therapy | Tat protein | Nef protein | Antiretroviral agents | Human immunodeficiency virus--HIV | γ-Interferon | Avidity | Drug therapy | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Immune system
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11. Full Text HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells
by Monel, Blandine and McKeon, Annmarie and Lamothe-Molina, Pedro and Jani, Priya and Boucau, Julie and Pacheco, Yovana and Jones, R. Brad and Le Gall, Sylvie and Walker, Bruce D
Cell Reports, ISSN 2211-1247, 04/2019, Volume 27, Issue 1, pp. 142 - 153.e4
Even with sustained antiretroviral therapy, resting CD4 T cells remain a persistent reservoir of HIV infection, representing a critical barrier to curing HIV.... 
perforin | granzyme | HIV | immunologic synapse | elite controllers | cytotoxic T lymphocytes | HLA | HIV cure | REPLICATION | FUSION | VIRUS INTEGRATION | QUANTITATION | INFECTED-CELLS | MECHANISMS | LATENT RESERVOIR | IMMUNOLOGICAL SYNAPSE | EFFICIENCY | STRATEGIES | CELL BIOLOGY
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12. Full Text Influence of Biological Sex, Age, and HIV Status in an in Vitro Primary Cell Model of HIV Latency Using a CXCR4 Tropic Virus
by Macedo, Amanda B and Resop, Rachel S and Martins, Laura J and Szaniawski, Matthew A and Sorensen, Eric S and Spivak, Adam M and Nixon, Douglas F and Jones, R. Brad and Planelles, Vicente and Bosque, Alberto
AIDS Research and Human Retroviruses, ISSN 0889-2229, 09/2018, Volume 34, Issue 9, pp. 769 - 777
Primary cell models of human immunodeficiency virus (HIV) latency have become tools to both understand the mechanisms involved in establishment of latency and... 
reservoirs | biological sex | HIV | primary cell models | age | latency | PLASMA VIREMIA | INFECTIOUS DISEASES | RECEPTOR 9 AGONIST | TRANSCRIPTION | CD4(+) T-CELLS | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | ESTABLISHMENT | REPLICATION | VIROLOGY | INFECTION | EXPRESSION | Cell culture | Immunological memory | Memory cells | Sex | Latent infection | Reversing | Viruses | Activation | Lymphocytes T | Infections | CXCR4 protein | CD4 antigen | Latency | Sexually transmitted diseases | Lymphocytes | Human immunodeficiency virus--HIV | Replication | Age | Index Medicus | AIDS/HIV | Her Legacy | The Krim Fellows | Review
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13. Full Text Antigen-independent induction of tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway
by Mujib, Shariq and Jones, R. Brad and Lo, Calvin and Aidarus, Nasra and Clayton, Kiera and Sakhdari, Ali and Benko, Erika and Kovacs, Colin and Ostrowski, Mario A
Journal of Immunology, ISSN 0022-1767, 04/2012, Volume 188, Issue 8, pp. 3745 - 3756
T cell Ig mucin domain-containing molecule 3 (Tim-3) is a glycoprotein found on the surface of a subset of CD8(+) and Th1 CD4(+) T cells. Elevated expression... 
IMMUNITY | ACTIVATION | HIV-INFECTION | VIRUS-INFECTION | INTERFERON-GAMMA | INTERLEUKIN-15 | ELEVATED FREQUENCIES | PERIPHERAL TOLERANCE | CD4(+) | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | CD8-Positive T-Lymphocytes - cytology | Humans | Interleukin-7 - pharmacology | Interleukin-15 - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Interleukin-2 - immunology | Interleukins - immunology | Galectins - immunology | Receptors, Antigen, T-Cell - immunology | Interleukins - pharmacology | CD4-Positive T-Lymphocytes - virology | Chromones - pharmacology | Signal Transduction | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | HIV Infections - virology | Cells, Cultured | Gene Expression Regulation | Morpholines - pharmacology | Membrane Proteins - immunology | CD28 Antigens - immunology | Hepatitis A Virus Cellular Receptor 2 | Interleukin-15 - pharmacology | Galectins - pharmacology | HIV-1 - immunology | Interleukin-7 - immunology | Phosphatidylinositol 3-Kinase - genetics | CD8-Positive T-Lymphocytes - virology | Interleukin-2 - pharmacology | Phosphatidylinositol 3-Kinase - immunology | Protein Kinase Inhibitors - pharmacology | CD8-Positive T-Lymphocytes - immunology | Index Medicus | Abridged Index Medicus
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14. Full Text Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy
by Bachtel, Nathaniel D and Beckerle, Greta A and Mota, Talia M and Rougvie, Miguel de Mulder and Raposo, Rui André Saraiva and Jones, R. Brad and Nixon, Douglas F and Apps, Richard
AIDS Research and Human Retroviruses, ISSN 0889-2229, 01/2019, Volume 35, Issue 1, pp. 18 - 111
Much has been learnt from the functions of host restriction factors during acute and chronic HIV-1 infection, but far less is known about their role in... 
Virology | viral reservoirs | restriction factors | HIV | persistent infection | antiretroviral therapy
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15. Full Text T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy
by Thomas, Allison S and Jones, Kimberley L and Gandhi, Rajesh T and McMahon, Deborah K and Cyktor, Joshua C and Chan, Dora and Huang, Szu-Han and Truong, Ronald and Bosque, Alberto and Macedo, Amanda B and Kovacs, Colin and Benko, Erika and Eron, Joseph J and Bosch, Ronald J and Lalama, Christina M and Simmens, Samuel and Walker, Bruce D and Mellors, John W and Jones, R Brad
PLoS pathogens, 09/2017, Volume 13, Issue 9, p. e1006629
HIV-specific CD8+ T-cell responses limit viral replication in untreated infection. After the initiation of antiretroviral therapy (ART), these responses decay... 
HIV Infections - immunology | Anti-Retroviral Agents - therapeutic use | nef Gene Products, Human Immunodeficiency Virus - immunology | Humans | Polymerase Chain Reaction | HIV Infections - drug therapy | Enzyme-Linked Immunospot Assay | CD8-Positive T-Lymphocytes - immunology | Virus Latency - immunology
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