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Journal of Clinical Investigation, ISSN 0021-9738, 02/2016, Volume 126, Issue 2, p. 455
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2016, Volume 126, Issue 2, p. 455
  After the success of combination antiretroviral therapy (cART) to treat HIV infection, the next great frontier is to cure infected persons, a formidable... 
Studies | Antigens | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Viruses | T cell receptors | Infections | Immune system
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2016, Volume 126, Issue 2, pp. 455 - 455
After the success of combination antiretroviral therapy (cART) to treat HIV infection, the next great frontier is to cure infected persons, a formidable... 
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2008, Volume 205, Issue 12, pp. 2763 - 2779
Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKEWED MATURATION | ACTIVATION | MULTIPLE-SCLEROSIS | IMMUNODEFICIENCY-VIRUS-INFECTION | IMPAIRED FUNCTION | CD4(+) | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | DISEASE PROGRESSION | LYMPHOCYTES | ANTIGEN | GATA3 Transcription Factor - genetics | T-Lymphocyte Subsets - immunology | Antigens, CD - immunology | HIV-1 - pathogenicity | T-Lymphocyte Subsets - cytology | GATA3 Transcription Factor - immunology | Humans | STAT5 Transcription Factor - immunology | T-Box Domain Proteins - immunology | Antigens, CD - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Extracellular Signal-Regulated MAP Kinases - immunology | HIV Infections - immunology | STAT5 Transcription Factor - genetics | Signal Transduction - immunology | HIV Infections - pathology | Apoptosis Regulatory Proteins - genetics | Apoptosis Regulatory Proteins - immunology | Membrane Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Membrane Proteins - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Hepatitis A Virus Cellular Receptor 2 | T-Box Domain Proteins - genetics | Disease Progression | Antiretroviral Therapy, Highly Active | HIV-1 - immunology | Phenotype | Animals | T-Lymphocytes - cytology | HIV Infections - drug therapy | Programmed Cell Death 1 Receptor | T-Lymphocytes - immunology | HIV Infections - physiopathology | HLA Antigens | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2018, Volume 128, Issue 2, pp. 876 - 889
The presence of persistent, latent HIV reservoirs in CD4(+) T cells obstructs current efforts to cure infection. The so-called kick and-kill paradigm proposes... 
MEDICINE, RESEARCH & EXPERIMENTAL | HIV-1-INFECTED CELLS | REPLICATION | BROADLY NEUTRALIZING ANTIBODIES | ACTIVE ANTIRETROVIRAL THERAPY | IMMUNODEFICIENCY-VIRUS TYPE-1 | CLASS-I | INFECTED-CELLS | VIRAL OUTGROWTH ASSAY | PROVIRUSES | LYMPHOCYTES | Index Medicus | Abridged Index Medicus
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 04/2017, Volume 21, Issue 4, pp. 494 - 506.e4
Journal Article
AIDS Research and Human Retroviruses, ISSN 0889-2229, 01/2019, Volume 35, Issue 1, pp. 18 - 111
Much has been learnt from the functions of host restriction factors during acute and chronic HIV-1 infection, but far less is known about their role in... 
Virology | viral reservoirs | restriction factors | HIV | persistent infection | antiretroviral therapy
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2016, Volume 12, Issue 4, pp. e1005545 - e1005545
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 06/2019, Volume 93, Issue 11
The low frequency of latently HIV-infected cells in vivo limits the testing of potential HIV cure strategies using cells from successfully suppressed... 
RESERVOIR | VIROLOGY | INTEGRATION | PERSISTENCE | REACTIVATION | human immunodeficiency virus | latency model | ELIMINATION | INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | EXPRESSION | primary CD4 T cells
Journal Article
Nature, ISSN 0028-0836, 09/2018, Volume 561, Issue 7723, pp. E20 - 3
The HIV-1 reservoir largely resides in quiescent CD4+ T cells2,3. [...]we sought to confirm the activation status of the CD4+ T cell populations by measuring... 
Antigens | Immunology | Lymphocytes | Cloning | Human immunodeficiency virus--HIV | Population | T cell receptors | Lymphocytes T | Deoxyribonucleic acid--DNA | Viral infections
Journal Article
Cytotherapy, ISSN 1465-3249, 8/2016, Volume 18, Issue 8, pp. 931 - 942
While antiretroviral therapy (ART) has been successful in controlling HIV infection, it does not provide a permanent cure solution, requires lifelong... 
artificial TCR | CRISPR | HDACIs | Adoptive T Cell Therapy | ZFN | HIV | chimeric antigen receptors | gene editing
Journal Article
AIDS Research and Human Retroviruses, ISSN 0889-2229, 09/2018, Volume 34, Issue 9, pp. 769 - 777
Primary cell models of human immunodeficiency virus (HIV) latency have become tools to both understand the mechanisms involved in establishment of latency and... 
Review Articles | The Krim Fellows: Her Legacy
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 38, pp. E8958 - E8967
Journal Article
Journal of Virology, ISSN 0022-538X, 03/2019, Volume 93, Issue 6
Curing HIV infection has been thwarted by the persistent reservoir of latently infected CD4(+) T cells, which reinitiate systemic infection after... 
HIV | Latent infection | Reservoir | PERSISTENCE | QUANTITATION | CD4(+) T-CELLS | VALPROIC ACID | VIRAL OUTGROWTH ASSAY | latent infection | COMBINATION | VIROLOGY | BROADLY NEUTRALIZING ANTIBODIES | ACTIVE ANTIRETROVIRAL THERAPY | INFECTION | CURE | reservoir | Index Medicus
Journal Article