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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 11, pp. 1923 - 1928
A collection of sixteen semisynthetic 17-hydroxycativic acid esters with alcohols containing a tertiary amine group was evaluated for their in vitro... 
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2017, Volume 25, Issue 24, p. 6523
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bmc.2017.10.032... 
Tyrosine | Alkaloids | Platelet-derived growth factor | Leukemia | Mitogens | Protein kinases
Journal Article
PURE AND APPLIED CHEMISTRY, ISSN 0033-4545, 07/2019, Volume 91, Issue 7, pp. 1085 - 1105
The synthesis and anticancer evaluation of new series of nucleosides constructed on 5/6-azidoglycosyl or glucuronamide moieties and containing an O- or an... 
SIGNALING PATHWAYS | ANALOGS | apoptosis | azido nucleosides | CELL-CYCLE KINASES | DRUG-RESISTANCE | CANCER | CHEMISTRY, MULTIDISCIPLINARY | GEMCITABINE | ICS-29 | nucleoside analogs | METABOLISM | PHARMACOLOGY | anticancer activity | glucuronamide-based nucleosides | MOLECULAR-MECHANISMS
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111663
Receptor tyrosine kinase PDGFRα is often constitutively activated in various tumours and is regarded as a drug target. Here, we present a collection of... 
PDGFRα | Acute myeloid leukaemia | Eosinophilic leukaemia | Kinase inhibitor
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 11/2017, Volume 40, Issue 11, p. 1923
A collection of sixteen semisynthetic 17-hydroxycativic acid esters with alcohols containing a tertiary amine group was evaluated for their in vitro... 
Biotechnology | Toxicity | Leukemia | Poly(ADP-ribose) polymerase | Cytotoxicity | Esters | Alcohol | Tumor cell lines | ADP | Alcohols | Anticancer properties | Polymerase | Poly(ADP-ribose) Polymerase 1 | Acids | Ribose | Cell death | Cell cycle | Diterpenes | Antitumor activity | Cancer | Apoptosis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 61, Issue 20, pp. 9105 - 9120
Cyclin-dependent kinases (CDKs) are an important and emerging class of drug targets for which many small-molecule inhibitors have been developed. However,... 
ANDROGEN RECEPTOR | THERMAL SHIFT ASSAY | IN-VITRO | CDK INHIBITORS | CHEMISTRY, MEDICINAL | 1ST GLOBAL APPROVAL | 2,6,9-TRISUBSTITUTED PURINES | SMALL-MOLECULE INHIBITORS | DNA-DAMAGE RESPONSE | METASTATIC BREAST-CANCER | HIGHLY POTENT
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2016, Volume 110, p. 291
A series of 5-substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives was synthesized and evaluated for their... 
Pyrimidines | Cell death | Phosphotransferases | Analysis | Protein kinases
Journal Article
Journal Article
ISSN 1477-0520, 5/2017, Volume 15, Issue 21, pp. 4667 - 468
The synthesis and anticancer evaluation of novel N -glycosyl derivatives containing N -substituted glucuronamide moieties, as nucleoside analogs or as... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 632 - 642
Journal Article
ACS Combinatorial Science, ISSN 2156-8952, 07/2015, Volume 17, Issue 7, pp. 426 - 432
Solid-phase synthesis of purine derivatives bearing an α-amino acid motif in position 9 is described herein. Polymer supported amines were acylated with... 
α-amino acids | anticancer activity | solid-phase synthesis | purine derivatives | Purines - chemical synthesis | Amino Acids - chemistry | Polymers - chemistry | Molecular Structure | Purines - chemistry
Journal Article
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