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Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7627, pp. 107 - 111
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7627, pp. 112 - 117
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL)(1,2). Because no other gene is... 
HIF-2-ALPHA | INHIBITION | RNA | GENE | PAS-B DOMAIN | DNA | MULTIDISCIPLINARY SCIENCES | HIF2-ALPHA | HYPOXIA-INDUCIBLE FACTOR-2 | TRANSCRIPTION FACTOR | EXPRESSION | Sulfones - therapeutic use | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Molecular Targeted Therapy | Sulfones - pharmacology | Indans - therapeutic use | Erythropoietin - blood | Sunitinib | Basic Helix-Loop-Helix Transcription Factors - metabolism | Female | Indoles - pharmacology | Indans - administration & dosage | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Binding Sites | Reproducibility of Results | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mice, SCID | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Pyrroles - pharmacology | Animals | Cell Transformation, Neoplastic | Cell Line, Tumor | Erythropoietin - antagonists & inhibitors | Indoles - therapeutic use | Kidney Neoplasms - pathology | Mice, Inbred NOD | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice | Mutation | Kidney Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Indans - pharmacology | Sulfones - administration & dosage | Physiological aspects | Molecular targeted therapy | Transcription factors | Carcinoma, Renal cell | Methods | kidney cancer | HIF-1β (F446L) | RCC | patient-derived xenograft | EPAS1 | HIF-2α (G323E) | renal cancer | ARNT
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 03/2018, Volume 36, Issue 9, pp. 867 - 867
Purpose The von Hippel-Lindau tumor suppressor is inactivated in the majority of clear cell renal cell carcinomas (ccRCCs), leading to inappropriate... 
HIF2-ALPHA | ONCOLOGY | PAS-B DOMAIN | TRANSCRIPTION FACTOR | CANCER | TUMORS | ORIGINAL REPORTS
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2008, Volume 52, Issue 12, pp. 4432 - 4441
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2018, Volume 61, Issue 21, pp. 9691 - 9721
HIF-2α, a member of the HIF family of transcription factors, is a key oncogenic driver in cancers such as clear cell renal cell carcinoma (ccRCC). A signature... 
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7627, p. 107
Clear cell renal cell carcinoma, the most common form of kidney cancer, is usually linked to inactivation of the pVHL tumour suppressor protein and consequent... 
Care and treatment | Genetic aspects | Carcinoma | Kidney cancer | Cancer | Biomarkers | Mutation | Metastasis | Tumors
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7627, pp. 107 - 111
Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is usually linked to inactivation of the pVHL tumor suppressor protein and... 
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. 2506 - 2506
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2019, Volume 62, Issue 15, pp. 6876 - 6893
The hypoxia-inducible factor 2 alpha (HIF-2 alpha) is a key oncogenic driver in clear cell renal cell carcinoma (ccRCC). Our first HIF-2 alpha inhibitor PT2385... 
CHEMISTRY, MEDICINAL | ANTAGONIST | FACTOR-2-ALPHA | POLYMORPHISMS | HIF | METABOLISM | PAS-B DOMAIN | HIF2-ALPHA | UGT2B17 | SUPPRESSION | SUFFICIENT | Index Medicus
Journal Article
by Aaron-Morrison, Arlene P and Ackerman, Steven A and Adams, Nicolaus G and Adler, Robert F and Albanil, Adelina and Alfaro, E. J and Allan, Rob and Alves, Lincoln M and Amador, Jorge A and Aneassen, L. M and Arendt, A and Arévalo, Juan and Arndt, Derek S and Arzhanova, N. M and Aschan, M. M and Azorin-Molina, César and Banzon, Viva and Bardin, M. U and Barichivich, Jonathan and Baringer, Molly O and Barreira, Sana and Baxter, Stephen and Bazo, Juan and Becker, Aneas and Bedka, Kristopher M and Behrenfeld, Michael J and Bell, Gerald D and Belmont, M and Benedetti, Angela and Bernhard, G and Berrisford, Paul and Berry, David I and Bettolli, María L and Bhatt, U. S and Bidegain, Mario and Bill, Brian D and Billheimer, Sam and Bissolli, Peter and Blake, Eric S and Blunden, Jessica and Bosilovich, Michael G and Boucher, Olivier and Boudet, Dagne and Box, J. E and Boyer, Tim and Braathen, Geir O and Bromwich, David H and Brown, R and Bulygina, Olga N and Burgess, D and Calderón, Blanca and Camargo, Suzana J and Campbell, Jayaka D and Cappelen, J and Carrasco, Gualberto and Carter, Brendan R and Chambers, Don P and Chandler, Elise and Christiansen, Hanne H and Christy, John R and Chung, Daniel and Chung, E. S and Cinque, Kathy and Clem, Kyle R and Coelho, Caio A and Cogley, J. G and Coldewey-Egbers, Melanie and Colwell, Steve and Cooper, Owen R and Copland, L and Cosca, Catherine E and Cross, Jessica N and Crotwell, Molly J and Crouch, Jake and Davis, Sean M and De Eyto, Elvira and De Jeu, Richard A.M and De Laat, Jos and Degasperi, Curtis L and Degenstein, Doug and Demircan, M and Derksen, C and Destin, Dale and Di Girolamo, Larry and Di Giuseppe, F and Diamond, Howard J and Dlugokencky, Ed J and Dohan, Kathleen and Dokulil, Martin T and Dolgov, A. V and Dolman, A. Johannes and Domingues, Catia M and Donat, Markus G and Dong, Shenfu and Dorigo, Wouter A and Dortch, Quay and Doucette, Greg and zdov, D. S and Ducklow, Hugh and Dunn, Robert J.H and ... and Stockholms universitet and Naturvetenskapliga fakulteten and Meteorologiska institutionen (MISU)
Bulletin of the American Meteorological Society, ISSN 0003-0007, 07/2015, Volume 96, Issue 7, pp. S1 - S267
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7627, p. 112
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL)1,2. Because no other gene is... 
Angiogenesis | Antagonist drugs | Kidney cancer | Clinical trials | Tumorigenesis | Mutation | Gene expression | Vascular endothelial growth factor | Cancer therapies | Tumors
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 13, pp. 3637 - 3641
Journal Article
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