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IEEE Microwave and Wireless Components Letters, ISSN 1531-1309, 07/2010, Volume 20, Issue 7, pp. 399 - 401
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e34693
LRRK2, a Parkinson's disease associated gene, is highly expressed in microglia in addition to neurons; however, its function in microglia has not been... 
PARKIN DEFICIENCY INCREASES | TRANSCRIPTIONAL ACTIVITY | DNA-BINDING | IN-VITRO | ACTIVATED PROTEIN-KINASE | LRRK2 EXPRESSION | CULTURED RAT MICROGLIA | NITRIC-OXIDE SYNTHASE | BIOLOGY | NEURONAL TOXICITY | NF-KAPPA-B | Cell Line | Microglia - metabolism | Nitric Oxide Synthase Type II - biosynthesis | Protein-Serine-Threonine Kinases - genetics | NF-kappa B - metabolism | Gene Knockdown Techniques | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Brain - metabolism | Animals | MAP Kinase Kinase 4 - metabolism | Encephalitis - metabolism | Lipopolysaccharides - pharmacology | Interleukin-1beta - biosynthesis | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Tumor Necrosis Factor-alpha - biosynthesis | Protein-Serine-Threonine Kinases - metabolism | RNA | Tumor necrosis factor | Nitric oxide | Luciferase | Inflammation | B cells | Protein kinases | Mitogens | Brain | Biotechnology | Neurosciences | Phosphorylation | Parkinson's disease | Transcription | Genes | Parkinsons disease | Kinases | Inflammatory diseases | Lipopolysaccharides | Interleukin 6 | Neurodegeneration | Rodents | LRRK2 protein | Deoxyribonucleic acid--DNA | Movement disorders | NF-κB protein | Immunoglobulins | Neurodegenerative diseases | Cloning | MAP kinase | JNK protein | Pharmacology | Tumor necrosis factor-α | Gene expression | Nitric-oxide synthase | Mutants | Microglia | Medicine | Polymerase chain reaction | Brain research | Ribonucleic acids | Protein kinase | Mutation | Alzheimers disease | NF- Kappa B protein | c-Jun amino-terminal kinase | DNA | Interleukin 1 | Microenvironments | Tumor necrosis factor- alpha | Deoxyribonucleic acid
Journal Article
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 07/2019, Volume 127, pp. 482 - 491
Dysfunctional regulation of inflammation may contribute to the progression of neurodegenerative diseases. The results of this study revealed that DJ-1, a... 
PGD2 | DJ-1 | Parkinson's disease | PTGDS | Brain inflammation
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2010, Volume 115, Issue 5, pp. 1161 - 1171
Microglia are known to be a primary inflammatory cell type in the brain. However, microglial inflammatory responses are attenuated in the injured brain... 
brain inflammation | brain injury | astrocytes | microglia | Astrocytes | Brain inflammation | Brain injury | Microglia | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | NEUROSCIENCES | CELL-DEATH | PIAS PROTEINS | INTERFERON-GAMMA | CULTURED RAT MICROGLIA | NITRIC-OXIDE | LIPOPOLYSACCHARIDE | ACTIVATED PROTEIN-KINASES | NF-KAPPA-B | EXPRESSION | L-Lactate Dehydrogenase - metabolism | Reactive Oxygen Species - metabolism | STAT Transcription Factors - metabolism | Culture Media, Conditioned - pharmacology | RNA, Messenger - metabolism | Cerebral Cortex - cytology | Hypoxia - metabolism | Intracellular Fluid - drug effects | Transfection - methods | Astrocytes - chemistry | Intracellular Fluid - metabolism | Animals, Newborn | Astrocytes - drug effects | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Hydrogen Peroxide - pharmacology | Gene Expression Regulation - physiology | Rats | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Electrophoretic Mobility Shift Assay - methods | Glucose - deficiency | Astrocytes - physiology | Oligonucleotides - metabolism | Animals | Interferon-gamma - pharmacology | Nitric Oxide Synthase Type II - metabolism | Brain | Medical colleges | Neurosciences | Messenger RNA | Anti-inflammatory drugs | Nitric oxide | Protein biosynthesis | Inflammation | Biological response modifiers | Injuries | Interferon gamma | Neurochemistry | Brain damage | Immunology | Cellular biology | Oxygen | Phosphorylation | Hydrogen peroxide | mRNA | Glucose | Nitric-oxide synthase | Nuclear transport | Promoters | gamma -Interferon
Journal Article
Glia, ISSN 0894-1491, 02/2018, Volume 66, Issue 2, pp. 445 - 458
Defects in repair of damaged brain accumulate injury and contribute to slow‐developing neurodegeneration. Here, we report that a deficiency of DJ‐1, a... 
Sox9 | Parkinson's disease | astrogliosis | brain repair | DJ‐1 | DJ-1 | SYSTEM | PROTEIN | SPINAL-CORD | NEUROSCIENCES | DEGENERATION | PINK1 | GDNF | ROLES | NEURONS | REACTIVE ASTROCYTES | EXPRESSION | SOX9 Transcription Factor - metabolism | Gliosis - genetics | Gliosis - metabolism | Mice, Inbred C57BL | Astrocytes - pathology | Cells, Cultured | Cerebral Cortex - pathology | Male | Protein Deglycase DJ-1 - genetics | Brain Injuries - genetics | Brain Injuries - metabolism | Parkinson Disease - genetics | Cerebral Cortex - metabolism | Mice, Knockout | Gliosis - pathology | Animals | Mice | Parkinson Disease - metabolism | Protein Stability | Brain Injuries - pathology | SOX9 Transcription Factor - genetics | Organ Culture Techniques | Astrocytes - metabolism | Protein Deglycase DJ-1 - deficiency | Ubiquitin | Tyrosine | Brain | Neurons | Genes | Genetic research | Brain damage | Diagnostic imaging | Hydroxylases | Injuries | Neuroimaging | Traumatic brain injury | Sox9 protein | Parkinsons disease | Tyrosine 3-monooxygenase | Neuronal-glial interactions | Defects | Ubiquitination | Head injuries | Neurodegeneration | Rodents | Neostriatum | Repair | Damage accumulation | Movement disorders | Neurodegenerative diseases | Axonogenesis | Astrocytes | Hydroxylase | Maintenance | PARK7 protein | Gliosis | Brain-derived neurotrophic factor | Magnetic resonance imaging | Destabilization | Brain injury
Journal Article
Cell Reports, ISSN 2211-1247, 01/2018, Volume 22, Issue 1, pp. 136 - 148
Recent evidence of prion-like propagation of α-synuclein (α-syn) into neighboring neurons set up a paradigm to elucidate the mechanism of progression of... 
SHP-2 | cell-to-cell transmission | SHP-1 | FcγRIIB | α-synuclein | PROTEOLYTIC CLEAVAGE | BETA RECEPTORS | NEGATIVE REGULATION | ALZHEIMERS-DISEASE | NEURODEGENERATION | PATHOLOGY | MODEL | FC-GAMMA-RIIB | GENOME-WIDE ASSOCIATION | PARKINSONS-DISEASE | CELL BIOLOGY
Journal Article
Journal Article
Journal Article
Acta Neuropathologica Communications, ISSN 2051-5960, 12/2019, Volume 7, Issue 1
Accumulating evidence indicates that endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD) and further suggests that several... 
Mitochondria | Neurodegeneration | Neurons | Protein folding | Parkinsons disease | Homeostasis | Mutation | Gene expression | Kinases | Endoplasmic reticulum | Autophagy | Apoptosis
Journal Article