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NATURE REVIEWS MOLECULAR CELL BIOLOGY, ISSN 1471-0072, 01/2013, Volume 14, Issue 1, pp. 49 - 55
Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of cell types and organisms. The newly-developed transcription... 
PLURIPOTENT STEM-CELLS | TRANSCRIPTION FACTORS | CLEAVAGE DOMAIN | DNA RECOGNITION | GENE DISRUPTION | DOUBLE-STRAND BREAKS | EFFECTOR NUCLEASES | EMBRYO MICROINJECTION | EFFICIENT GENERATION | ZINC-FINGER NUCLEASES | CELL BIOLOGY
Journal Article
NATURE BIOTECHNOLOGY, ISSN 1087-0156, 06/2014, Volume 32, Issue 6, pp. 569 - 569
Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we... 
ACTIVATION | ENDONUCLEASE | TALENS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CAS9
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7559, pp. 158 - 158
Journal Article
Nature Biotechnology, ISSN 1087-0156, 09/2013, Volume 31, Issue 9, pp. 822 - 826
Journal Article
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 3, pp. 279 - 284
Clustered, regularly interspaced, short palindromic repeat (CRISPR) RNA-guided nucleases (RGNs) are highly efficient genome editing tools(1-3).... 
ZINC-FINGER TARGETER | TRANSCRIPTION FACTORS | HUMAN GENOME | NICKING | ZIFIT | NICKASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN-CELLS | GENES | SYSTEMS | TOOL | Genetic research | Nucleases | Genetic engineering | Research | RNA | Methods | Enzymes | Mutation | Ribonucleic acid--RNA | Genomics | Index Medicus
Journal Article
Journal Article
Nature Methods, ISSN 1548-7091, 12/2017, Volume 14, Issue 12, pp. 1163 - 1166
Targeted and inducible regulation of mammalian gene expression is a broadly important capability. We engineered drug-inducible catalytically inactive Cpf1... 
SYSTEM | ACTIVATION | SPECIFICITIES | REPRESSION | HUMAN-CELLS | CRISPR RNA | CPF1 | BIOCHEMICAL RESEARCH METHODS | GENOME | Transcription factors | Genetic research | Models | Genetic engineering | Research | Properties | Genetic regulation | Multiplexing | Domains | CRISPR | Phenotypes | Gene regulation | Transcription activation | Nuclease | Gene expression | Screens | Combinatorial analysis | Index Medicus
Journal Article
Nature Methods, ISSN 1548-7091, 09/2011, Volume 8, Issue 9, pp. 765 - 772
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 10/2017, Volume 16, Issue 10
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