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clustered regularly interspaced short palindromic repeats (3) 3
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dna-binding proteins - metabolism (3) 3
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physiological aspects (3) 3
protein (3) 3
proto-oncogene proteins b-raf - antagonists & inhibitors (3) 3
ribonuclease (3) 3
rna, guide - genetics (3) 3
sensitivity (3) 3
sulfonamides - pharmacology (3) 3
transcription factors (3) 3
activation (2) 2
adaptive immunity (2) 2
adenosine (2) 2
antineoplastic agents - therapeutic use (2) 2
biochemistry & molecular biology (2) 2
cas9 (2) 2
catalysis (2) 2
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crispr-cas-systems (2) 2
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dengue virus - isolation & purification (2) 2
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drosophila (2) 2
drosophila melanogaster - embryology (2) 2
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drug resistance, neoplasm - drug effects (2) 2
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1. Full Text The 3rd Joint Symposium of the International and National Neurotrauma Societies and AANS/CNS Section on Neurotrauma and Critical Care August 11–16, 2018 Toronto, Canada
by Ghinda, Diana and Chen, Suzan and Bedaiwy, Mahmoud and Jabri, Hussam and Alshardan, Mohammad and Taccone, Michael S and Lai, Carolyn and Rabski, Jessica and Tsai, Eve and Dedek, Annemarie and Xu, Jian and Tsai, Eve and Lombroso, Paul and Hildebrand, Mike and Mothe, Andrea and Tator, Charles H and Siladi, Andrew and Nally, Jaqueline and Stirling, David and Keller, Anastasia and Buckley, Christian and Shum-Siu, Alice and Magnuson, David and Rosenbaum, Benjamin P and Kelly, Michael L and Ahuja, Christopher and Ahuja, Christopher and Nori, Satoshi and Khazaei, Mohamad and Ahlfors, Jan-Eric and Liu, Yang and Wang, Jian and Fuehrmann, Tobias and Pakulska, Malgosia and Hettiaratchi, Marian H and Poon, Peter and Shoichet, Molly S and Fehlings, Michael G and Fehlings, Michael G and Fehlings, Michael G and Hazrati, Lili-Naz and Cherian, Leela and Nilewski, Lizanne and Tour, James M and Kent, Thomas A and Robertson, Claudia S and Wilde, Elisabeth and Newsome, Mary and Scheibel, Randall and Troyanskaya, Maya and Velez, Carmen and Wade, Benjamin and Drennon, Ann Marie and York, Gerald and Bigler, Erin and Abildskov, Tracy and Taylor, Brian and Jaramillo, Carlos and Eapen, Blessen and Belanger, Heather and Morey, Rajendra and Haswell, Courtney and Levin, Harvey and Hinds, Sidney and Walker, William and Walker, William and Kochunov, Peter and Jahanshad, Neda and Thompson, Paul and Tate, David and Statz, Jonathan and Goodrich, Jessica and Goforth, Cdr Carl and Tschiffely, Anna E and Arena, John D and Smith, Douglas H and Wolf, John A and Johnson, Victoria E and Rhodes, James and Friess, Stuart and Lee, Taylor and Lycke, Roy J and Jang, Ikbeom and Vike, Nicole L and Nauman, Eric A and Talavage, Thomas M and Rispoli, Joseph V and Alonso-Escalante, Jose and Fulton, William and Sodhi, Chhinder and Hackam, David J and Nasr, Isam W and Hubbard, W B and Joseph, Binoy and Spry, Malinda L and Vekaria, Hemendra J and Saatman, Kathryn and Sullivan, Patrick G and Sullivan, Patrick G and Vascak, Michal and ...
Journal of Neurotrauma, ISSN 0897-7151, 08/2018, Volume 35, Issue 16, pp. A-1 - A-285
[...]the vast majority of basic science pain research ends at target identification and validation in rodent models of chronic pain without confirmation in... 
Abstracts | Neurosciences | Keywords | Traumatic brain injury | Cytokines | Central nervous system | Inflammation | Gene expression | Trauma | Studies | Brain research | Hospitals | Pain | Rodents | Stem cells | DNA methylation | Biomarkers | Spinal cord injuries | Growth factors | Research centers | Proteins
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2. Full Text Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a and Csm6
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Kellner, Max J and Joung, Julia and Collins, James J and Zhang, Feng
Science, ISSN 0036-8075, 04/2018, Volume 360, Issue 6387, pp. 439 - 444
Rapid detection of nucleic acids is integral for clinical diagnostics and biotechnological applications. We recently developed a platform termed SHERLOCK... 
IMMUNITY | SYSTEMS | CRISPR-CAS13 | THERMOPHILUS | CLEAVAGE | MULTIDISCIPLINARY SCIENCES | CRISPR-Associated Proteins - chemistry | RNA - analysis | DNA - analysis | Humans | Sensitivity and Specificity | Bacterial Proteins - chemistry | RNA, Viral - analysis | Dengue Virus - isolation & purification | Enzyme Assays | Zika Virus - isolation & purification | Endonucleases - chemistry | Multiplexing | Vector-borne diseases | CRISPR | Enzymes | RNA viruses | Single-stranded DNA | Dengue | Viral diseases | Viruses | Genomes | Nucleic acids | Ribonucleic acid--RNA | Sensitivity | Sample preparation | Acids | Biopsy | Technology | Diagnostic systems | Mutation | Enzymology | Deoxyribonucleic acid--DNA
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3. Full Text RNA editing with CRISPR-Cas13
by Cox, David B. T and Gootenberg, Jonathan S and Abudayyeh, Omar O and Franklin, Brian and Kellner, Max J and Joung, Julia and Zhang, Feng
Science, ISSN 0036-8075, 11/2017, Volume 358, Issue 6366, pp. 1019 - 1027
Nucleic acid editing holds promise for treating genetic disease, particularly at the RNA level, where disease-relevant sequences can be rescued to yield... 
IFIH1 | GUIDE | MULTIDISCIPLINARY SCIENCES | GENOME | ADAR1 | BASE | Biotechnology | Genetic Therapy | Endonucleases - genetics | Protein Engineering - methods | Adenosine Deaminase - genetics | Adenosine Deaminase - metabolism | RNA Editing | Humans | Bacterial Proteins - genetics | Endonucleases - metabolism | Recombinant Fusion Proteins - metabolism | Gene Knockdown Techniques | Endonucleases - classification | Diabetes Insipidus, Nephrogenic - therapy | Mutagenesis | Diabetes Insipidus, Nephrogenic - genetics | CRISPR-Cas Systems | HEK293 Cells | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Bacterial Proteins - classification | Fanconi Anemia - genetics | Fanconi Anemia - therapy | RNA | CRISPR | Protein engineering | Adenosine | RNA editing | Genetic disorders | Editing | Adenosine deaminase | Ribonuclease | Nucleic acids | Mammals | Gene expression | Ribonucleic acid--RNA | Gene sequencing | Mammalian cells | Engineering | Mutation | Repair
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4. Full Text Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
by Konermann, Silvana and Brigham, Mark D and Trevino, Alexandro E and Joung, Julia and Abudayyeh, Omar O and Barcena, Clea and Hsu, Patrick D and Habib, Naomi and Gootenberg, Jonathan S and Nishimasu, Hiroshi and Nureki, Osamu and Zhang, Feng
Nature, ISSN 0028-0836, 01/2015, Volume 517, Issue 7536, pp. 583 - 588
Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe... 
RAF INHIBITION | MELANOMA | RNA | PATHWAY | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | PROTEIN-COUPLED RECEPTORS | TARGET DNA | CAS9 | CANCER | Transcriptional Activation - genetics | Genetic Testing | RNA, Untranslated - metabolism | Humans | DNA, Complementary - genetics | Genetic Loci - genetics | RNA, Untranslated - genetics | Melanoma - genetics | DNA, Complementary - biosynthesis | Indoles - pharmacology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Expression Regulation, Neoplastic - genetics | Genetic Engineering - methods | Reproducibility of Results | Gene Library | CRISPR-Associated Proteins - genetics | Up-Regulation - genetics | Sulfonamides - pharmacology | CRISPR-Cas Systems - genetics | Genome, Human - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | RNA, Untranslated - biosynthesis | CRISPR-Associated Proteins - metabolism | Melanoma - drug therapy | Cell Line, Tumor | Drug Resistance, Neoplasm - drug effects | Enzymes | Nucleotide sequence | Genetic research | Genomes | Genetic aspects | Genetic engineering | Genetic transcription | Research | Proteins | Transcription factors | Genomics | Melanoma | Epigenetics | Drug resistance | Gene expression | Crystal structure
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5. Full Text C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Konermann, Silvana and Joung, Julia and Slaymaker, Ian M and Cox, David B. T and Shmakov, Sergey and Makarova, Kira S and Semenova, Ekaterina and Minakhin, Leonid and Severinov, Konstantin and Regev, Aviv and Lander, Eric S and Koonin, Eugene V and Zhang, Feng
Science, ISSN 0036-8075, 08/2016, Volume 353, Issue 6299, pp. aaf5573 - aaf5573
The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign... 
STREPTOCOCCUS-THERMOPHILUS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | BINDING PROTEINS | SURVEILLANCE COMPLEX | CAS IMMUNITY | THERMUS-THERMOPHILUS | PYROCOCCUS-FURIOSUS | ADAPTIVE BACTERIAL IMMUNITY | SPACER ACQUISITION | Bacteria | Ribonucleic acid--RNA | Genes | Immune system | Adaptive systems | Ribonucleic acids | Prokaryotes | Effectors | Interference | In vitro testing | Catalysis
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6. Full Text Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
by Chung, Won-Suk and Clarke, Laura E and Wang, Gordon X and Stafford, Benjamin K and Sher, Alexander and Chakraborty, Chandrani and Joung, Julia and Foo, Lynette C and Thompson, Andrew and Chen, Chinfei and Smith, Stephen J and Barres, Ben A
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7480, pp. 394 - 400
To achieve its precise neural connectivity, the developing mammalian nervous system undergoes extensive activity-dependent synapse remodelling. Recently,... 
REFINEMENT | RETINAL WAVES | PHAGOCYTOSIS | ENGULFMENT RECEPTOR DRAPER | MULTIDISCIPLINARY SCIENCES | CELL CORPSE ENGULFMENT | KINASE | BRAIN-DEVELOPMENT | C-ELEGANS | SEGREGATION | RETINOGENICULATE SYNAPSE | Lateral Thalamic Nuclei - cytology | Lateral Thalamic Nuclei - metabolism | Membrane Proteins - deficiency | Synapses - metabolism | c-Mer Tyrosine Kinase | Membrane Proteins - metabolism | Astrocytes - cytology | Proto-Oncogene Proteins - metabolism | Brain - cytology | Receptor Protein-Tyrosine Kinases - deficiency | Membrane Proteins - genetics | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins - deficiency | Receptor Protein-Tyrosine Kinases - metabolism | Retina - physiology | Learning - physiology | Animals | Receptor Protein-Tyrosine Kinases - genetics | Neural Pathways - cytology | Neural Pathways - metabolism | Mice | In Vitro Techniques | Phagocytosis | Astrocytes - metabolism | Proteins | Insects | Microscopy | Protein expression | Kinases | Laboratory animals | Gene expression
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7. Full Text Nucleic acid detection with CRISPR-Cas13a/C2c2
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Lee, Jeong Wook and Essletzbichler, Patrick and Dy, Aaron J and Joung, Julia and Verdine, Vanessa and Donghia, Nina and Daringer, Nichole M and Freije, Catherine A and Myhrvold, Cameron and Bhattacharyya, Roby P and Livny, Jonathan and Regev, Aviv and Koonin, Eugene V and Hung, Deborah T and Sabeti, Pardis C and Collins, James J and Zhang, Feng
Science, ISSN 0036-8075, 04/2017, Volume 356, Issue 6336, pp. 438 - 442
Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided,... 
CRISPR-CAS SYSTEMS | AMPLIFICATION | CIRCULATING TUMOR DNA | PROTEINS | MULTIDISCIPLINARY SCIENCES | ZIKA VIRUS | Circulating Tumor DNA - analysis | Zika Virus - genetics | Circulating Tumor DNA - genetics | Ribonucleases - chemistry | Humans | Bacterial Proteins - chemistry | RNA, Viral - analysis | RNA Cleavage | Zika Virus - isolation & purification | Dengue Virus - genetics | Bacteria - isolation & purification | RNA, Viral - genetics | Zika Virus Infection - diagnosis | Neoplasms - genetics | Point-of-Care Systems | Clustered Regularly Interspaced Short Palindromic Repeats | DNA, Bacterial - analysis | Bacteria - pathogenicity | Dengue Virus - isolation & purification | Mutation | Dengue - diagnosis | Methods | Nucleotide sequencing | DNA sequencing | Vector-borne diseases | Pathogens | CRISPR | Target recognition | Nucleotide sequence | Dengue | Viruses | Zika virus | Nucleic acids | Ribonuclease | Recombinase | Ribonucleic acid--RNA | Sensitivity | Genotyping | Reagents | Bacteria | Deoxyribonucleic acid--DNA | Amplification | Ribonucleic acids | Deoxyribonucleic acid
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8. Full Text RNA targeting with CRISPR-Cas13
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Essletzbichler, Patrick and Han, Shuo and Joung, Julia and Belanto, Joseph J and Verdine, Vanessa and Cox, David B. T and Kellner, Max J and Regev, Aviv and Lander, Eric S and Voytas, Daniel F and Ting, Alice Y and Zhang, Feng
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7675, pp. 280 - 284
RNA has important and diverse roles in biology, but molecular tools to manipulate and measure it are limited. For example, RNA interference(1-3) can... 
CELLS | ACTIVATION | MULTIDISCIPLINARY SCIENCES | CAS SYSTEMS | INTERFERENCE | KNOCKOUT | EXPRESSION | Binding | CRISPR | RNA-mediated interference | Genomics | Interference | Genomes | RNA polymerase | Mammals | Gene expression | Ribonucleic acid--RNA | Mammalian cells | Plant cells | E coli | Genetic engineering
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9. Full Text Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
by Joung, Julia and Konermann, Silvana and Gootenberg, Jonathan S and Abudayyeh, Omar O and Platt, Randall J and Brigham, Mark D and Sanjana, Neville E and Zhang, Feng
Nature Protocols, ISSN 1754-2189, 04/2017, Volume 12, Issue 4, pp. 828 - 863
Forward genetic screens are powerful tools for the unbiased discovery and functional characterization of specific genetic elements associated with a phenotype... 
SYSTEM | DOUBLE-STRANDED-RNA | ESSENTIAL GENES | DNA CLEAVAGE | CRISPR/CAS9 | HUMAN-CELLS | BIOCHEMICAL RESEARCH METHODS | INTERFERENCE | LENTIVIRAL RNAI LIBRARY | FUNCTIONAL GENOMICS | CAS9 NUCLEASE | Phenotype | Animals | Gene Library | Humans | Transcriptional Activation | Lentivirus - genetics | Mice | Genomics - methods | CRISPR-Cas Systems - genetics | Gene Knockout Techniques - methods | Genetic Vectors - genetics | Genetic engineering | Models | Genetic transcription | Analysis | Innovations
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10. Full Text Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
by Dahlman, James E and Abudayyeh, Omar O and Joung, Julia and Gootenberg, Jonathan S and Zhang, Feng and Konermann, Silvana
Nature Biotechnology, ISSN 1087-0156, 11/2015, Volume 33, Issue 11, pp. 1159 - 1161
We have developed a CRISPR-based method that uses catalytically active Cas9 and distinct single guide (sgRNA) constructs to knock out and activate different... 
IMMUNITY | CELLS | COMPLEX | ENDONUCLEASE | SPECIFICITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | TRANSCRIPTION | CRISPR-CAS9 | GUIDE RNA | GENOME | Endonucleases - genetics | RNA, Guide - genetics | Humans | Gene Knockout Techniques - methods | Bacterial Proteins - genetics | HEK293 Cells | Nucleases | Physiological aspects | Streptococcus pyogenes | Genetic aspects | Research | Gene expression | Structure | Health aspects | Genetic engineering | Catalysis | Ribonucleic acid--RNA | Genomics
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11. Full Text High-resolution interrogation of functional elements in the noncoding genome
by Sanjana, Neville E and Wright, Jason and Zheng, Kaijie and Shalem, Ophir and Fontanillas, Pierre and Joung, Julia and Cheng, Christine and Regev, Aviv and Zhang, Feng
Science, ISSN 0036-8075, 09/2016, Volume 353, Issue 6307, pp. 1545 - 1549
The noncoding genome affects gene regulation and disease, yet we lack tools for rapid identification and manipulation of noncoding elements. We developed a... 
TRANSCRIPTION FACTOR-BINDING | CHROMATIN | DISSECTION | MULTIDISCIPLINARY SCIENCES | SITES | MODEL | ENHANCERS | RNA, Guide - genetics | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Genetic Loci | Genes, Neurofibromatosis 1 | Genes, Neurofibromatosis 2 | Melanoma - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Genomics - methods | Gene Expression Regulation | Sulfonamides - pharmacology | Bacterial Proteins | Cullin Proteins - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Mutagenesis | Sulfonamides - therapeutic use | Melanoma - drug therapy | Endonucleases | Indoles - therapeutic use | Enhancer Elements, Genetic - genetics | Enhancer Elements, Genetic - physiology | Genome, Human | Noncoding DNA | Genetic regulation | Analysis | Epigenetics | Transcription factors | Genomes | Drug resistance | Melanoma | Index Medicus | Drugs | Mutations | Inhibitors | Genes | Interrogation | Gene expression | Screens
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12. Full Text RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
by Zeitlinger, Julia and Stark, Alexander and Kellis, Manolis and Hong, Joung-Woo and Nechaev, Sergei and Adelman, Karen and Levine, Michael and Young, Richard A
Nature Genetics, ISSN 1061-4036, 12/2007, Volume 39, Issue 12, pp. 1512 - 1516
It is widely assumed that the key rate-limiting step in gene activation is the recruitment of RNA polymerase II ( Pol II) to the core promoter(1). Although... 
RECRUITMENT | MESODERM DEVELOPMENT | TARGET GENES | PROTEIN | GENETICS & HEREDITY | TRANSCRIPTION ELONGATION | PROMOTER | EXPRESSION | DORSAL | PROXIMAL REGION | SNAIL | Drosophila melanogaster - metabolism | Drosophila melanogaster - embryology | Animals | Transcriptional Activation | Embryo, Nonmammalian | Gene Expression Regulation | Genome, Insect | DNA-Directed RNA Polymerases - metabolism | Drosophila melanogaster - genetics | Genes, Developmental | Physiological aspects | Embryo | Genetic aspects | Research | Drosophila | RNA polymerases | Enzymes | Insects | Ribonucleic acid | Genes | Genetic research | Prenatal development | Ribonucleic acid--RNA | Embryos
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