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1. Full Text Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a and Csm6
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Kellner, Max J and Joung, Julia and Collins, James J and Zhang, Feng
Science (American Association for the Advancement of Science), ISSN 0036-8075, 04/2018, Volume 360, Issue 6387, pp. 439 - 444
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CRISPR-Associated Proteins - chemistry | RNA - analysis | DNA - analysis | Humans | Sensitivity and Specificity | Bacterial Proteins - chemistry | RNA, Viral - analysis | Dengue Virus - isolation & purification | Enzyme Assays | Zika Virus - isolation & purification | Endonucleases - chemistry | Multiplexing | Vector-borne diseases | CRISPR | Enzymes | RNA viruses | Single-stranded DNA | Dengue | Viral diseases | Viruses | Genomes | Nucleic acids | Ribonucleic acid--RNA | Sensitivity | Human papillomavirus | Sample preparation | Acids | Biopsy | Technology | Diagnostic systems | Mutation | Enzymology | Deoxyribonucleic acid--DNA | Index Medicus
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2. Full Text RNA editing with CRISPR-Cas13
by Cox, David B. T and Gootenberg, Jonathan S and Abudayyeh, Omar O and Franklin, Brian and Kellner, Max J and Joung, Julia and Zhang, Feng
Science (American Association for the Advancement of Science), ISSN 0036-8075, 11/2017, Volume 358, Issue 6366, pp. 1019 - 1027
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biotechnology | Genetic Therapy | Endonucleases - genetics | Protein Engineering - methods | Adenosine Deaminase - genetics | Adenosine Deaminase - metabolism | RNA Editing | Humans | Bacterial Proteins - genetics | Endonucleases - metabolism | Recombinant Fusion Proteins - metabolism | Gene Knockdown Techniques | Endonucleases - classification | Diabetes Insipidus, Nephrogenic - therapy | Mutagenesis | Diabetes Insipidus, Nephrogenic - genetics | CRISPR-Cas Systems | HEK293 Cells | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Bacterial Proteins - classification | Fanconi Anemia - genetics | Fanconi Anemia - therapy | RNA | CRISPR | Protein engineering | Adenosine | RNA editing | Genetic disorders | Editing | Adenosine deaminase | Ribonuclease | Nucleic acids | Mammals | Gene expression | Ribonucleic acid--RNA | Gene sequencing | Mammalian cells | Engineering | Mutation | Repair | Index Medicus
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3. Full Text Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
by Konermann, Silvana and Brigham, Mark D and Trevino, Alexandro E and Joung, Julia and Abudayyeh, Omar O and Barcena, Clea and Hsu, Patrick D and Habib, Naomi and Gootenberg, Jonathan S and Nishimasu, Hiroshi and Nureki, Osamu and Zhang, Feng
Nature (London), ISSN 0028-0836, 01/2015, Volume 517, Issue 7536, pp. 583 - 588
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Transcriptional Activation - genetics | Genetic Testing | RNA, Untranslated - metabolism | Humans | DNA, Complementary - genetics | Genetic Loci - genetics | RNA, Untranslated - genetics | Melanoma - genetics | DNA, Complementary - biosynthesis | Indoles - pharmacology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Expression Regulation, Neoplastic - genetics | Genetic Engineering - methods | Reproducibility of Results | Gene Library | CRISPR-Associated Proteins - genetics | Up-Regulation - genetics | Sulfonamides - pharmacology | CRISPR-Cas Systems - genetics | Genome, Human - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | RNA, Untranslated - biosynthesis | CRISPR-Associated Proteins - metabolism | Melanoma - drug therapy | Cell Line, Tumor | Drug Resistance, Neoplasm - drug effects | Enzymes | Nucleotide sequence | Genetic research | Genomes | Genetic aspects | Genetic engineering | Genetic transcription | Research | Proteins | Transcription factors | Genomics | Melanoma | Epigenetics | Drug resistance | Gene expression | Crystal structure | Index Medicus
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4. Full Text RNA targeting with CRISPR-Cas13
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Essletzbichler, Patrick and Han, Shuo and Joung, Julia and Belanto, Joseph J and Verdine, Vanessa and Cox, David B. T and Kellner, Max J and Regev, Aviv and Lander, Eric S and Voytas, Daniel F and Ting, Alice Y and Zhang, Feng
Nature (London), ISSN 0028-0836, 10/2017, Volume 550, Issue 7675, pp. 280 - 284
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CRISPR-Associated Proteins - chemistry | Biocatalysis | Plant Cells - metabolism | RNA - analysis | CRISPR-Associated Proteins - genetics | Cell Survival | Humans | Leptotrichia - enzymology | Stress, Physiological | Substrate Specificity | Genes, Reporter - genetics | Gene Knockdown Techniques - methods | Gene Editing | RNA - genetics | Leptotrichia - genetics | RNA Interference | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | HEK293 Cells | Cell Line, Tumor | RNA - metabolism | Binding | CRISPR | RNA-mediated interference | Genomics | Interference | Genomes | RNA polymerase | Mammals | Gene expression | Ribonucleic acid--RNA | Mammalian cells | Plant cells | E coli | Genetic engineering | Index Medicus
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5. Full Text Nucleic acid detection with CRISPR-Cas13a/C2c2
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Lee, Jeong Wook and Essletzbichler, Patrick and Dy, Aaron J and Joung, Julia and Verdine, Vanessa and Donghia, Nina and Daringer, Nichole M and Freije, Catherine A and Myhrvold, Cameron and Bhattacharyya, Roby P and Livny, Jonathan and Regev, Aviv and Koonin, Eugene V and Hung, Deborah T and Sabeti, Pardis C and Collins, James J and Zhang, Feng
Science (American Association for the Advancement of Science), ISSN 0036-8075, 04/2017, Volume 356, Issue 6336, pp. 438 - 442
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Circulating Tumor DNA - analysis | Zika Virus - genetics | Circulating Tumor DNA - genetics | Ribonucleases - chemistry | Humans | Bacterial Proteins - chemistry | RNA, Viral - analysis | RNA Cleavage | Zika Virus - isolation & purification | Dengue Virus - genetics | Bacteria - isolation & purification | RNA, Viral - genetics | Zika Virus Infection - diagnosis | Neoplasms - genetics | Point-of-Care Systems | Clustered Regularly Interspaced Short Palindromic Repeats | DNA, Bacterial - analysis | Bacteria - pathogenicity | Dengue Virus - isolation & purification | Mutation | Dengue - diagnosis | Methods | Nucleotide sequencing | DNA sequencing | Vector-borne diseases | Pathogens | CRISPR | Target recognition | Nucleotide sequence | Dengue | Viruses | Zika virus | Nucleic acids | Ribonuclease | Recombinase | Ribonucleic acid--RNA | Sensitivity | Genotyping | Reagents | Bacteria | Deoxyribonucleic acid--DNA | Index Medicus | Amplification | Ribonucleic acids | Deoxyribonucleic acid
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6. Full Text Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
by Joung, Julia and Konermann, Silvana and Gootenberg, Jonathan S and Abudayyeh, Omar O and Platt, Randall J and Brigham, Mark D and Sanjana, Neville E and Zhang, Feng
Nature protocols, ISSN 1754-2189, 04/2017, Volume 12, Issue 4, pp. 828 - 863
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Phenotype | Animals | Gene Library | Humans | Transcriptional Activation | Lentivirus - genetics | Mice | Genomics - methods | CRISPR-Cas Systems - genetics | Gene Knockout Techniques - methods | Genetic Vectors - genetics | Genetic engineering | Models | Genetic transcription | Analysis | Innovations | Index Medicus
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7. Full Text Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
by Chung, Won-Suk and Clarke, Laura E and Wang, Gordon X and Stafford, Benjamin K and Sher, Alexander and Chakraborty, Chandrani and Joung, Julia and Foo, Lynette C and Thompson, Andrew and Chen, Chinfei and Smith, Stephen J and Barres, Ben A
Nature (London), ISSN 0028-0836, 2013, Volume 504, Issue 7480, pp. 394 - 400
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Biological and medical sciences | Lateral Thalamic Nuclei - cytology | Lateral Thalamic Nuclei - metabolism | Membrane Proteins - deficiency | Synapses - metabolism | c-Mer Tyrosine Kinase | Membrane Proteins - metabolism | Astrocytes - cytology | Proto-Oncogene Proteins - metabolism | Brain - cytology | Receptor Protein-Tyrosine Kinases - deficiency | Membrane Proteins - genetics | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins - deficiency | Receptor Protein-Tyrosine Kinases - metabolism | Retina - physiology | Learning - physiology | Animals | Receptor Protein-Tyrosine Kinases - genetics | Neural Pathways - cytology | Neural Pathways - metabolism | Mice | In Vitro Techniques | Phagocytosis | Astrocytes - metabolism | Proteins | Insects | Microscopy | Protein expression | Kinases | Laboratory animals | Gene expression | Index Medicus
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8. Full Text Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
by Dahlman, James E and Abudayyeh, Omar O and Joung, Julia and Gootenberg, Jonathan S and Zhang, Feng and Konermann, Silvana
Nature biotechnology, ISSN 1087-0156, 11/2015, Volume 33, Issue 11, pp. 1159 - 1161
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Endonucleases - genetics | RNA, Guide - genetics | Humans | Gene Knockout Techniques - methods | Bacterial Proteins - genetics | HEK293 Cells | Nucleases | Physiological aspects | Streptococcus pyogenes | Genetic aspects | Research | Gene expression | Structure | Health aspects | Genetic engineering | Catalysis | Ribonucleic acid--RNA | Genomics | Index Medicus
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9. Full Text High-resolution interrogation of functional elements in the noncoding genome
by Sanjana, Neville E and Wright, Jason and Zheng, Kaijie and Shalem, Ophir and Fontanillas, Pierre and Joung, Julia and Cheng, Christine and Regev, Aviv and Zhang, Feng
Science (American Association for the Advancement of Science), ISSN 0036-8075, 09/2016, Volume 353, Issue 6307, pp. 1545 - 1549
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA, Guide - genetics | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Genetic Loci | Genes, Neurofibromatosis 1 | Genes, Neurofibromatosis 2 | Melanoma - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Genomics - methods | Gene Expression Regulation | Sulfonamides - pharmacology | Bacterial Proteins | Cullin Proteins - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Mutagenesis | Sulfonamides - therapeutic use | Melanoma - drug therapy | Endonucleases | Indoles - therapeutic use | Enhancer Elements, Genetic - genetics | Enhancer Elements, Genetic - physiology | Genome, Human | Noncoding DNA | Genetic regulation | Analysis | Epigenetics | Transcription factors | Genomes | Drug resistance | Melanoma | Index Medicus | Drugs | Mutations | Inhibitors | Genes | Interrogation | Gene expression | Screens
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10. Full Text C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Konermann, Silvana and Joung, Julia and Slaymaker, Ian M and Cox, David B. T and Shmakov, Sergey and Makarova, Kira S and Semenova, Ekaterina and Minakhin, Leonid and Severinov, Konstantin and Regev, Aviv and Lander, Eric S and Koonin, Eugene V and Zhang, Feng
Science (American Association for the Advancement of Science), ISSN 0036-8075, 08/2016, Volume 353, Issue 6299, pp. aaf5573 - aaf5573
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Structure, Tertiary | Endoribonucleases - chemistry | Endoribonucleases - genetics | Endoribonucleases - metabolism | Levivirus - immunology | RNA, Guide - metabolism | Leptotrichia - enzymology | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Escherichia coli - immunology | Molecular Sequence Data | RNA Cleavage | Genetic Loci | Adaptive Immunity - genetics | Gene Knockdown Techniques | Leptotrichia - genetics | Escherichia coli - virology | Escherichia coli - genetics | Base Sequence | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Leptotrichia - immunology | Bacterial Proteins - metabolism | Bacteria | Ribonucleic acid--RNA | Genes | Immune system | Index Medicus | Adaptive systems | Ribonucleic acids | Prokaryotes | Effectors | Interference | In vitro testing | Catalysis
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