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1. Full Text PTH: Potential role in management of heart failure
by Gruson, D and Buglioni, A and Burnett, J.C
Clinica Chimica Acta, ISSN 0009-8981, 06/2014, Volume 433, pp. 290 - 296
Biomarkers play an important role for the diagnosis and prognosis of heart failure (HF), a disease with high morbidity and mortality as well as a huge impact... 
Heart failure | Aldosterone | Parathyroid hormone | BNP | FGF-23 | Multimarker | VITAMIN-D | SECONDARY HYPERPARATHYROIDISM | CALCIUM PARADOX | LEFT-VENTRICULAR HYPERTROPHY | PARATHYROID-HORMONE ASSAYS | ALL-CAUSE MORTALITY | GROWTH-FACTOR 23 | CARDIOVASCULAR-DISEASES | MEDICAL LABORATORY TECHNOLOGY | CHRONIC KIDNEY-DISEASE | PLASMA-ALDOSTERONE LEVELS | Heart Failure - therapy | Animals | Parathyroid Hormone - metabolism | Humans | Myocardium - metabolism | Heart Failure - diagnosis | Heart Failure - metabolism | Parathyroid Hormone - blood | Heart Failure - blood
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2. Full Text Insulin/glucose induces natriuretic peptide clearance receptor in human adipocytes: A metabolic link with the cardiac natriuretic pathway
by Bordicchia, M and Ceresiani, M and Pavani, M and Minardi, D and Polito, M and Wabitsch, M and Cannone, V and Burnett, J.C and Dessì-Fulgheri, P and Sarzani, R
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 07/2016, Volume 311, Issue 1, pp. R104 - R114
Cardiac natriuretic peptides (NP) are involved in cardiorenal regulation and in lipolysis. The NP activity is largely dependent on the ratio between the... 
Natriuretic peptide receptors | Insulin resistance | Insulin-induced genes | Lipolysis | PHYSIOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE | insulin-induced genes | PHOSPHOINOSITIDE 3-KINASE | WORTMANNIN | INSULIN | natriuretic peptide receptors | LIPOLYTIC PATHWAY | OBESE-PATIENTS | FAT-CELLS | lipolysis | GENETIC VARIANT | insulin resistance | EXPRESSION | ADIPOSE-TISSUE | Insulin - pharmacology | Natriuresis - drug effects | Natriuretic Peptides - metabolism | Receptors, Atrial Natriuretic Factor - metabolism | Humans | Cells, Cultured | Male | Glucose - pharmacology | Intra-Abdominal Fat - cytology | Adipocytes - drug effects | Receptors, Atrial Natriuretic Factor - antagonists & inhibitors | Insulin - blood | Intra-Abdominal Fat - metabolism | Hypoglycemic Agents - pharmacology | Up-Regulation - drug effects | Signal Transduction - drug effects | Adipocytes - metabolism | Lipids - blood | Heart - drug effects | Female | Aged | Intra-Abdominal Fat - drug effects | Receptors, Atrial Natriuretic Factor - drug effects | Adipose tissues | Physiological research | Fat cells | Research | Natriuretic peptides
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3. Full Text Low-dose nesiritide in human anterior myocardial infarction suppresses aldosterone and preserves ventricular function and structure: a proof of concept study
by Chen, H H and Martin, F L and Gibbons, R J and Schirger, J A and Wright, R S and Schears, R M and Redfield, M M and Simari, R D and Lerman, A and Cataliotti, A and Burnett, J C
Heart, ISSN 1355-6037, 08/2009, Volume 95, Issue 16, pp. 1315 - 1319
Background:B-type natriuretic peptide (BNP, nesiritide) has anti-fibrotic, anti-hypertrophic, anti-inflammatory, vasodilating, lusitropic and... 
CARDIAC FIBROBLASTS | CARDIAC & CARDIOVASCULAR SYSTEMS | DYSFUNCTION | ATRIAL-NATRIURETIC-PEPTIDE | HEART-FAILURE | Mineralocorticoid Receptor Antagonists - administration & dosage | Humans | Middle Aged | Stroke Volume - drug effects | Male | Natriuretic Peptide, Brain - administration & dosage | Recombinant Proteins - administration & dosage | Myocardial Infarction - drug therapy | Natriuretic Agents - administration & dosage | Female | Myocardial Infarction - physiopathology | Vasodilator Agents - administration & dosage | Ventricular Remodeling - drug effects | Care and treatment | Patient outcomes | Heart ventricles | Physiological aspects | Research | Aldosterone | Heart attack | Natriuretic peptides | Studies | Heart failure | Enzymes | Heart attacks | Peptides | Rodents | Clinical trials | Cardiovascular disease | Trends | Kinases
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4. Full Text PP.19.26
: NATRIURETIC PEPTIDE CLEARANCE RECEPTOR IS INDUCED BY INSULIN AND IS ASSOCIATED WITH CLINICAL METABOLIC PARAMETERS
by Sarzani, R and Bordicchia, M and Ceresiani, M and Pocognoli, A and Pavani, M and Spannella, F and Muzzonigro, G and Polito, M and Wabitsch, M and Cannone, V and Jr, J.C. Burnett and Dessì-Fulgheri, P
Journal of Hypertension, ISSN 0263-6352, 06/2015, Volume 33, p. e304
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5. Full Text BNP: Increasing importance in the pathophysiology and diagnosis of congestive heart failure
by Grantham, J.A and Burnett J.C, Jr
Circulation, ISSN 0009-7322, 1997, Volume 96, Issue 2, pp. 388 - 390
Heart failure | Editorials | Prognosis | Hormones | Natriuretic peptides | K MA HEMATOLOGY | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | ATRIAL-NATRIURETIC-PEPTIDE | hormones | K ZD PERIPHERAL VASCULAR DISEASE | editorials | RECEPTOR | MODEL | prognosis | natriuretic peptides | K DQ CARDIAC & CARDIOVASCULAR SYSTEMS | DOGS | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | HEMATOLOGY | BRAIN | Heart Failure - diagnosis | Heart Failure - metabolism | Natriuretic Peptide, Brain | Humans | Heart Failure - physiopathology | Nerve Tissue Proteins - urine
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6. Improving limits of detection for B-type natriuretic peptide using PC-IDMS: An application of the ALiPHAT strategy
by Shuford, C.M and Comins, D.L and Whitten, J.L and Burnett, J.C.,Jr and Muddiman, D.C
Analyst (Cambridge UK), ISSN 0003-2654, 01/2010, Volume 135, Issue 1, pp. 36 - 41
Hydrophobic tagging of biomolecules has been reported by our group and others to increase their ionization efficiency during electrospray ionization and... 
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7. Full Text Circulating Natriuretic Peptide Concentrations in Patients With End-Stage Renal Disease: Role of Brain Natriuretic Peptide as a Biomarker for Ventricular Remodeling
by Cataliotti, Alessandro and Malatino, Lorenzo S and Jougasaki, Michihisa and Zoccali, Carmine and Castellino, Pietro and Giacone, Giuseppe and Bellanuova, Ignazio and Tripepi, Rocco and Seminara, Giuseppe and Parlongo, Saverio and Stancanelli, Benedetta and Bonanno, Grazia and Fatuzzo, Pasquale and Rapisarda, Francesco and Belluardo, Paola and Signorelli, Salvatore S and Heublein, Denise M and Lainchbury, John G and Leskinen, Hanna K and Bailey, Kent R and Redfield, Margaret M and Burnett, John C
Mayo Clinic Proceedings, ISSN 0025-6196, 2001, Volume 76, Issue 11, pp. 1111 - 1119
To determine levels of natriuretic peptides (NPs) in patients with end-stage renal disease (ESRD) and to examine the relationship of these cardiovascular... 
CAD = coronary artery disease | CNP = C-type natriuretic peptide | LVD = left ventricular systolic dysfunction | AUC = area under the curve | ESRD = end-stage renal disease | DNP = Dendroaspis natriuretic peptide | Kt/V = fractional urea clearance rate | BNP = brain natriuretic peptide | DNP-LI = DNP-like immunoreactivity | PWT = posterior wall thickness | CHF = congestive heart failure | ANP = atrial natriuretic peptide | LVH = left ventricular hypertrophy | NP = natriuretic peptide | LVMI = left ventricular mass index | ROC = receiver operating characteristic | IVST = intraventricular septum thickness | LVEF = left ventricular ejection fraction | MI = myocardial infarction | MORTALITY | HYPERTROPHY | POPULATION | MEDICINE, GENERAL & INTERNAL | INDEPENDENT PREDICTOR | PLASMA | MORBIDITY | HEART-FAILURE | HEMODIALYSIS-PATIENTS | INDICATOR | DYSFUNCTION | Hypertrophy, Left Ventricular - blood | Comorbidity | Humans | Middle Aged | Risk Factors | Linear Models | Male | Natriuretic Peptide, Brain - physiology | Atrial Natriuretic Factor - blood | Case-Control Studies | Kidney Failure, Chronic - blood | Adolescent | Aged, 80 and over | Biomarkers | Adult | Female | ROC Curve | Aged | Hemodynamics | Natriuretic Peptide, Brain - blood | Kidney Failure, Chronic - etiology | Renal Dialysis
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8. Full Text Circulating N-terminal atrial natriuretic peptide as a marker for symptomless left-ventricular dysfunction
by Lerman, A and Gibbons, R.J and Rodeheffer, R.J and Bailey, K.R and McKinley, L.J and Heublein, D.M and Burnett, J.C
The Lancet, ISSN 0140-6736, 05/1993, Volume 341, Issue 8853, pp. 1105 - 1109
Early identification of patients with symptomless left-ventricular dysfunction and early pharmacologic intervention may have an impact on the outlook of... 
MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | CONGESTIVE-HEART-FAILURE | FACTOR PROHORMONE | Prospective Studies | Ventricular Function, Left | Humans | Middle Aged | Male | Radionuclide Angiography | Atrial Natriuretic Factor - blood | Sensitivity and Specificity | Aged, 80 and over | Adult | Female | Aged | Heart Failure - diagnosis | Heart Failure - diagnostic imaging | Measurement | Congestive heart failure | Diagnosis | Natriuretic peptides | Medical research | Cardiovascular disease | Hormones | Heart failure | Heart | Medical imaging | Angiography | Peptides | Radioisotopes | Pharmacology | Atrial natriuretic peptide | Ventricle | Patients | Beta blockers
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9. Full Text Biomedical Research at Mayo Clinic: A Tradition of Collaboration and a Vision for Year 2000 and Beyond
by Burnett, John C
Mayo Clinic Proceedings, ISSN 0025-6196, 2000, Volume 75, Issue 4, pp. 337 - 339
MEDICINE, GENERAL & INTERNAL | Research - history | Patient-Centered Care - trends | United States | History, 20th Century | Humans | Cooperative Behavior | Minnesota | Forecasting | Foundations - history | Research - trends
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10. Full Text C-type natriuretic peptide-induced vasodilation is dependent on hyperpolarization in human forearm resistance vessels
by Honing, M.L.H and Smits, P and Morrison, P.J and Burnett, J.C and Rabelink, T.J
Hypertension, ISSN 0194-911X, 2001, Volume 37, Issue 4, pp. 1179 - 1183
Animal studies have demonstrated that CNP causes endothelium-independent vasodilation, which is limited by neutral endopeptidase (NEP) activity. However, the... 
Tetraethylammonium chloride | Endopeptidase | Nitric oxide | Hyperpolarizing factor | Natriuretic peptides | nitric oxide | hyperpolarizing factor | ENDOPEPTIDASE-24.11 | PORCINE CORONARY-ARTERIES | tetraethylammonium chloride | HUMAN ENDOTHELIAL-CELLS | natriuretic peptides | INHIBITION | endopeptidase | IN-VIVO | PERIPHERAL VASCULAR DISEASE | EXPRESSION | SMOOTH-MUSCLE CELLS | Humans | Nitric Oxide Synthase - antagonists & inhibitors | Nitric Oxide Synthase - physiology | Biological Availability | Nitric Oxide - physiology | Natriuretic Peptide, C-Type - physiology | Neprilysin - metabolism | Vascular Resistance - physiology | Cyclooxygenase Inhibitors - pharmacology | Epoprostenol - antagonists & inhibitors | Epoprostenol - physiology | Potassium Channels - metabolism | Analysis of Variance | Adolescent | Forearm - blood supply | Neprilysin - antagonists & inhibitors | Adult | Potassium Channel Blockers | Vasodilation - drug effects | Vasodilation - physiology | Prostaglandin-Endoperoxide Synthases - physiology
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11. The natriuretic peptides in heart failure: Diagnostic and therapeutic potentials
by Chen, H.H and Burnett J.C, Jr
Proceedings of the Association of American Physicians, ISSN 1081-650X, 1999, Volume 111, Issue 5, pp. 406 - 416
The natriuretic peptides are a group of structurally similar but genetically distinct peptides that have diverse actions in cardiovascular, renal, and... 
Hormone | 3',5'-cyclic guanosine monophosphate | Ventricular dysfunction | Kidney | Markers | Neutral endopeptidase inhibition | MEDICINE, RESEARCH & EXPERIMENTAL | 3 ',5 '-cyclic guanosine monophosphate | MYOCARDIAL-INFARCTION | CONVERTING-ENZYME-INHIBITION | neutral endopeptidase inhibition | ventricular dysfunction | ANGIOTENSIN-II | DILATED CARDIOMYOPATHY | hormone | kidney | MEDICINE, GENERAL & INTERNAL | INTRAVENOUS-INJECTION | LEFT-VENTRICULAR DYSFUNCTION | EXPERIMENTAL-HYPERTENSION | markers | SMOOTH-MUSCLE CELLS | RENAL RESPONSE | Amino Acid Sequence | Natriuretic Peptide, Brain - therapeutic use | Natriuretic Peptide, Brain - genetics | Prognosis | Atrial Natriuretic Factor - metabolism | Humans | Natriuretic Peptide, Brain - metabolism | Molecular Sequence Data | Heart Failure - metabolism | Neprilysin - metabolism | Enzyme Inhibitors - therapeutic use | Heart Failure - drug therapy | Ventricular Dysfunction, Left - metabolism | Animals | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Natriuretic Peptide, C-Type - metabolism | Atrial Natriuretic Factor - genetics | Neprilysin - antagonists & inhibitors | Natriuretic Peptide, C-Type - genetics | Heart Failure - diagnosis
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12. Full Text Increase and uncoupling of adrenomedullin from the natriuretic peptide system in aneurysmal subarachnoid hemorrhage
by Wijdicks, E.F.M and Heublein, D.M and Burnett J.C, Jr
Journal of Neurosurgery, ISSN 0022-3085, 2001, Volume 94, Issue 2, pp. 252 - 256
Object. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage (SAH). Natriuresis and its accompanying hypovolemia may be a major... 
Adrenomedullin | Brain natriuretic factor cerebral vasospasm | Subarachnoid hemorrhage | Atrial natriuretic factor | SURGERY | adrenomedullin | subarachnoid hemorrhage | atrial natriuretic factor | brain natriuretic factor | ENDOTHELIN | cerebral vasospasm | CLINICAL NEUROLOGY | Peptides - blood | Intracranial Aneurysm - blood | Vasospasm, Intracranial - blood | Vasospasm, Intracranial - surgery | Humans | Middle Aged | Natriuretic Agents - blood | Male | Reference Values | Intracranial Aneurysm - diagnosis | Intracranial Aneurysm - surgery | Vasospasm, Intracranial - diagnosis | Aged, 80 and over | Adult | Female | Aged | Subarachnoid Hemorrhage - diagnosis | Vasodilation - physiology | Subarachnoid Hemorrhage - blood | Subarachnoid Hemorrhage - surgery
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13. Full Text Vascular Actions of C-Type Natriuretic Peptide in Isolated Porcine Coronary Arteries and Coronary Vascular Smooth Muscle Cells
by Wei, C.M and Hu, S.L and Miller, V.M and Burnett, J.C
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/1994, Volume 205, Issue 1, pp. 765 - 771
C-type natriuretic (CNP) caused concentration-dependent relaxations in porcine coronary arteries with a maximal relaxation (10(-6)M) of 46%. Relaxations to CNP... 
ACTIVATION | PLASMA | BIOPHYSICS | MECHANISM | CNP | POTASSIUM CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION | RECEPTOR | CA-2+-ACTIVATED K+-CHANNELS | Membrane Potentials - drug effects | Coronary Vessels - drug effects | Coronary Vessels - physiology | Potassium Channels - physiology | Arteries - drug effects | Muscle, Smooth, Vascular - cytology | Potassium Channels - drug effects | Natriuretic Peptide, C-Type | Animals | Arteries - physiology | Swine | Proteins - pharmacology | Atrial Natriuretic Factor - pharmacology | Muscle Relaxation - drug effects | In Vitro Techniques | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects
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14. Full Text Atrial Natriuretic Peptide Elevation in Congestive Heart Failure in the Human
by J. C. Burnett and P. C. Kao and D. C. Hu and D. W. Heser and D. Heublein and J. P. Granger and T. J. Opgenorth and G. S. Reeder
Science, ISSN 0036-8075, 3/1986, Volume 231, Issue 4742, pp. 1145 - 1147
A sensitive radioimmunoassay for atrial natriuretic peptide was used to examine the relation between circulating atrial natriuretic peptide and cardiac filling... 
Heart | Human experimentation | Antiserum | Sodium | Radioimmunoassay | Antibodies | Reports | Congestive heart failure | Cardiovascular diseases | Natriuretic peptides | Blood plasma | Humans | Middle Aged | Cardiovascular Diseases - blood | Adult | Female | Male | Aged | Hemodynamics | Heart Failure - blood | Atrial Natriuretic Factor - blood | Physiological aspects | Human physiology | Research | Peptides
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15. Full Text Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis
by Lerman, Amir and Edwards, Brooks S and Hallett, John W and Heublein, Denise M and Sandberg, Sharon M and Burnett, John C
The New England Journal of Medicine, ISSN 0028-4793, 10/1991, Volume 325, Issue 14, pp. 997 - 1001
ATHEROSCLEROSIS may be initiated by endothelial injury, which then leads to the proliferation of intimal smooth-muscle cells. 1 The atherogenic smooth-muscle... 
PATHOGENESIS | RESPONSES | MEDICINE, GENERAL & INTERNAL | ARTERIES | ANGINA | DISEASE | PROLIFERATION | PRIMATES | SMOOTH-MUSCLE CELLS | INCREASED PLASMA ENDOTHELIN | Physiological aspects | Development and progression | Endothelin | Atherosclerosis | Cell proliferation | Coronary artery | Smooth muscle | Endothelin 1 | Endothelial cells | Endothelium | Vascular diseases | Arteriosclerosis | Aorta | Immunoreactivity | Growth factors | Heart diseases | Plasma | Hypotheses | Heart attacks | Medical imaging | Cardiovascular disease | Metabolic disorders
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16. Full Text Natriuretic peptide system in human heart failure
by Wei, Chi-Ming and Wei, C.-M and Heublein, Denise M and Heublein, D.M and Perrella, Mark A and Perrella, M.A and Lerman, A and Lerman, Amir and Rodeheffer, R.J and Rodeheffer, Richard J and McGregor, C.G.A and McGregor, Christopher G.A and Edwards, W.D and Edwards, William D and Schaff, H.V and Schaff, Hartzell V and Burnett Jr, J.C and Burnett Jr, John C
Circulation, ISSN 0009-7322, 1993, Volume 88, Issue 3, pp. 1004 - 1009
Background. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are a family of structurally related... 
heart failure | natriuretic peptides | left ventricle | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | NATRIURETIC PEPTIDES | HEART FAILURE | ATRIAL | RATS | RECEPTOR | INFUSION | RESPONSES | LEFT VENTRICLE | GENE | PLASMA-LEVELS | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | EXPRESSION | Myocardium - chemistry | Humans | Middle Aged | Nerve Tissue Proteins - analysis | Male | Heart Failure - metabolism | Heart Ventricles - chemistry | Natriuretic Peptide, C-Type | Natriuretic Peptide, Brain | Radioimmunoassay | Female | Atrial Natriuretic Factor - analysis | Heart Atria - chemistry
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17. Full Text Renal localization and actions of adrenomedullin: a natriuretic peptide
by Jougasaki, M and Wei, C. M and Aarhus, L. L and Heublein, D. M and Sandberg, S. M and Burnett, J. C., Jr
AJP - Renal Physiology, ISSN 0363-6127, 04/1995, Volume 268, Issue 4, pp. 657 - F663
M. Jougasaki, C. M. Wei, L. L. Aarhus, D. M. Heublein, S. M. Sandberg and J. C. Burnett Jr Cardiorenal Research Laboratory, Mayo Clinic and Foundation,... 
Immunohistochemistry | Sodium excretion | Distal tubular function | guanosine 3',5'-cyclic monophosphate | Natriuretic peptide | Guanosine 3′,5′-cyclic monophosphate | Dose-Response Relationship, Drug | Tissue Distribution | Kidney - metabolism | Animals | Kidney - drug effects | Natriuretic Agents - physiology | Peptides - physiology | Dogs | Adrenomedullin | Kidney - cytology | Peptides - pharmacology | Regulation | Natriuresis | Research | Peptide hormones | Methods
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18. Full Text Intact and altered endothelium in regulation of vasomotion
by Lerman, A and Lerman, Amir and Burnett Jr, John C and Burnett Jr, J.C
Circulation, ISSN 0009-7322, 1992, Volume 86, Issue 6, pp. III12 - III19
The endothelium possesses the ability to modulate vascular tone by the release of vasodilator and vasoconstrictor substances, among them endothelium-derived... 
Endothelium-derived relaxing factor | Vascular resistance | Endothelin | CANINE FEMORAL-ARTERY | CARDIAC & CARDIOVASCULAR SYSTEMS | RELAXING FACTOR | HEART-FAILURE | DEPENDENT VASCULAR RELAXATION | VASCULAR RESISTANCE | CORONARY-ARTERIES | OXIDE-GENERATING VASODILATORS | ENDOTHELIUM-DERIVED RELAXING FACTOR | L-ARGININE | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | ESSENTIAL-HYPERTENSION | ENDOTHELIN | SMOOTH-MUSCLE CELLS | Myocardial Ischemia - metabolism | Endothelins - physiology | Endothelins - pharmacology | Humans | Arteriosclerosis - physiopathology | Nitric Oxide - physiology | Endothelium, Vascular - physiology | Animals | Endothelium, Vascular - metabolism | Vasomotor System - physiology | Dogs | Myocardial Ischemia - physiopathology | Arteriosclerosis - metabolism | Nitric Oxide - metabolism
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