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American Journal of Physiology, ISSN 1040-0605, 11/2014, Volume 307, Issue 9, p. L718
  Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease largely associated with cigarette smoke exposure (CSE) and characterized by... 
Smoke inhalation | Human exposure | Biomarkers | Chronic obstructive pulmonary disease | Mathematical models | Physiology
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2009, Volume 46, Issue 5, pp. 656 - 662
We previously reported that treatment of spontaneously hypertensive rats (SHR) with liver growth factor (LGF), an albumin–bilirubin complex with a covalent... 
Reactive oxygen species | Free radicals | Liver growth factor | Antioxidant | Nitric oxide | Arteries | CAPACITY | OXIDATIVE STRESS | ASSAY | LIPID-PEROXIDATION | SPONTANEOUSLY HYPERTENSIVE-RATS | HUMAN SERUM-ALBUMIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GUNN RAT | ANGIOTENSIN-II | FREE-RADICALS | ENDOCRINOLOGY & METABOLISM | NITRIC-OXIDE | Bilirubin - metabolism | Antioxidants - chemistry | Oxidative Stress - physiology | Male | Bilirubin - pharmacology | Nitric Oxide - analysis | Serum Albumin, Human | Chromans - pharmacology | Hydroxyl Radical - analysis | Hypertension - prevention & control | Serum Albumin, Bovine - chemistry | Hypertension - enzymology | Fibrosis - prevention & control | Serum Albumin - chemistry | Blood Pressure Determination | Endothelial Cells - physiology | Fibrosis - enzymology | Bilirubin - chemistry | Peroxides - analysis | Rats | Sulfonic Acids - analysis | Antioxidants - pharmacology | Serum Albumin, Bovine - metabolism | Rats, Sprague-Dawley | Hypertension - pathology | Bilirubin - physiology | Animals | Antioxidants - physiology | Benzothiazoles - analysis | Serum Albumin - pharmacology | Serum Albumin - physiology | Protein Binding | Carotid Arteries - pathology | Fibrosis - pathology | Oxidative Stress - drug effects | Endothelial Cells - pathology | Endothelial Cells - drug effects | Antioxidants | Hypertension | Liver | Albumin | Superoxide dismutase | Superoxide | Chemical properties | Bilirubin | Growth factors
Journal Article
Cardiovascular Research, ISSN 0008-6363, 02/2006, Volume 69, Issue 3, pp. 764 - 771
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e112995
Cigarette smoke (CS)-induced emphysema is a major component of chronic obstructive pulmonary disease (COPD). COPD treatment is based on the administration of... 
NEURAL STEM-CELLS | LUNG | OBSTRUCTIVE PULMONARY-DISEASE | OXIDATIVE STRESS | REPAIR | KERATINOCYTE | SPONTANEOUSLY HYPERTENSIVE-RATS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | II CELL | EXPRESSION | Smoking - adverse effects | Pulmonary Emphysema - physiopathology | Body Weight | Pulmonary Alveoli - pathology | Pulmonary Emphysema - etiology | Oxidative Stress | Serum Albumin - administration & dosage | Pulmonary Emphysema - pathology | Male | Pulmonary Emphysema - drug therapy | Vascular Endothelial Growth Factor A - metabolism | Bilirubin - pharmacology | Serum Albumin, Human | Bilirubin - administration & dosage | Animals | Serum Albumin - pharmacology | Mice | Matrix Metalloproteinases - metabolism | Respiratory Function Tests | Proliferating Cell Nuclear Antigen - metabolism | Disease Models, Animal | Liver diseases | Emphysema, Pulmonary | Liver | Respiratory agents | Health aspects | Vascular endothelial growth factor | Smoking | Cell proliferation | Corticoids | Animal models | Respiratory function | Critical care | Smoke | Bilirubin | Matrix metalloproteinase | Antioxidants | Rodents | Proliferating cell nuclear antigen | Bronchodilators | Physiology | Chronic obstructive pulmonary disease | Metalloproteinase | Alveoli | Enlargement | Medical research | Corticosteroids | Medical treatment | Lung diseases | Exposure | Nitrogen | Cigarettes | Medicine | Lungs | Hyperoxia | Obstructive lung disease | Stem cells | Emphysema | Cigarette smoke
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e67771
Liver growth factor (LGF) is a hepatic mitogen purified some years ago that promotes proliferation of different cell types and the regeneration of damaged... 
NEURAL STEM-CELLS | BCL-X-L | TUMOR-NECROSIS-FACTOR | OXIDATIVE STRESS | SPONTANEOUSLY HYPERTENSIVE-RATS | NEUROTROPHIC FACTOR PRODUCTION | MULTIDISCIPLINARY SCIENCES | DOPAMINERGIC-NEURONS | TNF-ALPHA | GLYCATION END-PRODUCTS | FACTOR-ALPHA | Dopamine Plasma Membrane Transport Proteins - metabolism | Tyrosine 3-Monooxygenase - metabolism | Substantia Nigra - pathology | Serum Albumin - isolation & purification | Substantia Nigra - metabolism | Oxidopamine | Bilirubin - pharmacology | Corpus Striatum - metabolism | Proto-Oncogene Proteins c-akt - genetics | Serum Albumin, Human | Neuroprotective Agents - pharmacology | Mitogen-Activated Protein Kinase 1 - genetics | Parkinson Disease, Secondary - drug therapy | Parkinson Disease, Secondary - metabolism | bcl-Associated Death Protein - metabolism | Behavior, Animal - drug effects | Female | Parkinson Disease, Secondary - chemically induced | Proto-Oncogene Proteins c-akt - metabolism | Corpus Striatum - pathology | Dopamine - metabolism | Disease Models, Animal | bcl-Associated Death Protein - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Tumor Necrosis Factor-alpha - secretion | Gene Expression Regulation | Rats | Dopamine Plasma Membrane Transport Proteins - genetics | Cyclic AMP Response Element-Binding Protein - genetics | Tyrosine 3-Monooxygenase - genetics | Substantia Nigra - drug effects | Animals | Parkinson Disease, Secondary - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Neuroprotective Agents - isolation & purification | Serum Albumin - pharmacology | Bilirubin - isolation & purification | Cyclic AMP Response Element-Binding Protein - metabolism | Corpus Striatum - drug effects | Tumor Necrosis Factor-alpha - biosynthesis | Mitogen-Activated Protein Kinase 1 - metabolism | Care and treatment | Parkinson's disease | Gene expression | Analysis | Neurotrophic functions | Risk factors
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 09/2011, Volume 301, Issue 3, pp. H1153 - H1165
Conde MV, Gonzalez MC, Quintana-Villamandos B, Abderrahim F, Briones AM, Condezo-Hoyos L, Regadera J, Susin C, de Diego JJ, Delgado-Baeza E, Diaz-Gil JJ,... 
Vascular remodeling | Mesenteric resistance arteries | Intramyocardial arteries | Nitric oxide | Left ventricular hypertrophy | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | CONFOCAL MICROSCOPY | MESENTERIC-ARTERIES | SPONTANEOUSLY HYPERTENSIVE-RATS | SERUM-ALBUMIN | mesenteric resistance arteries | HEART-FAILURE | TIME-COURSE | vascular remodeling | INTERNAL ELASTIC LAMINA | BLOOD-PRESSURE | ALBUMIN BILIRUBIN COMPLEX | left ventricular hypertrophy | intramyocardial arteries | PERIPHERAL VASCULAR DISEASE | ANTIHYPERTENSIVE TREATMENT | Immunohistochemistry | Mesenteric Arteries - physiopathology | Serum Albumin - administration & dosage | Extracellular Matrix - metabolism | Mesenteric Arteries - pathology | Hypertension - drug therapy | Male | Bilirubin - administration & dosage | Myocardium - metabolism | Myocytes, Smooth Muscle - drug effects | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Coronary Vessels - drug effects | Coronary Vessels - pathology | Rats | Mesenteric Arteries - metabolism | Hypertension - pathology | Hypertension - metabolism | Microscopy, Confocal | Analysis of Variance | Fibrosis | Nitric Oxide Synthase - metabolism | Hypertrophy, Left Ventricular - physiopathology | Vasodilation - drug effects | Myography | Coronary Vessels - physiopathology | Microscopy, Polarization | Myocytes, Smooth Muscle - pathology | Antihypertensive Agents - administration & dosage | Nitric Oxide Synthase - antagonists & inhibitors | Rats, Inbred WKY | Mesenteric Arteries - drug effects | Serum Albumin, Human | Coronary Vessels - metabolism | Dose-Response Relationship, Drug | Superoxides - metabolism | Ultrasonography | Vascular Resistance - drug effects | Blood Pressure - drug effects | Hypertrophy, Left Ventricular - drug therapy | Rats, Inbred SHR | Elastin - metabolism | Vasodilator Agents - pharmacology | Hypertrophy, Left Ventricular - etiology | Hypertrophy, Left Ventricular - metabolism | Cells, Cultured | Myocardium - pathology | Fibronectins - metabolism | Hypertension - physiopathology | Collagen - metabolism | Muscle, Smooth, Vascular - pathology | Animals | Hypertension - complications | Cell Proliferation - drug effects | Nitric Oxide - metabolism | Ventricular Remodeling - drug effects | Hypertrophy, Left Ventricular - diagnostic imaging | Hypertension | Measurement | Care and treatment | Vascular resistance | Physiological aspects | Extracellular matrix | Properties | Growth factors
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 2014, Volume 15, Issue 10, pp. 19056 - 19073
Journal Article
Recent Patents on CNS Drug Discovery, ISSN 1574-8898, 12/2014, Volume 9, Issue 3, pp. 173 - 180
Liver growth factor (LGF) is a hepatic mitogen purified by our group in 1986. In the following years we demonstrated its activity both in "in vivo" and "in... 
Journal Article
American Journal of Physiology, ISSN 0363-6135, 09/2011, Volume 301, Issue 3, p. H1153
Liver growth factor (LGF) is an endogenous albumin-bilirubin complex with antihypertensive effects in spontaneously hypertensive rats (SHR). We assessed the... 
Liver | Rodents | Medical treatment | Collagen | Blood pressure | Cells
Journal Article