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1. Full Text Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes
by Tricoci, Pierluigi and Huang, Zhen and Held, Claes and Moliterno, David J and Armstrong, Paul W and Van de Werf, Frans and White, Harvey D and Aylward, Philip E and Wallentin, Lars and Chen, Edmond and Lokhnygina, Yuliya and Pei, Jinglan and Leonardi, Sergio and Rorick, Tyrus L and Kilian, Ann M and Jennings, Lisa H.K and Ambrosio, Giuseppe and Bode, Christoph and Cequier, Angel and Cornel, Jan H and Diaz, Rafael and Erkan, Aycan and Huber, Kurt and Hudson, Michael P and Jiang, Lixin and Jukema, J. Wouter and Lewis, Basil S and Lincoff, A. Michael and Montalescot, Gilles and Nicolau, José Carlos and Ogawa, Hisao and Pfisterer, Matthias and Prieto, Juan Carlos and Ruzyllo, Witold and Sinnaeve, Peter R and Storey, Robert F and Valgimigli, Marco and Whellan, David J and Widimsky, Petr and Strony, John and Harrington, Robert A and Mahaffey, Kenneth W and TRACER Investigators
The New England journal of medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 1, pp. 20 - 33
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cardiology. Vascular system | Heart | General aspects | Biological and medical sciences | Myocarditis. Cardiomyopathies | Medical sciences | Coronary heart disease | Follow-Up Studies | Angioplasty | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Pyridines - adverse effects | Cardiovascular Diseases - mortality | Female | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Pyridines - therapeutic use | Double-Blind Method | Receptor, PAR-1 - antagonists & inhibitors | Kaplan-Meier Estimate | Combined Modality Therapy | Lactones - adverse effects | Lactones - therapeutic use | Acute Coronary Syndrome - drug therapy | Intracranial Hemorrhages - chemically induced | Coronary Artery Bypass | Acute Coronary Syndrome - therapy | Aged | Hemorrhage - chemically induced | Antagonists (Biochemistry) | Drugs | Dose-response relationship (Biochemistry) | Dosage and administration | Product/Service Evaluations | Drug therapy | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | Proteinase-activated receptor 1 | Thrombin | Cardiovascular disease | Hemorrhage | Bleeding | Investigations | Manuscripts | Ischemia | Blood platelets | Acute coronary syndromes | Research centers | Index Medicus | Abridged Index Medicus | Malalties cardiovasculars | Bypass cardiopulmonar | Medicaments | Bypass cardiopulmonary | Plaquetes sanguínies | Cardiovascular diseases
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2. Full Text Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
by Teumer, Alexander and Chaker, Layal and Groeneweg, Stefan and Li, Yong and Di Munno, C and Barbieri, Caterina and Schultheiss, Ulla T and Traglia, Michela and Ahluwalia, Tarunveer Singh and Akiyama, M and Appel, E.V.R and Arking, Dan and Arnold, Alice and Astrup, A and Beekman, Marian and Beilby, John and Bekaert, S and Boerwinkle, E and Brown, Stephen and Buyzere, Marc and Campbell, P.J and Ceresini, Graziano and Cerqueira, C and Cucca, Francesco and Deary, Ian and Deelen, Joris and Eckardt, K.-U and Ekici, A.B and Hagen, Knut and Ferrrucci, L and Fiers, T and Fiorillo, Edoardo and Ford, Ian and Fox, Caroline and Fuchsberger, Christian and Galesloot, Tessel and Gieger, Christian and Gögele, Martin and Grandi, Alessano and Grarup, Niels and Greiser, Karin Halina and Haljas, K and Hansen, Torben and Harris, Sarah and Heemst, Diana and Heijer, Martin and Hicks, A.A and Hollander, Wouter and Homuth, Georg and Hui, Jennie and Ikram, Arfan and Ittermann, Till and Jensen, R.A and Jing, J and Jukema, Jan Wouter and Kajantie, Eero and Kamatani, Y and Kasbohm, E and Kaufman, Jean-Marc and Kiemeney, L.A and Kloppenburg, Margreet and Kronenberg, Florian and Kubo, M and Lahti, J and Lapauw, B and Li, S and Liewald, D.C.M and Alizadeh, Behrooz and Boezen, Marike and Franke, Lude and van der Harst, P and Navis, Gerjan and Rots, M and Snieder, Harold and Swertz, M.A and Wijmenga, C and Lim, Ee Mun and Linneberg, Allan and Marina, M and Mascalzoni, Deborah and Matsuda, K and Medenwald, Daniel and Meisinger, Christa and Meulenbelt, I and Meyer, Thorsten and Meyer zu Schwabedissen, H.E and Mikolajczyk, R and Moed, Heleen and Netea-Maier, Romana and Nolte, Ilja and Okada, Yukinori and Pala, M and Penninx, B.W.J.H and Pedersen, Oluf and Petersmann, Astrid and Porcu, Eleonora and Postmus, Douwe and Pramstaller, Peter Paul and Psaty, Bruce and Ramos, Y.F.M and ... and Lifelines Cohort Study
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4455 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genome-Wide Association Study | Gene Expression Regulation - genetics | Hypothyroidism - physiopathology | Sodium-Phosphate Cotransporter Proteins, Type I - genetics | Humans | Risk Factors | Cercopithecus aethiops | European Continental Ancestry Group | 2-Aminoadipate Transaminase - genetics | Hyperthyroidism - physiopathology | Thyroid Hormones - genetics | Thyrotropin - metabolism | 2-Aminoadipate Transaminase - metabolism | Animals | Biological Transport | Thyroid Hormones - metabolism | Hyperthyroidism - genetics | Polymorphism, Single Nucleotide | Hypothyroidism - genetics | Thyroid Gland - metabolism | COS Cells | Sodium-Phosphate Cotransporter Proteins, Type I - metabolism | Thyroid Gland - physiopathology | Complications | Therapeutic applications | Health risks | Genomes | Thyroid gland | Metabolism | Morbidity | Genetic variance | Cardiovascular diseases | Health risk assessment | Transporter | Public health | Thyroid | Index Medicus
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3. Full Text A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
by Deelen, Joris and Kettunen, J and Fischer, Krista and Spek, Ashley and Trompet, Stella and Kastenmuller, Gabi and Boyd, A and Zierer, J and Akker, Erik and Ala-Korpela, Mika and Amin, N and Demirkan, A and Ghanbari, Mohsen and Heemst, Diana and Ikram, Arfan and Klinken, Jan Bert and Mooijaart, Simon and Peters, Annette and Salomaa, Veikko and Sattar, Naveed and Spector, Timothy and Tiemeier, Henning and Verhoeven, Aswin and Waldenberger, M and Würtz, Peter and Davey Smith, G and Metspalu, Anes and Perola, Markus and Menni, Cristina and Geleijnse, J.M and nos, F and Beekman, M and Jukema, Jan Wouter and Duijn, Cornelia and Slagboom, Eline
Nature communications, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3346 - 8
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Prognosis | Follow-Up Studies | Risk Assessment | Humans | Middle Aged | Mortality | Risk Factors | Metabolome | Male | Biomarkers - blood | Metabolomics - methods | Young Adult | Adolescent | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Metabolomics | Men | Predictions | Biomarkers | Health risk assessment | Metabolism | Risk analysis | Risk factors | Index Medicus
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4. Full Text Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study
by Bakker, Leontine E H, MD and Boon, Mariëtte R, MSc and van der Linden, Rianne A D, Bsc and Arias-Bouda, Lenka Pereira, MD and van Klinken, Jan B, PhD and Smit, Frits, MD and Verberne, Hein J, MD and Jukema, J Wouter, Prof and Tamsma, Jouke T, MD and Havekes, Louis M, Prof and van Marken Lichtenbelt, Wouter D, PhD and Jazet, Ingrid M, MD and Rensen, Patrick C N, Prof
The lancet. Diabetes & endocrinology, ISSN 2213-8587, 2014, Volume 2, Issue 3, pp. 210 - 217
Endocrinology & Metabolism | Other | Life Sciences & Biomedicine | Science & Technology | Body Mass Index | Disease Susceptibility | Prospective Studies | Humans | Metabolic Diseases - epidemiology | European Continental Ancestry Group | Male | Positron-Emission Tomography | Asian Continental Ancestry Group | Thermogenesis | Adiposity | Energy Metabolism | Adipose Tissue, Brown - diagnostic imaging | Adult | Index Medicus
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5. Full Text Novel Genetic Markers Associate With Atrial Fibrillation Risk in Europeans and Japanese
by Lubitz, Steven A., MD, MPH and Lunetta, Kathryn L., PhD and Lin, Honghuang, PhD and Arking, Dan E., PhD and Trompet, Stella, PhD and Li, Guo, MS and Krijthe, Bouwe P., MSc and Chasman, Daniel I., PhD and Barnard, John, PhD and Kleber, Marcus E., PhD and Dörr, Marcus, MD and Ozaki, Kouichi, PhD and Smith, Albert V., PhD and Müller-Nurasyid, Martina, MSc, PhD and Walter, Stefan, PhD and Agarwal, Sunil K., MD, PhD and Bis, Joshua C., PhD and Brody, Jennifer A., BA and Chen, Lin Y., MD, MS and Everett, Brendan M., MD, MPH and Ford, Ian, PhD and Franco, Oscar H., MD, PhD and Harris, Tamara B., MD and Hofman, Albert, MD, PhD and Kääb, Stefan, MD, PhD and Mahida, Saagar, MB, ChB and Kathiresan, Sekar, MD, MPH and Kubo, Michiaki, MD, PhD and Launer, Lenore J., PhD and Macfarlane, Peter W., DSc and Magnani, Jared W., MD, MSc and McKnight, Barbara, PhD and McManus, David D., MD, ScM and Peters, Annette, PhD, MPH and Psaty, Bruce M., MD, PhD and Rose, Lynda M., MSc and Rotter, Jerome I., MD and Silbernagel, Guenther, MD and Smith, Jonathan D., PhD and Sotoodehnia, Nona, MD, MPH and Stott, David J., MD and Taylor, Kent D., PhD and Tomaschitz, Andreas, MD and Tsunoda, Tatsuhiko, PhD and Uitterlinden, Andre G., PhD and Van Wagoner, David R., PhD and Völker, Uwe, PhD and Völzke, Henry, MD and Murabito, Joanne M., MD, ScM and Sinner, Moritz F., MD, MPH and Gudnason, Vilmundur, MD, PhD and Felix, Stephan B., MD and März, Winfried, MD and Chung, Mina, MD and Albert, Christine M., MD, MPH and Stricker, Bruno H., MB, PhD and Tanaka, Toshihiro, MD, PhD and Heckbert, Susan R., MD, PhD and Jukema, J. Wouter, MD, PhD and Alonso, Alvaro, MD, PhD and Benjamin, Emelia J., MD, ScM and Ellinor, Patrick T., MD, PhD
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2014, Volume 63, Issue 12, pp. 1200 - 1210
Cardiovascular | Internal Medicine | genetic | atrial fibrillation | risk | prognosis | atrial flutter | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | Cardiac dysrhythmias | European Continental Ancestry Group - genetics | Europe | Humans | Japan | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Chromosome Mapping | Genetic Markers | Transcription Factors - genetics | Atrial Fibrillation - genetics | Chromosomes, Human, Pair 4 | Homeodomain Proteins - genetics | Aged, 80 and over | Adult | Female | Genetic Predisposition to Disease - ethnology | Aged | Polymorphism, Single Nucleotide | Genetic research | Atrial fibrillation | Genetic aspects | Europeans | Genetic markers | Cardiac arrhythmia | Genealogy | Pathogenesis | Genes | Genomics | Genomes | Estimates | Studies | Confidence intervals | Hospitals | Chromosomes | Age | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
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6. Full Text Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
by Deelen, Joris and Beekman, Marian and Uh, Hae-Won and Broer, Linda and Ayers, Kristin and Tan, Qihua and Kamatani, Yoichiro and Bennet, Anna Michaela and Tamm, Riin and Trompet, Stella and Guobjartsson, Daníel and Flachsbart, Friederike and Rose, Giuseppina and Viktorin, Alexander and Fischer, Krista and Nygaard, Marianne and Cordell, Heather and Crocco, Paolina and Akker, Erik and Böhringer, Stefan and Helmer, Quinta and Nelson, Christopher P and Saunders, Gary and Alver, Maris and Andersen-Ranberg, Karen and Breen, Gerome and Breggen, Ruud and Caliebe, Amke and Capri, Yline and Cevenini, Elisa and Collerton, Joanna and Dato, Serena and Davies, Karen and Ford, Ian and Gampe, Jutta and Garagnani, Paolo and Geus, Eco and Harrow, Jennifer and Heemst, Diana and Heijmans, Bastiaan and Heinsen, Femke-Anouska and Hottenga, Jouke Jan and Hofman, Albert and Jeune, Bernard and Jonsson, Palmi and Lathrop, Mark and Lechner, Doris and Martin-Ruiz, Carmen and Mcnerlan, Susan and Mihailov, Evelin and Montesanto, Alberto and Mooijaart, Simon and Murphy, Anne and Nohr, Christian and Paternoster, Lavinia and Postmus, Douwe and Rivadeneira Ramirez, Fernando and Ross, Owen and Salvioli, Stefano and Sattar, Naveed and Schreiber, Stefan and Stefansson, Hreinn and Stott, David. J and Tiemeier, Henning and Uitterlinden, Ané and Westendorp, Rudi and Willemsen, Gonneke and Samani, Nilesh and Galan, Pilar and Sorensen, H.G and Boomsma, Dorret and Jukema, Jan Wouter and Rea, Dan and Passarino, Giuseppe and Craen, Anton and Christensen, Kaare and Nebel, Almut and Zwart, John-Anker and Metspalu, Anes and Magnusson, Patrik and Blanché, Hélène and Christiansen, Lene and Kirkwood, John and Duijn, Cornelia and Franceschi, Claudio and Houwing-Duistermaat, Jeanine and Slagboom, Eline
Human molecular genetics, ISSN 0964-6906, 01/2014, Volume 23, Issue 16, pp. 4420 - 4432
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Genome-Wide Association Study | Prospective Studies | Age Factors | Humans | European Continental Ancestry Group | Male | Chromosome Mapping | Genetic Loci - physiology | Longevity - genetics | Cardiovascular Diseases - genetics | Chromosomes, Human, Pair 5 | Chromosomes, Human, Pair 19 | Phenotype | Aged, 80 and over | Female | Aged | Hypertension - genetics | Index Medicus | Life Sciences | Human health and pathology | Tissues and Organs | Association Studies | Medicin och hälsovetenskap
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7. Full Text Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism
by Stott, David J and Rodondi, Nicolas and Kearney, Patricia M and Ford, Ian and Westendorp, Rudi G.J and Mooijaart, Simon P and Sattar, Naveed and Aubert, Carole E and Aujesky, Drahomir and Bauer, Douglas C and Baumgartner, Christine and Blum, Manuel R and Browne, John P and Byrne, Stephen and Collet, Tinh-Hai and Dekkers, Olaf M and den Elzen, Wendy P.J and Du Puy, Robert S and Ellis, Graham and Feller, Martin and Floriani, Carmen and Hendry, Kirsty and Hurley, Caroline and Jukema, J. Wouter and Kean, Sharon and Kelly, Maria and Krebs, Danielle and Langhorne, Peter and McCarthy, Vera and McCarthy, Gemma and McConnachie, Alex and McDade, Mairi and Messow, Martina and O’Flynn, Annemarie and O’Riordan, David and Poortvliet, Rosalinde K.E and Quinn, Terence J and Russell, Audrey and Sinnott, Carol and Smit, Jan W.A and Van Dorland, H. Anette and Walsh, Elaine K and Walsh, Kieran A and Watt, Torquil and Wilson, Robbie and Gussekloo, Jacobijn and TRUST Study Grp and TRUST Study Group
The New England journal of medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 26, pp. 2534 - 2544
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Double-Blind Method | Humans | Hypothyroidism - complications | Thyroxine - administration & dosage | Fatigue - etiology | Thyroxine - blood | Male | Thyroxine - adverse effects | Treatment Failure | Hypothyroidism - drug therapy | Intention to Treat Analysis | Aged, 80 and over | Quality of Life | Female | Aged | Thyrotropin - blood | Body weight | Clinical trials | Thyroid gland | Hypothyroidism | Epidemiology | Coronary artery disease | Quality of life | Thyroid-stimulating hormone | Older people | Thyroxine | Drug therapy | Heart diseases | Drug dosages | Endocrinology | Age | Thyroid | Index Medicus | Abridged Index Medicus
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8. Full Text Blood lipids influence DNA methylation in circulating cells
by Dekkers, K.F and Iterson, Maarten and Slieker, Roderick and Moed, Heleen and Bonder, Marc and Van Galen, Michiel and Mei, Shan and Zhernakova, Alexana and Berg, Leonard and Deelen, Joris and Dongen, Jenny and Heemst, Diana and Hofman, Albert and Hottenga, Jouke Jan and Kallen, C.J and Schalkwijk, Casper and Stehouwer, Coen and Tigchelaar, Ettje F and Uitterlinden, Ané and Willemsen, Gonneke and Franke, Lude and t Hoen, P.A.C and Jansen, R and Meurs, Joyce and Boomsma, Dorret and Duijn, Cornelia and Greevenbroek, M.M and Veldink, Jan and Wijmenga, Cisca and Zwet, Erik and Slagboom, Eline and Jukema, Jan Wouter and Heijmans, Bastiaan and BIOS Consortium
Genome Biology, ISSN 1474-7596, 06/2016, Volume 17, Issue 1, pp. 138 - 138
DNA methylation | Lipids | Mendelian randomization | Gene expression | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Nerve Tissue Proteins - blood | ATP Binding Cassette Transporter, Subfamily G, Member 1 - blood | Carnitine O-Palmitoyltransferase - genetics | Lipids - genetics | Epigenesis, Genetic | Humans | Middle Aged | Male | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | Lipids - blood | Oxidoreductases Acting on CH-CH Group Donors - blood | Aged, 80 and over | Adult | Cholesterol, LDL - blood | Female | Lipid Metabolism - genetics | Oxidoreductases Acting on CH-CH Group Donors - genetics | Carnitine O-Palmitoyltransferase - blood | Gene Expression Regulation - genetics | DNA Methylation - genetics | Cholesterol, HDL - genetics | Nerve Tissue Proteins - genetics | Cholesterol, LDL - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Sterol Regulatory Element Binding Protein 1 - blood | Adolescent | Triglycerides - blood | Cholesterol, HDL - blood | CpG Islands - genetics | Aged | Triglycerides - genetics | Genome, Human | Lipoproteins (low density) | Genomics | Triglycerides | Genomes | Ribonucleic acid--RNA | Blood | Cholesterol | Studies | Consortia | Genotype & phenotype | Pleiotropy | External stimuli | Arteriosclerosis | Atherosclerosis | Quality control | Standard deviation | Lipid metabolism | Bioinformatics | Lipoproteins (high density) | Deoxyribonucleic acid--DNA | CpG islands | Index Medicus
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