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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 11, pp. 4400 - 4405
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Artemisinins | Malaria | Half lives | Antimalarials | Peroxides | Parasites | Dosage | Ozonides | Blood | Blood plasma | 1,2,4-trioxolane | Antimalarial drug discovery | OZ277 | PHARMACODYNAMIC PROPERTIES | MULTIDISCIPLINARY SCIENCES | ARTEROLANE | TRIOXOLANE | 1-AMINOBENZOTRIAZOLE | antimalarial drug discovery | PEROXIDES | IN-VITRO ASSESSMENT | PLASMODIUM-FALCIPARUM | ANTIMALARIAL ACTIVITY | ARTEMISININ | Peroxides - administration & dosage | Plasmodium berghei - physiology | Male | Peroxides - therapeutic use | Peroxides - pharmacokinetics | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Heterocyclic Compounds - chemistry | Time Factors | Adamantane - therapeutic use | Adamantane - administration & dosage | Adamantane - pharmacokinetics | Artemisinins - chemistry | Adamantane - analogs & derivatives | Antimalarials - pharmacokinetics | Heterocyclic Compounds - administration & dosage | Drug Stability | Peroxides - chemistry | Rats | Treatment Outcome | Antimalarials - therapeutic use | Iron - metabolism | Rats, Sprague-Dawley | Animals | Artemisinins - therapeutic use | Antimalarials - administration & dosage | Antimalarials - chemistry | Malaria - parasitology | Heterocyclic Compounds - pharmacokinetics | Mice | Adamantane - chemistry | Heterocyclic Compounds - therapeutic use | Malaria - drug therapy | Care and treatment | Composition | Health aspects | Malaria vaccine | Biological Sciences
Journal Article
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Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2012, Volume 55, Issue 11, pp. 5506 - 5517
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Science Translational Medicine, ISSN 1946-6234, 2017, Volume 9, Issue 387, pp. eaad9735 - eaad9735
As part of the global effort toward malaria eradication, phenotypic whole-cell screening revealed the 2-aminopyridine class of small molecules as a good... 
MEDICINE, RESEARCH & EXPERIMENTAL | SINGLE-DOSE CURE | IN-VITRO | TRANSMISSION | FALCIPARUM | QUANTIFICATION | DRUG DISCOVERY | KINASE INHIBITORS | DNA-SEQUENCING DATA | MALARIA PARASITES | NEXT-GENERATION | CELL BIOLOGY
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Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2013, Volume 56, Issue 6, pp. 2547 - 2555
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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2012, Volume 55, Issue 7, pp. 3479 - 3487
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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2013, Volume 56, Issue 7, pp. 2975 - 2990
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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2017, Volume 60, Issue 7, pp. 2654 - 2668
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Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 51, pp. 44035 - 44044
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Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2010, Volume 53, Issue 1, pp. 481 - 491
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Drug Design, Development and Therapy, ISSN 1177-8881, 11/2013, Volume 7, pp. 1377 - 1384
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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2013, Volume 23, Issue 24, pp. 6868 - 6873
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