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Biophysical Journal, ISSN 0006-3495, 11/2016, Volume 111, Issue 9, p. 1876
  Eukaryotic CLC anion channels and transporters are homodimeric proteins composed of multiple a-helical membrane domains and large cytoplasmic C-termini... 
Proteins | Eukaryotes | Phosphorylation | Peptides | Mutation | Cytoplasm
Journal Article
Chemical Reviews, ISSN 0009-2665, 06/2016, Volume 116, Issue 11, p. 6424
  Understanding signaling and other complex biological processes requires elucidating the critical roles of intrinsically disordered proteins (IDPs) and... 
Proteins | Molecules | Cells | Binding sites
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 10/2019, Volume 58, pp. 88 - 96
Biological condensates, including membraneless organelles, can consist of hundreds of proteins, and it is important to identify which proteins are driving... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2017, Volume 114, Issue 39, p. E8194
Membrane encapsulation is frequently used by the cell to sequester biomolecules and compartmentalize their function. Cells also concentrate molecules into... 
Fluid mechanics | Solvents | Salts | Phase diagrams | Nuclear magnetic resonance--NMR | DNA probes | Particle spin | Amides | Solutes | Electrostatic properties | Ribonucleic acid--RNA | Organelles | Cells | Membrane proteins | Proteins | Magnetic resonance spectroscopy | Molecules | Phase separation | Biomolecules | NMR spectroscopy | Deoxyribonucleic acid--DNA
Journal Article
Biophysical Journal, ISSN 0006-3495, 04/2016, Volume 110, Issue 7, p. 1510
  Conformational states of the metastable drkN SH3 domain were characterized using single-molecule fluorescence techniques. Under nondenaturing conditions, two... 
Proteins | Molecules | Fluid mechanics | Nuclear magnetic resonance--NMR | Correlation analysis | Fluorescence
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, pp. 197 - 198a
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2019, Volume 75, Issue 1, pp. 1 - 2
In this issue of , demonstrate that phase separation of an engineered intrinsically disordered protein can be used to control translation via the formation of... 
PHASE-SEPARATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Children's hospitals
Journal Article
Biochemistry, ISSN 0006-2960, 05/2018, Volume 57, Issue 17, p. 2499
Journal Article
Biophysical Journal, ISSN 0006-3495, 05/2010, Volume 98, Issue 10, p. 2383
  Intrinsically disordered proteins (IDPs), which lack folded structure and are disordered under nondenaturing conditions, have been shown to perform important... 
Proteins | Fluid mechanics | Molecular structure | Protein folding | Amino acids | Cells
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, p. 311
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 325 - 326
Imagine two different ligand molecules, either of which can individually bind to the same site on a protein. Now imagine those ligands competing with each... 
Proteins | Ligands | Molecular biology | Binding sites
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2012, Volume 109, Issue 9, p. 3287
The ubiquitin ligase ... (Skp1/Cul1/F-box protein) recognizes its substrate, the cyclin-dependent kinase inhibitor Sic1, in a multisite... 
Proteins | Phosphorylation | Peptides | Enzyme kinetics | Binding sites
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 43, p. 18404
  Smad ubiquitination regulatory factor 2 (Smurf2) is an E3 ubiquitin ligase that participates in degradation of TGF-β receptors and other targets. Smurf2 WW... 
Proteins | Peptides | Genes | Binding sites
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 9, pp. 3287 - 3292
The ubiquitin ligase SCFCdc4 (Skp1/Cul1/F-box protein) recognizes its substrate, the cyclin-dependent kinase inhibitor Sid, in a multisite... 
Phosphates | Yeasts | Phosphorylation | Ubiquitins | Cephalopelvic disproportion | Alleles | Resins | Electrostatics | Viability | Cyclins
Journal Article
EMBO Journal, ISSN 0261-4189, 01/2010, Volume 29, Issue 1, p. 263
  The most common cystic fibrosis (CF)-causing mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) is deletion of Phe508 (DeltaF508) in... 
Nuclear magnetic resonance--NMR | Cystic fibrosis | Mutation | Molecular biology | Binding sites
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 12/2016, Volume 41, pp. 180 - 186
Liquid–liquid demixing or phase separation of protein with RNA is now recognized to be a key part of the mechanism for assembly of ribonucleoprotein granules.... 
R REGION | RECRUITMENT | CATION-PI INTERACTIONS | PROTEIN | CLUSTERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXITY | DISORDER | INTERACTION NETWORKS | DIX DOMAIN | PLASMA-MEMBRANE | CELL BIOLOGY | Cells - metabolism | Signal Transduction | Cells - cytology | Intrinsically Disordered Proteins - metabolism | RNA - metabolism | Children's hospitals
Journal Article
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