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by Heerspink, Hiddo J L and Parving, Hans-Henrik and Andress, Dennis L and Bakris, George and Correa-Rotter, Ricardo and Hou, Fan-Fan and Hou, Fanfan and Kitzman, Dalane W and Kohan, Donald and Makino, Shinya and Makino, Hirofumi and McMurray, John J V and Melnick, Joel Z and Miller, Michael G and Miller, Alan and Miller, Steven and Pergola, Pablo E and Pergola, Pablo and Perkovic, Vlado and Tobe, Sheldon and Yi, Joo Hark and Yi, Tingting and Wigderson, Melissa and de Zeeuw, Dick and Elbert, Alicia and Vallejos, Augusto and Alvarisqueta, Andres and Maffei, Laura and Juncos, Luis and de Arteaga, Javier and Greloni, Gustavo and Farias, Eduardo and Zucchini, Alfredo and Vogel, Daniel and Cusumano, Ana and Santos, Juan and Fraenkel, Margaret and Gallagher, Martin and Davis, Tim and Acharya, Shamasunder and Cooke, Duncan and Suranyi, Michael and Roger, Simon and Toussaint, Nigel and Pollock, Carol and Chan, Doris and Stranks, Stephen and MacIsaac, Richard and Endre, Zoltan and Schmidt, Alice and Schmidt, Rebecca and Prager, Rudolf and Mayer, Gert and Warling, Xavier and Jadoul, Michel and Hougardy, Jean and Vercammen, Chris and Van Vlem, Bruno and Gillard, Pieter and Costa e Forti, Adriana and Borges, Joao Lindolfo and Santos Canani, Luis and Eliaschewitz, Freddy and Leite, Silmara and Fraige Filho, Fadlo and Paschoalin, Raphael and Moura Neto, Jose Andrade and Deboni, Luciane and de Lourdes Noronha, Irene and Cercato, Cintia and Prompt, Carlos Alberto and Zanella, Maria and Rassi, Nelson and D'Avila, Domingos and Milagres, Rosangela and Felicio, Joao and Pecoits Filho, Roberto and Riella, Miguel Carlos and Salles, Joao and Keitel, Elizete and Draibe, Sergio and Amodeo, Celso and Youmbissi, Joseph and Roy, Louise and Cournoyer, Serge and Jolly, Shivinder and Pichette, Vincent and Nesrallah, Gihad and Bajaj, Harpreet Singh and Khandwala, Hasnain and Aronson, Ronnie and Goluch, Richard and Tam, Paul and Rabbat, Christian and Bailey, Gordon and Chow, Stephen and Castillo, Alvaro and Danin Vargas, Alfredo and Gonzalez, Fernando and Munoz, Rodrigo and ... and SONAR Comm Investigators and SONAR Committees and Investigators
The Lancet, ISSN 0140-6736, 05/2019, Volume 393, Issue 10184, pp. 1937 - 1947
Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without... 
MEDICINE, GENERAL & INTERNAL | INHIBITION | ENDOTHELIN | ALBUMINURIA | NEPHROPATHY | Humans | Middle Aged | Male | Diabetic Nephropathies - blood | Serum Albumin, Human - urine | Young Adult | Aged, 80 and over | Adult | Female | Diabetic Nephropathies - prevention & control | Endothelin A Receptor Antagonists - therapeutic use | Diabetic Nephropathies - urine | Glomerular Filtration Rate | Double-Blind Method | Endothelin A Receptor Antagonists - administration & dosage | Administration, Oral | Treatment Outcome | Creatinine - urine | Renal Insufficiency, Chronic - blood | Renal Insufficiency, Chronic - prevention & control | Atrasentan - therapeutic use | Creatinine - blood | Aged | Atrasentan - administration & dosage | Diabetes Mellitus, Type 2 - drug therapy | Renal Insufficiency, Chronic - urine | Short term | Enrichment | End-stage renal disease | Renal function | Endothelin | Heart attacks | Peptides | Clinical trials | Cardiovascular disease | Transplantation | Retention | Randomization | Renin | Motivation | Hemoglobin | Blood pressure | Safety | Diabetes mellitus (non-insulin dependent) | Heart diseases | Drug dosages | Heart failure | Urine | Creatinine | Enzymes | Kidneys | Epidermal growth factor receptors | Anemia | Diabetes mellitus | Health risks | Patients | Disease control | Glomerular filtration rate | Sodium | Angiotensin | Renal failure | Dialysis | Kidney diseases | Diabetes | Surface area | Potassium | Kidney transplantation | Long-term effects | Index Medicus | Abridged Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2012, Volume 367, Issue 23, pp. 2204 - 2213
Patients with type 2 diabetes at high risk for cardiovascular disease who were already taking a renin–angiotensin system blocker were randomly assigned to the... 
GLOMERULAR-FILTRATION-RATE | CHRONIC HEART-FAILURE | MEDICINE, GENERAL & INTERNAL | CONVERTING-ENZYME INHIBITORS | LEFT-VENTRICULAR DYSFUNCTION | MYOCARDIAL-INFARCTION | DOUBLE-BLIND | CARDIOVASCULAR MORTALITY | FOLLOW-UP | SYSTOLIC DYSFUNCTION | BLOOD-PRESSURE | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Patient Dropouts | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Kidney Diseases - epidemiology | Treatment Failure | Amides - adverse effects | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Hypokalemia | Female | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications | Double-Blind Method | Fumarates - therapeutic use | Kidney Diseases - prevention & control | Amides - therapeutic use | Fumarates - adverse effects | Antihypertensive Agents - therapeutic use | Antihypertensive Agents - adverse effects | Renin - antagonists & inhibitors | Hyperkalemia - chemically induced | Aged | Kidney Diseases - etiology | Diabetes Mellitus, Type 2 - drug therapy | Angiotensin Receptor Antagonists - therapeutic use | Myocardial infarction | Women | Creatinine | Cerebral infarction | End-stage renal disease | Stroke | Heart attacks | Kidneys | Diabetes mellitus | Cardiovascular disease | Coronary artery disease | Hypotension | Hyperkalemia | Renin | Angiotensin | Renal failure | Diabetes | Kidney diseases | Cardiovascular diseases | Diabetes mellitus (non-insulin dependent) | Heart diseases | Kidney transplantation | Index Medicus | Abridged Index Medicus
Journal Article
Nutrition, ISSN 0899-9007, 2012, Volume 28, Issue 9, pp. e23 - e28
Abstract Objective Oxidative stress and inflammation seem to mediate the cardiovascular risks associated with salt sensitivity. Because hydroxymethyl glutaryl... 
Gastroenterology and Hepatology | Hydroxymethyl glutaryl coenzyme A reductase inhibition | Sodium balance | Salt sensitivity | Nitric oxide/oxidant stress | Renal failure | Heptanoic Acids - therapeutic use | Hypertension - drug therapy | Male | Renal Insufficiency, Chronic - complications | Sodium - metabolism | Renal Insufficiency, Chronic - drug therapy | Renal Insufficiency, Chronic - metabolism | Kidney - metabolism | Nephrectomy | Hypertension - chemically induced | Blood Pressure - drug effects | Pyrroles - therapeutic use | Heptanoic Acids - pharmacology | Proteinuria - etiology | Kidney - drug effects | Sodium - adverse effects | Sodium Chloride, Dietary - adverse effects | Rats | Random Allocation | Rats, Sprague-Dawley | Hypertension - metabolism | Atorvastatin Calcium | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Proteinuria - drug therapy | Diet | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Sodium Chloride, Dietary - metabolism | Creatinine - blood | Nitric Oxide Synthase - metabolism | Oxidative Stress - drug effects | Fatty Acids, Unsaturated - urine | Nitric Oxide - metabolism | Heart Ventricles - drug effects | Hypertension | Enzymes | Thiols | Chronic kidney failure | Nitric oxide | Blood pressure | Antilipemic agents | Proteins | Cardiovascular disease | Kidney diseases | Rodents | Index Medicus
Journal Article
REVISTA DE NEFROLOGIA DIALISIS Y TRASPLANTE, ISSN 0326-3428, 06/2009, Volume 29, Issue 2, pp. 84 - 91
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 06/2013, Volume 304, Issue 11, pp. 951 - 958
Journal Article
Physiological Reports, 03/2019, Volume 7, Issue 5, pp. e14015 - n/a
Sodium transport in the thick ascending loop of Henle ( TAL ) is tightly regulated by numerous factors, especially angiotensin II (Ang II ), a key end‐product... 
Angiotensin 1‐7 | mas receptor | hypertension | TAL | Angiotensin 1-7 | Amiloride | Renin | Sodium | Nitric oxide | Angiotensin | Loop of Henle | Oxygen consumption | Angiotensin II | Protein transport | Vasodilation | Furosemide
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 07/2011, Volume 301, Issue 1, pp. F125 - F133
Journal Article