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Blood advances, ISSN 2473-9529, 10/2020, Volume 4, Issue 20, pp. 5174 - 5183
Chimeric antigen receptor (CAR) T-cells directed against CD19 have drastically altered outcomes for children with relapsed and refractory acute lymphoblastic... 
Life Sciences & Biomedicine | Hematology | Science & Technology | Index Medicus
Journal Article
10/2020
The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy... 
HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
Archives of gynecology and obstetrics, ISSN 0932-0067, 10/2020, Volume 302, Issue 4, pp. 935 - 945
Purpose Venous thromboembolism (VTE) is a leading cause of perioperative morbidity and mortality. We analyzed the trends in use of VTE prophylaxis over time in... 
Life Sciences & Biomedicine | Obstetrics & Gynecology | Science & Technology | Trends | Hysterectomy | Thromboembolism | Surgery | Index Medicus
Journal Article
10/2020
Various TnMUC1-specific chimeric antigen receptors (CARs), nucleic acids encoding the same, and methods of using the same, are provided. Compositions and... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
Journal of clinical pharmacology, ISSN 0091-2700, 10/2020, Volume 60, Issue S1 Suppl 1, pp. S147 - S159
Chimeric antigen receptor T cell (CAR‐T cell) therapies have shown significant efficacy in CD19+ leukemias and lymphomas. There remain many challenges and... 
model‐informed drug development (MIDD) | quantitative systems pharmacology (QSP) | chimeric antigen receptor‐T cell (CAR‐T cell) therapy | cellular kinetic‐pharmacodynamic model | Antigens | Pharmacodynamics | CD19 antigen | Cytokines | Lymphocytes | Mathematical models | Lymphocytes T | Index Medicus
Journal Article
Parasitology, ISSN 0031-1820, 10/2020, Volume 147, Issue 12, pp. 1290 - 1304
Recent declines of wild pollinators and infections in honey, bumble and other bee species have raised concerns about pathogen spillover from managed honey and... 
sweat bee | Alfalfa leafcutter bee | blue orchard bee | Halictus ligatus | Leishmaniiniae | Osmia lignaria | host-parasite specificity | flagellate | Kinetoplastidae | Megachile rotundata | Life Sciences & Biomedicine | Parasitology | Science & Technology | Index Medicus
Journal Article
Cell (Cambridge), ISSN 0092-8674, 10/2020, Volume 183, Issue 1, pp. 126 - 142.e17
CD19-directed immunotherapies are clinically effective for treating B cell malignancies but also cause a high incidence of neurotoxicity. A subset of patients... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
Journal Article
09/2020
The present invention provides compositions and methods for inducing tolerance in a human. The invention includes administering a genetically modified T cell... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
09/2020
The disclosure provides methods of making CAR-expressing immune effector cells (e.g., T cells, or NK cells), and compositions and reaction mixtures comprising... 
WINE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | ORGANIC CHEMISTRY | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PEPTIDES | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
Patent
Molecular therapy. Methods & clinical development, ISSN 2329-0501, 09/2020, Volume 18, pp. 595 - 606
Effective chimeric antigen receptor (CAR)-T cell therapy is dependent on optimal cell culture methods conducive to the activation and expansion of T cells... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine
Journal Article
08/2020
The invention provides compositions and methods for treating diseases such as cancer. The invention also relates to a method of administering a chimeric... 
HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
07/2020
본 발명은 BCMA의 발현과 관련된 질환을 치료하기 위한 조성물 및 방법을 제공한다. 본 발명은 또한 BCMA-표적화 키메라 항원 수용체(CAR) 요법제 및 추가 치료제를 투여하는 방법에 관한 것이다. The invention provides compositions and... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
JCI insight, ISSN 2379-3708, 07/2020, Volume 5, Issue 14
Off-tumor targeting of human antigens is difficult to predict in preclinical animal studies and can lead to serious adverse effects in patients. To address... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Index Medicus
Journal Article
07/2020
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell... 
METALLURGY | PEPTIDES | ORGANIC CHEMISTRY | CHEMISTRY
Patent
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