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1. R406, an orally available spleen tyrosine kinase inhibitor blocks Fc receptor signaling and reduces immune complex-mediated inflammation
by Braselmann, Sylvia and Taylor, Vanessa and Zhao, Haoran and Wang, Su and Sylvain, Catherine and Baluom, Muhammad and Qu, Kunbin and Herlaar, Ellen and Lau, Angela and Young, Chi and Wong, Brian R and Lovell, Scott and Sun, Thomas and Park, Gary and Argade, Ankush and Jurcevic, Stipo and Pine, Polly and Singh, Rajinder and Grossbard, Elliott B and Payan, Donald G and Masuda, Esteban S
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 998 - 1008
Recent compelling evidence has lead to renewed interest in the role of antibodies and immune complexes in the pathogenesis of several autoimmune disorders,... 
RHEUMATOID-ARTHRITIS | GAMMA RECEPTORS | COLLAGEN | BASOPHIL ACTIVATION | ARTHUS REACTION | CELL ACTIVATION | PLATELETS | MAST-CELLS | DEFICIENT | PHARMACOLOGY & PHARMACY | SYK KINASES | Inflammation - pathology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Pyridines - pharmacokinetics | Crystallography | Antigen-Antibody Complex - physiology | Arthritis, Experimental - pathology | Fluorescence Polarization Immunoassay | Oxazines - pharmacokinetics | Receptors, Fc - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Immunoglobulin G - biosynthesis | Spleen - enzymology | Immunoglobulin G - immunology | Inflammation - drug therapy | Platelet Aggregation - drug effects | Oxazines - pharmacology | Basophils - drug effects | Double-Blind Method | Cells, Cultured | Enzyme Inhibitors - pharmacology | B-Lymphocytes - physiology | Mast Cells - drug effects | Stimulation, Chemical | Blotting, Western | B-Lymphocytes - drug effects | Animals | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Arthus Reaction - physiopathology | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
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2. Full Text The effects of an anti–IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
by Nicholson, Grant C., BSc and Kariyawasam, Harsha H., MBBS, PhD and Tan, Andrew J., MSc and Hohlfeld, Jens M., MD and Quinn, Deborah, MD and Walker, Christoph, PhD and Rodman, David, MD and Westwick, John, PhD and Jurcevic, Stipo, PhD and Kon, Onn Min, MD and Barnes, Peter J., FMedSci, FRS and Krug, Norbert, MD and Hansel, Trevor T., MBBCh, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 128, Issue 4, pp. 800 - 807.e9
Background IL-13 is a key TH 2 cytokine that is implicated in allergic responses. Objective We evaluated the effects of an anti–IL-13–blocking antibody... 
Allergy and Immunology | nasal allergen challenge | anti–IL-13 | Allergic rhinitis | mAb | anti-IL-13 | MEPOLIZUMAB | EFFICACY | SAFETY | EOSINOPHILS | INTERLEUKIN-13 | ANTIBODY | RECEPTOR | IL-13 | IMMUNOLOGY | MUCOSA | ALLERGY | ASTHMA | Double-Blind Method | Interleukin-13 - antagonists & inhibitors | Humans | Middle Aged | Rhinitis, Allergic, Seasonal - drug therapy | Antibodies, Monoclonal - pharmacokinetics | Interleukin-13 - immunology | Male | Fluticasone | Phleum - immunology | Administration, Intranasal | Eosinophils - immunology | Rhinitis, Allergic, Seasonal - immunology | Allergens - administration & dosage | Androstadienes - administration & dosage | Antibodies, Monoclonal - administration & dosage | Rhinitis, Allergic, Seasonal - blood | Adolescent | Adult | Female | Anti-Allergic Agents - administration & dosage | Adrenal Cortex Hormones - administration & dosage | Therapeutic Irrigation | Allergy | Allergens | Universities and colleges | Cytokines | Allergic reaction | Studies | Allergies
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3. Full Text 155: STAT5 regulation of TOX: Its dependence on IL-2 and role in cancer
by Rani, Aradhana and Murphy, John and Jurcevic, Stipo
Cytokine, ISSN 1043-4666, 11/2014, Volume 70, Issue 1, pp. 65 - 65
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4. Full Text 155
by Rani, Aradhana and Murphy, John and Jurcevic, Stipo
Cytokine, ISSN 1043-4666, 11/2014, Volume 70, Issue 1, p. 65
The Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway represents a rapid membrane to nucleus signaling system used by cytokines,... 
Promoters (Genetics) | Analysis | Genomics | T cells | Methylation | Cell differentiation | Protein binding
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5. Full Text FRA2 Is a STAT5 target gene regulated by il-2 in human CD4 T cells
by Rani, Aradhana and Greenlaw, Roseanna and Runglall, Manohursingh and Jurcevic, Stipo and John, Susan
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e90370
Signal transducers and activators of transcription 5(STAT5) are cytokine induced signaling proteins, which regulate key immunological processes, such as... 
BREAST-CANCER | HUMAN GENOME | CHROMATIN IMMUNOPRECIPITATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | RECEPTOR | BINDING-SITES | IDENTIFICATION | EXPRESSION | DNASE HYPERSENSITIVE SITES | SOMATIC MUTATIONS | Luciferases - metabolism | Epigenesis, Genetic | Humans | Molecular Sequence Data | Fos-Related Antigen-2 - genetics | Luciferases - genetics | Janus Kinase 3 - antagonists & inhibitors | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Fos-Related Antigen-2 - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | Base Sequence | DNA, Intergenic - metabolism | HEK293 Cells | Immunoglobulin G - pharmacology | Transcription, Genetic | Janus Kinase 3 - metabolism | Binding Sites | Genes, Reporter | Signal Transduction | Introns | Lymphocyte Activation | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation | DNA, Intergenic - chemistry | Daclizumab | Histones - genetics | Janus Kinase 3 - genetics | Interleukin-2 - pharmacology | Protein Binding | Histones - metabolism | Primary Cell Culture | Methylation | CD4-Positive T-Lymphocytes - drug effects | Epigenetic inheritance | Chromatin | Cytokines | Genes | DNA binding proteins | Genetic transcription | T cells | Cell differentiation | Fos-related antigen | Transcription factors | Immunoprecipitation | Target recognition | Laboratories | Homeostasis | Lymphocytes T | Genomes | Biology | Activation | Leucine | Kinases | Experiments | Proteins | T-cell receptor | Signal transduction | Reporter gene | Immunology | Fos protein | Interleukin 2 | Fos-related antigen 2 | Lymphocytes | Transcription activation | DNA methylation | Elongation | Transducers | Cloning | Activator protein 1 | Stat5 protein | Gene expression | Immunological tolerance | Leucine zipper proteins | CD4 antigen | Studies | Signaling | Medical prognosis | γ-Interferon | Interferon | Gene mapping | Binding sites | Tumors | Cancer
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6. Full Text PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers
by Coffey, Greg and Rani, Aradhana and Betz, Andreas and Pak, Yvonne and Haberstock‐Debic, Helena and Pandey, Anjali and Hollenbach, Stanley and Gretler, Daniel D and Mant, Tim and Jurcevic, Stipo and Sinha, Uma
The Journal of Clinical Pharmacology, ISSN 0091-2700, 02/2017, Volume 57, Issue 2, pp. 194 - 210
The spleen tyrosine kinase (SYK) regulates immune cell activation in response to engagement of a variety of receptors, making it an intriguing target for the... 
allergy | immunopharmacology | SYK | PRT062607 | autoimmune | lymphoma | Protein Kinase Inhibitors - pharmacokinetics | Receptors, Antigen, B-Cell - drug effects | Single-Blind Method | Arthritis, Experimental - drug therapy | Humans | Half-Life | Rats | Male | Spleen - drug effects | Pyrimidines - pharmacology | Healthy Volunteers | Cyclohexylamines - pharmacokinetics | Respiratory Burst - drug effects | B-Lymphocytes - drug effects | Basophil Degranulation Test | Animals | Spleen - enzymology | Cyclohexylamines - pharmacology | Pyrimidines - pharmacokinetics | Adult | Dendritic Cells - drug effects | Protein Kinase Inhibitors - pharmacology | Macrophage Activation - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | B-CELL DEVELOPMENT | RHEUMATOID-ARTHRITIS | RECEPTOR | NEUTROPHILS | TARGETING BTK | SYK INHIBITOR | SIGNAL-TRANSDUCTION | IN-VIVO | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | Tyrosine | Care and treatment | Pharmacology | Research | Autoimmune diseases | Pharmacokinetics | Spleen | T cell receptors | Dosing | Antigens | Medical services | Activation | Arthritis | Selectivity | Kinases | Receptors | Inhibition | Immune system | Pharmacodynamics
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7. Full Text Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer
by Crnogorac-Jurcevic, Tatjana and Chelala, Claude and Barry, Sayka and Harada, Tomohiko and Bhakta, Vipul and Lattimore, Sam and Jurcevic, Stipo and Bronner, Mary and Lemoine, Nicholas R and Brentnall, Teresa A
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e54830
Background: With less than a 5% survival rate pancreatic adenocarcinoma (PDAC) is almost uniformly lethal. In order to make a significant impact on survival of... 
INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | GENES | STELLATE CELLS | INTRAEPITHELIAL NEOPLASIA | EXPRESSION | CARCINOMA | PROMOTES | TRANSCRIPTOME ANALYSIS | PROGRESSION | Carcinoma in Situ - pathology | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Male | Pancreatic Neoplasms - genetics | Gene Expression Profiling | Disease Progression | Carcinoma in Situ - genetics | Pedigree | Biomarkers, Tumor - metabolism | Adult | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - pathology | Neoplasm Staging | Cluster Analysis | Care and treatment | Pancreatic cancer | Genomics | Development and progression | Genetic aspects | Genetic transcription | Health aspects | Adenocarcinoma | Transcription | Genes | Oncology | Genomes | Malignancy | Medical diagnosis | Precursors | Surgery | Lesions | Pancreas | Immune response | Invasiveness | Health risks | Stroma | Histology | Breast cancer | Gene expression | Epithelium | Patients | Survival | Surveillance | Diagnostic systems | Mutation | Cancer
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8. Full Text Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans
by Jurcevic, Stipo and Juif, Pierre-Eric and Hamid, Colleen and Greenlaw, Roseanna and D’Ambrosio, Daniele and Dingemanse, Jasper
Drug Design, Development and Therapy, 2017, Volume 11, pp. 123 - 131
This study investigated the effects of ponesimod, a selective S1P1 receptor modulator, on T lymphocyte subsets in 16 healthy subjects. Lymphocyte subset... 
Multiple dose | CD45RA/CCR7 | S1P | receptor | Ponesimod | Lymphocyte subsets | Clearing | Lymphocyte receptors | CC chemokine receptors | CD8 antigen | CCR7 protein | CD45RA antigen | Effector cells | Cytotoxicity | Lymphocytes T | CD3 antigen | CD4 antigen | Homing | Lymphocytes B | Lymphocytes | Cell number | Natural killer cells | Cell migration | Flow cytometry | Multiple sclerosis | Memory cells | Immunoglobulins | Variance analysis | Cell adhesion & migration | Ethics | Immunology | Drug dosages
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9. Full Text Polymers imprinted with three REG1B peptides for electrochemical determination of Regenerating Protein 1B, a urinary biomarker for pancreatic ductal adenocarcinoma
by Lee, Mei-Hwa and Thomas, James L and Liao, Chun-Lin and Jurcevic, Stipo and Crnogorac-Jurcevic, Tatjana and Lin, Hung-Yin
Microchimica Acta, ISSN 0026-3672, 06/2017, Volume 184, Issue 6, pp. 1773 - 1780
Three peptides (each containing 13-18 amino acids) were synthesized and used as templates for molecular imprinting and epitope recognition of the Regenerating... 
Cyclic voltammetry | Hexacyanoferrate | Epitope recognition | PDAC | MIP | Peptide imprinted polymer | AFM | ESCA | CHEMISTRY, ANALYTICAL | RECOGNITION | POTENTIOSTAT | SENSORS | QUANTUM DOTS | TEMPLATES | NANOPARTICLES | POLY(ETHYLENE-CO-VINYL ALCOHOL) | SURFACE | Adenocarcinoma | Peptides | Analysis | Pancreatic cancer | Amino acids | Electric properties | Antigenic determinants | Urine | Proteins | Gold | Imprinted polymers | Biomarkers | Chemical synthesis | Molecular imprinting
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10. Full Text The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions
by Jurcevic, Stipo and Humfrey, Charles and Uddin, Mohib and Warrington, Steve and Larsson, Bengt and Keen, Christina
British Journal of Clinical Pharmacology, ISSN 0306-5251, 12/2015, Volume 80, Issue 6, pp. 1324 - 1336
Aims The aim of the present study was to investigate whether selective antagonism of the cysteine‐X‐cysteine chemokine receptor‐2 (CXCR2) receptor has any... 
phagocytosis | CXCR2 antagonist | oxidative burst | asthma | neutrophil recruitment | COPD | CHEMOKINE RECEPTOR CXCR2 | SEVERE ASTHMA | NADPH-OXIDASE | SPUTUM NEUTROPHILS | HEALTHY-SUBJECTS | AIRWAY INFLAMMATION | INTERLEUKIN-8 RECEPTORS | OBSTRUCTIVE PULMONARY-DISEASE | PHAGOCYTIC FUNCTION | PHARMACOLOGY & PHARMACY | CYSTIC-FIBROSIS | Phagocytosis - drug effects | Double-Blind Method | Immunity, Innate - drug effects | Humans | Middle Aged | Neutrophils - drug effects | Inflammation Mediators - blood | Neutrophils - immunology | Pyrimidines - pharmacology | Receptors, Interleukin-8B - antagonists & inhibitors | Sulfonamides - pharmacology | Respiratory Burst - drug effects | Cross-Over Studies | Granulocyte Colony-Stimulating Factor - pharmacology | Exercise | Adolescent | Pyrimidines - adverse effects | Sulfonamides - adverse effects | Adult | Leukocyte Count | Cysteine | Lung diseases, Obstructive | Superoxide | Escherichia coli | Clinical Trials
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11. Full Text The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions
: Effects of CXCR2 antagonism on human neutrophils
by Jurcevic, Stipo and Humfrey, Charles and Uddin, Mohib and Warrington, Steve and Larsson, Bengt and Keen, Christina
British Journal of Clinical Pharmacology, ISSN 0306-5251, 12/2015, Volume 80, Issue 6, pp. 1324 - 1336
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12. Full Text Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
by Hargreaves, Roseanna E G and Dyson, Julian and Jurcevic, Stipo and Marsh, James E and Farrar, Conrad A and Monk, Nicola J and Millrain, Maggie and Simpson, Elizabeth and Sacks, Steven H
Nature Medicine, ISSN 1078-8956, 10/2003, Volume 9, Issue 10, pp. 1275 - 1280
Although the underlying mechanisms are not well understood, it is generally believed that antigen recognition by T cells in the absence of costimulation may... 
MEDICINE, RESEARCH & EXPERIMENTAL | ANIMAL TRANSPLANT MODEL | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CD40 LIGAND | MONOCLONAL-ANTIBODY | DEFICIENT MICE | CUTTING EDGE | CELL BIOLOGY | RENAL-ALLOGRAFT REJECTION | NONOBESE DIABETIC MICE | DIABETOGENIC AUTOIMMUNITY | FUSION PROTEIN | Graft Survival - immunology | Immune System - physiology | Antibodies - metabolism | Immunoglobulin Fc Fragments - metabolism | Lymphocyte Activation | Mice, Inbred C57BL | Lymph Nodes - metabolism | Sirolimus - metabolism | Lymph Nodes - cytology | CD40 Ligand - immunology | Transplantation, Homologous | Complement System Proteins - metabolism | Immunosuppression | Animals | CD40 Antigens - metabolism | Immunoglobulin Fc Fragments - immunology | T-Lymphocytes - metabolism | Antibodies - immunology | Female | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | CD40 Antigens - immunology
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13. Full Text Epitope recognition of peptide-imprinted polymers for Regenerating protein 1 (REG1)
by Lee, Mei-Hwa and Thomas, James L and Liao, Chun-Lin and Jurcevic, Stipo and Crnogorac-Jurcevic, Tatjana and Lin, Hung-Yin
Separation and Purification Technology, ISSN 1383-5866, 02/2018, Volume 192, pp. 213 - 219
Seven peptides (13–18 amino acids) were synthesized and used as templates for imprinting and recognition of Regenerating Protein 1 (REG1). Peptide-imprinted... 
Peptide imprinting | Electrochemical sensing | Extraction | Regenerating protein | ENGINEERING, CHEMICAL | NANOPARTICLES | SERUM-ALBUMIN | URINE | ELECTROCHEMICAL SENSORS | BINDING | QUANTUM DOTS | Proteins | Usage | Pancreatic cancer | Escherichia coli | Antigenic determinants
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14. Full Text Effects of multiple-dose ponesimod, a selective S1[P.sub.1] receptor modulator, on lymphocyte subsets in healthy humans
by Jurcevic, Stipo and Juif, Pierre-Eric and Hamid, Colleen and Greenlaw, Roseanna and D'Ambrosio, Daniele and Dingemanse, Jasper
Drug Design, Development and Therapy, ISSN 1177-8881, 01/2017, Volume 11, p. 123
This study investigated the effects of ponesimod, a selective S1Pj receptor modulator, on T lymphocyte subsets in 16 healthy subjects. Lymphocyte subset... 
Pharmacology, Experimental | Lymphocytes | Sphingosine | Physiological aspects | Research | Health aspects | Immunopharmacology | Immunosuppressive agents
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15. Full Text Effects of multiple-dose ponesimod, a selective S1P 1 receptor modulator, on lymphocyte subsets in healthy humans
by Jurcevic, Stipo and Juif, Pierre-Eric and Hamid, Colleen and Greenlaw, Roseanna and D'Ambrosio, Daniele and Dingemanse, Jasper
Drug Design, Development and Therapy, ISSN 1177-8881, 12/2016, Volume 11, pp. 123 - 131
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16. Full Text Effects of multiple-dose ponesimod, a selective S1P 1 receptor modulator, on lymphocyte subsets in healthy humans
by Jurcevic, Stipo and Juif, Pierre-Eric and Hamid, Colleen and Greenlaw, Roseanna and D'Ambrosio, Daniele and Dingemanse, Jasper
Drug design, development and therapy, 2017, Volume 11, p. 123
This study investigated the effects of ponesimod, a selective S1P receptor modulator, on T lymphocyte subsets in 16 healthy subjects. Lymphocyte subset... 
Administration, Oral | Lymphocyte Subsets - drug effects | Humans | Thiazoles - administration & dosage | Healthy Volunteers | Dose-Response Relationship, Drug | B-Lymphocytes - drug effects | Lymphocyte Subsets - metabolism | Flow Cytometry | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Thiazoles - pharmacology | Receptors, Lysosphingolipid - metabolism | B-Lymphocytes - metabolism
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17. Full Text Two single-center, double-blind, randomized, placebo-controlled, phase i studies to investigate the tolerability and pharmacokinetics of ch-1504, an antifolate, in healthy male subjects
by Mant, Tim, BSc, FRCP, FFPM and Jurcevic, Stipo, MD and Szakacs, Cameron, PhD and Adams, Luthando, MBChB and Boland, John, BA and Hewitt, Lawrence Arthur, PhD
Clinical Therapeutics, ISSN 0149-2918, 2008, Volume 30, Issue 1, pp. 131 - 142
Abstract Background: Several studies have suggested that a significant proportion of the toxicity profile of the an-tifolate methotrexate can be attributed to... 
Internal Medicine | Medical Education | Psoriasis | Methotrexate | Autoimmune diseases | rheumatoid arthritis | CH-1504 | autoimmune diseases | psoriasis | RATS | methotrexate | PHARMACOLOGY & PHARMACY | Drug Eruptions - etiology | Folic Acid Antagonists - administration & dosage | Double-Blind Method | Humans | Aminopterin - pharmacokinetics | Male | Aminopterin - adverse effects | Aminopterin - administration & dosage | Dose-Response Relationship, Drug | Adult | Molecular Structure | Aminopterin - analogs & derivatives | Folic Acid Antagonists - adverse effects | Folic Acid Antagonists - pharmacokinetics | Index Medicus
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