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by Anttila, Verneri and Bulik-Sullivan, Brendan and Finucane, Hilary K and Walters, Raymond K and Bras, Jose and Duncan, Laramie and Escott-Price, Valentina and Falcone, Guido J and Gormley, Padhraig and Malik, Rainer and Patsopoulos, Nikolaos A and Ripke, Stephan and Wei, Zhi and Yu, Dongmei and Lee, Phil H and Turley, Patrick and Grenier-Boley, Benjamin and Chouraki, Vincent and Kamatani, Yoichiro and Berr, Claudine and Letenneur, Luc and Hannequin, Didier and Amouyel, Philippe and Boland, Anne and Deleuze, Jean-François and Duron, Emmanuelle and Vardarajan, Badri N and Reitz, Christiane and Goate, Alison M and Huentelman, Matthew J and Ilyas Kamboh, M and Larson, Eric B and Rogaeva, Ekaterina and George-Hyslop, Peter St and Hakonarson, Hakon and Kukull, Walter A and Farrer, Lindsay A and Barnes, Lisa L and Beach, Thomas G and Yesim Demirci, F and Head, Elizabeth and Hulette, Christine M and Jicha, Gregory A and Kauwe, John S.K and Kaye, Jeffrey A and Leverenz, James B and Levey, Allan I and Lieberman, Andrew P and Pankratz, Vernon S and Poon, Wayne W and Quinn, Joseph F and Saykin, Andrew J and Schneider, Lon S and Smith, Amanda G and Sonnen, Joshua A and Stern, Robert A and Van Deerlin, Vivianna M and Van Eldik, Linda J and Harold, Denise and Russo, Giancarlo and Rubinsztein, David C and Bayer, Anthony and Tsolaki, Magda and Proitsi, Petra and Fox, Nick C and Hampel, Harald and Owen, Michael J and Mead, Simon and Passmore, Peter and Morgan, Kevin and Nöthen, Markus M and Rossor, Martin and Lupton, Michelle K and Hoffmann, Per and Kornhuber, Johannes and Lawlor, Brian and McQuillin, Andrew and Al-Chalabi, Ammar and Bis, Joshua C and Ruiz, Agustin and Boada, Mercè and Seshadri, Sudha and Beiser, Alexa and Rice, Kenneth and Van Der Lee, Sven J and De Jager, Philip L and Geschwind, Daniel H and Riemenschneider, Matthias and Riedel-Heller, Steffi and Rotter, Jerome I and Ransmayr, Gerhard and Hyman, Bradley T and Cruchaga, Carlos and Alegret, Montserrat and Winsvold, Bendik and Palta, Priit and Farh, Kai-How and Cuenca-Leon, Ester and Furlotte, Nicholas and Kurth, Tobias and ... and Brainstorm Consortium and The Brainstorm Consortium
Science, ISSN 0036-8075, 06/2018, Volume 360, Issue 6395, pp. 1313 - 1313
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We... 
ANOREXIA-NERVOSA | POPULATION-BASED TWIN | DEFICIT HYPERACTIVITY DISORDER | LONG-TERM SURVIVAL | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | GENETIC CORRELATIONS | BODY-MASS INDEX | MAJOR DEPRESSIVE DISORDER | BIPOLAR DISORDER | GENOME-WIDE ASSOCIATION | Genetic Variation | Mental Disorders - genetics | Genome-Wide Association Study | Phenotype | Brain Diseases - classification | Quantitative Trait, Heritable | Brain Diseases - diagnosis | Humans | Mental Disorders - classification | Risk Factors | Brain Diseases - genetics | Mental Disorders - diagnosis | Anorexia | Disorders | Cognitive ability | Bipolar disorder | Posttraumatic stress disorder | Mental depression | Epidemiology | Risk factors | Consortia | Proteins | Ischemia | Etiology | Classification | Gilles de la Tourette syndrome | Alzheimer's disease | Neurological disorders | Neurodegenerative diseases | Comorbidity | Behavior disorders | Anorexia nervosa | Risk analysis | Patients | Neurological diseases | Correlation analysis | Heritability | Attention deficit disorder | Headache | Mental disorders | Medical services | Schizophrenia | Risk sharing | Genomes | Heterogeneity | Biological effects | Risk assessment | Stroke | Phenotypes | Migraine | Attention deficit hyperactivity disorder | Eating disorders | Personality | Genetic diversity | Statistics | Activity patterns | Crohn's Disease | Population (statistical) | Scaffolding | Diagnostic systems | Alzheimers disease | Life Sciences | Human health and pathology | Mental Disorders | Neurons and Cognition | Brain Diseases | Genetics
Journal Article
by Abou-Khalil, Bassel and Auce, Pauls and Avbersek, Andreja and Bahlo, Melanie and Balding, David J and Bast, Thomas and Baum, Larry and Becker, Albert J and Becker, Felicitas and Berghuis, Bianca and Berkovic, Samuel F and Boysen, Katja E and Bradfield, Jonathan P and Brody, Lawrence C and Buono, Russell J and Campbell, Ellen and Cascino, Gregory D and Catarino, Claudia B and Cavalleri, Gianpiero L and Cherny, Stacey S and Chinthapalli, Krishna and Coffey, Alison J and Compston, Alastair and Coppola, Antonietta and Cossette, Patrick and Craig, John J and de Haan, Gerrit-Jan and De Jonghe, Peter and de Kovel, Carolien G. F and Delanty, Norman and Depondt, Chantal and Devinsky, Orrin and Dlugos, Dennis J and Doherty, Colin P and Elger, Christian E and Eriksson, Johan G and Ferraro, Thomas N and Feucht, Martha and Francis, Ben and Franke, Andre and French, Jacqueline A and Freytag, Saskia and Gaus, Verena and Geller, Eric B and Gieger, Christian and Glauser, Tracy and Glynn, Simon and Goldstein, David B and Gui, Hongsheng and Guo, Youling and Haas, Kevin F and Hakonarson, Hakon and Hallmann, Kerstin and Haut, Sheryl and Heinzen, Erin L and Helbig, Ingo and Hengsbach, Christian and Hjalgrim, Helle and Iacomino, Michele and Ingason, Andrés and Jamnadas-Khoda, Jennifer and Johnson, Michael R and Kälviäinen, Reetta and Kantanen, Anne-Mari and Kasperavičiūte, Dalia and Kasteleijn-Nolst Trenite, Dorothee and Kirsch, Heidi E and Knowlton, Robert C and Koeleman, Bobby P. C and Krause, Roland and Krenn, Martin and Kunz, Wolfram S and Kuzniecky, Ruben and Kwan, Patrick and Lal, Dennis and Lau, Yu-Lung and Lehesjoki, Anna-Elina and Lerche, Holger and Leu, Costin and Lieb, Wolfgang and Lindhout, Dick and Lo, Warren D and Lopes-Cendes, Iscia and Lowenstein, Daniel H and Malovini, Alberto and Marson, Anthony G and Mayer, Thomas and McCormack, Mark and Mills, James L and Mirza, Nasir and Moerzinger, Martina and Møller, Rikke S and Molloy, Anne M and Muhle, Hiltrud and Newton, Mark and Ng, Ping-Wing and Nöthen, Markus M and Nürnberg, Peter and O’Brien, Terence J and Oliver, Karen L and ... and Int League Against Epilepsy Conso and International League Against Epilepsy Consortium on Complex Epilepsies and The International League Against Epilepsy Consortium on Complex Epilepsies
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5269 - 15
The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving... 
FRONTAL-LOBE | METAANALYSIS | ILAE COMMISSION | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | GENETIC ARCHITECTURE | ABSENCE | LD SCORE REGRESSION | SNP HERITABILITY | ASSOCIATION | EXPRESSION | Brain | Transcription factors | Coding | Epilepsy | Genes | Genomes | Single-nucleotide polymorphism | Heritability | Gene expression | Metabolism | Antiepileptic agents | Loci
Journal Article
by Feng, Yen-Chen Anne and Howrigan, Daniel P and Abbott, Liam E and Tashman, Katherine and Cerrato, Felecia and Singh, Tarjinder and Heyne, Henrike and Byrnes, Andrea and Churchhouse, Claire and Watts, Nick and Solomonson, Matthew and Lal, Dennis and Heinzen, Erin L and Dhindsa, Ryan S and Stanley, Kate E and Cavalleri, Gianpiero L and Hakonarson, Hakon and Helbig, Katherine L and Helbig, Ingo and Krause, Roland and May, Patrick and Weckhuysen, Sarah and Weckhuysen, Dorien and Petrovski, Slavé and Kamalakaran, Sitharthan and Sisodiya, Sanjay M and Cossette, Patrick and Cotsapas, Chris and De Jonghe, Peter and Dixon-Salazar, Tracy and Guerrini, Renzo and Kwan, Patrick and Marson, Anthony G and Stewart, Randy and Depondt, Chantal and Dlugos, Dennis J and Scheffer, Ingrid E and Striano, Pasquale and Freyer, Catharine and McKenna, Kevin and Regan, Brigid M and Bellows, Susannah T and Leu, Costin and Bennett, Caitlin A and Johns, Esther M.C and Macdonald, Alexandra and Shilling, Hannah and Burgess, Rosemary and Bahlo, Melanie and O’Brien, Terence J and Todaro, Marian and Stamberger, Hannah and Andrade, Danielle M and Sadoway, Tara R and Mo, Kelly and Krestel, Heinz and Gallati, Sabina and Papacostas, Savvas S and Kousiappa, Ioanna and Tanteles, George A and Štěrbová, Katalin and Vlčková, Markéta and Sedláčková, Lucie and Laššuthová, Petra and Klein, Karl Martin and Rosenow, Felix and Reif, Philipp S and Reif, Andreas and Knake, Susanne and Kunz, Wolfram S and Zsurka, Gábor and Elger, Christian E and Bauer, Jürgen and Rademacher, Michael and Rademacher, Annika and Pendziwiat, Manuela and Muhle, Hiltrud and van Baalen, Andreas and von Spiczak, Sarah and Stephani, Ulrich and Afawi, Zaid and Korczyn, Amos D and Kanaan, Moien and Canavati, Christina and Kurlemann, Gerhard and Müller-Schlüter, Karen and Kluger, Gerhard and Häusler, Martin and Blatt, Ilan and Lemke, Johannes R and Krey, Ilona and Weber, Yvonne G and Wolking, Stefan and Becker, Felicitas and Hengsbach, Christian and Rau, Sarah and Maisch, Ana F and Steinhoff, Bernhard J and Schulze-Bonhage, Andreas and Schubert-Bast, Susanne and ... and Epi25 Collaborative and Genomic Psychiat Cohort GPC Consor and Epi25 Collaborative. Electronic address: s.berkovic@unimelb.edu.au
The American Journal of Human Genetics, ISSN 0002-9297, 08/2019, Volume 105, Issue 2, pp. 267 - 282
Sequencing-based studies have identified novel risk genes associated with severe epilepsies and revealed an excess of rare deleterious variation in less-severe... 
epilepsy | seizures | exome | epileptic encephalopathy | burden analysis | sequencing | PROTEIN | METAANALYSIS | DE-NOVO MUTATIONS | VARIANTS | SUSCEPTIBILITY | GENETICS & HEREDITY | EPILEPTIC SEIZURES | GAMMA-2-SUBUNIT | GENOME | EPIDEMIOLOGY | COMMON EPILEPSIES | Psychological aspects | Genetic variation | Epilepsy | Physiological aspects | Genetic aspects | Research | Risk factors
Journal Article
by Brainstorm Consortium and Anttila, Verneri and Bulik-Sullivan, Brendan and Finucane, Hilary K and Walters, Raymond K and Bras, Jose and Duncan, Laramie and Escott-Price, Valentina and Falcone, Guido J and Gormley, Padhraig and Malik, Rainer and Patsopoulos, Nikolaos A and Ripke, Stephan and Wei, Zhi and Yu, Dongmei and Lee, Phil H and Turley, Patrick and Grenier-Boley, Benjamin and Chouraki, Vincent and Kamatani, Yoichiro and Berr, Claudine and Letenneur, Luc and Hannequin, Didier and Amouyel, Philippe and Boland, Anne and Deleuze, Jean-François and Duron, Emmanuelle and Vardarajan, Badri N and Reitz, Christiane and Goate, Alison M and Huentelman, Matthew J and Kamboh, M Ilyas and Larson, Eric B and Rogaeva, Ekaterina and St George-Hyslop, Peter and Hakonarson, Hakon and Kukull, Walter A and Farrer, Lindsay A and Barnes, Lisa L and Beach, Thomas G and Demirci, F Yesim and Head, Elizabeth and Hulette, Christine M and Jicha, Gregory A and Kauwe, John SK and Kaye, Jeffrey A and Leverenz, James B and Levey, Allan I and Lieberman, Andrew P and Pankratz, Vernon S and Poon, Wayne W and Quinn, Joseph F and Saykin, Andrew J and Schneider, Lon S and Smith, Amanda G and Sonnen, Joshua A and Stern, Robert A and Van Deerlin, Vivianna M and Van Eldik, Linda J and Harold, Denise and Russo, Giancarlo and Rubinsztein, David Chaim and Bayer, Anthony and Tsolaki, Magda and Proitsi, Petra and Fox, Nick C and Hampel, Harald and Owen, Michael J and Mead, Simon and Passmore, Peter and Morgan, Kevin and Nöthen, Markus M and Rossor, Martin and Lupton, Michelle K and Hoffmann, Per and Kornhuber, Johannes and Lawlor, Brian and McQuillin, Andrew and Al-Chalabi, Ammar and Bis, Joshua C and Ruiz, Agustin and Boada, Mercè and Seshadri, Sudha and Beiser, Alexa and Rice, Kenneth and van der Lee, Sven J and De Jager, Philip L and Geschwind, Daniel H and Riemenschneider, Matthias and Riedel-Heller, Steffi and Rotter, Jerome I and Ransmayr, Gerhard and Hyman, Bradley T and Cruchaga, Carlos and Alegret, Montserrat and Winsvold, Bendik and Palta, Priit and Farh, Kai-How and Cuenca-Leon, Ester and Furlotte, Nicholas and ...
Science (New York, N.Y.), ISSN 0036-8075, 2018, Volume 360, Issue 6395, p. 1313
Disorders of the brain can exhibit considerable epidemiological comorbidity and share symptoms, provoking debate about their etiologic overlap. We quantified... 
Genetic Variation | Brainstorm Consortium | Phenotype | Genome-Wide Association Study | Quantitative Trait, Heritable | Humans | Risk Factors | Mental Disorders | Brain Diseases
Journal Article
by Tomson, Torbjörn and Battino, D and Bonizzoni, E and Craig, J and Lindhout, D and Perucca, E and Sabers, A and Vajda, F and Brodie, M.J and Schmidt, B and Faravelli, F and Finnell, R and Messina, S and Moche, B and Ratti, S and Erba, A and Giavoni, D and Prato, L and Kochen, S and Luef, G and Ten Berg, K and De Marinis, A and Vitezic, D and Zarubova, J and Kuba, R and Dahl, M and Kälviäinen, R and Beaussart, M and Sturua, L and Toidze, O and Schmitz, B and Kwan, P and Barcs, G and Thomas, S.V and Neufeld, M and Mamoli, D and Tanaka, M and Mameniskiene, R and Kiteva-Trencevska, G and Nakken, K.-O and Liao, W and Jedrzejczak, J and Guekht, A and Lokshina, O and Russell, A and Sokic, D and Safcak, V and Cebular, B and Ferri, M Martinez and Baier, H and Tettenborn, B and Lai, C.-W and Özkara, Ç and Escaray, G and Baumgartner, C and Feichtinger, M and Graf, M and Hamberger, M and Nagler, M and Hitchcock, A and Graham, J and Beran, R and Berkovic, S and Black, A and Cook, M and Dunne, J and Lawn, N and Silbert, P and Kilpatrick, C and O’brien, T and Lander, C and McLaughlin, D and Somerville, E and Boon, P and Vonck, K and Asmad, C and Sepic-Grahovac, D and Brázdil, M and Novotná, I and Tyrlíková, I and Krijtova, H and Nemcova, I and Tislerova, D and Vacovska, H and Alving, J and Stubbings, V and Arentsen, J and Tørring, J and A’ Rogvi Hansen, B and Gulliksen, G and Pedersen, B and Sidenius, P and Sørensen, T and Worm, M and Rainesalo, S and Roivanen, R and Salmivaara, A and Kasradze, S and Coban, I and Gaus, V and ... and EURAP Study Group and The EURAP Study Group
Neurology, ISSN 0028-3878, 02/2006, Volume 66, Issue 3, pp. 354 - 360
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 05/2010, Volume 86, Issue 5, pp. 707 - 718
Journal Article
by Whelan, Christopher D and Altmann, Andre and Botía, Juan A and Jahanshad, Neda and Hibar, Derrek P and Absil, Julie and Alhusaini, Saud and Alvim, Marina K M and Auvinen, Pia and Bartolini, Emanuele and Bergo, Felipe P G and Bernardes, Tauana and Blackmon, Karen and Braga, Barbara and Caligiuri, Maria Eugenia and Calvo, Anna and Carr, Sarah J and Chen, Jian and Chen, Shuai and Cherubini, Andrea and David, Philippe and Domin, Martin and Foley, Sonya and França, Wendy and Haaker, Gerrit and Isaev, Dmitry and Keller, Simon S and Kotikalapudi, Raviteja and Kowalczyk, Magdalena A and Kuzniecky, Ruben and Langner, Soenke and Lenge, Matteo and Leyden, Kelly M and Liu, Min and Loi, Richard Q and Martin, Pascal and Mascalchi, Mario and Morita, Marcia E and Pariente, Jose C and Rodríguez-Cruces, Raul and Rummel, Christian and Saavalainen, Taavi and Semmelroch, Mira K and Severino, Mariasavina and Thomas, Rhys H and Tondelli, Manuela and Tortora, Domenico and Vaudano, Anna Elisabetta and Vivash, Lucy and von Podewils, Felix and Wagner, Jan and Weber, Bernd and Yao, Yi and Yasuda, Clarissa L and Zhang, Guohao and Bargalló, Nuria and Bender, Benjamin and Bernasconi, Neda and Bernasconi, Andrea and Bernhardt, Boris C and Blümcke, Ingmar and Carlson, Chad and Cavalleri, Gianpiero L and Cendes, Fernando and Concha, Luis and Delanty, Norman and Depondt, Chantal and Devinsky, Orrin and Doherty, Colin P and Focke, Niels K and Gambardella, Antonio and Guerrini, Renzo and Hamandi, Khalid and Jackson, Graeme D and Kälviäinen, Reetta and Kochunov, Peter and Kwan, Patrick and Labate, Angelo and McDonald, Carrie R and Meletti, Stefano and O'Brien, Terence J and Ourselin, Sebastien and Richardson, Mark P and Striano, Pasquale and Thesen, Thomas and Wiest, Roland and Zhang, Junsong and Vezzani, Annamaria and Ryten, Mina and Thompson, Paul M and Sisodiya, Sanjay M and UK Brain Expression Consortium and ENIGMA-Epilepsy Working Grp
Brain, ISSN 0006-8950, 02/2018, Volume 141, Issue 2, pp. 391 - 408
Journal Article
by Tabassum, R and Ramo, JT and Ripatti, P and Koskela, JT and Kurki, M and Karjalainen, J and Palta, P and Hassan, S and Nunez-Fontarnau, J and Kiiskinen, TTJ and Soderlund, S and Matikainen, N and Gerl, MJ and Surma, MA and Klose, C and Stitziel, NO and Laivuori, H and Havulinna, AS and Service, SK and Salomaa, V and Pirinen, M and Jauhiainen, M and Daly, MJ and Freimer, NB and Palotie, A and Taskinen, MR and Simons, K and Ripatti, S and Jalanko, A and Kaprio, J and Donner, K and Kaunisto, M and Mars, N and Dada, A and Shcherban, A and Ganna, A and Lehisto, A and Kilpelainen, E and Brein, G and Awaisa, G and Harju, J and Parr, K and Parolo, PD and Kajanne, R and Lemmela, S and Sipila, TP and Sipila, T and Lyhs, U and Llorens, V and Niiranen, T and Kristiansson, K and Mannikko, L and Jimenez, MG and Perola, M and Wong, R and Kilpi, T and Hiekkalinna, T and Jarvensivu, E and Kaiharju, E and Mattsson, H and Laukkanen, M and Laiho, P and Lahteenmaki, S and Sistonen, T and Soini, S and Ziemann, A and Lehtonen, A and Lertratanakul, A and Georgantas, B and Riley-Gillis, B and Quarless, D and Rahimov, F and Heap, G and Jacob, H and Waring, J and Davis, JW and Smaoui, N and Popovic, R and Esmaeeli, S and Matakidou, A and Challis, B and Close, D and Petrovski, S and Karlsson, A and Schleutker, J and Pulkki, K and Virolainen, P and Kallio, L and Mannermaa, A and Heikkinen, S and Kosma, VM and Chen, CY and Runz, H and Liu, J and Bronson, P and John, S and Landenpera, S and Eaton, S and Zhou, W and Hendolin, M and ... and FinnGen Project
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 14
Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here,... 
INSULIN | PREDIMED TRIAL | HOSPITAL DISCHARGE REGISTER | RISK-FACTORS | RARE VARIANTS | GENOTYPE IMPUTATION | CERAMIDES | MULTIDISCIPLINARY SCIENCES | DEATH | VALIDITY | GENOME-WIDE ASSOCIATION | Phenotypes | Architecture | Lipids | Genomes | Lipoprotein lipase | Triglycerides | Lipase | Gene expression | Metabolism | Fatty acids | Loci | Blood plasma | Genetic variance | Heritability | Lipid metabolism | Cardiovascular diseases | Species
Journal Article