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1. Full Text The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
by Calado, Dinis Pedro and Sasaki, Yoshiteru and Godinho, Susana A and Pellerin, Alex and Köchert, Karl and Sleckman, Barry P and De Alborán, Ignacio Moreno and Janz, Martin and Rodig, Scott and Rajewsky, Klaus
Nature Immunology, ISSN 1529-2908, 11/2012, Volume 13, Issue 11, pp. 1092 - 1100
Germinal centers (GCs) are sites of intense B cell proliferation and are central for T cell dependent antibody responses. However, the role of c-Myc, a key... 
PROTOONCOGENE EXPRESSION | SEQUESTRATION | PATHOGENESIS | CENTER B-CELLS | RESPONSES | ORIGIN | BCL6 | GENE-EXPRESSION | DIFFERENTIATION | IMMUNOLOGY | TRANSCRIPTION FACTOR | Cell Cycle - genetics | Green Fluorescent Proteins | Translocation, Genetic | Cell Proliferation | Germinal Center - immunology | Genetic Loci | Lymphoma - metabolism | Signal Transduction - immunology | T-Lymphocytes - metabolism | Cell Transformation, Neoplastic - genetics | Cell Cycle - immunology | Gene Deletion | B-Lymphocyte Subsets - immunology | Lymphoma - pathology | B-Lymphocytes - pathology | T-Lymphocytes - pathology | B-Lymphocytes - metabolism | Genes, Reporter | Gene Expression Regulation - immunology | Lymphoma - genetics | Proto-Oncogene Proteins c-myc - immunology | Mice, Transgenic | Signal Transduction - genetics | Germinal Center - pathology | Cell Transformation, Neoplastic - immunology | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Proto-Oncogene Proteins c-myc - deficiency | T-Lymphocytes - immunology | Mice | Proto-Oncogene Proteins c-myc - genetics | Immunization | Care and treatment | Cell cycle | Development and progression | Genetic aspects | Lymphomas | Research | Genetic transcription | Genetic regulation
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2. Full Text AKT1E17K mutation profiling in breast cancer: Prevalence, concurrent oncogenic alterations, and blood-based detection
by Rudolph, Marion and Anzeneder, Tobias and Schulz, Anke and Beckmann, Georg and Byrne, Annette T and Jeffers, Michael and Pena, Carol and Politz, Oliver and Köchert, Karl and Vonk, Richardus and Reischl, Joachim
BMC Cancer, ISSN 1471-2407, 2016, Volume 16, Issue 1
The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise... 
mutation | AKT1 | Breast cancer | Blood-based mutation detection | Complications and side effects | Care and treatment | Gene mutations | Menopause | Metastasis | Diagnosis | Research | Health aspects
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3. Full Text Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
by Walter, Korden and Köchert, Karl and Dörken, Bernd and Kreher, Stephan and Callen, David F and Bouhlel, Mohamed Amine and Siebert, Reiner and Barlow, Rachael and Soler, Eric and Anagnostopoulos, Ioannis and Stein, Harald and Richter, Julia and Jöhrens, Korinna and Stadhouders, Ralph and Bonifer, Constanze and Janz, Martin and Kumar, Raman and Wurster, Kathrin D and Harte, Michael F and Cockerill, Peter N and Hummel, Michael and Mathas, Stephan and Lenze, Dido and Giefing, Maciej and Lamprecht, Björn
Nature Medicine, ISSN 1078-8956, 05/2010, Volume 16, Issue 5, pp. 571 - 579
Mammalian genomes contain many repetitive elements, including long terminal repeats (LTRs), which have long been suspected to have a role in tumorigenesis.... 
MEDICINE, RESEARCH & EXPERIMENTAL | REED-STERNBERG CELLS | DNA HYPOMETHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | KAPPA-B | STIMULATING FACTOR-I | CELL BIOLOGY | BREAST-CANCER | B-CELLS | DIFFERENTIAL TRANSCRIPTION | GENE | HODGKIN LYMPHOMA | Gene Expression | Tumor Suppressor Proteins - metabolism | Hodgkin Disease - genetics | Humans | Lymphoma - genetics | Repressor Proteins - genetics | Phosphoproteins - genetics | Colony-Stimulating Factors - genetics | Lymphoma, B-Cell - genetics | Phosphoproteins - metabolism | Proto-Oncogenes - genetics | Tumor Suppressor Proteins - genetics | Macrophage Colony-Stimulating Factor - genetics | Terminal Repeat Sequences | Repressor Proteins - metabolism | Development and progression | Lymphomas | Genetic aspects | Research | Gene expression | Health aspects | Oncogenes | Medical research | Cellular biology | Genomics
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4. Full Text Abstract 2606: Biological interpretation of circulating miRNA biomarkers predicting regorafenib clinical benefit in patients with hepatocellular carcinoma (HCC) in the RESORCE trial
by Seidel, Henrik and Köchert, Karl and Teufel, Michael
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 2606 - 2606
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5. Full Text Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression
by Ascherio, Alberto and Munger, Kassandra L and White, Rick and Köchert, Karl and Simon, Kelly Claire and Polman, Chris H and Freedman, Mark S and Hartung, Hans-Peter and Miller, David H and Montalbán, Xavier and Edan, Gilles and Barkhof, Frederik and Pleimes, Dirk and Radü, Ernst-Wilhelm and Sandbrink, Rupert and Kappos, Ludwig and Pohl, Christoph
JAMA Neurology, ISSN 2168-6149, 03/2014, Volume 71, Issue 3, pp. 306 - 314
IMPORTANCE It remains unclear whether vitamin D insufficiency, which is common in individuals with multiple sclerosis (MS), has an adverse effect on MS... 
GENETIC-DETERMINANTS | RELAPSE RISK | 25-HYDROXYVITAMIN D | DOUBLE-BLIND | INTERFERON BETA-1B | CLINICALLY ISOLATED SYNDROMES | PLACEBO-CONTROLLED TRIAL | DIAGNOSTIC-CRITERIA | AUTOIMMUNE ENCEPHALOMYELITIS | CLINICAL NEUROLOGY | GENOME-WIDE ASSOCIATION | Predictive Value of Tests | Recurrence | Demyelinating Diseases - blood | Follow-Up Studies | Multiple Sclerosis - blood | Humans | Risk Factors | Male | Biomarkers - blood | Disease Progression | Randomized Controlled Trials as Topic | Vitamin D - blood | Magnetic Resonance Imaging | Time Factors | Multiple Sclerosis - pathology | Adult | Female | Vitamin D - analogs & derivatives | Demyelinating Diseases - pathology | Demyelinating Diseases - drug therapy | Multiple Sclerosis - drug therapy | Life Sciences | Neurons and Cognition
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6. Full Text Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells
by Emmanuel Derudder and Sebastian Herzog and Verena Labi and Tomoharu Yasuda and Karl Köchert and Martin Janz and Andreas Villunger and Marc Schmidt-Supprian and Klaus Rajewsky
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2016, Volume 113, Issue 18, pp. 5065 - 5070
Although canonical NF-κB signaling is crucial to generate a normal mature B-cell compartment, its role in the persistence of resting mature B cells is... 
SURVIVAL | RECEPTOR SIGNALS | follicular B cells | ACTIVATION | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | IMMUNOGLOBULIN | canonical signaling | PROLIFERATION | MAINTENANCE | NF-kappa B | persistence | MICE | EXPRESSION | LYMPHOCYTES | Signal Transduction - immunology | B-Lymphocytes - cytology | Animals | B-Lymphocytes - immunology | Mice, Inbred C57BL | Cells, Cultured | NF-kappa B - immunology | Mice | Cell Survival - immunology | Biological Sciences | NF-κB
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7. Full Text Phosphatidylinositol 3-kinase inhibition by Copanlisib in relapsed or refractory indolent lymphoma
by Dreyling, Martin and Santoro, Armando and Mollica, Luigina and Leppä, Sirpa and Follows, George A and Lenz, Georg and Kim, Won Seog and Nagler, Arnon and Panayiotidis, Panayiotis and Demeter, Judit and Öcan, Muhit and Kosinova, Marina and Bouabdallah, Krimo and Morschhauser, Franck and Stevens, Don A and Trevarthen, David and Giurescu, Marius and Cupit, Lisa and Liu, Li and Köchert, Karl and Seidel, Henrik and Peña, Carol and Yin, Shuxin and Hiemeyer, Florian and Garcia-Vargas, Jose and Childs, Barrett H and Zinzani, Pier Luigi
Journal of Clinical Oncology, ISSN 0732-183X, 12/2017, Volume 35, Issue 35, pp. 3898 - 3905
PurposePhosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K... 
BAY 80-6946 | ADVANCED SOLID TUMORS | PI3K-DELTA | RESPONSE CRITERIA | ONCOLOGY | IDELALISIB | PI3K INHIBITORS | 1ST-IN-HUMAN PHASE-I | CHRONIC LYMPHOCYTIC-LEUKEMIA | MALIGNANCIES | FOLLICULAR LYMPHOMA | Isoenzymes | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Middle Aged | Transcriptome | Male | Protein Kinase Inhibitors - adverse effects | Lymphoma, B-Cell - genetics | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Quinazolines - therapeutic use | Lymphoma, B-Cell - enzymology | Pyrimidines - adverse effects | Quinazolines - adverse effects | Aged, 80 and over | Adult | Female | Aged | Lymphoma, B-Cell - drug therapy | Index Medicus
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8. Full Text Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma
by Teufel, Michael and Seidel, Henrik and Köchert, Karl and Meinhardt, Gerold and Finn, Richard S and Llovet, Josep M and Bruix, Jordi
Gastroenterology, ISSN 0016-5085, 05/2019, Volume 156, Issue 6, pp. 1731 - 1741
In a phase 3 trial (RESORCE), regorafenib increased overall survival compared with placebo in patients with hepatocellular carcinoma (HCC) previously treated... 
Time to Progression | NGS | Predictive | Prognostic Factor | ANGIOGENESIS | CLASSIFICATION | MUTATIONS | SORAFENIB | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | VEGFA | Development and progression | Care and treatment | Hepatoma | Biological markers | Analysis | Blood proteins
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9. Full Text Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma
by Stephan Kreher and M. Amine Bouhlel and Pierre Cauchy and Björn Lamprecht and Shuang Li and Michael Grau and Franziska Hummel and Karl Köchert and Ioannis Anagnostopoulos and Korinna Jöhrens and Michael Hummel and John Hiscott and Sören-Sebastian Wenzel and Peter Lenz and Markus Schneider and Ralf Küppers and Claus Scheidereit and Maciej Giefing and Reiner Siebert and Klaus Rajewsky and Georg Lenz and Peter N. Cockerill and Martin Janz and Bernd Dörken and Constanze Bonifer and Stephan Mathas
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2014, Volume 111, Issue 42, pp. E4513 - E4522
Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires... 
SYSTEM | FACTOR-BINDING | ACTIVATION | MULTIDISCIPLINARY SCIENCES | GENE-REGULATION | INDUCTION | NF-KAPPA-B | EXPRESSION | STERNBERG CELLS | T-CELLS | GENOME | Chromatin - metabolism | Oligonucleotide Array Sequence Analysis | Hodgkin Disease - genetics | Humans | Gene Expression Regulation, Neoplastic | Interferon Regulatory Factors - metabolism | NF-kappa B - metabolism | Gene Expression Profiling | Transcription Factor AP-1 - metabolism | Lymphoma - metabolism | B-Lymphocytes - cytology | Cytokines - metabolism | Hodgkin Disease - metabolism | Inflammation | Spleen - cytology | Chemotaxis | Plasmids - metabolism | Amino Acid Motifs | Cell Lineage | Deoxyribonuclease I - metabolism | Animals | Lymphoma, Non-Hodgkin - metabolism | Cell Line, Tumor | Leukocytes, Mononuclear - cytology | Chemokines - metabolism | Mice | PNAS Plus | Biological Sciences
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10. Full Text Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials
by Buck, Dorothea and Andlauer, Till Fm and Igl, Wilmar and Wicklein, Eva-Maria and Mühlau, Mark and Weber, Frank and Köchert, Karl and Pohl, Christoph and Arnason, Barry and Comi, Giancarlo and Cook, Stuart and Filippi, Massimo and Hartung, Hans-Peter and Jeffery, Douglas and Kappos, Ludwig and Barkhof, Frederik and Edan, Gilles and Freedman, Mark S and Montalbán, Xavier and Müller-Myhsok, Bertram and Hemmer, Bernhard and BEYOND Study Grp and BENEFIT Study Grp and BEYOND and BENEFIT Study Groups and The BEYOND and BENEFIT Study Groups
Multiple Sclerosis, ISSN 1352-4585, 04/2019, Volume 25, Issue 4, pp. 565 - 573
BACKGROUND: Treatment of multiple sclerosis (MS) with interferon β can lead to the development of antibodies directed against interferon β that interfere with... 
interferon beta | anti-drug antibodies | genetic variation | Multiple sclerosis | HLA-DRB1 | genome-wide association study | GENOTYPE | GUIDELINES | LINKS | NEUROSCIENCES | CLINICAL NEUROLOGY | IMMUNOGENICITY | THERAPY | MULTIPLE-SCLEROSIS | Immunoglobulins | Clinical trials | Antibodies | Genomes | Single-nucleotide polymorphism | Patients | Genetic variance | Genetic markers | Alleles | Drb1 protein | Histocompatibility antigen HLA | Interferon
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11. Full Text Efficacy of regorafenib (REG) in patients with hepatocellular carcinoma (HCC) in the phase III RESORCE trial according to alpha-fetoprotein (AFP) and c-Met levels as predictors of poor prognosis
by Teufel, Michael and Köchert, Karl and Meinhardt, Gerold and Bruix, Jordi
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 4078 - 4078
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12. Full Text Synergy between PI3K Signaling and MYC in Burkitt Lymphomagenesis
by Sander, Sandrine and Calado, Dinis P and Srinivasan, Lakshmi and Köchert, Karl and Zhang, Baochun and Rosolowski, Maciej and Rodig, Scott J and Holzmann, Karlheinz and Stilgenbauer, Stephan and Siebert, Reiner and Bullinger, Lars and Rajewsky, Klaus
Cancer Cell, ISSN 1535-6108, 08/2012, Volume 22, Issue 2, pp. 167 - 179
In Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic properties of c-MYC must be counterbalanced. Predicting that survival... 
PATHOGENESIS | ACTIVATION | SIGNATURES | ONCOLOGY | B-CELL LYMPHOMAS | CYCLIN D3 | C-MYC | RECEPTOR | MICE | P53 | CELL BIOLOGY | Burkitt Lymphoma - enzymology | B-Lymphocytes - enzymology | Humans | Mice, Inbred C57BL | Gene Expression Regulation, Neoplastic | Germinal Center - enzymology | Molecular Sequence Data | Phosphatidylinositol 3-Kinases - metabolism | Signal Transduction - genetics | Germinal Center - pathology | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Burkitt Lymphoma - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Cell Transformation, Neoplastic - genetics | Base Sequence | Burkitt Lymphoma - genetics | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | B-Lymphocytes - pathology | Enzyme Activation | Cell Transformation, Neoplastic - pathology | Medical colleges | Lymphomas | Gene expression | Genes | Medical informatics
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13. Full Text An Oncogenic Role for Alternative NF-κB Signaling in DLBCL Revealed upon Deregulated BCL6 Expression
by Zhang, Baochun and Calado, Dinis Pedro and Wang, Zhe and Fröhler, Sebastian and Köchert, Karl and Qian, Yu and Koralov, Sergei B and Schmidt-Supprian, Marc and Sasaki, Yoshiteru and Unitt, Christine and Rodig, Scott and Chen, Wei and Dalla-Favera, Riccardo and Alt, Frederick W and Pasqualucci, Laura and Rajewsky, Klaus
Cell Reports, ISSN 2211-1247, 05/2015, Volume 11, Issue 5, pp. 715 - 726
Diffuse large B cell lymphoma (DLBCL) is a complex disease comprising diverse subtypes and genetic profiles. Possibly because of the prevalence of genetic... 
MULTIPLE-MYELOMA | ALPHA PROTEOLYSIS | ACTIVATION | PATHWAY | BAFF-RECEPTOR | DIFFUSE | GENE-EXPRESSION | SURVIVAL SIGNALS | LYMPHOMA | PLASMA-CELL DIFFERENTIATION | CELL BIOLOGY | B-Lymphocytes - cytology | Lymphoma, Large B-Cell, Diffuse - pathology | Signal Transduction | Cell Survival | Humans | Gene Expression Regulation, Neoplastic | Protein-Serine-Threonine Kinases - genetics | NF-kappa B - metabolism | TNF Receptor-Associated Factor 3 - metabolism | Lymphoma, Large B-Cell, Diffuse - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - deficiency | Mice, Knockout | DNA-Binding Proteins - metabolism | Animals | B-Lymphocytes - immunology | TNF Receptor-Associated Factor 3 - genetics | Cell Line, Tumor | Cell Differentiation | Mice | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins c-bcl-6
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14. Full Text Structural Insights into the Mechanism of GTPase Activation in the GIMAP Family
by Schwefel, David and Arasu, B. Sivanandam and Marino, Stephen F and Lamprecht, Björn and Köchert, Karl and Rosenbaum, Eva and Eichhorst, Jenny and Wiesner, Burkhard and Behlke, Joachim and Rocks, Oliver and Mathas, Stephan and Daumke, Oliver
Structure, ISSN 0969-2126, 04/2013, Volume 21, Issue 4, pp. 550 - 559
GTPases of immunity-associated proteins (GIMAPs) are regulators of lymphocyte survival and homeostasis. We previously determined the structural basis of... 
SURVIVAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | G-PROTEINS | TUMOR-CELLS | 3 DIMENSIONS | CELL BIOLOGY | IAN FAMILY | BIOPHYSICS | GENE | TOXOPLASMA-GONDII | HODGKIN LYMPHOMA | T-CELL DEVELOPMENT | BINDING | Cell Line | GTP-Binding Proteins - chemistry | Humans | Crystallization | Models, Molecular | Ultracentrifugation | Reverse Transcriptase Polymerase Chain Reaction | GTP Phosphohydrolases - chemistry | Hydrolysis | GTP Phosphohydrolases - metabolism | Membrane Proteins - chemistry | T-Lymphocytes - metabolism | Calorimetry | Protein Conformation | Membrane Proteins - metabolism | Dimerization | Enzyme Activation - physiology | Lipid Metabolism - physiology | Microscopy, Fluorescence | GTP-Binding Proteins - metabolism | Proteins | Crystals | Non-Hodgkin's lymphomas | G proteins | Structure | T cells
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15. Canonical NF-[kappa]B signaling is uniquely required for the long-term persistence of functional mature B cells
by Emmanuel Derudder and Sebastian Herzog and Verena Labi and Tomoharu Yasuda and Karl Köchert and Martin Janz and Andreas Villunger and Marc Schmidt-Supprian and Klaus Rajewsky
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2016, Volume 113, Issue 18, p. 5065
  Although canonical NF-...B signaling is crucial to generate a normal mature B-cell compartment, its role in the persistence of resting mature B cells is... 
Signal transduction | Gene expression | Cells
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16. Full Text Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving Interferon Beta-1b
by Fitzgerald, Kathryn C and Munger, Kassandra L and Köchert, Karl and Arnason, Barry G. W and Comi, Giancarlo and Cook, Stuart and Goodin, Douglas S and Filippi, Massimo and Hartung, Hans-Peter and Jeffery, Douglas R and O’Connor, Paul and Suarez, Gustavo and Sandbrink, Rupert and Kappos, Ludwig and Pohl, Christoph and Ascherio, Alberto
JAMA Neurology, ISSN 2168-6149, 12/2015, Volume 72, Issue 12, pp. 1458 - 1465
IMPORTANCE: Low serum 25-hydroxyvitamin D (25[OH]D) levels are associated with an increased risk of multiple sclerosis (MS) as well as with increased disease... 
CONTROLLED-TRIAL | DETERMINANTS | RELAPSE RISK | D SUPPLEMENTATION | 25-HYDROXYVITAMIN D | DOUBLE-BLIND | CLINICAL NEUROLOGY | Disability Evaluation | Age Factors | Double-Blind Method | HLA-DRB1 Chains - genetics | Multiple Sclerosis - blood | Humans | Middle Aged | Genotype | Male | Multiple Sclerosis - genetics | Disease Progression | Vitamin D - blood | Dose-Response Relationship, Drug | Vitamin D-Binding Protein - genetics | Time Factors | Interferon beta-1b - therapeutic use | Adult | Female | Vitamin D - analogs & derivatives | Retrospective Studies | Adjuvants, Immunologic - therapeutic use | Longitudinal Studies | Multiple Sclerosis - drug therapy
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17. Full Text Arabidopsis thaliana AtGpp1 and AtGpp2: two novel low molecular weight phosphatases involved in plant glycerol metabolism
by Caparrós-Martín, José Antonio and Caparrós-Martín, José Antonio and Reiland, Sonja and Reiland, Sonja and Köchert, Karl and Köchert, Karl and Cutanda, Mari Cruz and Cutanda, Mari Cruz and Culiáñez-Macià, Francisco A and Culiáñez-Macià, Francisco A
Plant Molecular Biology, ISSN 0167-4412, 3/2007, Volume 63, Issue 4, pp. 505 - 517
We have isolated two Arabidopsis thaliana genes, AtGpp1 and AtGpp2, showing homology with the yeast low molecular weight phosphatases GPP1 and GPP2, which have... 
Life Sciences | Plant Pathology | Biochemistry, general | Glycerol-3-phosphate | Arabidopsis | Glycerol-3-phosphatases | Plant Sciences | Transgenic plants | Stress | Glycerol metabolism | Glycerol-3- phosphatases | PHOSPHOMONOESTERASE | transgenic plants | stress | LOCALIZATION | GLYCEROL-3-PHOSPHATE DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SACCHAROMYCES-CEREVISIAE | glycerol-3-phosphate | PLANT SCIENCES | YEAST | COMPANION CELLS | GENE | glycerol-3-phosphatases | glycerol metabolism | EXPRESSION | Physiological aspects | Proteins | Oxidative stress
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