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Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1382, pp. 81 - 91
This chapter outlines some general principles of transcriptional targeting approaches using viral vectors in the central nervous system. Transcriptional... 
Promoter | Enhancer | AAV | Transcriptional targeting | Vector tropism | Mir-binding site | Transcription blocker | Dependovirus - genetics | Genetic Therapy | Promoter Regions, Genetic | Gene Expression | Animals | Central Nervous System - metabolism | Genetic Vectors - administration & dosage | Humans | Transcription, Genetic | Organ Specificity
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 07/2016, Volume 25, Issue 2, pp. 61 - 77
Aims: This preclinical study was aimed at determining whether pharmacological targeting of transcription factor NRF2, a master controller of many homeostatic... 
Original Research Communications | OXIDATIVE STRESS | IN-VITRO | TRANSCRIPTION FACTOR NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | MPTP MOUSE MODEL | ALPHA-SYNUCLEIN | HEME OXYGENASE-1 | AUTOPHAGY | NF-KAPPA-B | EXPRESSION | NEUROPROTECTION | Immunohistochemistry | NF-E2-Related Factor 2 - agonists | Parkinson Disease - drug therapy | RNA, Messenger - metabolism | Autophagy | Brain - metabolism | Gliosis - pathology | Neuroprotective Agents - pharmacology | Dimethyl Fumarate - pharmacology | NF-E2-Related Factor 2 - genetics | Parkinson Disease - metabolism | Neuroprotective Agents - administration & dosage | Disease Models, Animal | Gene Expression | Gliosis - genetics | Parkinson Disease - pathology | Synucleins - genetics | Gliosis - metabolism | RNA, Messenger - genetics | Drug Repositioning | Synucleins - metabolism | Mice, Knockout | Phenotype | Animals | Mice | Dimethyl Fumarate - administration & dosage | Care and treatment | Parkinson's disease | Research | Gene expression | Dimethyl | Neuroprotection | Brain | Therapy | Oxidative stress | Basal ganglia | Multiple sclerosis | Mesencephalon | Toxicity | Substantia nigra | Parkinsons disease | Innovations | Synuclein | Proteins | Neurotoxicity | Autopsy | Movement disorders | Dopamine receptors | Recombinant | Phenotypes | Dopamine | Wound healing | Neurodegenerative diseases | Pharmacology | Inflammation | Disease control | Ganglia | Lewy bodies | Gliosis | Cell death | Phagocytosis | Index Medicus
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PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e88833
Strategies to induce recovery from lesions of the spinal cord have not fully resulted in clinical applications. This is a consequence of a number of... 
NEUROPATHIC PAIN | VESICULAR GLUTAMATE TRANSPORTERS | NEUROTROPHIC FACTOR | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | CL-COTRANSPORTER KCC2 | GAMMA-AMINOBUTYRIC-ACID | SYNAPTIC PLASTICITY | CORD-INJURY | TRANSMITTER SYSTEMS | Thoracic Vertebrae - physiopathology | Brain-Derived Neurotrophic Factor - genetics | Glycine - metabolism | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Male | Motor Activity | RNA, Messenger - metabolism | Recovery of Function | Range of Motion, Articular | Thoracic Vertebrae - pathology | Brain-Derived Neurotrophic Factor - therapeutic use | Spinal Cord Injuries - therapy | Lumbar Vertebrae - physiopathology | Green Fluorescent Proteins - metabolism | Transduction, Genetic | Dependovirus - metabolism | Spinal Cord Injuries - metabolism | RNA, Messenger - genetics | Genetic Vectors - metabolism | Rats | Glutamate Decarboxylase - genetics | Vesicular Glutamate Transport Proteins - metabolism | Vesicular Glutamate Transport Proteins - genetics | Symporters - metabolism | Animals | Glutamate Decarboxylase - metabolism | Lumbar Vertebrae - pathology | Spinal Cord Injuries - physiopathology | Lumbar Vertebrae - enzymology | GABA | Brain | Neurosciences | Spinal cord | Body weight | Amino acids | Nervous system | Biology | Spinal cord injury | Recovery | Potassium-chloride cotransporter | γ-Aminobutyric acid | Rodents | Lesions | Therapeutic applications | Neurons | Excitability | Data processing | Gene expression | Axons | Walking | Brain-derived neurotrophic factor | Neural networks | Spinal cord injuries | Glutamatergic transmission | Potassium | Transporter | Neurotransmission
Journal Article