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Journal Article
Cardiorenal Medicine, ISSN 1664-3828, 05/2012, Volume 2, Issue 2, pp. 134 - 142
The risk of developing type 2 diabetes and cardiovascular disease in women who had previously been diagnosed with gestational diabetes (GDM) is well... 
Review | LEPTIN | CARDIAC & CARDIOVASCULAR SYSTEMS | MELLITUS | Fetal programming | BLOOD-PRESSURE | PREGNANCY | Offspring | Cardiorenal syndrome | OBESITY | INSULIN-RESISTANCE | INTRAUTERINE EXPOSURE | GROWTH | MATERNAL SERUM | UROLOGY & NEPHROLOGY | BODY-MASS INDEX | Gestational diabetes
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 03/2007, Volume 7, Issue 6, pp. 569 - 578
Xanthines and xanthine-like DPP-IV inhibitors were first disclosed in 2002. Since then, several dozen accounts of xanthine-based DPP-IV inhibitors have been... 
URACIL-BASED DPP-IV INHIBITORS | PYRIMIDINE-BASED DPP-IV INHIBITORS | Xanthine mimetics | ADME | Imidazole | CHEMISTRY, MEDICINAL
Journal Article
Organic Letters, ISSN 1523-7060, 04/2005, Volume 7, Issue 9, pp. 1833 - 1835
Purines, xanthines, and other fused imidazoles can be prepared from amidines or guanidines, with retrosynthetic disconnection at the ring fusion. Ring closure... 
CHEMISTRY, ORGANIC | Guanidines - chemistry | Purines - chemical synthesis | Cyclization | Molecular Structure | Catalysis | Imidazoles - chemical synthesis | Amidines - chemistry
Journal Article
Organic Letters, ISSN 1523-7060, 01/2002, Volume 4, Issue 1, pp. 111 - 113
Treatment of a variety of alcohols, amines, and N-hydroxylamines with 2,2,2-trifluoroethyl formate gave the corresponding formylated adducts in high yields. 
CHEMISTRY, ORGANIC | FORMIC ANHYDRIDE | ACID-ESTERS | EFFICIENT | Amines - chemistry | Metalloendopeptidases - antagonists & inhibitors | Alcohols - chemistry | Formates - chemistry | Indicators and Reagents | Hydroxylamines - chemistry | Protease Inhibitors - chemical synthesis
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2016, Volume 7, Issue 3, pp. 261 - 265
Using the collective body of known (CETP) inhibitors as inspiration for design, a structurally novel series of tetrahydroquinoxaline CETP inhibitors were... 
indoline | HDL | cholesterol ester transfer protein | tetrahydroquinoxaline | CETP inhibition | TARGET | CHEMISTRY, MEDICINAL | EFFICACY | 14 RANDOMIZED-TRIALS
Journal Article
Organic letters, ISSN 1523-7060, 08/2006, Volume 8, Issue 18, p. 3963
A convergent synthesis of structurally novel butyrolactam 11beta-HSD1 inhibitors is described. The approach features an efficient Ireland-Claisen reaction to... 
Lactams - pharmacology | Lactams - chemical synthesis | Molecular Structure | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors
Journal Article
Current topics in medicinal chemistry, 2007, Volume 7, Issue 6, p. 569
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2004, Volume 14, Issue 9, pp. 2047 - 2050
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 11/2006, Volume 16, Issue 21, p. 5555
A series of metabolically stable butyrolactam 11beta-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1... 
Animals | Administration, Oral | Humans | Lactams - pharmacology | Lactams - chemical synthesis | Lactams - pharmacokinetics | Lactams - administration & dosage | Mice | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors | Metabolic Syndrome - drug therapy
Journal Article
Cardiorenal Medicine, ISSN 1664-3828, 10/2011, Volume 1, Issue 4, pp. I - IV
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 11/2019, Volume 10, Issue 11, pp. 1530 - 1536
Checkpoint inhibitors have demonstrated unprecedented efficacy and are evolving to become standard of care for certain types of cancers. However, low overall... 
Indoleamine-2,3-dioxygenase 1 | ENERGY | CHEMISTRY, MEDICINAL | IMMUNE-SYSTEM | SMALL MOLECULES | cancer immunotherapy | cyclobutarene | electrocyclic ring opening | IDO1
Journal Article
06/2017
3,3′-Disubstituted indoline compounds, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
Photochemistry and Photobiology, ISSN 0031-8655, 08/1997, Volume 66, Issue 2, pp. 245 - 252
Journal Article
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