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Inflammatory Bowel Diseases, ISSN 1078-0998, 11/2012, Volume 18, Issue 11, pp. 2107 - 2119
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 11/2014, Volume 70, Issue 2, pp. 439 - 441
Journal Article
Inflammatory Bowel Diseases, ISSN 1078-0998, 11/2012, Volume 18, Issue 11, p. 2107
A series of experiments were conducted to investigate potential intra- and extraintestinal effects in healthy nonhuman primates dosed repeatedly with the... 
Primates | Integrins
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2015, Volume 6, Issue 6, pp. 630 - 634
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational... 
MLN8237 | Aurora A kinase | MLN8054 | Alisertib | CHEMISTRY, MEDICINAL | ADVANCED SOLID TUMORS | VIVO | SAFETY | PHARMACODYNAMICS | KINASE INHIBITOR | SMALL-MOLECULE INHIBITOR | PHARMACOKINETICS | A KINASE | PHASE-I
Journal Article
ISSN 2045-452X, 10/2016, Volume 5, Issue 6, pp. 1619 - 1628
The proteasome inhibitor bortezomib is associated with the development of peripheral neuropathy in patients, but the mechanism by which bortezomib can induce... 
Journal Article
Inflammatory Bowel Diseases, ISSN 1078-0998, 11/2012, Volume 18, Issue 11, pp. 2107 - 2119
Background: Biological therapies that antagonize specific molecules have demonstrated efficacy in inflammatory bowel diseases, but infections resulting from... 
MLN0002 | vedolizumab | MLN02 | LDP‐02 | α4β7
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/1998, Volume 273, Issue 8, pp. 4734 - 4739
Journal Article
Toxicology Research, ISSN 2045-452X, 2016, Volume 5, Issue 6, pp. 1619 - 1628
The proteasome inhibitor bortezomib is associated with the development of peripheral neuropathy in patients, but the mechanism by which bortezomib can induce... 
MITOCHONDRIAL LON PROTEASE | CELLS | APOPTOSIS | OMI/HTRA2 | SPECIFICITY | INITIATION-FACTOR 4G | DEGRADATION | TOXICOLOGY | TRANSLATION | CLEAVAGE | IDENTIFICATION
Journal Article
Toxicology Research, ISSN 2045-452X, 10/2016, Volume 5, Issue 6, pp. 1619 - 1628
The proteasome inhibitor bortezomib is associated with the development of peripheral neuropathy in patients, but the mechanism by which bortezomib can induce... 
Journal Article
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 09/2010, Volume 62, Issue 2, pp. e20 - e20
Journal Article
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 2008, Volume 58, Issue 2, pp. 155 - 155
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2001, Volume 283, Issue 5, pp. 1061 - 1068
Action of protein kinases and phosphatases contributes to myocardial hypertrophy. PRL-3, a protein tyrosine phosphatase, was identified in a cDNA library from... 
calcium | phosphoprotein | cell proliferation | hypertrophy | signal transduction | cardiomyocyte | heart | vanadate | Cell proliferation | Heart | Vanadate | Signal transduction | Calcium | Cardiomyocyte | Phosphoprotein | Hypertrophy | ACTIVATION | PROTEIN | MYOCYTES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | RECEPTOR | P21(RAS) | BIOPHYSICS | CARDIAC-HYPERTROPHY | INHIBITORS | ASSOCIATION | Immediate-Early Proteins - isolation & purification | Calcium - metabolism | Calcium Signaling - physiology | Escherichia coli | Humans | Protein Tyrosine Phosphatases - metabolism | Cardiomyopathies - enzymology | Protein Tyrosine Phosphatases - isolation & purification | Recombinant Proteins - isolation & purification | Cardiomyopathies - genetics | Immediate-Early Proteins - metabolism | Protein Tyrosine Phosphatases - genetics | Phenanthrolines - pharmacology | Transfection | Neoplasm Proteins | Vanadates - pharmacology | Cloning, Molecular | Organ Culture Techniques | Recombinant Proteins - metabolism | Cell Line | Angiotensin II - pharmacology | Muscle, Skeletal - enzymology | Mutagenesis, Site-Directed | Gene Library | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Cell Division - drug effects | Myocardium - enzymology | Chromatography, Affinity | Immediate-Early Proteins - genetics | Calcium Signaling - drug effects | Cytosol - metabolism | Signal Transduction - physiology | Organometallic Compounds - pharmacology | Amino Acid Substitution | PRL-3 protein | Angiotensin II
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/1996, Volume 97, Issue 2, pp. 533 - 539
Phospholamban is the regulator of the cardiac sarcoplasmic reticulum (SR) Ca2+-ATPase activity and an important modulator of basal contractility in the heart.... 
transgenic | phospholamban | left ventricular function | overexpression | cardiomyocyte | MEDICINE, RESEARCH & EXPERIMENTAL | STIMULATION | PHOSPHORYLATION | PROTEIN-KINASE | CA-2+-ATPASE | SARCOPLASMIC-RETICULUM | TROPONIN-I | TRANSPORT
Journal Article
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 03/2020, Volume 107, Issue 3, pp. 514 - 520
A significant regulatory gap exists to facilitate global development of therapeutics for nononcology severely debilitating or life‐threatening diseases or... 
PHARMACOLOGY & PHARMACY | PARKINSONS-DISEASE
Journal Article
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 09/2009, Volume 60, Issue 2, pp. 243 - 243
Journal Article
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