X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (24) 24
chemistry, medicinal (20) 20
humans (20) 20
pyridines - pharmacology (18) 18
pyridine (17) 17
structure-activity relationship (17) 17
cell line, tumor (16) 16
cytotoxicity (16) 16
anticancer agents (15) 15
pyridines - chemical synthesis (15) 15
antineoplastic agents - chemical synthesis (14) 14
antineoplastic agents - pharmacology (14) 14
derivatives (14) 14
pyridines - chemistry (14) 14
chemistry, organic (13) 13
dna topoisomerases (12) 12
dna topoisomerases, type ii - metabolism (12) 12
antineoplastic agents - chemistry (11) 11
cell proliferation - drug effects (11) 11
design (10) 10
pharmacy (10) 10
topoisomerase ii inhibitors - chemical synthesis (10) 10
topoisomerase ii inhibitors - pharmacology (10) 10
biochemistry & molecular biology (9) 9
dna topoisomerases, type i - metabolism (9) 9
drugstores (9) 9
molecular structure (9) 9
dose-response relationship, drug (8) 8
drug screening assays, antitumor (8) 8
hydroxides (8) 8
alkaloids (7) 7
analysis (7) 7
cells (7) 7
2,4,6-triphenyl pyridines (6) 6
cancer (6) 6
drug design (6) 6
expression (6) 6
potent (6) 6
topoisomerase i inhibitors - chemical synthesis (6) 6
topoisomerase i inhibitors - pharmacology (6) 6
topoisomerase ii inhibitors - chemistry (6) 6
alpha (5) 5
cell survival - drug effects (5) 5
etoposide (5) 5
topoisomerase i and ii inhibition (5) 5
animals (4) 4
antiproliferative activity (4) 4
cancer-chemotherapy (4) 4
discovery (4) 4
dna topoisomerases, type i - chemistry (4) 4
dna topoisomerases, type ii - chemistry (4) 4
hela cells (4) 4
indenes - pharmacology (4) 4
phenols - chemistry (4) 4
poisons (4) 4
rats (4) 4
topoisomerase i inhibitors - chemistry (4) 4
topoisomerase inhibitors - chemistry (4) 4
topoisomerase inhibitors - pharmacology (4) 4
2,4-diaryl (3) 3
anticancer (3) 3
antitumor agents (3) 3
benzofurans - chemistry (3) 3
biological evaluation (3) 3
chemistry, multidisciplinary (3) 3
dna-binding proteins - antagonists & inhibitors (3) 3
drug discovery (3) 3
hydroxylation (3) 3
in-vitro (3) 3
indenes - chemical synthesis (3) 3
indenes - chemistry (3) 3
inflammatory bowel disease (3) 3
molecular docking simulation (3) 3
neoplasms - drug therapy (3) 3
neoplasms - enzymology (3) 3
phenols (3) 3
phenols - chemical synthesis (3) 3
phenols - pharmacology (3) 3
terpyridine (3) 3
tnf-alpha (3) 3
tnf-α (3) 3
topoisomerase i (3) 3
topoisomerase ii (3) 3
topoisomerase inhibitors - chemical synthesis (3) 3
2,4,6-trisubstituted pyridine (2) 2
administration, oral (2) 2
anticancer activity (2) 2
apoptosis (2) 2
apoptosis - drug effects (2) 2
benzofurans - chemical synthesis (2) 2
benzofurans - pharmacology (2) 2
beta (2) 2
beta/delta (2) 2
binding sites (2) 2
biocatalysis (2) 2
biphenyl compounds - chemistry (2) 2
biphenyl compounds - pharmacology (2) 2
camptothecin (2) 2
care and treatment (2) 2
cell-cycle (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Tetrahedron Letters, ISSN 0040-4039, 12/2018, Volume 59, Issue 50, p. 4384
Peroxisome proliferator-activated receptor delta (PPAR[delta]) is considered as a promising biological target for the development of new drugs to treat... 
Medical colleges | Penicillamine
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2015, Volume 90, pp. 302 - 314
For the development of novel anticancer agents, we designed and synthesized hydroxylated 2,4-diphenyl indenopyridines, and evaluated their topoisomerase... 
Topoisomerase IIa non-intercalative | catalytic inhibitorAntiproliferative activity | Anticancer agents | Hydroxylated 2,4-diphenyl indenopyridine | Terpyridine
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2018, Volume 26, Issue 15, p. 4382
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bmc.2018.06.044 In this... 
Drug discovery | Research institutes
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 8, p. 1909
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bmc.2018.02.035 As part... 
Antimitotic agents | Care and treatment | Hydroxides | Pyridine | Antineoplastic agents | Cancer
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 137, pp. 575 - 597
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 318 - 333
Novel series of conformationally constrained 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines were rationally designed and synthesized.... 
Dual topoisomerase I and II inhibition | Non-intercalative catalytic inhibiton | Anticancer agent | 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines | Antiproliferative activity | APOPTOSIS | CHEMISTRY, MEDICINAL | PROLIFERATION | 2,4-chloro- and hydroxy-substituted | diphenyl benzofuro[3,2-b]pyridines | CANCER | DISCOVERY | ANTICANCER ACTIVITY | POTENT | BIOLOGICAL EVALUATION | DNA TOPOISOMERASES | CELL-CYCLE | DERIVATIVES | Topoisomerase I Inhibitors - metabolism | Apoptosis - drug effects | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - metabolism | Benzofurans - chemistry | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type II - metabolism | Biocatalysis | Chemistry Techniques, Synthetic | DNA Topoisomerases, Type I - metabolism | Pyridines - chemical synthesis | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Topoisomerase II Inhibitors - metabolism | Antineoplastic Agents - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Pyridines - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Pyridines - pharmacology | Drugstores | Alkaloids | Pyridine | Design and construction | Analysis | Pharmacy
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 12/2018, Volume 59, Issue 50, pp. 4384 - 4386
[Display omitted] •Method for unique dimethyl thiazoline containing intermediate of PPARδ agonists.•TBAHS as catalyst for efficient coupling of 11 with... 
GW501516 | d-Penicillamine | 4-Mercapto-2-methylphenol | PPAR agonists | TBAHS catalyst | D-Penicillamine | BETA/DELTA | DESIGN | PPAR-DELTA | GROWTH | CHEMISTRY, ORGANIC
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 05/2018, Volume 827, pp. 94 - 102
The pathogenesis of inflammatory bowel disease (IBD) is associated with production of immense pro-inflammatory cytokines including TNF-α. Once generated, TNF-α... 
Epithelial apoptosis | RIP-1 | Hydroxyindenone derivative TI-1-162 | Inflammatory bowel disease (IBD) | TNF-α | ASK-1 | CELLS | APOPTOSIS | TNF-alpha | ULCERATIVE-COLITIS | MUCOSAL INFLAMMATION | IBD | CLOTRIMAZOLE | FECAL CALPROTECTIN | INTESTINAL INFLAMMATION | INFLAMMATORY-BOWEL-DISEASE | PHARMACOLOGY & PHARMACY | EXPRESSION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 360 - 378
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2018, Volume 28, Issue 14, pp. 2436 - 2441
[Display omitted] •Synthesis of pyridine-linked indanone derivatives 2, 5a–l, 8a–c and 11a–c.•Potent anti-inflammatory effect by compounds 2, 5a, 5b, 5d, 5f,... 
Inflammatory bowel disease | Pyridine-linked indanones | Synthesis | Antiinflammatory agents | TNF-α | CHRONIC INTESTINAL INFLAMMATION | CELLS | CHEMISTRY, MEDICINAL | MECHANISM | TNF-alpha | CHEMISTRY, ORGANIC | IMBALANCE | E-CADHERIN | DISCOVERY | PATHOGENESIS | IL-1-BETA | NECROSIS-FACTOR INHIBITORS | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Pyridines - chemistry | Epithelial Cells - drug effects | Humans | Colitis - pathology | Monocytes - metabolism | Structure-Activity Relationship | Trinitrobenzenesulfonic Acid | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Colitis - chemically induced | Inflammatory Bowel Diseases - pathology | Colitis - drug therapy | Indans - administration & dosage | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Disease Models, Animal | Inflammatory Bowel Diseases - drug therapy | Pyridines - administration & dosage | Administration, Oral | Rats | Epithelial Cells - pathology | Cell Adhesion - drug effects | HT29 Cells | Monocytes - drug effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Indans - chemical synthesis | Pyridines - pharmacology | Indans - pharmacology | Alkaloids | Hydroxides | Pyridine | Analysis | Gastrointestinal diseases | Pharmacy | Therapeutics | Colitis | Derivatives (Financial instruments) | Homeopathy | Materia medica and therapeutics
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2019, Volume 62, Issue 17, pp. 8194 - 8234
With the aim of developing new effective topoisomerase II alpha-targeted anticancer agents, we synthesized a series of hydroxy- and halogenated 2,4-diphenyl... 
CELLS | DESIGN | CHEMISTRY, MEDICINAL | ANTICANCER | RELAXATION | CHLORINE | INHIBITORS | PYRIDINES | EXPRESSION | POSITIVELY SUPERCOILED DNA | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 302 - 314
Journal Article