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Nature Reviews Cancer, ISSN 1474-175X, 11/2008, Volume 8, Issue 11, pp. 865 - 873
The von Hippel-Lindau disease is caused by inactivating germline mutations of the VHL tumour suppressor gene and is associated with an increased risk of a... 
RNA-POLYMERASE-II | HYDROXYLASE DOMAIN PROTEIN-2 | ONCOLOGY | HYPOXIA-INDUCIBLE-FACTOR | PROLINE HYDROXYLATION | RENAL-CELL-CARCINOMA | VASCULAR TUMORS | HIF-ALPHA | GENE-PRODUCT | PROLYL HYDROXYLASE | FACTOR-ALPHA
Journal Article
Nature, ISSN 0028-0836, 06/2010, Volume 465, Issue 7298, pp. 562 - 564
Journal Article
The American Journal of Medicine, ISSN 0002-9343, 03/2018, Volume 131, Issue 3, pp. 216 - 217
Journal Article
JAMA, ISSN 0098-7484, 08/2017, Volume 318, Issue 7, pp. 611 - 611
Twenty-five years as a physician-scientist have taught him a few things about science and scientists that help him when viewing the climate change debate. For... 
MEDICINE, GENERAL & INTERNAL | History, 19th Century | Climate Change | National Academy of Sciences (U.S.) - history | Science - history | United States | Famous Persons | Climate change | Research | Scientists | Environmental policy | Theory | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2014, Volume 26, Issue 6, pp. 779 - 780
Reprogramming of cellular metabolism by oncogenic mutations probably creates specific vulnerabilities that could be exploited therapeutically. In this issue of... 
PHENOTYPE | ONCOLOGY | RENAL-CELL CARCINOMA | CELL BIOLOGY | Animals | Piperidines - pharmacology | Humans | Proto-Oncogene Proteins c-abl - metabolism | Fumarate Hydratase - deficiency | Oxidative Stress - drug effects | Kidney Neoplasms - drug therapy | Quinazolines - pharmacology | Health aspects | Genetic aspects | Cancer | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2017, Volume 66, Issue 6, p. 772
The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIF[alpha] subunits, represent the core of an ancient oxygen-monitoring... 
Enzymes | Medical colleges | Physiological aspects | Antisense RNA
Journal Article
JAMA, The Journal of the American Medical Association, ISSN 0098-7484, 09/2016, Volume 316, Issue 12, p. 1252
The article discusses how the discoveries by the authors of pathways for oxygen regulation and homeostatis are creating a revolution in medical science. Some... 
Homeostasis | Biological control systems | Authors | Achievements and awards
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 01/2017, Volume 114, Issue 5, p. 1027
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 01/2017, Volume 114, Issue 5, pp. 1027 - 1027
Most clear cell renal carcinomas (ccRCCs) are initiated by somatic inactivation of the VHL tumor suppressor gene. The VHL gene product, pVHL, is the substrate... 
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7390, pp. 484 - 488
Journal Article
Cell, ISSN 0092-8674, 02/2016, Volume 164, Issue 5, p. 884
Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more prolonged, ischemic insult. In remote... 
Muscles | Analysis | Organic acids | Cardiovascular agents | Medical colleges
Journal Article
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6093, pp. 421 - 422
For decades, scientists studying mammalian cells could only marvel at the genetic tools available to scientists who studied organisms such as yeasts or... 
Animal genetics | Phenotypes | Disease models | Genes | Medical genetics | PERSPECTIVES | Small interfering RNA | Libraries | Viability | Genetic screening | Preclinical drug evaluation | SCREENS | INTERFERENCE | EXPRESSION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | Pharmacology | Molecular biology | Ribonucleic acid--RNA | Mammals | Genomics
Journal Article
Science, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, p. 929
Activation of the serine-threonine kinase Akt promotes the survival and proliferation of various cancers. Hypoxia promotes the resistance of tumor cells to... 
Hypoxia | Cell research | Research | Protein kinases | Carcinogenesis | Cancer cells
Journal Article
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