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animals (11) 11
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proteins (9) 9
parasites (8) 8
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malaria (7) 7
parasitology (7) 7
gene expression (6) 6
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plasmodium falciparum (5) 5
protozoan proteins - genetics (5) 5
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cells, cultured (4) 4
erythrocytes (4) 4
female (4) 4
genomes (4) 4
host-parasite interactions (4) 4
plasmodium-falciparum (4) 4
protozoan proteins - metabolism (4) 4
toxoplasma (4) 4
amino acid sequence (3) 3
biology (3) 3
deoxyribonucleic acid--dna (3) 3
flow cytometry (3) 3
gametocytes (3) 3
host-cells (3) 3
invasion (3) 3
malaria - parasitology (3) 3
male (3) 3
mice (3) 3
molecular biology (3) 3
molecular sequence data (3) 3
motility (3) 3
parasite (3) 3
physiological aspects (3) 3
plasmodium falciparum - cytology (3) 3
plasmodium falciparum - genetics (3) 3
plasmodium falciparum - physiology (3) 3
reproduction, asexual (3) 3
toxoplasma - physiology (3) 3
toxoplasma-gondii (3) 3
analysis (2) 2
biochemistry & molecular biology (2) 2
calcium (2) 2
cancer research (2) 2
cell adhesion (2) 2
disease transmission (2) 2
dna-binding proteins - deficiency (2) 2
dna-binding proteins - genetics (2) 2
dna-binding proteins - metabolism (2) 2
electrophoresis, gel, two-dimensional (2) 2
expression (2) 2
gene silencing (2) 2
genes (2) 2
genetic aspects (2) 2
germ cells - cytology (2) 2
germ cells - growth & development (2) 2
germ cells - metabolism (2) 2
immunology and microbiology (2) 2
infection (2) 2
life cycles (2) 2
ligands (2) 2
mass spectrometry (2) 2
mass-spectrometry (2) 2
mathematical & computational biology (2) 2
medical research (2) 2
mosquito (2) 2
parasitology - methods (2) 2
plasmodium berghei - genetics (2) 2
plasmodium berghei - physiology (2) 2
potassium signaling (2) 2
protein (2) 2
protozoan proteins - analysis (2) 2
protozoan proteins - physiology (2) 2
pulse invasion (2) 2
research (2) 2
ribonucleic acid--rna (2) 2
rna (2) 2
rna sequencing (2) 2
schizonts (2) 2
sexual development - genetics (2) 2
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stage (2) 2
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tachyzoites (2) 2
toxoplasma - chemistry (2) 2
toxoplasma - drug effects (2) 2
toxoplasma - genetics (2) 2
toxoplasma - metabolism (2) 2
transcription factors (2) 2
transmission (2) 2
virology (2) 2
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1. Full Text A transcriptional switch underlies commitment to sexual development in malaria parasites
by Kafsack, Björn F. C and Rovira-Graells, Núria and Clark, Taane G and Bancells, Cristina and Crowley, Valerie M and Campino, Susana G and Williams, April E and Drought, Laura G and Kwiatkowski, Dominic P and Baker, David A and Cortés, Alfred and Llinás, Manuel
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7491, pp. 248 - 252
The life cycles of many parasites involve transitions between disparate host species, requiring these parasites to go through multiple developmental stages... 
TRANSMISSION | PLASMODIUM-FALCIPARUM GAMETOCYTES | PROTEIN | MULTIDISCIPLINARY SCIENCES | GENES | EXPRESSION | REGION | Parasites - physiology | Genes, Protozoan - genetics | Sexual Development - genetics | Male | Plasmodium falciparum - cytology | Protozoan Proteins - genetics | DNA-Binding Proteins - deficiency | Parasites - genetics | DNA-Binding Proteins - metabolism | Protozoan Proteins - metabolism | Plasmodium falciparum - genetics | Female | Germ Cells - cytology | Germ Cells - metabolism | Plasmodium falciparum - physiology | Parasites - cytology | Gene Expression Regulation - genetics | Reproduction, Asexual | Sex Differentiation - genetics | Gene Silencing | Germ Cells - growth & development | DNA-Binding Proteins - genetics | Animals | Malaria - parasitology | Genome, Protozoan - genetics | Transcription, Genetic - genetics | Life cycle assessment | Physiological aspects | Plasmodium falciparum | Genetic aspects | Gametocytes | Malaria | Proteins | Ligands | Infections | Parasites | Gene expression | Deoxyribonucleic acid--DNA
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2. Full Text A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium
by Sinha, Abhinav and Hughes, Katie R and Modrzynska, Katarzyna K and Otto, Thomas D and Pfander, Claudia and Dickens, Nicholas J and Religa, Agnieszka A and Bushell, Ellen and Graham, Anne L and Cameron, Rachael and Kafsack, Bjorn F. C and Williams, April E and Llinás, Manuel and Berriman, Matthew and Billker, Oliver and Waters, Andrew P
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7491, pp. 253 - 257
Commitment to and completion of sexual development are essential for malaria parasites (protists of the genus Plasmodium) to be transmitted through... 
SPECIFICITIES | FALCIPARUM | MULTIDISCIPLINARY SCIENCES | SEQUENCE | MALARIA PARASITE | BERGHEI | GENERATION | TRANSCRIPTION-FACTOR | MICROARRAYS | SELECTION | FERTILITY | Sexual Development - genetics | Plasmodium berghei - physiology | Reproduction, Asexual | Plasmodium berghei - genetics | Gene Expression Regulation | Male | Germ Cells - growth & development | DNA-Binding Proteins - genetics | Mutation - genetics | Protozoan Proteins - genetics | DNA-Binding Proteins - deficiency | Protein Transport | DNA-Binding Proteins - metabolism | Plasmodium berghei - cytology | Feedback, Physiological | Animals | Protozoan Proteins - metabolism | Malaria - parasitology | Female | Transcription, Genetic | Culicidae - parasitology | Germ Cells - cytology | Germ Cells - metabolism | Plasmodium falciparum | Malaria | Physiological aspects | DNA binding proteins | Nucleotide sequencing | Properties | Gene expression | Methods | DNA sequencing | Proteins | Flow cytometry | Mosquitoes | Transcription factors | Epigenetics | Genomes | Mutation | Parasites | Deoxyribonucleic acid--DNA
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3. Full Text Single-Cell Transcriptome Profiling of Protozoan and Metazoan Parasites
by Nötzel, Christopher and Poran, Asaf and Kafsack, Björn F.C
Trends in Parasitology, ISSN 1471-4922, 09/2018, Volume 34, Issue 9, pp. 731 - 734
Single-cell RNA sequencing (scRNAseq) technologies are changing the way we study populations of cells by allowing for an unbiased characterization of the... 
host–parasite interaction | single-cell transcriptomics | cell fate decisions | gene expression analysis | bet-hedging strategies | parasite development | SEQ | PARASITOLOGY | Animals | Eukaryota - genetics | Parasitology - methods | Transcriptome | Parasitology - trends | Eukaryota - metabolism | Single-Cell Analysis | RNA sequencing | Microbiology | RNA | Molecular biology | Gene expression | Analysis
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4. Full Text Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites
by Poran, Asaf and Nötzel, Christopher and Aly, Omar and Mencia-Trinchant, Nuria and Harris, Chantal T and Guzman, Monica L and Hassane, Duane C and Elemento, Olivier and Kafsack, Björn F. C
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7678, pp. 95 - 99
Pathogens have to balance transmission with persistence. For Plasmodium falciparum, the most widespread and virulent malaria parasite, persistence within its... 
GENE-EXPRESSION DATA | GAMETOCYTES | ANTIGENIC VARIATION | ERYTHROCYTES | CONVERSION | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | INTRAERYTHROCYTIC DEVELOPMENTAL CYCLE | MECHANISMS | DIFFERENTIATION | BISTABLE SWITCH | Gametogenesis - genetics | Schizonts - genetics | Reproduction, Asexual | Humans | Nucleosomes - metabolism | Male | Nucleosomes - genetics | Plasmodium falciparum - cytology | Gene Expression Profiling | Transcriptome - genetics | Transcription Factors - metabolism | Schizonts - cytology | Sequence Analysis, RNA | Cell Cycle | Plasmodium falciparum - genetics | Malaria - parasitology | Female | Histones - metabolism | Plasmodium falciparum - growth & development | Plasmodium falciparum - physiology | Single-Cell Analysis | RNA sequencing | Plasmodium falciparum | Medical research | Malaria | Host-parasite relationships | Medicine, Experimental | Genetic aspects | Research | Flow cytometry | Transcription factors | Erythrocytes | Genomes | Parasites | Kinases | Aquatic insects | Gene sequencing | Proteins | Replicating | Red blood cells | Developmental stages | Transcription activation | Cell cycle | Gametocytes | Deoxyribonucleic acid--DNA | Growth conditions | Vector-borne diseases | Schizonts | Blood cells | Sexual stages | Gene expression | Ribonucleic acid--RNA | Merozoites | Gene silencing | Replication | Ligands | Differentiation
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5. Full Text Rapid Membrane Disruption by a Perforin-like Protein Facilitates Parasite Exit from Host Cells
by Björn F. C. Kafsack and Janethe D. O. Pena and Isabelle Coppens and Sandeep Ravindran and John C. Boothroyd and Vern B. Carruthers
Science, ISSN 0036-8075, 1/2009, Volume 323, Issue 5913, pp. 530 - 533
Perforin-like proteins are expressed by many bacterial and protozoan pathogens, yet little is known about their function or mode of action. Here, we describe... 
Proteins | Calcium | Secretion | Reports | Cell membranes | Parasitism | Parasites | Tachyzoites | Vacuoles | Parasite hosts | P branes | DEFENSE | DOMAIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | TOXOPLASMA-GONDII | ATTACK | SPOROZOITES | INFECTION | DEATH | PORE-FORMING TOXINS | FAMILY | Perforin - genetics | Humans | Cell Membrane Permeability | Molecular Sequence Data | Protozoan Proteins - genetics | Protozoan Proteins - metabolism | Toxoplasma - growth & development | Protozoan Proteins - chemistry | Cell Membrane - metabolism | Host-Parasite Interactions | Vacuoles - parasitology | Toxoplasma - metabolism | Ionophores - pharmacology | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Perforin - chemistry | Cells, Cultured | Models, Molecular | Permeability | Calcimycin - pharmacology | Toxoplasma - pathogenicity | Animals | Toxoplasma - genetics | Vacuoles - metabolism | Protein Conformation | Perforin - metabolism | Intracellular Membranes - metabolism | Toxoplasma | Physiological aspects | Cellular proteins | Research | Membranes | Cellular biology
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6. Full Text A Plasmodium falciparum Histone Deacetylase Regulates Antigenic Variation and Gametocyte Conversion
by Coleman, Bradley I and Skillman, Kristen M and Jiang, Rays H.Y and Childs, Lauren M and Altenhofen, Lindsey M and Ganter, Markus and Leung, Yvette and Goldowitz, Ilana and Kafsack, Björn F.C and Marti, Matthias and Llinás, Manuel and Buckee, Caroline O and Duraisingh, Manoj T
Cell Host & Microbe, ISSN 1931-3128, 08/2014, Volume 16, Issue 2, pp. 177 - 186
The asexual forms of the malaria parasite are adapted for chronic persistence in human red blood cells, continuously evading host immunity using epigenetically... 
PROTEIN | MUTUALLY EXCLUSIVE EXPRESSION | MICROBIOLOGY | MALARIA PARASITES | VIRULENCE GENES | VIROLOGY | ERYTHROCYTES | HETEROCHROMATIN | TOXOPLASMA-GONDII | REPRODUCTIVE RESTRAINT | GIARDIA-LAMBLIA | SEXUAL DEVELOPMENT | PARASITOLOGY | Plasmodium falciparum - enzymology | Amino Acid Sequence | Antigens, Protozoan - immunology | Epigenesis, Genetic | Humans | Cells, Cultured | Molecular Sequence Data | Genes, Protozoan | Plasmodium falciparum - cytology | Protozoan Proteins - physiology | Heterochromatin - genetics | Heterochromatin - metabolism | Virulence - genetics | Histone Deacetylases - physiology | Host-Parasite Interactions | Plasmodium falciparum | Virulence (Microbiology) | Malaria | Gene expression | Analysis | Public health
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7. Full Text Eating at the Table of Another: Metabolomics of Host-Parasite Interactions
by Kafsack, Björn F.C and Llinás, Manuel
Cell Host & Microbe, ISSN 1931-3128, 2010, Volume 7, Issue 2, pp. 90 - 99
The application of metabolomics, the global analysis of metabolite levels, to the study of protozoan parasites has become an important tool for understanding... 
PROCYCLIC TRYPANOSOMA-BRUCEI | NUCLEAR-MAGNETIC-RESONANCE | MICROBIOLOGY | ENTAMOEBA-HISTOLYTICA | CHLOROQUINE RESISTANCE | MASS-SPECTROMETRY | COMPUTATIONAL ANALYSIS | PROTEIN INTERACTIONS | VIROLOGY | PLASMODIUM-FALCIPARUM | HUMAN MALARIA PARASITE | PATHOGEN TOXOPLASMA-GONDII | PARASITOLOGY | Parasites - pathogenicity | Metabolomics | Animals | Host-Parasite Interactions | Parasites - metabolism | Humans | Metabolites | Parasitic diseases | Usage
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8. Full Text Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors
by Zhan, WH and Visone, J and Ouellette, T and Harris, JC and Wang, R and Zhang, H and Singh, PK and Ginn, J and Sukenick, G and Wong, TT and Okoro, JI and Scales, RM and Tumwebaze, PK and Rosenthal, PJ and Kafsack, BFC and Cooper, RA and Meinke, PT and Kirkman, LA and Lin, G
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6137 - 6145
The Plasmodium proteasome (Pf20S) emerged as a target for antimalarials. Pf20S inhibitors are active at multiple stages of the parasite life cycle and... 
POTENT | CHEMISTRY, MEDICINAL | NONCOVALENT INHIBITORS | ARTEMISININ RESISTANCE
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9. Full Text Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters
by McLean, KJ and Straimer, J and Hopp, CS and Vega-Rodriguez, J and Small-Saunders, JL and Kanatani, S and Tripathi, A and Mlambo, G and Dumoulin, PC and Harris, CT and Tong, XR and Shears, MJ and Ankarklev, J and Kafsack, BFC and Fidock, DA and Sinnis, P and Stockholms universitet and Naturvetenskapliga fakulteten and Institutionen för molekylär biovetenskap, Wenner-Grens institut
SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 13131 - 10
Malaria parasites have a complex life cycle that includes specialized stages for transmission between their mosquito and human hosts. These stages are an... 
PFS47 | MOSQUITO | PROTEINS | PLASMODIUM-FALCIPARUM | STAGE | MULTIDISCIPLINARY SCIENCES | Flow cytometry | Disease transmission | Malaria | Erythrocytes | Genomes | Parasites | Nuclease | Life cycles | Biological Sciences | Clinical Medicine | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Infektionsmedicin | Infectious Medicine | Natural Sciences | Klinisk medicin
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10. Full Text Synchronous invasion of host cells by Toxoplasma gondi
by Kafsack, BFC and Beckers, C and Carruthers, VB
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ISSN 0166-6851, 08/2004, Volume 136, Issue 2, pp. 309 - 311
Toxoplasma | BIOCHEMISTRY & MOLECULAR BIOLOGY | motility | POTASSIUM | SECRETION | pulse invasion | synchrony | potassium signaling | PARASITOLOGY
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11. Full Text The Opportunistic Pathogen Toxoplasma gondii Deploys a Diverse Legion of Invasion and Survival Proteins
by Xing W. Zhou and Björn F. C. Kafsack and Robert N. Cole and Phil Beckett and Rong F. Shen and Vern B. Carruthers
Journal of Biological Chemistry, ISSN 0021-9258, 10/2005, Volume 280, Issue 40, pp. 34233 - 34244
Host cell invasion is an essential step during infection by Toxoplasma gondii , an intracellular protozoan that causes the severe opportunistic disease... 
MOLECULAR CHARACTERIZATION | DENSE GRANULE PROTEIN | HOST-CELL INVASION | NUCLEOSIDE TRIPHOSPHATE HYDROLASE | APICOMPLEXAN PARASITES | PLASMODIUM-FALCIPARUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURFACE-ANTIGEN | PARASITOPHOROUS VACUOLE MEMBRANE | MASS-SPECTROMETRY | MICRONEME PROTEIN | Animals | Spectrometry, Mass, Electrospray Ionization | Toxoplasma - chemistry | Mass Spectrometry | Electrophoresis, Gel, Two-Dimensional | Protozoan Proteins - analysis | Protozoan Proteins - physiology | Survival | Toxoplasma - pathogenicity | Toxoplasmosis - physiopathology
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12. Full Text Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites
by Lagal, Vanessa and Binder, Emily M and Huynh, My‐Hang and Kafsack, Bjorn F. C and Harris, Philippa K and Diez, Roberto and Chen, Dawn and Cole, Robert N and Carruthers, Vern B and Kim, Kami
Cellular Microbiology, ISSN 1462-5814, 12/2010, Volume 12, Issue 12, pp. 1792 - 1808
Summary Host cell invasion by Toxoplasma gondii is critically dependent upon adhesive proteins secreted from the micronemes. Proteolytic trimming of microneme... 
HOST-CELLS | INVASION | ORGANELLES | TRANSEPITHELIAL MIGRATION | MICROBIOLOGY | PROTEOLYSIS | SECRETION | PARASITE | PROTEINS | MIC2 | MOTILITY | CELL BIOLOGY | Virulence Factors - genetics | Humans | Virulence | Cells, Cultured | Toxoplasma - physiology | Protozoan Proteins - genetics | Cell Adhesion | Cell Adhesion Molecules - metabolism | Genetic Complementation Test | Toxoplasma - enzymology | Toxoplasma - pathogenicity | Locomotion | Animals | Protozoan Proteins - metabolism | Toxoplasmosis, Animal - parasitology | Gene Deletion | Subtilisins - genetics | Virulence Factors - metabolism | Membrane Proteins - metabolism | Mice | Subtilisins - metabolism | Toxoplasma - metabolism | Disease Models, Animal | Proteins | Proteases | tachyzoites | Proteolysis | Secretion | Macromolecules | Proteinase | Cell adhesion | Micronemes | Subtilisin | Parasites | Cell surface | Gliding
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13. Full Text Kinetic modeling of Toxoplasma gondii invasion (vol 249, pg 817, 2007)
by Kafsack, BFC and Carruthers, VB and Pineda, FJ
JOURNAL OF THEORETICAL BIOLOGY, ISSN 0022-5193, 10/2009, Volume 260, Issue 4, pp. 598 - 598
BIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY
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14. Full Text New Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research community
by Kafsack, Björn F.C and Painter, Heather J and Llinás, Manuel
Malaria Journal, ISSN 1475-2875, 2012, Volume 11, Issue 1, pp. 187 - 187
Background: DNA microarrays have been a valuable tool in malaria research for over a decade but remain in limited use in part due their relatively high cost,... 
LIFE-CYCLE | STRAINS | INFECTIOUS DISEASES | STAGE | IDENTIFICATION | DISCOVERY | TROPICAL MEDICINE | GENOME SEQUENCE | DATABASE | NONCODING RNAS | GENE-EXPRESSION | PARASITE | PARASITOLOGY | Oligonucleotide Array Sequence Analysis - methods | Plasmodium berghei - physiology | Plasmodium berghei - genetics | Plasmodium falciparum - genetics | Parasitology - methods | Plasmodium falciparum - pathogenicity | Gene Expression Profiling - methods | Plasmodium falciparum - physiology | Plasmodium berghei - pathogenicity | Plasmodium falciparum | DNA microarrays | RNA | Malaria | Genomics | DNA | Genomes | Instrument industry | Proteins | Medical research | Parasites | Gene expression
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15. Full Text Synchronous invasion of host cells by Toxoplasma gondii
by Kafsack, B.F.C and Beckers, C and Carruthers, V.B
Molecular & Biochemical Parasitology, ISSN 0166-6851, 2004, Volume 136, Issue 2, pp. 309 - 311
Toxoplasma | Potassium signaling | Motility | Pulse invasion | Synchrony | Temperature | Animals | Humans | Staining and Labeling | Cells, Cultured | Toxoplasma - drug effects | Toxoplasma - physiology | Potassium - pharmacology | Cell Adhesion | Toxoplasma - pathogenicity
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16. Full Text Kinetic modeling of Toxoplasma gondii invasion
by Kafsack, Björn F.C and Carruthers, Vern B and Pineda, Fernando J
Journal of Theoretical Biology, ISSN 0022-5193, 2007, Volume 249, Issue 4, pp. 817 - 825
The phylum Apicomplexa includes parasites responsible for global scourges such as malaria, cryptosporidiosis, and toxoplasmosis. Parasites in this phylum... 
Compartment model | Host–pathogen interaction | Apicomplexa | Invasion | Protozoan parasites | host-pathogen interaction | HOST-CELLS | ENTRY | protozoan parasites | PARASITE INVASION | ADHESION | VACUOLE | invasion | compartment model | BIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | SECRETION | PROTEINS | Animals | Models, Biological | Humans | Virulence - physiology | Host-Parasite Interactions | Toxoplasma - physiology | Toxoplasma - pathogenicity | Toxoplasmosis - parasitology
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