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1. Full Text Retinoic acids exert direct effects on T cells to suppress T(h)1 development and enhance T(h)2 development via retinoic acid receptors
by Iwata, M and Eshima, Y and Kagechika, H
INTERNATIONAL IMMUNOLOGY, ISSN 0953-8178, 08/2003, Volume 15, Issue 8, pp. 1017 - 1025
The vitamin A metabolite, retinoic acid (RA), affects T(h)1 and T(h)2 development. The effect is partly exerted through the modulation of antigen-presenting... 
cytokine | differentiation | X-RECEPTOR | IMMUNOLOGY | vitamin | VITAMIN-A | BALB/C MICE | INHIBITION | RETINOBENZOIC ACIDS | INTERLEUKIN-12 PRODUCTION | IN-VIVO | nuclear receptor | T lymphocyte | TH1 | TRANSCRIPTION FACTOR | EXPRESSION
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2. Retinoic acids exert direct effects on T cells to suppress T sub(h)1 development and enhance T sub(h)2 development via retinoic acid receptors
by Iwata, M and Eshima, Y and Kagechika, H
International Immunology, ISSN 0953-8178, 01/2003, Volume 15, Issue 8, pp. 1017 - 1025
The vitamin A metabolite, retinoic acid (RA), affects T sub(h)1 and T sub(h)2 development. The effect is partly exerted through the modulation of antigen-... 
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3. Full Text Redox-responsive conformational alteration of aromatic amides bearing N-quinonyl system
by Okamoto, Iwao and Takahashi, Yusuke and Sawamura, Mika and Matsumura, Mio and Masu, Hyuma and Katagiri, Kosuke and Azumaya, Isao and Nishino, Masanori and Kohama, Yukari and Morita, Nobuyoshi and Tamura, Osamu and Kagechika, Hiroyuki and Tanatani, Aya
Tetrahedron, ISSN 0040-4020, 07/2012, Volume 68, Issue 27-28, pp. 5346 - 5355
Redox-induced conformational alteration of -aryl- -phenylamides, in which the -aryl group consists of a hydroquinone– -quinone system, was examined. The... 
Reduction | Oxidation | Molecular switch | Aromatic amide | Molecular device | External stimulus responsive | ACID | C-H...O | CHEMISTRY, ORGANIC | HYDROGEN-BONDS | CHIROPTICAL MOLECULAR SWITCHES | MACHINES | CRYSTALS | MOTORS | Amides | Universities and colleges | Optical properties | Analysis | Quinone | Alterations | Crystals | Tetrahedrons | Switching | Bearing
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4. Full Text A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1
by Park, SW and Nhieu, J and Persaud, SD and Miller, MC and Xia, YL and Lin, YW and Lin, YL and Kagechika, H and Mayo, KH and Wei, LN
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10929 - 12
The rapidly accelerated fibrosarcoma (Raf) kinase is canonically activated by growth factors that regulate multiple cellular processes. In this kinase cascade... 
BINDING PROTEIN-I | CELLS | ERK1/2 | COMPLEX | NMR | PHOSPHORYLATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | PURIFICATION | PROLIFERATION | RECEPTORS | Nuclear magnetic resonance--NMR | Toxicity | Retinoic acid receptors | Extracellular signal-regulated kinase | Fibrosarcoma | Raf protein | Ras protein | Kinases | Mimicry | Stem cells | Cell cycle | Growth factors | Retinoic acid
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5. Full Text Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid
by Qin, Xian-Yang and Suzuki, Harukazu and Honda, Masao and Okada, Hikari and Kaneko, Shuichi and Inoue, Ikuyo and Ebisui, Etsuko and Hashimoto, Kosuke and Carninci, Piero and Kanki, Keita and Tatsukawa, Hideki and Ishibashi, Naoto and Masaki, Takahiro and Matsuura, Tomokazu and Kagechika, Hiroyuki and Toriguchi, Kan and Hatano, Etsuro and Shirakami, Yohei and Shiota, Goshi and Shimizu, Masahito and Moriwaki, Hisataka and Kojima, Soichi
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2018, Volume 115, Issue 19, pp. 4969 - 4974
Hepatocellular carcinoma (HCC) is a highly lethal cancer that has a high rate of recurrence, in part because of cancer stem cell (CSC)dependent field... 
Cancer stem cell | Hepatocellular carcinoma | MYCN | Acyclic retinoid | Transcriptome | RISK-FACTORS | VIRUS | INTRAHEPATIC RECURRENCE | RESECTION | transcriptome | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | acyclic retinoid | cancer stem cell | EPCAM | PERETINOIN | GROWTH | EXPRESSION | hepatocellular carcinoma | ALPHA-FETOPROTEIN | Prevention | Liver cancer | Cancer cells | Stem cells | Hepatoma | Retinoids | Health aspects | Biological Sciences
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6. Full Text Dendritic cells: function (PP-024)
International Immunology, ISSN 0953-8178, 08/2010, Volume 22, Issue Suppl_1_Pt_2, pp. ii10 - ii24
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7. Full Text Synthesis and Conformational Analysis of Alternately N‑Alkylated Aromatic Amide Oligomers
by Urushibara, Ko and Masu, Hyuma and Mori, Hirotoshi and Azumaya, Isao and Hirano, Tomoya and Kagechika, Hiroyuki and Tanatani, Aya
The Journal of Organic Chemistry, ISSN 0022-3263, 12/2018, Volume 83, Issue 23, pp. 14338 - 14349
Alternately N-alkylated aromatic amides such as 1–3 bearing various side chains were designed and synthesized as novel helical foldamers. The CD spectra of... 
CHAIN | POLYMERS | DOUBLE-HELICES | MOLECULAR-STRUCTURE | STEREOCHEMISTRY | CHEMISTRY, ORGANIC | COMBINATION | SECONDARY-AMINES | BENZANILIDES
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8. Full Text The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
by Tomita, M and Ezaki, O and Yoda, M and Vinson, C and Yamauchi, T and Akanuma, Y and Kimura, S and Kamon, J and Nakano, Y and Froguel, P and Murakami, K and Mori, Y and Waki, H and Gavrilova, O and Reitman, M.L and Hara, K and Kagechika, H and Ide, T and Terauchi, Y and Tsuboyama-Kasaoka, N and Nagai, R and Kubota, N and Kadowaki, T and Shudo, K and Tobe, K
Nature Medicine, ISSN 1078-8956, 08/2001, Volume 7, Issue 8, pp. 941 - 946
Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and metabolic syndrome to... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVITY | ACTIVATED RECEPTOR-ALPHA | CELL BIOLOGY | DIABETES-MELLITUS | GENE | METABOLISM | PPAR-GAMMA | MICE | EXPRESSION | ADIPOSE-TISSUE | Amino Acid Sequence | Proteins - physiology | Transcription Factors - physiology | Oxidation-Reduction | Signal Transduction | Intercellular Signaling Peptides and Proteins | Leptin - metabolism | Adipose Tissue - physiopathology | Insulin Resistance | Molecular Sequence Data | Obesity - physiopathology | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Adiponectin | Triglycerides - metabolism | Adipose Tissue - metabolism | Animals | Mice | Obesity | Triglycerides | Receptors, Cytoplasmic and Nuclear | Proteins | Life Sciences | Leptin | Genetics | Transcription Factors | Adipose Tissue | Human genetics
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9. Full Text Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer
by Ishigami-Yuasa, Mari and Ekimoto, Hisao and Kagechika, Hiroyuki
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 3, pp. 448 - 452
Combination therapy is often an effective strategy to treat cancer. In this study, we examined the growth-inhibitory effects of Am80 (tamibarotene), a specific... 
prostate cancer | androgen receptor-positive prostate cancer (LNCaP) | Am80 | retinoid | histone deacetylase (HDAC) inhibitor | retinoic acid receptor (RAR) α | APOPTOSIS | CELLS | HISTONE DEACETYLASE INHIBITOR | COMBINATION | ACID RECEPTORS | retinoic acid receptor (RAR) alpha | IN-VITRO | GROWTH | PHARMACOLOGY & PHARMACY | PHASE-I | EXPRESSION | N-(4-HYDROXYPHENYL)RETINAMIDE | Histone deacetylase | Therapy | Retinoic acid receptors | Hydroxamic acid | Tumor cell lines | Inhibitors | Acids | Cell lines | Prostate cancer | Prostate | Retinoic acid | Deoxyribonucleic acid--DNA | Cancer
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10. Full Text Crystal structure of spherical aromatic amide: Pseudopolymorphs and formation of infinite water cluster in the channel structure
by Masu, Hyuma and Sagara, Yuko and Imabeppu, Fumiaki and Takayanagi, Hiroaki and Katagiri, Kosuke and Kawahata, Masatoshi and Tominaga, Masahide and Kagechika, Hiroyuki and Yamaguchi, Kentaro and Azumaya, Isao
CrystEngComm, ISSN 1466-8033, 01/2011, Volume 13, Issue 2, pp. 406 - 409
A simple spherical aromatic amide constructed a channel-shaped network structure by weak intermolecular interactions in the crystalline state. The channel... 
COVALENT ORGANIC FRAMEWORKS | STORAGE | HEXAMER | SUPRAMOLECULAR COMPLEX | METHANE | MOLECULAR-CRYSTALS | C-H...O | HOST | CRYSTALLOGRAPHY | CHEMISTRY, MULTIDISCIPLINARY | HYDROGEN-BONDS | RETICULAR SYNTHESIS | Networks | Construction | Acetonitrile | Clusters | Amides | Chains | Channels | Crystal structure
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11. Full Text Structural development of canthin-5,6-dione moiety as a fluorescent dye and its application to novel fluorescent sensors
by Yokoo, Hidetomo and Ohsaki, Ayumi and Kagechika, Hiroyuki and Hirano, Tomoya
Tetrahedron, ISSN 0040-4020, 09/2016, Volume 72, Issue 39, pp. 5872 - 5879
Canthin-5,6-dione is a common structure of the fluorescent natural products amarastelline A and nigakinone. Here, we synthesized various derivatives, and... 
Fluorescence | Canthin-5,6-dione | Sensor | OFF-ON-OFF | CHEMISTRY, ORGANIC | 6-ARYLCOUMARINS | INTRAMOLECULAR PROTON-TRANSFER | PICRASMA-QUASSIOIDES BENNET | PROBES | TIME-RESOLVED FLUORESCENCE | SWITCHES | DERIVATIVES | ALKALOIDS | Biological products | Sensors
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12. Full Text Increased Hydrophobicity and Estrogenic Activity of Simple Phenols with Silicon and Germanium-Containing Substituents
by Fujii, Shinya and Miyajima, Yu and Masuno, Hiroyuki and Kagechika, Hiroyuki
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 160 - 166
Here, we report the systematic synthesis and characterization of simple phenols bearing a trialkyl(aryl)silyl or trialkyl(aryl)germyl functional group as a... 
DICARBA-CLOSO-DODECABORANES | MEDICINAL CHEMISTRY | ANDROGEN RECEPTOR | CHEMISTRY, MEDICINAL | CARBORANE | RECEPTOR LIGANDS | DRUG DISCOVERY | BEARING | CORE STRUCTURE | ANTAGONISTS | AGONISTS | Transcription, Genetic - drug effects | Organosilicon Compounds - chemical synthesis | Estrogens - pharmacology | Luciferases - metabolism | Organosilicon Compounds - pharmacology | Phenols - chemical synthesis | Humans | Estrogens - chemical synthesis | Luciferases - genetics | Estrogen Receptor alpha - agonists | Estrogens - chemistry | Estrogen Receptor alpha - metabolism | Radioligand Assay | Genes, Reporter | Phenols - pharmacology | Binding, Competitive | Estradiol - metabolism | Organosilicon Compounds - chemistry | Organometallic Compounds - chemical synthesis | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Germanium | Organometallic Compounds - chemistry | Phenols - chemistry | Cell Proliferation - drug effects | Molecular Docking Simulation | Organometallic Compounds - pharmacology
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13. Full Text Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models
by Shimada, Shu and Akiyama, Yoshimitsu and Mogushi, Kaoru and Ishigami-Yuasa, Mari and Kagechika, Hiroyuki and Nagasaki, Hiromi and Fukamachi, Hiroshi and Yuasa, Yasuhito and Tanaka, Shinji
British Journal of Cancer, ISSN 0007-0920, 04/2018, Volume 118, Issue 7, pp. 972 - 984
BACKGROUND: Diffuse-type gastric cancer (DGC) exhibits rapid disease progression and poor patient prognosis. We have previously established an E-cadherin/p53... 
BREAST-CANCER | STEM-CELLS | ONCOLOGY | DRUGS | ESTROGEN | ASSAYS | AGENTS | E-CADHERIN | MUTATIONS | CARCINOMA | STOMACH | Drugs | Biotechnology | Animal models | p53 Protein | DNA damage | Cytotoxicity | Stomach cancer | E-cadherin | Modulators | Anticancer properties | Gastric cancer | Deoxyribonucleic acid--DNA | Cell survival | Immunomodulation | Immunodeficiency | Tumor cell lines | Chemical compounds | Immunological tolerance | Screening | Medical prognosis | Cell lines | Mice | Genetic engineering | Viability | Cancer | Tumors | Apoptosis | Cancer screening
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14. Full Text Conformational Properties of Aromatic Oligoamides Bearing Pyrrole Rings
by Tojo, Yukiko and Urushibara, Ko and Yamamoto, Sawori and Mori, Hirotoshi and Masu, Hyuma and Kudo, Mayumi and Hirano, Tomoya and Azumaya, Isao and Kagechika, Hiroyuki and Tanatani, Aya
The Journal of Organic Chemistry, ISSN 0022-3263, 04/2018, Volume 83, Issue 8, pp. 4606 - 4617
N-Alkylbenzanilides generally exist in cis conformation both in the crystalline state and in various solvents, and this cis conformational preference can be... 
ACID | PEPTIDES | RECOGNITION | FOLDAMERS | CHEMISTRY, ORGANIC | CRYSTAL | SECONDARY-AMINES | BINDING | OLIGOMERS | PROTONATION | MOLECULES
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15. Full Text Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells
by Shrestha, R and Tatsukawa, H and Shrestha, R and Ishibashi, N and Matsuura, T and Kagechika, H and Kose, S and Hitomi, K and Imamoto, N and Kojima, S
Cell Death and Disease, ISSN 2041-4889, 12/2015, Volume 6, Issue 12, pp. e2002 - e2002
Nuclear accumulation of transglutaminase 2 (TG2) is an important step in TG2-dependent cell death. However, the underlying molecular mechanisms for nuclear... 
PROTEIN | INHIBITION | MODELS | STRUCTURAL BASIS | PREVENTION | SIGNALS | EXPORT RECEPTOR | DEATH | TISSUE TRANSGLUTAMINASE | IMPORTIN-ALPHA | CELL BIOLOGY | Amino Acid Sequence | Apoptosis - drug effects | Humans | Cell Proliferation - physiology | Liver Neoplasms - drug therapy | Molecular Sequence Data | Carcinoma, Hepatocellular - enzymology | Cell Nucleus - enzymology | Carcinoma, Hepatocellular - drug therapy | Cell Differentiation - drug effects | Transglutaminases - metabolism | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Tretinoin - analogs & derivatives | Liver Neoplasms - pathology | Cell Proliferation - drug effects | Cell Nucleus - drug effects | Liver Neoplasms - enzymology | Cell Differentiation - physiology | GTP-Binding Proteins - metabolism | Tretinoin - pharmacology | Original
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16. Full Text Unique Properties of 1,5‐Naphthyridin‐2(1H)‐one Derivatives as Environment‐Polarity‐Sensitive Fluorescent Dyes
by Yokoo, Hidetomo and Ohsaki, Ayumi and Kagechika, Hiroyuki and Hirano, Tomoya
European Journal of Organic Chemistry, ISSN 1434-193X, 02/2018, Volume 2018, Issue 5, pp. 679 - 687
1,5‐Naphthyridin‐2(1H)‐one is structural component of the fluorescent natural products amarastelline A and nigakinone. Herein, we synthesized several... 
Fluorescence | Sensors | Nitrogen heterocycles | Functional organic materials | CELLS | CHEMISTRY, ORGANIC | STATE | 6-ARYLCOUMARINS | INTRAMOLECULAR PROTON-TRANSFER | PROBES | CHEMICAL BIOLOGY | DUAL EMISSION | 7-HYDROXYQUINOLINE | ABSORPTION | Analysis
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