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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 9, pp. 2320 - 2330
The β -adrenergic receptor (β AR), a G protein-coupled receptor, is an important therapeutic target. We recently described Cmpd-15, the first small molecule... 
Binding competition assays | Synthesis | Negative allosteric modulator | Structure-activity relationships | β2-Adrenergic receptor (β2AR) | AR | Adrenergic receptor (β
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 9, p. 2320
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7668, p. 480
G-protein-coupled receptors (GPCRs) pose challenges for drug discovery efforts because of the high degree of structural homology in the orthosteric pocket,... 
Drugs | Polyethylenes | G protein-coupled receptors | Homology | Hormones | Carboxylic acids | Proteins | Signaling | Side effects | Receptors | Neurotransmitters | Allosteric properties | Mutagenesis | Polyethylene glycol | Inverse agonists | Ligands | Adrenergic receptors | Cooperativity | Intracellular | Protein structure | Receptors (physiology) | Deoxyribonucleic acid--DNA | Crystal structure
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 09/2016, Volume 12, Issue 9, p. 709
  G-protein-coupled receptor (GPCR) ligands function by stabilizing multiple, functionally distinct receptor conformations. This property underlies the ability... 
Membranes | Pharmacology | Ribonucleic acid--RNA | Adapter proteins
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 7, p. 1708
  The β^sub 2^-adrenergic receptor (β^sub 2^AR) has been a model system for understanding regulatory mechanisms of G-protein-coupled receptor (GPCR) actions... 
Proteins | Molecules | Signal transduction | Deoxyribonucleic acid--DNA | Binding sites
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2011, Volume 7, Issue 10, pp. 692 - 700
Seven-transmembrane receptors (7TMRs), also called G protein-coupled receptors (GPCRs), represent the largest class of drug targets, and they can signal... 
Ligands | Humans | Mass Spectrometry | Molecular Conformation | Receptors, Adrenergic, beta-2 - metabolism | Receptors, Adrenergic, beta-2 - chemistry
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 218 - 222
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2011, Volume 7, Issue 10, p. 692
  Seven-transmembrane receptors (7TMRs), also called G protein-coupled receptors (GPCRs), represent the largest class of drug targets, and they can signal... 
Proteins | Signal transduction | Biochemistry | Pharmacology | Molecular biology | Mass spectrometry
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 10, pp. 2562 - 2567
Journal Article
Science, ISSN 0036-8075, 06/2019, Volume 364, Issue 6447, pp. 1283 - 1287
Drugs targeting the orthosteric, primary binding site of G protein–coupled receptors are the most common therapeutics. Allosteric binding sites, elsewhere on... 
Drugs | G protein-coupled receptors | Drug delivery | Selectivity | Proteins | Receptors | Allosteric properties | Respiratory diseases | Agonists | Ligands | Adrenergic receptors | Intracellular | Drug discovery | Binding sites | Crystal structure
Journal Article
Journal Article
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