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1. Full Text Oxidative stress and antioxidant defense
by Birben, E and Sahiner, Umit Murat and Sackesen, Cansin and Erzurum, Serpil and Kalayci, Omer
World Allergy Organization Journal, ISSN 1939-4551, 2012, Volume 5, Issue 1, pp. 9 - 19
Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabolism and environmental factors, such as air pollutants or... 
Edox | Xidative stress | Oxidant | Antioxidant | Eactive oxygen species | Antioxidants | Oxidative stress | Enzymes | Physiological aspects | Lipids | Nucleic acids | Cigarettes | Smoking | Asthma | Acute respiratory distress syndrome | Ionizing radiation
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2. Full Text In-vitro diagnosis of allergic diseases
by Kalayci, Omer
Clinical Biochemistry, ISSN 0009-9120, 06/2014, Volume 47, Issue 9, pp. 728 - 729
TOLERANCE | MEDICAL LABORATORY TECHNOLOGY | CHILDREN | Food Hypersensitivity - immunology | Clinical Laboratory Techniques | Humans | Basophils - immunology | Food Hypersensitivity - blood | Food Hypersensitivity - diagnosis | Immunoglobulin E - blood | Allergy | Allergic reaction | Diagnosis
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3. Full Text A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma
by Sackesen, Cansin, MD and Ercan, Hulya, MD and Dizdar, Evrim, MD and Soyer, Ozge, MD and Gumus, Pinar, MD and Tosun, Berat Nursal, PhD and Büyüktuncer, Zehra, MS and Karabulut, Erdem, PhD and Besler, Tanju, PhD and Kalayci, Omer, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2008, Volume 122, Issue 1, pp. 78 - 85
Background Even though there is ample evidence on the oxidative stress in asthma, there is limited information on the antioxidant defense systems. Objectives... 
Allergy and Immunology | antioxidant | ascorbic acid | Amino acid | lycopene | glutathione | superoxide dismutase | β-carotene | asthma | malondialdehyde | oxidative stress | glutathione peroxidase | α-tocopherol | amino acid | PROTEIN OXIDATION | beta-carotene | alpha-tocopherol | CYSTEINE KINETICS | SERUM | IMMUNOLOGY | EXTRACELLULAR-SUPEROXIDE-DISMUTASE | FREE-RADICALS | CHILDREN | ALLERGY | AMINO-ACIDS | PLASMA LYCOPENE | Malondialdehyde - metabolism | Glutathione Peroxidase - metabolism | Asthma - metabolism | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Humans | Male | beta Carotene - metabolism | Ascorbic Acid - metabolism | Amino Acids - metabolism | Adolescent | Asthma - immunology | Carotenoids - metabolism | Female | alpha-Tocopherol - metabolism | Child | Superoxide Dismutase - metabolism | Antioxidants | Enzymes | Asthma in children | Analysis | Studies | Oxidative stress | Amino acids | Skin
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4. Full Text Doublesex and mab-3 related transcription factor 1 ( DMRT1 ) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages
by Schieck, Maximilian, PhD and Schouten, Jan P., MSc and Michel, Sven, PhD and Suttner, Kathrin, PhD and Toncheva, Antoaneta A., PhD and Gaertner, Vincent D., BSc and Illig, Thomas, PhD and Lipinski, Simone, PhD and Franke, Andre, PhD and Klintschar, Michael, MD and Kalayci, Omer, MD and Sahiner, Umit M., MD and Birben, Esra, PhD and Melén, Erik, MD and Pershagen, Göran, MD, PhD and Freidin, Maxim B., PhD and Ogorodova, Ludmila M., MD, PhD, DSc and Granell, Raquel, PhD and Henderson, John, MD, PhD and Brunekreef, Bert, PhD and Smit, Henriëtte A., PhD and Vogelberg, Christian, MD and von Berg, Andrea, MD and Bufe, Albrecht, MD and Heinzmann, Andrea, MD and Laub, Otto, MD and Rietschel, Ernst, MD and Simma, Burkhard, MD and Genuneit, Jon, MD and Jonigk, Danny, MD and Postma, Dirkje S., MD, PhD and Koppelman, Gerard H., MD, PhD and Vonk, Judith M., PhD and Timens, Wim, MD, PhD and Boezen, H. Marike, PhD and Kabesch, Michael, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 2, pp. 421 - 431
Background Asthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific... 
Allergy and Immunology | DMRT1 | single nucleotide polymorphism | sex | genetic association | interaction | rs3812523 | Asthma | VARIANTS | RISK | IMMUNOLOGY | HUMAN GENOME | ALLERGY | COHORT | HEALTH | ASSOCIATION | Immunohistochemistry | Testis - metabolism | Humans | Male | Genetic Loci | Organ Specificity - genetics | Asthma - immunology | Female | Odds Ratio | Binding Sites | Child | Macrophages - immunology | Promoter Regions, Genetic | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Chromosome Mapping | Transcription Factors - genetics | Asthma - genetics | Linkage Disequilibrium | Transcription Factors - metabolism | Macrophages - metabolism | Age of Onset | Alleles | Sex Factors | Polymorphism, Single Nucleotide | Allergy | Medical colleges | Asthma in children | Genetic research | Macrophages | Allergic reaction | Epidemiology | Analysis | Proteins | Datasets | Transcription factors | Genes | Population | Software | Gender differences | Genomes | Deoxyribonucleic acid--DNA | Methods
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5. Full Text Physicians' preference for controller medication in mild persistent asthma
by Bakirtas, Arzu and Kutlu, Ali and Baccioglu, Ayse and Erkekol, Ferda Oner and Bavbek, Sevim and Kalayci, Omer and Turkish Natl Soc Allergy Clinical and Asthma Section Board Members of Turkish National Society of Allergy and Clinical Immunology
Respiratory Medicine, ISSN 0954-6111, 10/2017, Volume 131, pp. 236 - 240
Although the asthma guidelines recommend inhaled corticosteroids(ICS) or leukotriene receptor antagonists-(LTRAs) for the treatment of mild persistent asthma,... 
Mild | Physician | Persistent | Treatment | Preference | Asthma | MONTELUKAST | CARDIAC & CARDIOVASCULAR SYSTEMS | REALITY | INHALED CORTICOSTEROIDS | CHILDREN | RESPIRATORY SYSTEM | SEASONAL ALLERGIC RHINITIS | INSIGHTS | Severity of Illness Index | Attitude of Health Personnel | Physicians | Humans | Administration, Inhalation | Internal Medicine | Logistic Models | Male | Physicians, Family | Adrenal Cortex Hormones - therapeutic use | Asthma - drug therapy | Pulmonologists | Turkey | Clinical Decision-Making | Pediatricians | Adult | Female | Surveys and Questionnaires | Allergists | Leukotriene Antagonists - therapeutic use | Drug therapy | Analysis | Medical societies | Corticoids | Medical personnel | Preschool education | Drugs | Corticosteroids | Compliance | Hypersensitivity | Regression analysis | Patients | Allergies | Guidelines | Studies | Immunology | Questionnaires | Drug dosages
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6. Full Text Challenges in Identifying Asthma Subgroups Using Unsupervised Statistical Learning Techniques
by Prosperi, MCF and Sahiner, UM and Belgrave, D and Sackesen, C and Buchan, IE and Simpson, A and Yavuz, TS and Kalayci, O and Custovic, A
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ISSN 1073-449X, 12/2013, Volume 188, Issue 11, pp. 1303 - 1312
Rationale: Unsupervised statistical learning techniques, such as exploratory factor analysis (EFA) and hierarchical clustering (HC), have been used to identify... 
MIXTURE | asthma | PHENOTYPES | SYMPTOMS | machine learning | CLUSTER-ANALYSIS | EXERCISE | endotypes | children | RESPIRATORY SYSTEM | TREE | clustering | SELECTION | CRITICAL CARE MEDICINE | Asthma - diagnosis | Severity of Illness Index | Predictive Value of Tests | Data Interpretation, Statistical | Prognosis | Cross-Sectional Studies | Humans | Male | Factor Analysis, Statistical | Asthma - drug therapy | Phenotype | Turkey | Analysis of Variance | Bayes Theorem | Female | Asthma - classification | Child | Cluster Analysis
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7. Full Text MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis
by Bousquet, Jean, MD and Schünemann, Holger J., MD and Hellings, Peter W., MD and Arnavielhe, Sylvie, PhD and Bachert, Claus, MD and Bedbrook, Anna, BSc and Bergmann, Karl-Christian, MD and Bosnic-Anticevich, Sinthia, PhD and Brozek, Jan, MD and Calderon, Moises, MD and Canonica, G. Walter, MD and Casale, Thomas B., MD and Chavannes, Niels H., MD and Cox, Linda, MD and Chrystyn, Henry, PhD and Cruz, Alvaro A., MD and Dahl, Ronald, MD and De Carlo, Giuseppe, MD and Demoly, Pascal, MD and Devillier, Phillipe, MD and Dray, Gérard, PhD and Fletcher, Monica, MSc and Fokkens, Wytske J., MD and Fonseca, Joao, MD and Gonzalez-Diaz, Sandra N., MD and Grouse, Lawrence, MD and Keil, Thomas, MD and Kuna, Piotr, MD and Larenas-Linnemann, Désirée, MD and Lodrup Carlsen, Karin C., MD and Meltzer, Eli O., MD and Mullol, Jaoquim, MD and Muraro, Antonella, MD and Naclerio, Robert N., MD and Palkonen, Susanna, MD and Papadopoulos, Nikolaos G., MD and Passalacqua, Giovanni, MD and Price, David, MD and Ryan, Dermot, MD and Samolinski, Boleslaw, MD and Scadding, Glenis K., MD and Sheikh, Aziz, MD and Valiulis, Arunas, MD and Valovirta, Erkka, MD and Walker, Samantha, PhD and Wickman, Magnus, MD and Yorgancioglu, Arzu, MD and Zuberbier, Torsten, MD and MASK Study Grp
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 2, pp. 367 - 374.e2
The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity,... 
Allergy and Immunology | clinical decision support system | MACVIA-LR | Allergic Rhinitis and its Impact on Asthma | conjunctivitis | information and communication technology | Allergic rhinitis | INTRANASAL THERAPY | MOMETASONE FUROATE | IMMUNOLOGY | FUROATE NASAL SPRAY | VISUAL ANALOG SCALE | IMPORTANT DIFFERENCE | PRIMARY-CARE | ALLERGY | EUROPEAN INNOVATION PARTNERSHIP | DOUBLE-BLIND | QUALITY-OF-LIFE | POSITION PAPER | Allergens | Algorithms | Rhinitis | Travelers | Chronic diseases | Youth | Teenagers | Chairpersons | Consulting services | Studies | Pain | Decision making | Patient satisfaction | Drug therapy | Preferences | Patients | Disease control | Allergies | Asthma | Quality of life | Clinical decision support system | Conjuctivitis | Information and communication technology | Life Sciences | Human health and pathology
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8. Full Text Genetic associations of the response to inhaled corticosteroids in children during an asthma exacerbation
by Keskin, Ozlem and Uluca, Ünal and Birben, Esra and Coşkun, Yavuz and Ozkars, Mehmet Yasar and Keskin, Mehmet and Kucukosmanoglu, Ercan and Kalayci, Omer
Pediatric Allergy and Immunology, ISSN 0905-6157, 08/2016, Volume 27, Issue 5, pp. 507 - 513
BackgroundGenetic associations of the response to inhaled corticosteroids (ICSs) during an asthma exacerbation are unknown. ObjectiveTo evaluate the role of... 
asthma | gene | inhaled corticosteroid | pharmacogenetics | child | exacerbation | Exacerbation | Pharmacogenetics | Gene | Child | Inhaled corticosteroid | Asthma | GLUCOCORTICOID-RECEPTOR GENE | SPIROMETRY | PHENOTYPES | IMMUNOLOGY | BCLI POLYMORPHISM | CHILDHOOD ASTHMA | METABOLISM | ALLERGY | DISEASE | PEDIATRICS | FLUTICASONE | Genetic Association Studies | Anti-Asthmatic Agents - therapeutic use | Gene Frequency | Humans | Administration, Inhalation | Genotype | Male | Treatment Outcome | Asthma - drug therapy | Asthma - genetics | Fluticasone - therapeutic use | Adolescent | Receptors, Glucocorticoid - genetics | Female | Biomarkers, Pharmacological - metabolism | Corticosteroids | Fluticasone | Single nucleotide polymorphisms | Asthma in children | Pediatrics | Genetics | Steroids
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9. Full Text Oxidative stress in asthma
by Sahiner, Umit M and Birben, Esra and Erzurum, Serpil and Sackesen, Cansin and Kalayci, Omer
World Allergy Organization Journal, ISSN 1939-4551, 2011, Volume 4, Issue 10, pp. 151 - 158
Asthma is a chronic inflammatory lung disease that results in airflow limitation, hyperreactivity, and airway remodeling. There is strong evidence that an... 
Redox | Oxidative stress | Reactive oxygen species | Asthma | Antioxidants | Nitric oxide | Peroxides | Inflammation | Superoxide
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10. Full Text Electronic Clinical Decision Support System for allergic rhinitis management: MASK e‐CDSS
by Courbis, Anne‐Lise and Murray, Ruth Brigid and Arnavielhe, Sylvie and Caimmi, Davide and Bedbrook, Anna and Van Eerd, Michiel and De Vries, Govert and Dray, Gerard and Agache, Ioana and Morais‐Almeida, Mario and Bachert, Claus and Bergmann, Karl Christian and Bosnic‐Anticevich, Sinthia and Brozek, Jan and Bucca, Caterina and Camargos, Paulo and Canonica, Giorgio Walter and Carr, Warner and Casale, Thomas and Fonseca, Joao A and Haahtela, Tari and Kalayci, Omer and Klimek, Ludger and Kuna, Piotr and Kvedariene, Violeta and Larenas Linnemann, Desiree and Lieberman, Phil and Mullol, Joaquim and Ohehir, Robyn and Papadopoulos, Nikolaos and Price, David and Ryan, Dermot and Samolinski, Boleslaw and Simons, F. Estelle and Tomazic, Peter and Triggiani, Massimo and Valiulis, Arunas and Valovirta, Erkka and Wagenmann, Martin and Wickman, Magnus and Yorgancioglu, Arzu and Bousquet, Jean and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Centrum för klinisk forskning i Sörmland (CKFD)
Clinical & Experimental Allergy, ISSN 0954-7894, 12/2018, Volume 48, Issue 12, pp. 1640 - 1653
Background: Allergic rhinitis (AR) management has changed in recent years following the switch from the concept of disease severity to the concept of disease... 
VISUAL ANALOG SCALE | IMPACT | ALLERGY | VALIDATION | ASTHMA | QUALITY-OF-LIFE | IMMUNOLOGY | Rhinitis | Health care industry | Algorithms | Decision support systems | Health care | Diaries | Tablets | Health | Hypersensitivity | Medical services | Embedding | Management | Disease control | Allergies | Augmented reality | Interfaces | Java (programming language) | Allergic rhinitis | Digitization | Life Sciences | Human health and pathology | Embedded Systems | Computer Science | Information Systems | Data- och informationsvetenskap | Naturvetenskap | Natural Sciences | Computer and Information Sciences | Systemvetenskap, informationssystem och informatik
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11. Full Text Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma
by Ercan, Hulya and Birben, Esra and Dizdar, Evrim A and Keskin, Ozlem and Karaaslan, Cagatay and Soyer, Ozge U and Dut, Raziye and Sackesen, Cansin and Besler, Tanju and Kalayci, Omer
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2006, Volume 118, Issue 5, pp. 1097 - 1104
The factors contributing to the oxidant/antioxidant imbalance in asthma are incompletely understood. To determine the factors associated with oxidative stress... 
severity | glutathione | oxidation | malondialdehyde | glutathione S transferase | Asthma | genotype | BRONCHIAL HYPERRESPONSIVENESS | RISK-FACTORS | LIPID-PEROXIDATION | AIRWAY INFLAMMATION | asthma | IMMUNOLOGY | ALLERGIC SUBJECTS | IN-VITRO | ALLERGY | SUPERGENE FAMILY | GSTP1 LOCUS | GLUTATHIONE-S-TRANSFERASE | SUPEROXIDE-DISMUTASE | Malondialdehyde - metabolism | Severity of Illness Index | Asthma - metabolism | Glutathione - metabolism | Humans | Oxidative Stress - genetics | Oxidative Stress - immunology | Genotype | Male | Oxidants - adverse effects | Asthma - genetics | Glutathione Transferase - genetics | Adolescent | Female | Asthma - pathology | Child | Asthma - epidemiology | Glutathione S-Transferase pi - genetics | Antioxidants | Medical colleges | Thiols | Asthma in children | Superoxide dismutase | Superoxide | Glutathione | Studies | Oxidative stress | Enzymes | Free radicals | Hydrogen peroxide | Disease | Population | Age
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12. Full Text The effect of montelukast on early‐life wheezing: A randomized, double‐blinded placebo‐controlled study
by Keskin, Ozlem and Arik Yilmaz, Ebru and Motzkus, Christine and Sackesen, Cansin and Lilly, Craig M and Kalayci, Omer
Pediatric Allergy and Immunology, ISSN 0905-6157, 02/2018, Volume 29, Issue 1, pp. 50 - 57
Background: Cysteinyl-leukotrienes are increased in the airways of infants with virus-associated wheezing. We aimed to determine the effects of a... 
asthma | wheezing | leukotriene | exhaled breath condensate | child | MEPOLIZUMAB | MANAGEMENT | PRACTICAL GUIDE | NUMBERS | ANTIBODY | IMMUNOLOGY | CHILDREN | THERAPY | ALLERGY | HYPEREOSINOPHILIC SYNDROME | PEDIATRICS | EOSINOPHILIC ESOPHAGITIS | Clinical trials | Medicine, Experimental | Medical research | Wheeze | Analysis | Asthma | Caregivers | Randomization | Leukotrienes | Montelukast | Viruses | Wheezing | Infants | Salbutamol | Children
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13. Full Text Neuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients with Intracranial Hemorrhage
by Alatas, Omer Doʇan and Gürger, Mehtap and Ateşçelik, Metin and Yildiz, Mustafa and Demir, Caner Feyzi and Ekingen, Evren and Kalayci, Mehmet and Ilhan, Nevin and Acar, Ethem
Medicine (United States), ISSN 0025-7974, 11/2015, Volume 94, Issue 45, p. e2007
The authors evaluated neuron-specific enolase (NSE), S100 calcium-binding protein B (S100B), and heat shock protein 70 (HSP 70) levels and their relationships... 
SHOCK | MEDICINE, GENERAL & INTERNAL | HSP70 | TRAUMATIC BRAIN-INJURY | STRESS GENE | MARKERS | S-100B | PATTERNS | EXPRESSION | DAMAGE | SPONTANEOUS INTRACEREBRAL HEMORRHAGE | Prognosis | Hospital Mortality | Humans | Middle Aged | Male | Academic Medical Centers | S100 Calcium Binding Protein beta Subunit - blood | HSP70 Heat-Shock Proteins - blood | Intracranial Hemorrhages - diagnosis | Glasgow Coma Scale | Phosphopyruvate Hydratase - blood | Intracranial Hemorrhages - blood | Biomarkers | Female | Aged | CT imaging | Brain | Usage | Heat shock proteins | Research | Medical screening | Hemorrhage | Health aspects
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14. Full Text Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology
by Bousquet, Jean and Bousquet, P.J and Bousquet, J and Hellings, P.W and Hellings, Peter W and Agache, Ioana and Agache, I and Amat, F and Amat, Flore and Annesi-Maesano, Isabella and Annesi-Maesano, I and Ansotegui, Ignacio J and Ansotegui, I.J and Anto, Josep M and Anto, J.M and Bachert, Claus and Bachert, C and Bateman, Eric D and Bateman, E.D and Bedbrook, Anna and Bedbrook, A and Bennoor, K.S and Bennoor, Kazi and Bewick, M and Bewick, Mickael and Bindslev-Jensen, C and Bindslev-Jensen, Carsten and Bosnic-Anticevich, Sinthia and Bosnic-Anticevich, C.S and Bosse, Isabelle and Bosse, I and Brozek, J and Brozek, Jan and Brussino, Luisa and Canonica, G.W and Canonica, Giorgio W and Cardona, V and Cardona, Victoria and Casale, Thomas and Casale, T and Cepeda Sarabia, A.M and Cepeda Sarabia, Alfonso M and Chavannes, N.H and Chavannes, Niels H and Cecchi, Lorenzo and Cecchi, L and Correia de Sousa, J and Correia de Sousa, Jaime and Costa, E and Costa, Elisio and Cruz, A.A and Cruz, Alvaro A and Czarlewski, W and Czarlewski, Wienczyslawa and De Carlo, G and De Carlo, Giuseppe and De Feo, G and De Feo, Giulia and Demoly, Pascal and Demoly, P and Devillier, P and Devillier, Philippe and Dykewicz, Mark S and Dykewicz, M.S and El-Gamal, Yehia and El-Gamal, Y and Eller, E and Eller, Esben E and Fonseca, Joao A and Fonseca, J.A and Fontaine, J.F and Fontaine, Jean-François and Fokkens, Wytske J and Fokkens, W.J and Guzmán, M.A and Guzmán, Maria-Antonieta and Haahtela, Tari and Haahtela, T and Illario, Maddalena and Illario, M and Ivancevich, Juan-Carlos and Ivancevich, J.C and Just, Jocelyne and Kaidashev, Igor and Kaidashev, I and Khaitov, M and Khaitov, Musa and Kalayci, Omer and Kalayci, O and Keil, T and Keil, Thomas and Klimek, L and Klimek, Ludger and Kowalski, Marek L and Kowalski, M.L and Kuna, Piotr and Kuna, P and Kvedariene, Violeta and Kvedariene, V and Larenas-Linnemann, D and ... and Mobile Airways Sentinel Network M
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 03/2019, Volume 143, Issue 3, pp. 864 - 879
Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology...