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by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Science, ISSN 0036-8075, 11/2018, Volume 362, Issue 6416, pp. 834 - 839
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA.... 
CELLS | SITE | BASE MODIFICATIONS | OXIDATIVE DNA-DAMAGE | SPECIFICITY | REPAIR ENZYME | DEMETHYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | 8-OXOGUANINE-DNA GLYCOSYLASE | DEFICIENCY | Gene Expression - drug effects | Guanine - analogs & derivatives | Humans | Guanine - antagonists & inhibitors | NF-kappa B - metabolism | DNA Repair - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Guanine - metabolism | Inflammation - drug therapy | Mice, Mutant Strains | Enzyme Inhibitors - chemistry | HEK293 Cells | DNA Glycosylases - metabolism | Promoter Regions, Genetic | DNA Repair - drug effects | Jurkat Cells | Enzyme Inhibitors - pharmacology | Gene Knockout Techniques | Enzyme Inhibitors - therapeutic use | Tumor Necrosis Factor-alpha - pharmacology | Animals | NF-kappa B - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | DNA Glycosylases - antagonists & inhibitors | Inflammation - genetics | Mice | Care and treatment | Physiological aspects | Genetic research | DNA glycosylases | Inflammation | DNA repair | Methods | Chromatin | Reactive oxygen species | Genes | DNA damage | DNA glycosylase | Base excision repair | Guanine | Lipopolysaccharides | Oxidation resistance | Tumor necrosis factor-TNF | Inhibition | Repair | Deoxyribonucleic acid--DNA | Binding | Macromolecules | Leukocytes (neutrophilic) | Gene expression | Substrates | Immune systems | Inhibitors | Lungs | OGG1 protein | Tumor necrosis factor | Tumors | Index Medicus | Medical Biotechnology | Biological Sciences | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinsk bioteknologi | Natural Sciences | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2011, Volume 81, Issue 3, pp. 402 - 411
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Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2012, Volume 83, Issue 12, pp. 1655 - 1662
Journal Article
Cell, ISSN 0092-8674, 07/2017, Volume 170, Issue 2, p. 407
Our study reported the discovery of a class of small molecules that induces the massive vacuolization and cell death of glioblastoma cells in vitro, attenuates... 
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Journal Article
Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7651, p. 508
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