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Free Radical Biology and Medicine, ISSN 0891-5849, 05/2019, Volume 135, p. 28
Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the degeneration of dopamine neurons of the substantia nigra pars compacta... 
Oxidative stress
Journal Article
Mitochondrion, ISSN 1567-7249, 05/2019, Volume 46, pp. 158 - 163
Amongst various therapeutic properties of the natural product embelin, its anti-cancer effects are being extensively studied. We observed that, embelin induced... 
Mitochondrial respiration | Oxidative stress | p38 MAP kinase | Embelin | p53 | Apoptosis | PROTEIN | PHOSPHORYLATION | SUPPRESSION | CELL BIOLOGY | INHIBITION | NUCLEAR-FACTOR | GENETICS & HEREDITY | LYMPHOCYTES | COX-2 inhibitors | Analysis | Cancer cells | Mitochondrial DNA | Tumor proteins | Mitogens | Protein kinases | Cancer
Journal Article
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2010, Volume 48, Issue 3, pp. 377 - 383
a-Synuclein (a-syn) is a presynaptic protein that is widely implicated in the pathophysiology of Parkinson's disease (PD). Emerging evidence indicates a strong... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 603 - 619
Three series of compounds; pyridinyl-1H-1,2,3-triazoles, pyridinyl-1H-1,2,3-triazolylisoxazoles and pyridinyl-1H-1,2,3-triazolyldihydroisoxazoles with TMP... 
Triazolyldihydroisoxazoles | Pyridinyl-1H-1,2,3-triazoles | Molecular modeling | Anti-cancer activity | Anti-tubulin activity | Triazolylisoxazoles | 2-Chloronicotinaldehyes
Journal Article
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2010, Volume 49, Issue 11, pp. 1674 - 1684
The objective of this study was to assess the neuroprotective effects of a mitochondria-targeted antioxidant, Mito-Q , the coenzyme-Q analog attached to a... 
Co-Q | Oxidative stress | Parkinson's disease | Free radicals | Oxidants | Mito-Q 10 | MPTP | MPP | Mito-Q | SELECTIVE-INHIBITION | MONOAMINE-OXIDASE | MPTP MODEL | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIOXIDANT MITOQUINONE | Mito Q | DOPAMINERGIC-NEURONS | NEURODEGENERATIVE DISEASES | BRAIN MITOCHONDRIA | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | Co Q | Male | Ubiquinone - pharmacology | Neuroprotective Agents - pharmacology | Osmolar Concentration | Cytoprotection - drug effects | Neurons - physiology | Organophosphorus Compounds - pharmacology | Neurons - metabolism | Drug Evaluation, Preclinical | Neurons - drug effects | Neuroprotective Agents - administration & dosage | Dopamine - metabolism | Disease Models, Animal | Neurotoxins | Ubiquinone - administration & dosage | Cells, Cultured | Rats | Mitochondria - metabolism | Parkinsonian Disorders - chemically induced | Mitochondria - drug effects | Animals | Parkinsonian Disorders - pathology | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Mice | Organophosphorus Compounds - administration & dosage | Parkinsonian Disorders - prevention & control | Mitochondria - physiology | Drug Delivery Systems - methods | Antioxidants | Phosphates | Metabolites | Analysis | Models | Mitochondrial DNA | Drug therapy | Free radicals (Chemistry) | Antiparkinsonian agents | Index Medicus
Journal Article
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2010, Volume 48, Issue 3, pp. 377 - 383
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2005, Volume 39, Issue 5, pp. 567 - 583
The purpose of this study was to test the hypothesis whether Mito-carboxy proxyl (Mito-CP), a mitochondria-targeted nitroxide, inhibits peroxide-induced... 
Oxidative stress | Mitochondria | Nitrooxide | SOD | Iron | Free radical | Apoptosis | ACTIVATION | mitochondria | nitrooxide | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | DEPENDENT IRON UPTAKE | COMPLEX I DEFICIENCY | ELECTRON-TRANSPORT CHAIN | REACTIVE OXYGEN | ENDOTHELIAL-CELLS | PROTEASOME | ENDOCRINOLOGY & METABOLISM | NITRIC-OXIDE | TARGETED ANTIOXIDANTS | iron | free radical | STRESS | oxidative stress | Aconitate Hydratase - metabolism | Endothelium, Vascular - cytology | Mitochondria - enzymology | Gas Chromatography-Mass Spectrometry | Models, Chemical | Oxidative Stress | Peroxides - pharmacology | Oxygen - metabolism | Hydrogen Peroxide - chemistry | Lipids - chemistry | Caspases - metabolism | Flow Cytometry | Time Factors | Cattle | Cyclic N-Oxides - pharmacology | Organophosphorus Compounds - pharmacology | Catalysis | Xanthine Oxidase - metabolism | Glucose Oxidase - metabolism | Electron Spin Resonance Spectroscopy | Free Radicals | Cell Survival | Cytochromes c - metabolism | Hydrogen Peroxide - pharmacology | Superoxides - chemistry | Proteasome Endopeptidase Complex - chemistry | Mitochondria - metabolism | Xanthine - chemistry | Antioxidants - pharmacology | Iron - metabolism | Receptors, Transferrin - metabolism | Superoxide Dismutase - chemistry | Animals | Membrane Potentials | Endothelial Cells - cytology | Cytosol - metabolism | Aorta - cytology | Proteasome Endopeptidase Complex - metabolism | Lipid Peroxidation | Nitric Oxide - metabolism | Transferrin - metabolism | Microscopy, Fluorescence | Receptors, Transferrin - chemistry | Oxidases | Transferrin | Cell research | Membrane potentials | Superoxide dismutase | Mitochondrial DNA | Superoxide | Glucose | Sulfates | Dextrose | Endothelium | Cytochrome c | Purines | Surface active agents | Molybdenum compounds | Index Medicus
Journal Article