X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (9) 9
histone deacetylase inhibitors - chemistry (5) 5
humans (5) 5
molecular dynamics simulation (5) 5
protein (5) 5
analysis (4) 4
hdac inhibitors (4) 4
histone deacetylases - chemistry (4) 4
histone deacetylases - metabolism (4) 4
molecular dynamics (4) 4
protein binding (4) 4
binding (3) 3
binding sites (3) 3
biochemistry & molecular biology (3) 3
chemistry, multidisciplinary (3) 3
enzymes (3) 3
force-field (3) 3
models (3) 3
pharmacology & pharmacy (3) 3
acid (2) 2
biochemical research methods (2) 2
biophysics (2) 2
cancer (2) 2
chemistry, medicinal (2) 2
computer science, interdisciplinary applications (2) 2
crystal-structure (2) 2
design (2) 2
drug design (2) 2
drug discovery (2) 2
histone deacetylase inhibitors (2) 2
histone deacetylase inhibitors - metabolism (2) 2
hydrogen bonding (2) 2
inhibitors (2) 2
ligands (2) 2
models, molecular (2) 2
molecular conformation (2) 2
molecular docking simulation (2) 2
proteins (2) 2
structure-activity relationship (2) 2
thermodynamics (2) 2
3-dimensional structures (1) 1
3-isopropylmalate dehydrogenase (1) 1
access channels (1) 1
accuracy (1) 1
accurate prediction (1) 1
activation (1) 1
acute promyelocytic leukemia (1) 1
algorithms (1) 1
amino acid sequence (1) 1
amino-acid (1) 1
animals (1) 1
apoptosis (1) 1
article (1) 1
arzneimittelzusammensetzung (1) 1
ausgangsmaterial (1) 1
benzamides - chemistry (1) 1
benzamides - pharmacology (1) 1
binding free energies (1) 1
binding mode (1) 1
binding-sites (1) 1
biocatalysts (1) 1
bioinformatics (1) 1
biokatalysator (1) 1
blockade (1) 1
calcium channels (1) 1
cancer-cells (1) 1
cancer-therapy (1) 1
cardiac k+ channels (1) 1
cardiotoxicity (1) 1
cardiotoxicity - pathology (1) 1
care and treatment (1) 1
catalytic domain (1) 1
channels (1) 1
charge-material (1) 1
chemical properties (1) 1
chemistry (1) 1
chemistry, physical (1) 1
chromosome mapping - standards (1) 1
class-i (1) 1
clinical-trials (1) 1
complex (1) 1
computational biology - methods (1) 1
computational simulation (1) 1
computer science, information systems (1) 1
computer simulation (1) 1
computer-aided design (1) 1
continuum solvent (1) 1
crystal-structures (1) 1
crystallography (1) 1
crystallography, x-ray (1) 1
cycle arrest (1) 1
cytochrome p450s (1) 1
data-bank (1) 1
database (1) 1
database searching (1) 1
databases, protein (1) 1
de-novo design (1) 1
directed evolution (1) 1
dna-sequences (1) 1
drug approval (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


BBA - General Subjects, ISSN 0304-4165, 06/2019, Volume 1863, Issue 6, pp. 1116 - 1126
Human Ca 1.2 (hCav1.2), a calcium selective voltage-gated channel, plays important roles in normal cardiac and neuronal functions. Calcium influx and gating... 
External-electric field | Near-open conformation | Steered MD | Human CaV
Journal Article
BBA - General Subjects, ISSN 0304-4165, 06/2019, Volume 1863, Issue 6, p. 1116
Human Ca.sub.V1.2 (hCav1.2), a calcium selective voltage-gated channel, plays important roles in normal cardiac and neuronal functions. Calcium influx and... 
Calcium channels | Analysis | Molecular dynamics | Models | Electric fields | Neurophysiology
Journal Article
Drug Discovery Today, ISSN 1359-6446, 2011, Volume 16, Issue 17, pp. 831 - 839
Several technology-based strategies have been developed to address the significance of the two phases of drug discovery: hit identification and lead... 
DE-NOVO DESIGN | HIGH-THROUGHPUT | PROTEIN-LIGAND DOCKING | STRATEGY | SURFACE | PHARMACOLOGY & PHARMACY | INHIBITORS | MOLECULAR DOCKING | BINDING | PROGRAM | PREDICTION | Computational Biology - methods | Molecular Conformation | Drug Design | Software | Structure-Activity Relationship | Computer-Aided Design | Internet
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 01/2013, Volume 1834, Issue 1, pp. 317 - 328
Histone deacetylases (HDACs) are important class of enzymes that deacetylate the ε-amino group of the lysine residues in the histone tails to form a closed... 
structure based descriptors | HDAC inhibitors | e-Pharmacophore | HDAC | CANCER-CELLS | APOPTOSIS | DESIGN | PROTEIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLE ARREST | ISOFORM SELECTIVITY | BIOPHYSICS | LYMPHOCYTIC-LEUKEMIA CELLS | FORCE-FIELD | HISTONE DEACETYLASE INHIBITORS | Enzymes | Care and treatment | Gene expression | Analysis | Cancer
Journal Article
ISSN 1463-9076, 1/2014, Volume 16, Issue 8, pp. 3777 - 3791
The inhibitors of class I histone deacetylases (HDACIs) have gained significant interest in cancer therapeutics. Virtual high throughput screening (vHTS) is... 
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, pp. 247a - 247a
Journal Article
ISSN 1463-9262, 11/2017, Volume 19, Issue 22, pp. 5375 - 538
The development of new biocatalysts using ancestral sequence reconstruction is reported. When applied to an ω-transaminase, the ancestral proteins demonstrated... 
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 03/2018, Volume 38, Issue 2, pp. i - i
Journal Article
Biochimica et Biophysica Acta: Proteins and Proteomics, ISSN 1570-9639, 01/2013, Volume 1834, Issue 1, pp. 317 - 328
Histone deacetylases (HDACs) are important class of enzymes that deacetylate the [e]-amino group of the lysine residues in the histone tails to form a closed... 
Journal Article
Expert Opinion on Drug Discovery, ISSN 1746-0441, 03/2018, Volume 13, Issue 3, pp. 207 - 210
Journal Article