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Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11185
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2018, Volume 20, Issue suppl_6, pp. vi205 - vi205
Abstract Anaplastic astrocytomas are aggressive cancers of glial cells that present poor prognosis and high recurrence. Heterozygous mutations in IDH1 and IDH2... 
Abstracts
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 400, pp. 110 - 116
Abstract Diffuse intrinsic pontine glioma (DIPG) is an invasive and treatment-refractory pediatric brain tumor. Primary DIPG tumors harbor a number of... 
Hematology, Oncology and Palliative Medicine | mTOR | Pediatric brain tumor | Sapanisertib | INK128 | MLN0128 | ACTIVATION | GRADE GLIOMA | ANTITUMOR-ACTIVITY | BREAST-CANCER CELLS | NEURAL STEM-CELLS | GLIOBLASTOMA | ONCOLOGY | K27M MUTATION | IN-VIVO | GROWTH | THERAPEUTIC TARGETS | Benzoxazoles - pharmacology | Phosphorylation | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | Brain Stem Neoplasms - pathology | Humans | Mechanistic Target of Rapamycin Complex 2 | Chemoradiotherapy | Mechanistic Target of Rapamycin Complex 1 | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Time Factors | Glioma - pathology | Glioma - therapy | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Brain Stem Neoplasms - enzymology | Glioma - enzymology | Neoplasm Invasiveness | Radiation-Sensitizing Agents - pharmacology | Pyrimidines - pharmacology | Mice, SCID | Cell Movement - radiation effects | Radiation Tolerance - drug effects | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Brain Stem Neoplasms - therapy | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Cell Proliferation - radiation effects | Physiological aspects | Medical colleges | Gliomas | Analysis | Brain tumors | TOR protein | Cell proliferation | Brain | Cell survival | Inhibitor drugs | Brain cancer | Radiation | AKT protein | Pharmacology | Rapamycin | Tumorigenicity | Metabolism | Kinases | Survival | Cell growth | Inhibitors | Radiosensitization | Glioma | Mutation | Inhibition | Tumors | Apoptosis | sapanisertib | pediatric brain tumor
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 6/2014, Volume 127, Issue 6, pp. 881 - 895
Journal Article
Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 05/2019, Volume 78, Issue 5, pp. 380 - 388
Abstract Diffuse intrinsic pontine gliomas (DIPGs) are deadly tumors comprising 10%-15% of all childhood CNS cancers. Standard treatment is considered... 
PEDIATRIC HIGH-GRADE | CELLS | SUPPRESSOR GENE | WT1 PROTEIN | SUBGROUPS | PATHOLOGY | Childhood midline glioma | NEUROSCIENCES | CLINICAL NEUROLOGY | Wilms tumor protein (WT1) | GLIOBLASTOMA | MUTATIONS | Brainstem glioma | Diffuse intrinsic pontine glioma (DIPG) | Original
Journal Article
Neuro-Oncology, ISSN 1522-8517, 04/2019, Volume 21, Issue Supplement_2, pp. ii76 - ii76
Abstract Pediatric brain cancers remain amongst the most lethal childhood cancers with over five decades of failed clinical trials. However, precision based... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 04/2019, Volume 21, Issue Supplement_2, pp. ii76 - ii76
Journal Article
Neuro-Oncology, ISSN 1522-8517, 04/2019, Volume 21, Issue Supplement_2, pp. ii85 - ii85
Abstract INTRODUCTION: Molecular profiling of the tumor genome is critical for diagnosis and clinical management of CNS tumors. In the case of pediatric... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 04/2019, Volume 21, Issue Supplement_2, pp. ii75 - ii76
Abstract INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) has one of the lowest overall survival amongst pediatric brain cancers. DIPG can be stratified... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 04/2019, Volume 21, Issue Supplement_2, pp. ii91 - ii92
Abstract In order to define the mutational landscape across histone genes in pediatric CNS cancers, we surveyed 1,000 patients from the Children’s Brain Tumor... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i59 - i59
Abstract Diffuse intrinsic pontine glioma (DIPG) is the leading cause of mortality in pediatric central nervous system cancers. Histone mutations are found in... 
Abstracts
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i59 - i60
Abstract INTRODUCTION Childhood thalamic gliomas are rare cancers, accounting for 5% of all pediatric brain tumors and are of glial origin. The recent WHO... 
Abstracts
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 01/2020, Volume 9
Anaplastic astrocytomas are aggressive glial cancers that present poor prognosis and high recurrence. Heterozygous IDH1 R132H mutations are common in... 
ddPCR | AYA (adolescents and young adults) | cancer predisposition | IDH1 R132H mutation | anaplastic astrocytoma | mosaicism
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 810 - 810
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 4887 - 4887
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i59 - i59
Abstract INTRODUCTION Sharing research ready data between multiple institutions and across different platforms is a lengthy and cumbersome process which can... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i55 - i55
Abstract Immunotherapy is currently being used to treat pediatric brain cancer, though its efficacy in treating patients with diffuse intrinsic pontine glioma... 
Abstracts
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2018, Volume 20, Issue suppl_6, pp. vi206 - vi207
Abstract Pediatric midline gliomas, especially those associated with the pons, known as diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain... 
Abstracts
Journal Article
Neuro-Oncology, ISSN 1522-8517, 06/2018, Volume 20, Issue suppl_2, pp. i97 - i97
Abstract Midline high-grade gliomas (HGGs) are amongst the most challenging childhood cancers to treat. Recent advances in understanding the molecular drivers... 
Abstracts
Journal Article
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