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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 29, pp. 12030 - 12035
Death of pancreatic β cells is a pathological hallmark of type 1 diabetes (T1D). However, the molecular mechanisms of β cell death and its regulation are... 
Beta cells | MicroRNA | Cytokines | Cell death | Islet cells | Mice | Diabetes | Bone marrow cells | Type 1 diabetes mellitus | Apoptosis | Autoimmunity | APOPTOSIS | NOD MICE | autoimmunity | AUTOIMMUNE INFLAMMATION | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR PDCD4 | MICRORNAS | UP-REGULATION | EXPRESSION | CANCER | PROGRAMMED CELL-DEATH-4 | Diabetes Mellitus, Type 1 - prevention & control | NF-kappa B - immunology | Immunoblotting | MicroRNAs - metabolism | NF-kappa B - metabolism | DNA Primers - genetics | Insulin-Secreting Cells - metabolism | Flow Cytometry | Cell Death - genetics | Apoptosis Regulatory Proteins - deficiency | Diabetes Mellitus, Type 1 - immunology | Insulin-Secreting Cells - physiology | Apoptosis Regulatory Proteins - immunology | Gene Expression Regulation - immunology | Mice, Inbred C57BL | RNA-Binding Proteins - immunology | MicroRNAs - immunology | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Animals | Analysis of Variance | Cell Death - physiology | Mice, Inbred NOD | RNA-Binding Proteins - metabolism | Index Medicus | Bax protein | RNA | Transcription | Streptozocin | Diabetes mellitus | Lymphocytes T | Promoters | NF- Kappa B protein | Molecular modelling | Tumor suppressor genes | miRNA | Toxins | Pancreas | Biological Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2019, Volume 129, Issue 1, pp. 209 - 214
Journal Article
Diabetes, ISSN 0012-1797, 09/2018, Volume 67, Issue 9, pp. 1807 - 1815
Type 2 diabetes mellitus (T2DM) is characterized by the inability of the insulin-producing -cells to overcome insulin resistance. We previously identified an... 
DLK1-GTL2 IMPRINTED DOMAIN | POOR-PROGNOSIS | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | HISTONE MODIFICATIONS | IDENTIFICATION | AFFECTS CELL-PROLIFERATION | EXPRESSION | CANCER | NONCODING RNA MEG3 | REGION | Tissue Banks | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Humans | DNA (Cytosine-5-)-Methyltransferase 1 - chemistry | Green Fluorescent Proteins - genetics | Diabetes Mellitus, Type 2 - metabolism | Genetic Loci | Recombinant Fusion Proteins - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | DNA Methylation | DNA (Cytosine-5-)-Methyltransferase 1 - genetics | Islets of Langerhans - metabolism | Membrane Proteins - metabolism | Green Fluorescent Proteins - chemistry | Repressor Proteins - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | Repressor Proteins - chemistry | Cytokines - metabolism | Islets of Langerhans - pathology | Membrane Proteins - genetics | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Repressor Proteins - genetics | Locus Control Region | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Homeodomain Proteins - chemistry | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Enhancer Elements, Genetic | Mice | Diabetes Mellitus, Type 2 - pathology | Mutation | Oxidative Stress - drug effects | RNA, Long Noncoding - metabolism | Type 2 diabetes | Diabetics | Care and treatment | Usage | Pancreatic beta cells | Genetic aspects | High-throughput screening (Biochemical assaying) | Research | Health aspects | Oxidative stress | Transcription factors | Cytokines | Diabetes mellitus | Regulatory sequences | Nkx2.2 protein | Preadipocyte factor 1 | Insulin | Next-generation sequencing | Alleles | DNA methylation | Insulin resistance | Diabetes | Chromosome 14 | Methylation | Diabetes mellitus (non-insulin dependent) | Conformation | Index Medicus | Abridged Index Medicus | 0709 | Islet Studies
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 07/2014, Volume 5
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2014, Volume 19, Issue 1, pp. 135 - 145
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2017, Volume 127, Issue 1, p. 215
The recognition of [beta] cell dedifferentiation in type 2 diabetes raises the translational relevance of mechanisms that direct and maintain [beta] cell... 
Pancreatic beta cells | Genetic transcription | Gene expression | Analysis | Transcription factors | Funding | Genomics | Colleges & universities | Childrens health | Glucose | Insulin | Children & youth | Proteins | Hospitals | Rodents | Epigenetics | Software | Diabetes
Journal Article
Journal Article
01/2016, ISBN 1339827395
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by inadequate insulin secretion by the pancreatic β-cell in response to increased... 
Cellular biology | Genetics | Molecular biology
Dissertation
Journal of Clinical Investigation, ISSN 0021-9738, 01/2019, Volume 129, Issue 1, p. 209
The loss of insulin-secreting [beta] cells is characteristic among type I and type II diabetes. Stimulating proliferation to expand sources of [beta] cells for... 
Pancreatic beta cells | Research | Gene expression | Cell cycle
Journal Article
Journal Article
Epigenetics & Chromatin, ISSN 1756-8935, 12/2015, Volume 8, Issue 1
We have applied the BisPCR.sup.2 technique to validate differential methylation at several type 2 diabetes risk loci identified in genome-wide studies of human... 
Type 2 diabetes | Epigenetic inheritance | Sulfites | Analysis | Bar codes | Genes | Genomics | Genomes | Nucleotide sequencing | Methylation | DNA sequencing
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 01/2011, Volume 22, Issue 2, pp. 189 - 201
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2017, Volume 127, Issue 1, pp. 215 - 229
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2011, Volume 108, Issue 29, pp. 12030 - 12035
Death of pancreatic [beta] cells is a pathological hallmark of type 1 diabetes (T1D). However, the molecular mechanisms of [beta] cell death and its regulation... 
Prevention | Pancreatic beta cells | MicroRNA | Cell death | Type 1 diabetes | Physiological aspects | Research | Signal transduction | Diabetes | Ribonucleic acid--RNA | Pancreas | Apoptosis
Journal Article