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Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 105 - 109
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK... 
MESSENGER-RNA TRANSLATION | SILVESTROL | MELANOMA | INITIATION | RAF | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | LEUKEMIA-CELLS | MODEL | FEEDBACK INHIBITION | Triterpenes - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Melanoma - genetics | Protein Binding - drug effects | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphorylation - drug effects | Eukaryotic Initiation Factor-4F - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Eukaryotic Initiation Factor-4F - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Eukaryotic Initiation Factor-4A - metabolism | Drug Resistance, Neoplasm - drug effects | Thyroid Neoplasms - pathology | Antimitotic agents | Pharmaceutical research | Vemurafenib | Protein research | Research | Antineoplastic agents | Drug resistance | Phosphorylation | Biopsy | Melanoma | Mutation | Metastasis | Cancer therapies | Tumors | Cancer | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Cancer Research, ISSN 0008-5472, 01/2017, Volume 77, Issue 2, pp. 557 - 565
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2012, Volume 18, Issue 1, pp. 263 - 272
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2011, Volume 17, Issue 20, pp. 6522 - 6530
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 65, pp. 108786 - 108801
Gradients of hypoxia occur in most solid tumors and cells found in hypoxic regions are associated with the most aggressive and therapy-resistant fractions of... 
Glucose transporter 1 | Hypoxia | BNIP3 | GBE1 | Melanoma | hypoxia | glucose transporter 1 | SUSCEPTIBILITY | METASTASES | melanoma | MELANOGENESIS | PROLIFERATION | CELL BIOLOGY | IMMUNOTHERAPY | SENESCENCE | HIF-1-ALPHA EXPRESSION | T-CELLS | TUMOR OXYGENATION | LYMPHOCYTES
Journal Article
Journal Article
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