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PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0148327 - e0148327
During ER-associated degradation (ERAD), misfolded polytopic membrane proteins are ubiquitinated and retrotranslocated to the cytosol for proteasomal... 
COENZYME-A REDUCTASE | RETICULUM-ASSOCIATED DEGRADATION | PROTEIN-QUALITY CONTROL | MULTIDISCIPLINARY SCIENCES | MAMMALIAN 20S PROTEASOMES | HMG-COA REDUCTASE | ENDOPLASMIC-RETICULUM | MISFOLDED PROTEINS | STEROL-INDUCED DISLOCATION | SACCHAROMYCES-CEREVISIAE | LIGASE | Endoplasmic Reticulum-Associated Degradation | Ubiquitins - genetics | Valosin Containing Protein | Cell Cycle Proteins - metabolism | Adenosine Triphosphatases - metabolism | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | ATP-Binding Cassette Transporters - isolation & purification | Cytosol - chemistry | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Ubiquitination | Chemical Fractionation | Saccharomyces cerevisiae Proteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Cytosol - metabolism | Saccharomyces cerevisiae Proteins - isolation & purification | Subcellular Fractions | Ubiquitins - metabolism | Intracellular Membranes - metabolism | Degeneration (Pathology) | Physiological aspects | Development and progression | Genetic aspects | Research | Ubiquitin-proteasome system | Risk factors | Membrane proteins | Biodegradation | Enzymes | Flotation | Fractionation | Yeast | Polypeptides | Centrifugation | Science | Lipids | Cytosol | Physical properties | Substrates | Degradation | Proteins | Plasmids | Quality control | Proteasomes | Extraction | Localization | Endoplasmic reticulum | Ubiquitin-protein ligase | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2013, Volume 45, Issue 8, pp. 860 - 867
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 4, p. e0175593
Ubiquitin ligase von Hippel-Lindau tumor suppressor (pVHL) negatively regulates protein levels of hypoxia-inducible factor-α (HIF-α). Loss of pVHL causes HIF-α... 
Cell Hypoxia - physiology | Proteasome Inhibitors - pharmacology | Humans | Cell Cycle Proteins - metabolism | Down-Regulation - drug effects | Gene Knockdown Techniques | Cell Nucleus - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Up-Regulation - physiology | HEK293 Cells | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Cell Line, Tumor | Protein Domains | Trans-Activators - metabolism | RNA, Small Interfering | Protein Stability | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Hypoxia-inducible factors | Genetic disorders | Pathogenesis | MYB protein | Homology | Gene expression | Von Hippel-Lindau disease | Proteins | Rodents | Proteasomes | Hypoxia | Tumor suppressor genes | VHL protein | Mutation | Neoplasia | Ubiquitin-protein ligase | Tumors | Avian myeloblastosis | Transcription factors | Downstream effects | Liver | Attachment | Males | Cyclin D1 | Nuclei | Degradation | Angiogenesis | Alterations | Genetics | Inhibition | Vascular endothelial growth factor | Binding | Acinar cells | Splicing | Denaturation | Beta cells | Covalence | Inhibitors | Ribonucleic acids | B-myb gene | Clear cell-type renal cell carcinoma | Kidney transplantation | b-Myb protein | Residues | Genes | Complement | Immunology | Aromatic compounds | Division | Children | Lesions | Alanine | Data processing | Radioactive half-life | Cycloheximide | Lymphocytes B | Females | Cancer
Journal Article
Nature Cell Biology, ISSN 1465-7392, 12/2004, Volume 6, Issue 12, pp. 1229 - 1235
  The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the... 
Physiological aspects | Genetic aspects | Research | Gene expression | Proteolysis | Ligases
Journal Article
Journal Article
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2012, Volume 2, p. 10
The Elongin complex was originally identified as a positive regulator of RNA polymerase II and is composed of a transcriptionally active subunit (A) and two... 
Ubiquitin | ECS complex | SCF complex | Cullin | Elongin
Journal Article
Zairyo/Journal of the Society of Materials Science, Japan, ISSN 0514-5163, 07/2018, Volume 67, Issue 7, pp. 694 - 699
Journal Article
Zairyo, ISSN 0514-5163, 01/2018, Volume 67, Issue 7, p. 694
This paper introduces the evaluation of rolling contact fatigue (RCF) under insufficient lubrication condition for carbonitrided bearing steel, JIS SUJ2. The... 
Axial stress | Heat treatment | Parameters | Bearing steels | X-ray diffraction | Rolling contact | Grain orientation | Carbonitriding | Peeling | Carbon nitride | Retained austenite | Mathematical analysis | Lubrication | Martensite | Residual stress
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2000, Volume 97, Issue 19, pp. 10430 - 10435
Mutations in the VHL tumor suppressor gene result in constitutive expression of many hypoxia-inducible genes, at least in part because of increases in the... 
Proteins | Enzymes | Biological Sciences | Genes | Ubiquitins | Antibodies | Insect viruses | Hypoxia | Cellular immunity | Western blotting | Tumors | DEPENDENT PROTEOLYSIS | PROTEIN | MULTIDISCIPLINARY SCIENCES | ELONGIN-B | SCF | F-BOX | LIGASE COMPLEX | BINDING | SOCS-BOX MOTIF | ENDOTHELIAL GROWTH-FACTOR | FAMILY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2003, Volume 100, Issue 18, pp. 10231 - 10236
Journal Article