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1. Full Text JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
by Schwartz, Daniella M and Kanno, Yuka and Villarino, Alejandro and Ward, Michael and Gadina, Massimo and O'Shea, John J
Nature Reviews Drug Discovery, ISSN 1474-1776, 11/2017, Volume 16, Issue 12, pp. 843 - 862
The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts to target their associated signalling pathways. Janus kinases (JAKs)... 
C-REACTIVE PROTEIN | PHASE 2B TRIAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SPLEEN TYROSINE KINASE | MODIFYING ANTIRHEUMATIC DRUG | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | JANUS KINASE INHIBITOR | ACTIVE RHEUMATOID-ARTHRITIS | CONVENTIONAL SYNTHETIC DMARDS | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | PATIENT-REPORTED OUTCOMES | Humans | Immune System Diseases - drug therapy | Janus Kinases - metabolism | Immune System Diseases - physiopathology | Janus Kinase Inhibitors - adverse effects | Janus Kinase Inhibitors - pharmacology | Animals | Janus Kinase Inhibitors - therapeutic use | Signal Transduction - drug effects | Inflammation - drug therapy | Drug Design | Janus Kinases - drug effects | Cytokines - immunology | Inflammation - physiopathology | Care and treatment | Development and progression | Cellular signal transduction | Genetic aspects | Immunologic diseases | Phosphotransferases | Health aspects | Cytokines | Clinical trials | Inflammatory diseases
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2. Full Text Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease
by Hirahara, Kiyoshi, MD, PhD and Poholek, Amanda, PhD and Vahedi, Golnaz, PhD and Laurence, Arian, PhD, MRCP, FRCPath and Kanno, Yuka, MD, PhD and Milner, Joshua D., MD and O’Shea, John J., MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 131, Issue 5, pp. 1276 - 1287
CD4 helper T cells are critical for proper immune cell homeostasis and host defense but are also major contributors to immune and inflammatory disease. Arising... 
Allergy and Immunology | T-cell plasticity | asthma | histone modification | allergic disease | therapy | epigenetics | IMMUNOLOGY | TRANSCRIPTION FACTOR GATA-3 | ANTI-INTERLEUKIN-17 MONOCLONAL-ANTIBODY | LINEAGE COMMITMENT | ALLERGY | IFN-GAMMA PROMOTER | ALLERGIC-ASTHMA | IN-VIVO | AIRWAY HYPERRESPONSIVENESS | GENOME-WIDE ASSOCIATION | TH17 CELLS | MOLECULAR-MECHANISMS | Immune System Diseases - etiology | Models, Immunological | T-Lymphocytes, Helper-Inducer - metabolism | Gene Expression Regulation - immunology | T-Lymphocytes, Helper-Inducer - immunology | Humans | Immune System Diseases - immunology | T-Lymphocytes, Helper-Inducer - pathology | Cytokines - genetics | Immune System Diseases - pathology | Cytokines - biosynthesis | T cells | Gene expression | Analysis | Transcription factors | Disease | Biology | Genomes | Metabolism | Kinases | Asthma | Studies | Lymphocytes | Epigenetics | Ligands | Influence | Mutation | Binding sites | Deoxyribonucleic acid--DNA | Immune system | T cell plasticity
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3. Full Text GoldiRunx and Remembering Cytotoxic Memory
by Mikami, Yohei and Kanno, Yuka
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 614 - 615
The molecular basis for T cell memory differentiation remains elusive. identify Runx3 as an initiating transcription factor that specifies regulatory regions... 
EFFECTOR | T-CELL DIFFERENTIATION | IMMUNOLOGY | PROTEINS | Chromatin | Cell Differentiation | T-Lymphocytes, Cytotoxic | Transcription Factors | Memory | Gene Expression Regulation | T cells | Cell differentiation | Skin diseases | Pathogens | Memory cells | Immunological memory | Transcription factors | Differentiation (biology) | Cytotoxicity | Infections | T cell receptors | Lymphocytes T | Regulatory sequences | Experiments | T-cell receptor | Lymphocytes | Runx3 protein
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4. Full Text Genomic views of STAT function in CD4 + T helper cell differentiation
by O'Shea, John J and Laurence, Arian and Lahesmaa, Riitta and Vahedi, Golnaz and Kanno, Yuka
Nature Reviews Immunology, ISSN 1474-1733, 04/2011, Volume 11, Issue 4, pp. 239 - 250
Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and... 
HYPER-IGE SYNDROME | SYSTEMIC-LUPUS-ERYTHEMATOSUS | TRANSCRIPTION FACTOR-BINDING | DNA-BINDING | ROR-GAMMA-T | IN-VIVO | GENE-EXPRESSION | WIDE ASSOCIATION | IMMUNOLOGY | MICE LACKING JAK3 | TH17 CELLS | Genome-Wide Association Study | Gene Expression Regulation - immunology | Humans | Nucleosomes - genetics | STAT Transcription Factors - immunology | Signal Transduction - genetics | Sequence Analysis, DNA | Autoimmune Diseases - genetics | Signal Transduction - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | STAT Transcription Factors - genetics | Animals | T-Lymphocytes, Helper-Inducer - immunology | Immunologic Deficiency Syndromes - genetics | Mice | Genomics - methods | Immunologic Deficiency Syndromes - immunology | Nucleosomes - immunology | Cytokines - immunology
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5. Full Text Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought conditions
by Uga, Yusaku and Sugimoto, Kazuhiko and Ogawa, Satoshi and Rane, Jagadish and Ishitani, Manabu and Hara, Naho and Kitomi, Yuka and Inukai, Yoshiaki and Ono, Kazuko and Kanno, Noriko and Inoue, Haruhiko and Takehisa, Hinako and Motoyama, Ritsuko and Nagamura, Yoshiaki and Wu, Jianzhong and Matsumoto, Takashi and Takai, Toshiyuki and Okuno, Kazutoshi and Yano, Masahiro
Nature Genetics, ISSN 1061-4036, 09/2013, Volume 45, Issue 9, pp. 1097 - 1102
The genetic improvement of drought resistance is essential for stable and adequate crop production in drought-prone areas(1). Here we demonstrate that... 
ORYZA-SATIVA L | FIELD | GROWTH | GENETICS & HEREDITY | AUXIN-RESPONSIVE GENE | UPLAND RICE | IDENTIFICATION | EXPRESSION | PHYTOHORMONE | FAMILY | WATER | Genes, Plant | Adaptation, Biological - genetics | Molecular Sequence Data | Plant Roots - genetics | Genotype | Plant Roots - cytology | Gene Expression Regulation, Plant - drug effects | Oryza - growth & development | Phenotype | Oryza - genetics | Droughts | Quantitative Trait Loci | Gene Order | Plant Growth Regulators - pharmacology | Plant Roots - growth & development | Physiological aspects | Crop yields | Hardiness | Genetic aspects | Research | Plants | Proteins | Plasma | Architecture | Cloning | Drought | Gene expression | Experiments | Rice | Cultivars
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6. Full Text Super-enhancers delineate disease-associated regulatory nodes in T cells
by Vahedi, Golnaz and Kanno, Yuka and Furumoto, Yasuko and Jiang, Kan and Parker, Stephen C. J and Erdos, Michael R and Davis, Sean R and Roychoudhuri, Rahul and Restifo, Nicholas P and Gadina, Massimo and Tang, Zhonghui and Ruan, Yijun and Collins, Francis S and Sartorelli, Vittorio and O'Shea, John J
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7548, pp. 558 - 562
Enhancers regulate spatiotemporal gene expression and impart cellspecific transcriptional outputs that drive cell identity'. Super-enhancers (SEs), also known... 
RISK LOCI | METAANALYSIS | IDENTITY GENES | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | SUSCEPTIBILITY LOCI | GENETIC ARCHITECTURE | DIFFERENTIATION | IDENTIFICATION | EXPRESSION | DOMAINS | Genetic Predisposition to Disease - genetics | Basic-Leucine Zipper Transcription Factors - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Pyrimidines - pharmacology | RNA, Untranslated - genetics | Arthritis, Rheumatoid - pathology | Janus Kinase 3 - antagonists & inhibitors | Cell Differentiation - genetics | p300-CBP Transcription Factors - metabolism | Arthritis, Rheumatoid - genetics | Pyrroles - pharmacology | Animals | Piperidines - pharmacology | T-Lymphocytes, Helper-Inducer - immunology | Enhancer Elements, Genetic - genetics | Mice | T-Lymphocytes, Helper-Inducer - pathology | Transcription, Genetic - genetics | Arthritis, Rheumatoid - immunology | Cell Lineage - genetics | Cytokines | Genetic aspects | Single nucleotide polymorphisms | T cells | Gene expression | Health aspects | Identification and classification | Transcription factors | Genomes | Disease | Lymphocytes | Immune system
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7. Full Text Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis
by Durant, Lydia and Watford, Wendy T and Ramos, Haydeé L and Laurence, Arian and Vahedi, Golnaz and Wei, Lai and Takahashi, Hayato and Sun, Hong-Wei and Kanno, Yuka and Powrie, Fiona and O'Shea, John J
Immunity, ISSN 1074-7613, 2010, Volume 32, Issue 5, pp. 605 - 615
STAT3, an essential transcription factor with pleiotropic functions, plays critical roles in the pathogenesis of autoimmunity. Despite recent data linking with... 
SYSBIO | MOLIMMUNO | CELLIMMUNO | Sysbio | Molimmuno | Cellimmuno | HYPER-IGE SYNDROME | INTESTINAL INFLAMMATION | INFLAMMATORY-BOWEL-DISEASE | IN-VIVO | HELPER-CELLS | ROR-GAMMA | DIFFERENTIATION | IMMUNOLOGY | T-H-17 CELLS | GENOME-WIDE ASSOCIATION | TH17 CELLS | Cell Proliferation | Cells, Cultured | Interleukin-17 - immunology | Homeostasis - immunology | Lymphocyte Subsets - immunology | Mice, Knockout | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Animals | Colitis - physiopathology | T-Lymphocytes - cytology | T-Lymphocytes - immunology | Cell Differentiation | Mice | STAT3 Transcription Factor - immunology | Colitis - immunology | Disease Models, Animal | Flow cytometry | Transcription factors | Cytokines | Disease | Pathogenesis | Homeostasis | Genomes | Gene expression | Confidence intervals | Inflammatory bowel disease | Pathology | Rodents | Bone marrow
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8. Full Text Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
by Milner, Joshua D and Brenchley, Jason M and Laurence, Arian and Freeman, Alexandra F and Hill, Brenna J and Elias, Kevin M and Kanno, Yuka and Spalding, Christine and Elloumi, Houda Z and Paulson, Michelle L and Davis, Joie and Hsu, Amy and Asher, Ava I and O'Shea, John and Holland, Steven M and Paul, William E and Douek, Daniel C
Nature, ISSN 0028-0836, 04/2008, Volume 452, Issue 7188, pp. 773 - 776
The autosomal dominant hyper-IgE syndrome (HIES, 'Job's syndrome') is characterized by recurrent and often severe pulmonary infections, pneumatoceles, eczema,... 
Genetics | Infections | Biomedical research | Immunology | Mutation | Cellular biology
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