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1. Full Text PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
by McCormack, Sheena, Dr and Ramjee, Gita, Prof and Kamali, Anatoli, MSc and Rees, Helen, Prof and Crook, Angela M, PhD and Gafos, Mitzy, MSc and Jentsch, Ute, PhD and Pool, Robert, Prof and Chisembele, Maureen, MBBS and Kapiga, Saidi, MD and Mutemwa, Richard, MD and Vallely, Andrew, PhD and Palanee, Thesla, PhD and Sookrajh, Yuki, MBChB and Lacey, Charles J, Prof and Darbyshire, Janet, Prof and Grosskurth, Heiner, Prof and Profy, Albert, PhD and Nunn, Andrew, Prof and Hayes, Richard, DSc and Weber, Jonathan, Prof
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9749, pp. 1329 - 1337
Summary Background Innovative prevention strategies for HIV-1 transmission are urgently needed. PRO2000 vaginal gel was efficacious against HIV-1 transmission... 
Internal Medicine | PRO 2000 GEL | MEDICINE, GENERAL & INTERNAL | VIRUS-INFECTION | INHIBITION | PRO-2000 GEL | EFFICACY | SAFETY | CANDIDATE TOPICAL MICROBICIDES | CONDOMS | ACCEPTABILITY | III TRIAL | HIV-1 | HIV Infections - prevention & control | Polymers - administration & dosage | Sexual Behavior | Double-Blind Method | HIV Infections - epidemiology | Humans | Middle Aged | Sexually Transmitted Diseases - prevention & control | Vaginal Creams, Foams, and Jellies - adverse effects | Antiviral Agents - administration & dosage | Young Adult | Naphthalenesulfonates - administration & dosage | Adolescent | Adult | Female | Naphthalenesulfonates - adverse effects | Condoms - utilization | Polymers - adverse effects | Africa South of the Sahara - epidemiology | Prevention | Antiviral agents | Product development | HIV infection | Anti-HIV agents | Gels (Pharmacy) | Clinics | Drug resistance | Womens health | Human immunodeficiency virus--HIV | Molecular weight | Infection | Vagina | Disease transmission | Gels | microbicides
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2. Full Text Preparedness of Tanzanian health facilities for outpatient primary care of hypertension and diabetes: a cross-sectional survey
by Peck, Robert, Dr and Mghamba, Janneth, MD and Vanobberghen, Fiona, PhD and Kavishe, Bazil, MD and Rugarabamu, Vivian, MD and Smeeth, Liam, Prof and Hayes, Richard, Prof and Grosskurth, Heiner, Prof and Kapiga, Saidi, MD
Lancet Global Health, ISSN 2214-109X, 2014, Volume 2, Issue 5, pp. e285 - e292
Summary Background Historically, health facilities in sub-Saharan Africa have mainly managed acute, infectious diseases. Few data exist for the preparedness of... 
Internal Medicine | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MANAGEMENT | COUNTRIES | THERAPY | SUB-SAHARAN AFRICA | BARRIERS | CHRONIC NONCOMMUNICABLE DISEASES | HIV Infections | Cross-Sectional Studies | Diabetes Mellitus - therapy | Humans | Tanzania | Ambulatory Care Facilities | Cost of Illness | Health Planning | Primary Health Care | Hypertension - therapy | Ambulatory Care
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3. Full Text Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
by Lingappa, Jairam R, Dr and Baeten, Jared M, MD and Wald, Anna, MD and Hughes, James P, PhD and Thomas, Katherine K, MS and Mujugira, Andrew, MBChB and Mugo, Nelly, MBChB and Bukusi, Elizabeth A, MBChB and Cohen, Craig R, MD and Katabira, Elly, MBChB and Ronald, Allan, MD and Kiarie, James, MBChB and Farquhar, Carey, MD and Stewart, Grace John, MD and Makhema, Joseph, MBChB and Essex, Myron, DVM and Were, Edwin, MBChB and Fife, Kenneth H, MD and de Bruyn, Guy, MBBCh and Gray, Glenda E, MBBCh and McIntyre, James A, FRCOG and Manongi, Rachel, MD and Kapiga, Saidi, MD and Coetzee, David, MBBCh and Allen, Susan, MD and Inambao, Mubiana, MBChB and Kayitenkore, Kayitesi, MD and Karita, Etienne, MD and Kanweka, William, MD and Delany, Sinead, MD and Rees, Helen, MBBChir and Vwalika, Bellington, MD and Magaret, Amalia S, PhD and Wang, Richard S, MS and Kidoguchi, Lara, MPH and Barnes, Linda, MHA and Ridzon, Renee, MD and Corey, Lawrence, MD and Celum, Connie, MD and Partners Prevention HSV HIV Transm
Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9717, pp. 824 - 833
Summary Background Most people infected with HIV-1 are dually infected with herpes simplex virus type 2. Daily suppression of this herpes virus reduces plasma... 
Internal Medicine | VIRAL LOAD | CUBIC MILLIMETER | MEDICINE, GENERAL & INTERNAL | COTRIMOXAZOLE PROPHYLAXIS | LINKED-IMMUNOSORBENT-ASSAY | GENITAL HERPES | HIV-1-INFECTED PATIENTS | HUMAN-IMMUNODEFICIENCY-VIRUS | ANTIRETROVIRAL TREATMENT | DISCORDANT COUPLES | TRIMETHOPRIM-SULFAMETHOXAZOLE | Human subjects | Plasma | Disease transmission | Herpes viruses | Human immunodeficiency virus--HIV | Mortality
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4. Full Text Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection
by Francis, Suzanna C and Hou, Yanwen and Baisley, Kathy and Van De Wijgert, Janneke and Watson-Jones, Deborah and Ao, Trong T and Herrera, Carolina and Maganja, Kaballa and Andreasen, Aura and Kapiga, Saidi and Coulton, Gary R and Hayes, Richard J and Shattock, Robin J
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0143109
Soluble cervicovaginal biomarkers of inflammation, immune activation and risk of HIV acquisition are needed to reliably assess the safety of new biomedical... 
HORMONAL CONTRACEPTION | MENSTRUAL-CYCLE | MICROBICIDE SAFETY | TRIAL | VAGINAL FLUID | REPRODUCTIVE-TRACT | SEMINAL FLUID | PROSTATE-SPECIFIC ANTIGEN | MULTIDISCIPLINARY SCIENCES | DOUBLE-BLIND | BACTERIAL VAGINOSIS | HIV Infections - prevention & control | Demography | Cytokines - analysis | Humans | Contraceptives, Oral, Hormonal - administration & dosage | Menstrual Cycle | Vagina - immunology | Risk | Prostate-Specific Antigen - analysis | Young Adult | Reproductive Tract Infections - genetics | Vaginal Douching | Reproductive Tract Infections - diagnosis | Adult | Female | Neisseria gonorrhoeae - genetics | Aniline Compounds - administration & dosage | Leukocytes - cytology | RNA, Ribosomal, 16S - metabolism | Reproductive Tract Infections - microbiology | Cytokines - metabolism | Simplexvirus - genetics | Immunoglobulins - analysis | Neisseria gonorrhoeae - isolation & purification | RNA, Ribosomal, 16S - chemistry | Simplexvirus - isolation & purification | Adolescent | Vagina - virology | RNA, Ribosomal, 16S - genetics | Vagina - metabolism | Hemoglobins - analysis | Hydrogen-Ion Concentration | Reproductive organs, Female | Immune response | Demographic aspects | Physiological aspects | Research | HIV infection | Risk factors | Genital tract | Peptides | Systematic review | Vaccines | Proteins | Contraceptives | Contraceptives (oral) | Human immunodeficiency virus--HIV | Bioindicators | Growth factors | Antiretroviral drugs | Medical research | Antigens | Immunoglobulins | Menstruation | Cytokines | Menstrual cycle | Contraception | Exposure | Ovulation | Disease prevention | Birth control | Biomarkers | Monocyte chemoattractant protein 1 | Plasma | Adaptive systems | Prostate-specific antigen | Immunoglobulin G | Clinical trials | Infections | Activation | Immunoglobulin A | Interleukin 6 | Sexually transmitted diseases | Microbicides | Interleukin 2 | IP-10 protein | Tumor necrosis factor-TNF | Safety | Interleukin 8 | Immune system | Granulocyte-macrophage colony-stimulating factor | Health risks | Feasibility studies | Adenoviruses | Prostate | Chemokines | Human immunodeficiency virus | HIV
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5. Full Text The HIV prevention cascade: integrating theories of epidemiological, behavioural, and social science into programme design and monitoring
by Hargreaves, James R, PhD and Delany-Moretlwe, Sinead, MD and Hallett, Timothy B, Prof and Johnson, Saul, MS and Kapiga, Saidi, ScD and Bhattacharjee, Parinita, MA and Dallabetta, Gina, MD and Garnett, Geoff P, Prof
Lancet HIV, The, ISSN 2352-3018, 2016, Volume 3, Issue 7, pp. e318 - e322
Summary Theories of epidemiology, health behaviour, and social science have changed the understanding of HIV prevention in the past three decades. The HIV... 
Infectious Disease | INFECTIOUS DISEASES | TRANSMISSION | EFFICACY | IMPLEMENTATION | FRAMEWORK | RISK | INFECTION | SEX WORKERS | OPPORTUNITIES | IMMUNOLOGY | STRUCTURAL INTERVENTIONS | CHALLENGES | HIV Infections - prevention & control | Social Sciences | HIV Infections - epidemiology | HIV Infections - virology | Humans | Social Support | Acquired Immunodeficiency Syndrome - prevention & control | Male | Health Knowledge, Attitudes, Practice | Health Behavior | Health Services Needs and Demand | HIV | Acquired Immunodeficiency Syndrome - epidemiology | Preventive Health Services | Adult | Female | HIV Infections - transmission
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6. Full Text Preexposure Prophylaxis for HIV Infection among African Women
by Van Damme, Lut and Corneli, Amy and Ahmed, Khatija and Agot, Kawango and Lombaard, Johan and Kapiga, Saidi and Malahleha, Mookho and Owino, Fredrick and Manongi, Rachel and Onyango, Jacob and Temu, Lucky and Monedi, Modie Constance and Mak'Oketch, Paul and Makanda, Mankalimeng and Reblin, Ilse and Makatu, Shumani Elsie and Saylor, Lisa and Kiernan, Haddie and Kirkendale, Stella and Wong, Christina and Grant, Robert and Kashuba, Angela and Nanda, Kavita and Mandala, Justin and Fransen, Katrien and Deese, Jennifer and Crucitti, Tania and Mastro, Timothy D and Taylor, Douglas and FEM-PrEP Study Grp and FEM-PrEP Study Group
The New England Journal of Medicine, ISSN 0028-4793, 08/2012, Volume 367, Issue 5, pp. 411 - 422
In this study, more than 2000 woman in sub-Saharan Africa at high risk for HIV infection were assigned to receive daily tenofovir plus emtricitabine or placebo... 
MEDICINE, GENERAL & INTERNAL | HIV Infections - prevention & control | HIV Infections - epidemiology | Humans | Drug Resistance, Viral | RNA, Viral - blood | Alanine Transaminase - blood | Case-Control Studies | Viral Load | Incidence | Tenofovir | Young Adult | Deoxycytidine - therapeutic use | Adenine - adverse effects | Adenine - therapeutic use | HIV-1 - isolation & purification | Risk-Taking | Treatment Failure | Adult | Deoxycytidine - adverse effects | Female | Emtricitabine | Anti-Retroviral Agents - therapeutic use | Adenine - analogs & derivatives | Double-Blind Method | HIV Seropositivity | Organophosphonates - therapeutic use | Anti-Retroviral Agents - adverse effects | Kaplan-Meier Estimate | Organophosphonates - adverse effects | Sexual Behavior - statistics & numerical data | HIV-1 - genetics | Medication Adherence | Adolescent | Deoxycytidine - analogs & derivatives | Drug Combinations | Prevention | Drugs | Dose-response relationship (Biochemistry) | Dosage and administration | Product/Service Evaluations | Drug therapy | Women, Black | Health aspects | HIV infection | Diseases | Women | Alanine | Prophylaxis | Infections | Nausea | Seroconversion | Disease prevention | Vomiting | Consent | Human immunodeficiency virus--HIV | Alanine transaminase
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7. Full Text Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
by Xueling Wu and Tongqing Zhou and Jiang Zhu and Baoshan Zhang and Ivelin Georgiev and Charlene Wang and Xuejun Chen and Nancy S. Longo and Mark Louder and Krisha McKee and Sijy O'Dell and Stephen Perfetto and Stephen D. Schmidt and Wei Shi and Lan Wu and Yongping Yang and Zhi-Yong Yang and Zhongjia Yang and Zhenhai Zhang and Mattia Bonsignori and John A. Crump and Saidi H. Kapiga and Noel E. Sam and Barton F. Haynes and Melissa Simek and Dennis R. Burton and Wayne C. Koff and Nicole A. Doria-Rose and Mark Connors and James C. Mullikin and Gary J. Nabel and Mario Roederer and Lawrence Shapiro and Peter D. Kwong and John R. Mascola and NISC Comparative Sequencing Progra and NISC Comparative Sequencing Program and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Science, ISSN 0036-8075, 9/2011, Volume 333, Issue 6049, pp. 1593 - 1602
Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used... 
Germ cells | Neutralizing antibodies | B lymphocytes | RESEARCH ARTICLES | Genomics | Alleles | Antibodies | Phylogenetics | Epitopes | HIV 1 | High throughput nucleotide sequencing | DESIGN | DOMAIN | EPITOPE | MULTIDISCIPLINARY SCIENCES | BROAD | DIVERSITY | GLYCOPROTEIN | GP120 | MONOCLONAL-ANTIBODIES | SELECTION | BREADTH | Antibody Specificity | Complementarity Determining Regions - genetics | Humans | Immunoglobulin Heavy Chains - chemistry | Molecular Sequence Data | Crystallography, X-Ray | HIV Antibodies - isolation & purification | HIV Envelope Protein gp120 - metabolism | Genes, Immunoglobulin Heavy Chain | HIV Envelope Protein gp120 - immunology | Immunoglobulin Light Chains - chemistry | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Immunoglobulin J-Chains - genetics | Base Sequence | HIV Envelope Protein gp120 - chemistry | Binding Sites | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Light Chains - immunology | Amino Acid Sequence | Models, Molecular | Antibody Affinity | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | Sequence Analysis, DNA | Antibodies, Neutralizing - isolation & purification | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | AIDS Vaccines | High-Throughput Nucleotide Sequencing | HIV Antibodies - genetics | Immunoglobulin Fab Fragments - immunology | Mutation | Binding Sites, Antibody | CD4 Antigens - metabolism | Evolution, Molecular | Viral antibodies | X-ray crystallography | Immunoglobulins | Physiological aspects | Genetic aspects | HIV (Viruses) | Health aspects | Methods | ANTIBODIES | IMMUNITY | BASIC BIOLOGICAL SCIENCES | GENETICS | IMMUNOGLOBULINS | CRYSTAL STRUCTURE | CRYSTALLOGRAPHY | CHAINS | 60 APPLIED LIFE SCIENCES | FUNCTIONALS
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8. Full Text Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women
by Nel, Annalene and van Niekerk, Neliëtte and Kapiga, Saidi and Bekker, Linda-Gail and Gama, Cynthia and Gill, Katherine and Kamali, Anatoli and Kotze, Philip and Louw, Cheryl and Mabude, Zonke and Miti, Nokuthula and Kusemererwa, Sylvia and Tempelman, Hugo and Carstens, Hannelie and Devlin, Brid and Isaacs, Michelle and Malherbe, Mariëtte and Mans, Winel and Nuttall, Jeremy and Russell, Marisa and Ntshele, Smangaliso and Smit, Marlie and Solai, Leonard and Spence, Patrick and Steytler, John and Windle, Kathleen and Borremans, Maarten and Resseler, Sophie and Van Roey, Jens and Parys, Wim and Vangeneugden, Tony and Van Baelen, Ben and Rosenberg, Zeda and Ring Study Team
The New England Journal of Medicine, ISSN 0028-4793, 12/2016, Volume 375, Issue 22, pp. 2133 - 2143
Preventing HIV-1 infection, especially with female-controlled approaches, is a high priority. In this trial in South Africa and Uganda, a dapivirine vaginal... 
MEDICINE, GENERAL & INTERNAL | INFECTION | PREEXPOSURE PROPHYLAXIS | ADHERENCE | HIV Infections - prevention & control | Double-Blind Method | HIV Seropositivity | Pyrimidines - administration & dosage | HIV Infections - epidemiology | Humans | Middle Aged | South Africa - epidemiology | Drug Resistance, Viral | Uganda - epidemiology | Vagina | RNA, Viral - blood | Reverse Transcriptase Inhibitors - administration & dosage | Incidence | Pregnancy | Reverse Transcriptase Inhibitors - adverse effects | Young Adult | HIV-1 - isolation & purification | Adolescent | Pyrimidines - adverse effects | Adult | Female | Women | Drug delivery devices | Prevention | Safety and security measures | HIV (Viruses) | Health aspects | Disease prevention | Antiretroviral drugs | Microbicides | Human immunodeficiency virus--HIV | Patient safety | Safety | Seroconversion | Age | Viral infections
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9. Full Text Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
by McLellan, Jason S and Pancera, Marie and Carrico, Chris and Gorman, Jason and Julien, Jean-Philippe and Khayat, Reza and Louder, Robert and Pejchal, Robert and Sastry, Mallika and Dai, Kaifan and O'Dell, Sijy and Patel, Nikita and Shahzad-Ul-Hussan, Syed and Yang, Yongping and Zhang, Baoshan and Zhou, Tongqing and Zhu, Jiang and Boyington, Jeffrey C and Chuang, Gwo-Yu and Diwanji, Devan and Georgiev, Ivelin and Do Kwon, Young and Lee, Doyung and Louder, Mark K and Moquin, Stephanie and Schmidt, Stephen D and Yang, Zhi-Yong and Bonsignori, Mattia and Crump, John A and Kapiga, Saidi H and Sam, Noel E and Haynes, Barton F and Burton, Dennis R and Koff, Wayne C and Walker, Laura M and Phogat, Sanjay and Wyatt, Richard and Orwenyo, Jared and Wang, Lai-Xi and Arthos, James and Bewley, Carole A and Mascola, John R and Nabel, Gary J and Schief, William R and Ward, Andrew B and Wilson, Ian A and Kwong, Peter D and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Nature, ISSN 0028-0836, 12/2011, Volume 480, Issue 7377, pp. 336 - 343
Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody... 
SYSTEM | POTENT NEUTRALIZATION | DEXTRAN SULFATE | EPITOPE | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | ENVELOPE GLYCOPROTEIN | RECEPTOR | BINDING | T-CELLS | SOFTWARE | AIDS Vaccines - immunology | Glycopeptides - chemistry | Molecular Sequence Data | Antibody Affinity - immunology | Crystallography, X-Ray | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | Glycopeptides - immunology | Antibody Specificity - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Protein Structure, Quaternary | Conserved Sequence | Polysaccharides - chemistry | HIV Envelope Protein gp120 - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Binding Sites, Antibody - immunology | Models, Molecular | Glycosylation | Polysaccharides - immunology | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Amino Acid Motifs | HIV-1 - immunology | Immune Evasion | Hydrogen Bonding | Antigen-Antibody Complex - chemistry | Antibodies, Neutralizing - chemistry | Epitopes - chemistry | Antigen-Antibody Complex - immunology | Viral envelopes | Genetic aspects | Research | HIV (Viruses) | Structure | Binding sites (Biochemistry) | Proteins | Crystals | Vaccines | ANTIBODIES | AIDS VIRUS | BASIC BIOLOGICAL SCIENCES | AFFINITY | BIOLOGY | GLYCOPROTEINS | VULNERABILITY | ANTIGENS | IMMUNOLOGY | 60 APPLIED LIFE SCIENCES
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