Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 13624
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural...
BRAIN-REGIONS | COMMON VARIANTS | METAANALYSIS | TEMPORAL-LOBE EPILEPSY | MEMORY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | BIPOLAR DISORDER | SUBFIELDS | GENOME-WIDE ASSOCIATION | Glycoproteins - genetics | Alzheimer Disease - physiopathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Protein-Serine-Threonine Kinases - genetics | Organ Size | Dipeptidyl Peptidase 4 - genetics | Male | Genetic Loci | Methionine Sulfoxide Reductases - genetics | Nerve Tissue Proteins - genetics | Young Adult | Adolescent | Aged, 80 and over | Adult | Female | Aged | Alzheimer Disease - genetics | Child | Hippocampus - growth & development | Cohort Studies | Neuroscience | Cognitive science | Basic Medicine | Medical Genetics | Medicinsk genetik | Biological Sciences | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Natural Sciences | Bioinformatik och systembiologi | Bioinformatics and Systems Biology
BRAIN-REGIONS | COMMON VARIANTS | METAANALYSIS | TEMPORAL-LOBE EPILEPSY | MEMORY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | BIPOLAR DISORDER | SUBFIELDS | GENOME-WIDE ASSOCIATION | Glycoproteins - genetics | Alzheimer Disease - physiopathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Protein-Serine-Threonine Kinases - genetics | Organ Size | Dipeptidyl Peptidase 4 - genetics | Male | Genetic Loci | Methionine Sulfoxide Reductases - genetics | Nerve Tissue Proteins - genetics | Young Adult | Adolescent | Aged, 80 and over | Adult | Female | Aged | Alzheimer Disease - genetics | Child | Hippocampus - growth & development | Cohort Studies | Neuroscience | Cognitive science | Basic Medicine | Medical Genetics | Medicinsk genetik | Biological Sciences | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Natural Sciences | Bioinformatik och systembiologi | Bioinformatics and Systems Biology
Journal Article
Neuron, ISSN 0896-6273, 06/2015, Volume 86, Issue 5, pp. 1189 - 1202
Depression risk is exacerbated by genetic factors and stress exposure; however, the biological mechanisms through which these factors interact to confer...
LIFE EVENTS | EXPRESSION | NEUROSCIENCES | Gene Regulatory Networks - genetics | Humans | Mice, Inbred C57BL | Risk Factors | Male | Transcriptome - genetics | Brain - physiology | Forecasting | Stress, Psychological - diagnosis | Mental Disorders - genetics | Stress, Psychological - genetics | Animals | Polymorphism, Single Nucleotide - genetics | Genetic Variation - genetics | Mice | Mental Disorders - diagnosis | Cohort Studies | Animal experimentation | Medicine, Experimental | Brain | Medical research | Corticosteroids | Depression, Mental | Neurosciences | Neural circuitry | Genomics | Genetic research | Single nucleotide polymorphisms | Genetic transcription | Attention deficit disorder | Working groups | Gene expression | Risk factors | Binding sites
LIFE EVENTS | EXPRESSION | NEUROSCIENCES | Gene Regulatory Networks - genetics | Humans | Mice, Inbred C57BL | Risk Factors | Male | Transcriptome - genetics | Brain - physiology | Forecasting | Stress, Psychological - diagnosis | Mental Disorders - genetics | Stress, Psychological - genetics | Animals | Polymorphism, Single Nucleotide - genetics | Genetic Variation - genetics | Mice | Mental Disorders - diagnosis | Cohort Studies | Animal experimentation | Medicine, Experimental | Brain | Medical research | Corticosteroids | Depression, Mental | Neurosciences | Neural circuitry | Genomics | Genetic research | Single nucleotide polymorphisms | Genetic transcription | Attention deficit disorder | Working groups | Gene expression | Risk factors | Binding sites
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0135807
Background Currently, limited data of the outcome of inflammatory bowel disease (IBD) in patients after solid organ transplantation (SOT) are available. We...
HEMOLYTIC-UREMIC SYNDROME | RISK-FACTORS | CROHNS-DISEASE | KIDNEY-TRANSPLANTATION | ORTHOTOPIC LIVER-TRANSPLANTATION | IMMUNOSUPPRESSION | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | CASE SERIES | CLINICAL-COURSE | PRIMARY SCLEROSING CHOLANGITIS | Liver Transplantation - adverse effects | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Heart Transplantation - adverse effects | Male | Survival Rate | Treatment Outcome | Colitis, Ulcerative - pathology | Tacrolimus - therapeutic use | Immunosuppression | Crohn Disease - pathology | Crohn Disease - drug therapy | Adult | Female | Aged | Colitis, Ulcerative - drug therapy | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Kidney Transplantation - adverse effects | Heart | Care and treatment | Immunotherapy | Analysis | Patient outcomes | Liver | Transplantation | Liver cirrhosis | Ulcerative colitis | Therapy | Inflammatory bowel diseases | Nephrology | Transplants & implants | Syngeneic grafts | Clinical trials | Immunosuppressive agents | Intestine | Hepatology | Gastroenterology | Remission | Tumor necrosis factor-TNF | Liver diseases | Heart transplantation | Cholangitis | Disease control | Patients | Crohns disease | Inflammatory bowel disease | Heart rate | Medicine | Studies | Cirrhosis | Tacrolimus | Tumor necrosis factor | Surgeons | Liver transplantation | Kidney transplantation
HEMOLYTIC-UREMIC SYNDROME | RISK-FACTORS | CROHNS-DISEASE | KIDNEY-TRANSPLANTATION | ORTHOTOPIC LIVER-TRANSPLANTATION | IMMUNOSUPPRESSION | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | CASE SERIES | CLINICAL-COURSE | PRIMARY SCLEROSING CHOLANGITIS | Liver Transplantation - adverse effects | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Heart Transplantation - adverse effects | Male | Survival Rate | Treatment Outcome | Colitis, Ulcerative - pathology | Tacrolimus - therapeutic use | Immunosuppression | Crohn Disease - pathology | Crohn Disease - drug therapy | Adult | Female | Aged | Colitis, Ulcerative - drug therapy | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Kidney Transplantation - adverse effects | Heart | Care and treatment | Immunotherapy | Analysis | Patient outcomes | Liver | Transplantation | Liver cirrhosis | Ulcerative colitis | Therapy | Inflammatory bowel diseases | Nephrology | Transplants & implants | Syngeneic grafts | Clinical trials | Immunosuppressive agents | Intestine | Hepatology | Gastroenterology | Remission | Tumor necrosis factor-TNF | Liver diseases | Heart transplantation | Cholangitis | Disease control | Patients | Crohns disease | Inflammatory bowel disease | Heart rate | Medicine | Studies | Cirrhosis | Tacrolimus | Tumor necrosis factor | Surgeons | Liver transplantation | Kidney transplantation
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33682
Background: Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel...
INSULIN-RECEPTOR | INFLAMMATORY-BOWEL-DISEASE | ATG16L1 | IL23R | MULTIDISCIPLINARY SCIENCES | LOCI | CARD15 | IDENTIFICATION | PROTEIN-TYROSINE-PHOSPHATASE | GENOME-WIDE ASSOCIATION | CELIAC-DISEASE | Tyrosine | Phosphatases | Analysis | Gastrointestinal diseases | Genetic aspects | Disease susceptibility | DNA binding proteins | Colitis | Inflammatory bowel diseases | Transcription factors | Epithelial cells | Epistasis | Genomes | Single-nucleotide polymorphism | CCAAT/enhancer-binding protein | Kinases | Phosphatase | Autophagy | Small intestine | Proteins | Genotype & phenotype | Intestine | Trends | Deoxyribonucleic acid--DNA | NOD2 protein | NF-κB protein | Cytokines | Crohn's disease | Dentistry | Gene expression | Patients | Crohns disease | Inflammatory bowel disease | Disease prevention | Medicine | Studies | Celiac disease | GATA-3 protein | Gene loci | Diabetes | Binding sites | Ulcerative colitis | Protein-tyrosine-phosphatase | PTPN2 protein | Deoxyribonucleic acid | DNA
INSULIN-RECEPTOR | INFLAMMATORY-BOWEL-DISEASE | ATG16L1 | IL23R | MULTIDISCIPLINARY SCIENCES | LOCI | CARD15 | IDENTIFICATION | PROTEIN-TYROSINE-PHOSPHATASE | GENOME-WIDE ASSOCIATION | CELIAC-DISEASE | Tyrosine | Phosphatases | Analysis | Gastrointestinal diseases | Genetic aspects | Disease susceptibility | DNA binding proteins | Colitis | Inflammatory bowel diseases | Transcription factors | Epithelial cells | Epistasis | Genomes | Single-nucleotide polymorphism | CCAAT/enhancer-binding protein | Kinases | Phosphatase | Autophagy | Small intestine | Proteins | Genotype & phenotype | Intestine | Trends | Deoxyribonucleic acid--DNA | NOD2 protein | NF-κB protein | Cytokines | Crohn's disease | Dentistry | Gene expression | Patients | Crohns disease | Inflammatory bowel disease | Disease prevention | Medicine | Studies | Celiac disease | GATA-3 protein | Gene loci | Diabetes | Binding sites | Ulcerative colitis | Protein-tyrosine-phosphatase | PTPN2 protein | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e64872
Patients with schizophrenia and their siblings typically show subtle changes of brain structures, such as a reduction of hippocampal volume. Hippocampal volume...
HUMAN CEREBRAL-CORTEX | GENE | DATA QUALITY-CONTROL | HIPPOCAMPAL ATROPHY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | QUANTITATIVE TRAIT | STRUCTURAL MRI | PSYCHOTIC DISORDERS | VERBAL MEMORY | BIPOLAR DISORDER | Genome-Wide Association Study | Schizophrenia - metabolism | Humans | Gene Expression Regulation | Male | Gene Expression Profiling | Genetic Loci | Schizophrenia - diagnostic imaging | Hippocampus - diagnostic imaging | Hippocampus - metabolism | Schizophrenia - genetics | Adolescent | Female | Polymorphism, Single Nucleotide | Brain | Nervous system diseases | Genetic markers | Genomics | Genes | Schizophrenia | Genetic aspects | Genomes | Single nucleotide polymorphisms | Gene expression | Chromosome 19 | Neuroimaging | Adolescence | Mental disorders | Pathogenesis | Memory | Cognitive ability | Single-nucleotide polymorphism | Epidemiology | Consortia | Genotype & phenotype | Genetics | Neuropsychology | Adolescents | Siblings | Brain architecture | Medical imaging | Computer engineering | Interdisciplinary aspects | Chromosome 1 | Studies | Brain research | Hospitals | Alzheimers disease | Health informatics | Hippocampus | Child & adolescent psychiatry
HUMAN CEREBRAL-CORTEX | GENE | DATA QUALITY-CONTROL | HIPPOCAMPAL ATROPHY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | QUANTITATIVE TRAIT | STRUCTURAL MRI | PSYCHOTIC DISORDERS | VERBAL MEMORY | BIPOLAR DISORDER | Genome-Wide Association Study | Schizophrenia - metabolism | Humans | Gene Expression Regulation | Male | Gene Expression Profiling | Genetic Loci | Schizophrenia - diagnostic imaging | Hippocampus - diagnostic imaging | Hippocampus - metabolism | Schizophrenia - genetics | Adolescent | Female | Polymorphism, Single Nucleotide | Brain | Nervous system diseases | Genetic markers | Genomics | Genes | Schizophrenia | Genetic aspects | Genomes | Single nucleotide polymorphisms | Gene expression | Chromosome 19 | Neuroimaging | Adolescence | Mental disorders | Pathogenesis | Memory | Cognitive ability | Single-nucleotide polymorphism | Epidemiology | Consortia | Genotype & phenotype | Genetics | Neuropsychology | Adolescents | Siblings | Brain architecture | Medical imaging | Computer engineering | Interdisciplinary aspects | Chromosome 1 | Studies | Brain research | Hospitals | Alzheimers disease | Health informatics | Hippocampus | Child & adolescent psychiatry
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e109290
textabstractGenome-wide association studies (GWAS) have revealed 74 single nucleotide polymorphisms (SNPs) associated with high-density lipoprotein cholesterol...
RISK | LOCI | DNA METHYLATION | CORONARY-HEART-DISEASE | MULTIDISCIPLINARY SCIENCES | Genome-Wide Association Study | Humans | Middle Aged | Cholesterol, HDL - blood | Female | Male | Polymorphism, Single Nucleotide | Genomes | Single nucleotide polymorphisms | Chromosomes | Analysis | Genomics | Cholesterol | Biometrics | Heart | Demography | Laboratories | Graphics processing units | Lipids | Cardiovascular disease | Single-nucleotide polymorphism | Epidemiology | Blood | Research methodology | DNA methylation | Lipoproteins (high density) | Public health | Deoxyribonucleic acid--DNA | Medical research | Departments | Filtration | Internal medicine | Regression analysis | Blood levels | Medicine | Studies | Gene loci | Software | Psychiatry | Deoxyribonucleic acid | DNA
RISK | LOCI | DNA METHYLATION | CORONARY-HEART-DISEASE | MULTIDISCIPLINARY SCIENCES | Genome-Wide Association Study | Humans | Middle Aged | Cholesterol, HDL - blood | Female | Male | Polymorphism, Single Nucleotide | Genomes | Single nucleotide polymorphisms | Chromosomes | Analysis | Genomics | Cholesterol | Biometrics | Heart | Demography | Laboratories | Graphics processing units | Lipids | Cardiovascular disease | Single-nucleotide polymorphism | Epidemiology | Blood | Research methodology | DNA methylation | Lipoproteins (high density) | Public health | Deoxyribonucleic acid--DNA | Medical research | Departments | Filtration | Internal medicine | Regression analysis | Blood levels | Medicine | Studies | Gene loci | Software | Psychiatry | Deoxyribonucleic acid | DNA
Journal Article
Human Heredity, ISSN 0001-5652, 09/2012, Volume 73, Issue 4, pp. 220 - 236
Due to recent advances in genotyping technologies, mapping phenotypes to single loci in the genome has become a standard technique in statistical genetics....
Original Paper | Epistasis | Genome-wide interaction analysis | Graphics processing units | Computational biology | SUSCEPTIBILITY | HIPPOCAMPAL | LOCI | MAJOR DEPRESSION | IDENTIFICATION | GENES | GENETICS & HEREDITY | DIVERSITY | COMPLEX DISEASES | ASSOCIATION | EXPRESSION | Computational Biology - methods | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Humans | Organ Size | Linear Models | Genetic Loci | Bipolar Disorder - diagnosis | Bipolar Disorder - genetics | Phenotype | Genetics, Population - methods | Time Factors | Epistasis, Genetic | Chromosome Mapping - methods | Hippocampus - anatomy & histology | Polymorphism, Single Nucleotide | Bipolar Disorder - epidemiology | Databases, Factual | Genotype & phenotype | Gene loci | Heredity | Disease | Genomics
Original Paper | Epistasis | Genome-wide interaction analysis | Graphics processing units | Computational biology | SUSCEPTIBILITY | HIPPOCAMPAL | LOCI | MAJOR DEPRESSION | IDENTIFICATION | GENES | GENETICS & HEREDITY | DIVERSITY | COMPLEX DISEASES | ASSOCIATION | EXPRESSION | Computational Biology - methods | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Humans | Organ Size | Linear Models | Genetic Loci | Bipolar Disorder - diagnosis | Bipolar Disorder - genetics | Phenotype | Genetics, Population - methods | Time Factors | Epistasis, Genetic | Chromosome Mapping - methods | Hippocampus - anatomy & histology | Polymorphism, Single Nucleotide | Bipolar Disorder - epidemiology | Databases, Factual | Genotype & phenotype | Gene loci | Heredity | Disease | Genomics
Journal Article
Genome Research, ISSN 1088-9051, 2014, Volume 24, Issue 4, pp. 592 - 603
Genome-wide association studies (GWAS) identified the MEIS1 locus for Restless Legs Syndrome (RLS), but causal single nucleotide polymorphisms (SNPs) and their...
VISUALIZATION | TRANSCRIPTION FACTOR-BINDING | NONCODING SEQUENCES | BIOCHEMISTRY & MOLECULAR BIOLOGY | LABEL-FREE | CONSERVATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOTOR RESTLESSNESS | DNA | DISEASE | GENETICS & HEREDITY | CHROMATIN INTERACTIONS | GENOME-WIDE ASSOCIATION | Genome-Wide Association Study | Introns | Basal Ganglia - metabolism | Basal Ganglia - pathology | Homeodomain Proteins - genetics | Restless Legs Syndrome - genetics | Animals | Enhancer Elements, Genetic | Telencephalon - growth & development | Telencephalon - pathology | Alleles | Mice | Polymorphism, Single Nucleotide | Myeloid Ecotropic Viral Integration Site 1 Protein | Neoplasm Proteins - genetics | Disease Models, Animal | Restless legs syndrome | Genetic variation | Telencephalon | Physiological aspects | Genetic aspects | Research | Risk factors
VISUALIZATION | TRANSCRIPTION FACTOR-BINDING | NONCODING SEQUENCES | BIOCHEMISTRY & MOLECULAR BIOLOGY | LABEL-FREE | CONSERVATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOTOR RESTLESSNESS | DNA | DISEASE | GENETICS & HEREDITY | CHROMATIN INTERACTIONS | GENOME-WIDE ASSOCIATION | Genome-Wide Association Study | Introns | Basal Ganglia - metabolism | Basal Ganglia - pathology | Homeodomain Proteins - genetics | Restless Legs Syndrome - genetics | Animals | Enhancer Elements, Genetic | Telencephalon - growth & development | Telencephalon - pathology | Alleles | Mice | Polymorphism, Single Nucleotide | Myeloid Ecotropic Viral Integration Site 1 Protein | Neoplasm Proteins - genetics | Disease Models, Animal | Restless legs syndrome | Genetic variation | Telencephalon | Physiological aspects | Genetic aspects | Research | Risk factors
Journal Article
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Full Text
GWAS for executive function and processing speed suggests involvement of the CADM2 gene
Molecular Psychiatry, ISSN 1359-4184, 02/2016, Volume 21, Issue 2, pp. 189 - 197
textabstractTo identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide...
COMMON VARIANTS | METAANALYSIS | PSYCHIATRY | PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCE | SCHIZOPHRENIA | LOCI | NEUROSCIENCES | COGNITIVE FUNCTION | LINKAGE ANALYSIS | EXPRESSION | GENOME-WIDE ASSOCIATION | gamma-Aminobutyric Acid | Cell Adhesion Molecules - genetics | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Cell Adhesion Molecules - physiology | Genetic Association Studies | Introns | Genomics | Humans | Middle Aged | Male | Executive Function - physiology | Neuropsychological Tests | Aged, 80 and over | Cognition - physiology | Female | Aged | Genetic Variation - genetics | Polymorphism, Single Nucleotide | Cohort Studies | GABA | Physiological aspects | Genetic aspects | Single nucleotide polymorphisms | Research | Diagnosis | Dementia
COMMON VARIANTS | METAANALYSIS | PSYCHIATRY | PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCE | SCHIZOPHRENIA | LOCI | NEUROSCIENCES | COGNITIVE FUNCTION | LINKAGE ANALYSIS | EXPRESSION | GENOME-WIDE ASSOCIATION | gamma-Aminobutyric Acid | Cell Adhesion Molecules - genetics | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Cell Adhesion Molecules - physiology | Genetic Association Studies | Introns | Genomics | Humans | Middle Aged | Male | Executive Function - physiology | Neuropsychological Tests | Aged, 80 and over | Cognition - physiology | Female | Aged | Genetic Variation - genetics | Polymorphism, Single Nucleotide | Cohort Studies | GABA | Physiological aspects | Genetic aspects | Single nucleotide polymorphisms | Research | Diagnosis | Dementia
Journal Article